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Tribenzor Drug Description
Tribenzor™
(olmesartan medoxomil, amlodipine, hydrochlorothiazide) Tablets

WARNING
AVOID USE IN PREGNANCY When pregnancy is detected, discontinue Tribenzor
as soon as possible. Drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus [see WARNING AND PRECAUTIONS].


DRUG DESCRIPTION
Tribenzor is a fixed combination of olmesartan medoxomil (ARB), amlodipine
(CCB), and hydrochlorothiazide (thiazide diuretic).
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption
from the gastrointestinal tract.
The olmesartan medoxomil component of Tribenzor is chemically described as
2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate. Its empirical formula is C29H30N6O6.
The amlodipine besylate component of Tribenzor is chemically described as 3-ethyl-5methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate,
monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S.
The hydrochlorothiazide component of Tribenzor is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiazidiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8CIN3O4S2.
The structural formula for olmesartan medoxomil is:








The structural formula for amlodipine besylate is:








The structural formula for hydrochlorothiazide is:








Tribenzor contains olmesartan medoxomil, a white to light yellowish-white powder
or crystalline powder, amlodipine besylate, a white to off-white crystalline
powder, and hydrochlorothiazide, a white or practically white, crystalline powder.
The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide
are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically
insoluble in water and sparingly soluble in methanol. Amlodipine besylate is
slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide
is slightly soluble in water but freely soluble in sodium hydroxide solution.
Each tablet of Tribenzor also contains the following inactive ingredients:
silicified microcrystalline cellulose, pregelatinized starch, croscarmellose
sodium, and magnesium stearate. The color coating contains polyvinyl alcohol,
macrogol/polyethylene glycol 3350, titanium dioxide, talc, iron oxide yellow
(20 /5 /12.5 mg, 40 /5 /12.5 mg, 40 /5 /25 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), iron oxide red (20 /5 /12.5 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), and iron oxide black (20 /5 /12.5 mg tablets).
Last reviewed on RxList: 8/16/2010




Tribenzor Drug Description
Tribenzor™
(olmesartan medoxomil, amlodipine, hydrochlorothiazide) Tablets

WARNING
AVOID USE IN PREGNANCY When pregnancy is detected, discontinue Tribenzor
as soon as possible. Drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus [see WARNING AND PRECAUTIONS].


DRUG DESCRIPTION
Tribenzor is a fixed combination of olmesartan medoxomil (ARB), amlodipine
(CCB), and hydrochlorothiazide (thiazide diuretic).
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption
from the gastrointestinal tract.
The olmesartan medoxomil component of Tribenzor is chemically described as
2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate. Its empirical formula is C29H30N6O6.
The amlodipine besylate component of Tribenzor is chemically described as 3-ethyl-5methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate,
monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S.
The hydrochlorothiazide component of Tribenzor is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiazidiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8CIN3O4S2.
The structural formula for olmesartan medoxomil is:








The structural formula for amlodipine besylate is:








The structural formula for hydrochlorothiazide is:








Tribenzor contains olmesartan medoxomil, a white to light yellowish-white powder
or crystalline powder, amlodipine besylate, a white to off-white crystalline
powder, and hydrochlorothiazide, a white or practically white, crystalline powder.
The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide
are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically
insoluble in water and sparingly soluble in methanol. Amlodipine besylate is
slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide
is slightly soluble in water but freely soluble in sodium hydroxide solution.
Each tablet of Tribenzor also contains the following inactive ingredients:
silicified microcrystalline cellulose, pregelatinized starch, croscarmellose
sodium, and magnesium stearate. The color coating contains polyvinyl alcohol,
macrogol/polyethylene glycol 3350, titanium dioxide, talc, iron oxide yellow
(20 /5 /12.5 mg, 40 /5 /12.5 mg, 40 /5 /25 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), iron oxide red (20 /5 /12.5 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), and iron oxide black (20 /5 /12.5 mg tablets).
Last reviewed on RxList: 8/16/2010




Tribenzor Drug Description
Tribenzor™
(olmesartan medoxomil, amlodipine, hydrochlorothiazide) Tablets

WARNING
AVOID USE IN PREGNANCY When pregnancy is detected, discontinue Tribenzor
as soon as possible. Drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus [see WARNING AND PRECAUTIONS].


DRUG DESCRIPTION
Tribenzor is a fixed combination of olmesartan medoxomil (ARB), amlodipine
(CCB), and hydrochlorothiazide (thiazide diuretic).
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption
from the gastrointestinal tract.
The olmesartan medoxomil component of Tribenzor is chemically described as
2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate. Its empirical formula is C29H30N6O6.
The amlodipine besylate component of Tribenzor is chemically described as 3-ethyl-5methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate,
monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S.
The hydrochlorothiazide component of Tribenzor is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiazidiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8CIN3O4S2.
The structural formula for olmesartan medoxomil is:








The structural formula for amlodipine besylate is:








The structural formula for hydrochlorothiazide is:








Tribenzor contains olmesartan medoxomil, a white to light yellowish-white powder
or crystalline powder, amlodipine besylate, a white to off-white crystalline
powder, and hydrochlorothiazide, a white or practically white, crystalline powder.
The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide
are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically
insoluble in water and sparingly soluble in methanol. Amlodipine besylate is
slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide
is slightly soluble in water but freely soluble in sodium hydroxide solution.
Each tablet of Tribenzor also contains the following inactive ingredients:
silicified microcrystalline cellulose, pregelatinized starch, croscarmellose
sodium, and magnesium stearate. The color coating contains polyvinyl alcohol,
macrogol/polyethylene glycol 3350, titanium dioxide, talc, iron oxide yellow
(20 /5 /12.5 mg, 40 /5 /12.5 mg, 40 /5 /25 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), iron oxide red (20 /5 /12.5 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), and iron oxide black (20 /5 /12.5 mg tablets).
Last reviewed on RxList: 8/16/2010




Tribenzor Drug Description
Tribenzor™
(olmesartan medoxomil, amlodipine, hydrochlorothiazide) Tablets

WARNING
AVOID USE IN PREGNANCY When pregnancy is detected, discontinue Tribenzor
as soon as possible. Drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus [see WARNING AND PRECAUTIONS].


DRUG DESCRIPTION
Tribenzor is a fixed combination of olmesartan medoxomil (ARB), amlodipine
(CCB), and hydrochlorothiazide (thiazide diuretic).
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption
from the gastrointestinal tract.
The olmesartan medoxomil component of Tribenzor is chemically described as
2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate. Its empirical formula is C29H30N6O6.
The amlodipine besylate component of Tribenzor is chemically described as 3-ethyl-5methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate,
monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S.
The hydrochlorothiazide component of Tribenzor is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiazidiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8CIN3O4S2.
The structural formula for olmesartan medoxomil is:








The structural formula for amlodipine besylate is:








The structural formula for hydrochlorothiazide is:








Tribenzor contains olmesartan medoxomil, a white to light yellowish-white powder
or crystalline powder, amlodipine besylate, a white to off-white crystalline
powder, and hydrochlorothiazide, a white or practically white, crystalline powder.
The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide
are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically
insoluble in water and sparingly soluble in methanol. Amlodipine besylate is
slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide
is slightly soluble in water but freely soluble in sodium hydroxide solution.
Each tablet of Tribenzor also contains the following inactive ingredients:
silicified microcrystalline cellulose, pregelatinized starch, croscarmellose
sodium, and magnesium stearate. The color coating contains polyvinyl alcohol,
macrogol/polyethylene glycol 3350, titanium dioxide, talc, iron oxide yellow
(20 /5 /12.5 mg, 40 /5 /12.5 mg, 40 /5 /25 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), iron oxide red (20 /5 /12.5 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), and iron oxide black (20 /5 /12.5 mg tablets).
Last reviewed on RxList: 8/16/2010




Tribenzor Drug Description
Tribenzor™
(olmesartan medoxomil, amlodipine, hydrochlorothiazide) Tablets

WARNING
AVOID USE IN PREGNANCY When pregnancy is detected, discontinue Tribenzor
as soon as possible. Drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus [see WARNING AND PRECAUTIONS].


DRUG DESCRIPTION
Tribenzor is a fixed combination of olmesartan medoxomil (ARB), amlodipine
(CCB), and hydrochlorothiazide (thiazide diuretic).
Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption
from the gastrointestinal tract.
The olmesartan medoxomil component of Tribenzor is chemically described as
2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate. Its empirical formula is C29H30N6O6.
The amlodipine besylate component of Tribenzor is chemically described as 3-ethyl-5methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5pyridinedicarboxylate,
monobenzenesulphonate. Its empirical formula is C20H25CIN2O5•C6H6O3S.
The hydrochlorothiazide component of Tribenzor is chemically described as 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiazidiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8CIN3O4S2.
The structural formula for olmesartan medoxomil is:








The structural formula for amlodipine besylate is:








The structural formula for hydrochlorothiazide is:








Tribenzor contains olmesartan medoxomil, a white to light yellowish-white powder
or crystalline powder, amlodipine besylate, a white to off-white crystalline
powder, and hydrochlorothiazide, a white or practically white, crystalline powder.
The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide
are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically
insoluble in water and sparingly soluble in methanol. Amlodipine besylate is
slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide
is slightly soluble in water but freely soluble in sodium hydroxide solution.
Each tablet of Tribenzor also contains the following inactive ingredients:
silicified microcrystalline cellulose, pregelatinized starch, croscarmellose
sodium, and magnesium stearate. The color coating contains polyvinyl alcohol,
macrogol/polyethylene glycol 3350, titanium dioxide, talc, iron oxide yellow
(20 /5 /12.5 mg, 40 /5 /12.5 mg, 40 /5 /25 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), iron oxide red (20 /5 /12.5 mg, 40 /10 /12.5 mg, and 40 /10 /25
mg tablets), and iron oxide black (20 /5 /12.5 mg tablets).
Last reviewed on RxList: 8/16/2010





Other reviews about Tribenzor on wordpress

Combination Drug Approved for High Blood Pressure
  by nalonsospc
MONDAY, July 26 (HealthDay News) -- Tribenzor, a three-in-one drug to treat high blood pressure, has been approved by the U.S. Food and Drug Administration. Tribenzor combines amlodipine, marketed […]


FDA approves new hypertension polypill from Daiichi Sankyo
  by ComplianceOnline
The FDA, last week, approved a combination of three hypertension drugs in different classes -- olmesartan medoxomil (which blocks angiotensin II receptors), amlodipine (which inhibits the entrance of […]



Other reviews about Tribenzor on web:

WARNING: AVOID USE IN PREGNANCY When pregnancy is detected, discontinue TRIBENZOR as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and ... Tribenzor


Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide) is used to treat hypertension. Includes Tribenzor side effects, interactions and indications. Tribenzor Information from Drugs.com


Learn about the prescription medication Tribenzor (Olmesartan Medoxomil Amlodipine Hydrochlorothiazide Tablets), drug uses, dosage, side effects, drug interactions, warnings ... Tribenzor (Olmesartan Medoxomil Amlodipine Hydrochlorothiazide ...


Learn about TRIBENZOR.ORG from this free business profile provided by Network Solutions Free business profile for TRIBENZOR.ORG provided by Network Solutions


Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide) is used to treat hypertension. Includes Tribenzor side effects, interactions and indications. FDA Approves Tribenzor, A New Three-In-One Combination Product for ...


Daiichi Sankyo, has received approval from the FDA for Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide), a new three-in-one combination product taken once-daily ... Daiichi Sankyo Tribenzor Receives FDA Nod ...


Daiichi Sankyo, Inc. announced that the U.S. Food and Drug Administration approved TRIBENZOR, a new three-in-one combination product taken once-daily for the treatment of ... FDA Approves TRIBENZOR


Drug information and side-effects for Tribenzor (olmesartan medoxomil + amlodipine + hydrochlorothiazide) Tribenzor (olmesartan medoxomil + amlodipine + hydrochlorothiazide ...


The drug is not recommended for patients with impaired renal functions and contains a diuretic for water volume. BD PARSIPPANY, N.J., July 26 /PRNewswire/ -- Daiichi Sankyo ... The Medical Quack: FDA Approves Tribenzor For High Blood Pressure ...


Daiichi Sankyo announced that the FDA has approved Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide tablets), a fixed-dose combination therapy for the treatment ... Tribenzor approved for treatment of hypertension - MPR





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