Reviews Verelan PM


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Verelan PM Drug Description
Verelan PM
(verapamil hydrochloride) Extended-Release Capsules for Oral use
DRUG DESCRIPTION



What are the possible side effects of verapamil?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fast or slow heartbeats;
feeling like you might pass out;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;...
Read All Potential Side Effects for Verelan PM »




Verelan PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow
channel blocker or calcium ion antagonist). Verelan PM is available for oral
administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body),
a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a
300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is
administered as a racemic mixture of the R and S enantiomers.
The structural formulae of the verapamil HC1 enantiomers are:








C27H38N204•HCl          
M.W.=491.07
Chemical name: Benzeneacetonitrile, α-[3-[[2-(3, 4dimethoxyphenyl)ethyl]methylamino]propyl]-
3, 4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (±)-.
Verapamil HCl is an almost white, crystalline powder, practically free of odor,
with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil
HCl is not structurally related to other cardioactive drugs.
In addition to verapamil HCl the Verelan PM capsule contains the following
inactive ingredients: D&C Red #28, FD & C Blue #1, FD&C red #40,
fumaric acid, gelatin, povidone, shellac, silicon dioxide, sodium lauryl sulfate,
starch, sugar spheres, talc, and titanium dioxide.
System Components and Performance: Verelan PM uses the proprietary
CODAS® (Chronotherapeutic Oral Drug Absorption System) technology, which
is designed for bedtime dosing, incorporating a 4 to 5-hour delay in drug delivery.
The controlled-onset delivery system results in a maximum plasma concentration
(Cmax) of verapamil in the morning hours. These pellet filled capsules provide
for extended-release of the drug in the gastrointestinal tract. The Verelan
PM formulation has been designed to initiate the release of verapamil 4-5 hours
after ingestion. This delay is introduced by the level of non-enteric release-controlling
polymer applied to drug loaded beads. The release-controlling polymer is a combination
of water soluble and water insoluble polymers. As water from the gastrointestinal
tract comes into contact with the polymer coated beads, the water soluble polymer
slowly dissolves and the drug diffuses through the resulting pores in the coating.
The water insoluble polymer continues to act as a barrier, maintaining the controlled
release of the drug. The rate of release is essentially independent of pH, posture
and food. Multiparticulate systems such as Verelan PM have been shown to be
independent of gastrointestinal motility.Last reviewed on RxList: 4/28/2010




Verelan PM Drug Description
Verelan PM
(verapamil hydrochloride) Extended-Release Capsules for Oral use
DRUG DESCRIPTION



What are the possible side effects of verapamil?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fast or slow heartbeats;
feeling like you might pass out;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;...
Read All Potential Side Effects for Verelan PM »




Verelan PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow
channel blocker or calcium ion antagonist). Verelan PM is available for oral
administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body),
a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a
300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is
administered as a racemic mixture of the R and S enantiomers.
The structural formulae of the verapamil HC1 enantiomers are:








C27H38N204•HCl          
M.W.=491.07
Chemical name: Benzeneacetonitrile, α-[3-[[2-(3, 4dimethoxyphenyl)ethyl]methylamino]propyl]-
3, 4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (±)-.
Verapamil HCl is an almost white, crystalline powder, practically free of odor,
with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil
HCl is not structurally related to other cardioactive drugs.
In addition to verapamil HCl the Verelan PM capsule contains the following
inactive ingredients: D&C Red #28, FD & C Blue #1, FD&C red #40,
fumaric acid, gelatin, povidone, shellac, silicon dioxide, sodium lauryl sulfate,
starch, sugar spheres, talc, and titanium dioxide.
System Components and Performance: Verelan PM uses the proprietary
CODAS® (Chronotherapeutic Oral Drug Absorption System) technology, which
is designed for bedtime dosing, incorporating a 4 to 5-hour delay in drug delivery.
The controlled-onset delivery system results in a maximum plasma concentration
(Cmax) of verapamil in the morning hours. These pellet filled capsules provide
for extended-release of the drug in the gastrointestinal tract. The Verelan
PM formulation has been designed to initiate the release of verapamil 4-5 hours
after ingestion. This delay is introduced by the level of non-enteric release-controlling
polymer applied to drug loaded beads. The release-controlling polymer is a combination
of water soluble and water insoluble polymers. As water from the gastrointestinal
tract comes into contact with the polymer coated beads, the water soluble polymer
slowly dissolves and the drug diffuses through the resulting pores in the coating.
The water insoluble polymer continues to act as a barrier, maintaining the controlled
release of the drug. The rate of release is essentially independent of pH, posture
and food. Multiparticulate systems such as Verelan PM have been shown to be
independent of gastrointestinal motility.Last reviewed on RxList: 4/28/2010




Verelan PM Drug Description
Verelan PM
(verapamil hydrochloride) Extended-Release Capsules for Oral use
DRUG DESCRIPTION



What are the possible side effects of verapamil?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fast or slow heartbeats;
feeling like you might pass out;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;...
Read All Potential Side Effects for Verelan PM »




Verelan PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow
channel blocker or calcium ion antagonist). Verelan PM is available for oral
administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body),
a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a
300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is
administered as a racemic mixture of the R and S enantiomers.
The structural formulae of the verapamil HC1 enantiomers are:








C27H38N204•HCl          
M.W.=491.07
Chemical name: Benzeneacetonitrile, α-[3-[[2-(3, 4dimethoxyphenyl)ethyl]methylamino]propyl]-
3, 4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (±)-.
Verapamil HCl is an almost white, crystalline powder, practically free of odor,
with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil
HCl is not structurally related to other cardioactive drugs.
In addition to verapamil HCl the Verelan PM capsule contains the following
inactive ingredients: D&C Red #28, FD & C Blue #1, FD&C red #40,
fumaric acid, gelatin, povidone, shellac, silicon dioxide, sodium lauryl sulfate,
starch, sugar spheres, talc, and titanium dioxide.
System Components and Performance: Verelan PM uses the proprietary
CODAS® (Chronotherapeutic Oral Drug Absorption System) technology, which
is designed for bedtime dosing, incorporating a 4 to 5-hour delay in drug delivery.
The controlled-onset delivery system results in a maximum plasma concentration
(Cmax) of verapamil in the morning hours. These pellet filled capsules provide
for extended-release of the drug in the gastrointestinal tract. The Verelan
PM formulation has been designed to initiate the release of verapamil 4-5 hours
after ingestion. This delay is introduced by the level of non-enteric release-controlling
polymer applied to drug loaded beads. The release-controlling polymer is a combination
of water soluble and water insoluble polymers. As water from the gastrointestinal
tract comes into contact with the polymer coated beads, the water soluble polymer
slowly dissolves and the drug diffuses through the resulting pores in the coating.
The water insoluble polymer continues to act as a barrier, maintaining the controlled
release of the drug. The rate of release is essentially independent of pH, posture
and food. Multiparticulate systems such as Verelan PM have been shown to be
independent of gastrointestinal motility.Last reviewed on RxList: 4/28/2010




Verelan PM Drug Description
Verelan PM
(verapamil hydrochloride) Extended-Release Capsules for Oral use
DRUG DESCRIPTION



What are the possible side effects of verapamil?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fast or slow heartbeats;
feeling like you might pass out;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;...
Read All Potential Side Effects for Verelan PM »




Verelan PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow
channel blocker or calcium ion antagonist). Verelan PM is available for oral
administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body),
a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a
300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is
administered as a racemic mixture of the R and S enantiomers.
The structural formulae of the verapamil HC1 enantiomers are:








C27H38N204•HCl          
M.W.=491.07
Chemical name: Benzeneacetonitrile, α-[3-[[2-(3, 4dimethoxyphenyl)ethyl]methylamino]propyl]-
3, 4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (±)-.
Verapamil HCl is an almost white, crystalline powder, practically free of odor,
with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil
HCl is not structurally related to other cardioactive drugs.
In addition to verapamil HCl the Verelan PM capsule contains the following
inactive ingredients: D&C Red #28, FD & C Blue #1, FD&C red #40,
fumaric acid, gelatin, povidone, shellac, silicon dioxide, sodium lauryl sulfate,
starch, sugar spheres, talc, and titanium dioxide.
System Components and Performance: Verelan PM uses the proprietary
CODAS® (Chronotherapeutic Oral Drug Absorption System) technology, which
is designed for bedtime dosing, incorporating a 4 to 5-hour delay in drug delivery.
The controlled-onset delivery system results in a maximum plasma concentration
(Cmax) of verapamil in the morning hours. These pellet filled capsules provide
for extended-release of the drug in the gastrointestinal tract. The Verelan
PM formulation has been designed to initiate the release of verapamil 4-5 hours
after ingestion. This delay is introduced by the level of non-enteric release-controlling
polymer applied to drug loaded beads. The release-controlling polymer is a combination
of water soluble and water insoluble polymers. As water from the gastrointestinal
tract comes into contact with the polymer coated beads, the water soluble polymer
slowly dissolves and the drug diffuses through the resulting pores in the coating.
The water insoluble polymer continues to act as a barrier, maintaining the controlled
release of the drug. The rate of release is essentially independent of pH, posture
and food. Multiparticulate systems such as Verelan PM have been shown to be
independent of gastrointestinal motility.Last reviewed on RxList: 4/28/2010




Verelan PM Drug Description
Verelan PM
(verapamil hydrochloride) Extended-Release Capsules for Oral use
DRUG DESCRIPTION



What are the possible side effects of verapamil?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fast or slow heartbeats;
feeling like you might pass out;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;...
Read All Potential Side Effects for Verelan PM »




Verelan PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow
channel blocker or calcium ion antagonist). Verelan PM is available for oral
administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body),
a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a
300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is
administered as a racemic mixture of the R and S enantiomers.
The structural formulae of the verapamil HC1 enantiomers are:








C27H38N204•HCl          
M.W.=491.07
Chemical name: Benzeneacetonitrile, α-[3-[[2-(3, 4dimethoxyphenyl)ethyl]methylamino]propyl]-
3, 4-dimethoxy-α-(1-methylethyl)-, monohydrochloride, (±)-.
Verapamil HCl is an almost white, crystalline powder, practically free of odor,
with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil
HCl is not structurally related to other cardioactive drugs.
In addition to verapamil HCl the Verelan PM capsule contains the following
inactive ingredients: D&C Red #28, FD & C Blue #1, FD&C red #40,
fumaric acid, gelatin, povidone, shellac, silicon dioxide, sodium lauryl sulfate,
starch, sugar spheres, talc, and titanium dioxide.
System Components and Performance: Verelan PM uses the proprietary
CODAS® (Chronotherapeutic Oral Drug Absorption System) technology, which
is designed for bedtime dosing, incorporating a 4 to 5-hour delay in drug delivery.
The controlled-onset delivery system results in a maximum plasma concentration
(Cmax) of verapamil in the morning hours. These pellet filled capsules provide
for extended-release of the drug in the gastrointestinal tract. The Verelan
PM formulation has been designed to initiate the release of verapamil 4-5 hours
after ingestion. This delay is introduced by the level of non-enteric release-controlling
polymer applied to drug loaded beads. The release-controlling polymer is a combination
of water soluble and water insoluble polymers. As water from the gastrointestinal
tract comes into contact with the polymer coated beads, the water soluble polymer
slowly dissolves and the drug diffuses through the resulting pores in the coating.
The water insoluble polymer continues to act as a barrier, maintaining the controlled
release of the drug. The rate of release is essentially independent of pH, posture
and food. Multiparticulate systems such as Verelan PM have been shown to be
independent of gastrointestinal motility.Last reviewed on RxList: 4/28/2010





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Other reviews about Verelan PM on web:

Learn about the prescription medication Verelan PM (Verapamil), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Verelan PM (Verapamil) Drug Information: Uses, Side Effects, Drug ...


Comprehensive and trusted information about Verelan PM - plus advice on 24,000 other FDA approved drugs and medications from Drugs.com. Verelan PM patient advice including side effects


Physician reviewed Verelan PM (oral) patient information - includes Verelan PM description, dosage and directions. Verelan PM (verapamil oral) medical facts from Drugs.com


Find patient medical information for Verelan PM Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Verelan PM Oral : Uses, Side Effects, Interactions, Pictures ...


Clarifies the medication verapamil (Calan, Verelan, Verelan PM, Isoptin, Covera-HS), a drug used for the treatment and prevention of angina resulting from coronary artery spasm ... verapamil (Calan, Verelan, Verelan PM, Isoptin, Covera-HS) - drug ...


Learn about Verelan PM (Verapamil) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Verelan PM (Verapamil) Patient Drug Information and Side Effects ...


Verelan PM is medicine licensed for the treatment of high blood pressure. This eMedTV article offers dosing information for this medication, describes its effects, explains ... Verelan PM


Verelan PM is a calcium channel blocker used to treat high blood pressure. Side effects and interactions are available at drugstore.com; plus get home delivery from a trusted ... Verelan Pm - drugstore.com. Low prices, side effects, interactions.


As this eMedTV article explains, there are three strengths of generic Verelan PM currently available. This resource also discusses how the FDA has determined that generic ... Generic Verelan PM


VERELAN PM SUMMARY Verelan ® PM capsules (verapamil hydrochloride) extended-release capsules controlled-onset. Verelan® PM (verapamil hydrochloride) is a calcium ion influx ... Verelan PM (Verapamil) - Drug Info, Side Effects, Research ...





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