Reviews Testosterone Transdermal System


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Androderm Drug Description
Androderm®
(testosterone) Transdermal System
Controlled Delivery for Once-Daily Application
DRUG DESCRIPTION



What are the possible side effects of testosterone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using testosterone topical and call your doctor at once if you have any of these serious side effects:

burn-like blistering of the skin where the transdermal patch is worn;
skin irritation with patch-wearing that does not get better with time;
problems with urination;
swelling of your...
Read All Potential Side Effects for Androderm »




Androderm (testosterone transdermal system) provides continuous delivery of
testosterone (the primary endogenous androgen) for 24 hours following application
to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms).
Two strengths of Androderm are available which deliver in vivo
2.5 mg or 5 mg of testosterone per day across skin of average permeability.
Androderm has a central drug delivery reservoir surrounded by a peripheral
adhesive area. The Androderm 2.5 mg system has a total contact surface
area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir
containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The
Androderm 5 mg system has a total contact surface area of 44 cm2
with a 15 cm2 central drug delivery reservoir containing 24.3 mg
testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white,
or creamy white crystalline powder or crystals chemically described as 17β-hydroxyandrost-4-en-3-one.







C19H28O2        mw
288.43
The Androderm systems have six components as shown in Figure 1. Proceeding
from the top toward the surface attached to the skin, the system is composed
of (1) metallized polyester/Surlyn®* (ethylene-methacrylic acid copolymer)/ethylene
vinyl acetate backing film with alcohol resistant ink, (2) a drug reservoir
of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, methyl
laurate, sodium hydroxide NF, to adjust pH, and purified water USP, gelled with
carbomer copolymer Type B NF, (3) a permeable polyethylene microporous membrane,
and (4) a peripheral layer of acrylic adhesive surrounding the central, active
drug delivery area of the system. Prior to opening of the system and application
to the skin, the central delivery surface of the system is sealed with a peelable
laminate disc (5) composed of a five-layer laminate containing polyester/polyesterurethane
adhesive/aluminum foil/ polyester-urethane adhesive/polyethylene. The disc is
attached to and removed with the release liner (6), a silicone-coated polyester
film, which is removed before the system can be used.







Figure 1: System Schematic
The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.Last reviewed on RxList: 7/15/2008




Androderm Drug Description
Androderm®
(testosterone) Transdermal System
Controlled Delivery for Once-Daily Application
DRUG DESCRIPTION



What are the possible side effects of testosterone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using testosterone topical and call your doctor at once if you have any of these serious side effects:

burn-like blistering of the skin where the transdermal patch is worn;
skin irritation with patch-wearing that does not get better with time;
problems with urination;
swelling of your...
Read All Potential Side Effects for Androderm »




Androderm (testosterone transdermal system) provides continuous delivery of
testosterone (the primary endogenous androgen) for 24 hours following application
to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms).
Two strengths of Androderm are available which deliver in vivo
2.5 mg or 5 mg of testosterone per day across skin of average permeability.
Androderm has a central drug delivery reservoir surrounded by a peripheral
adhesive area. The Androderm 2.5 mg system has a total contact surface
area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir
containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The
Androderm 5 mg system has a total contact surface area of 44 cm2
with a 15 cm2 central drug delivery reservoir containing 24.3 mg
testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white,
or creamy white crystalline powder or crystals chemically described as 17β-hydroxyandrost-4-en-3-one.







C19H28O2        mw
288.43
The Androderm systems have six components as shown in Figure 1. Proceeding
from the top toward the surface attached to the skin, the system is composed
of (1) metallized polyester/Surlyn®* (ethylene-methacrylic acid copolymer)/ethylene
vinyl acetate backing film with alcohol resistant ink, (2) a drug reservoir
of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, methyl
laurate, sodium hydroxide NF, to adjust pH, and purified water USP, gelled with
carbomer copolymer Type B NF, (3) a permeable polyethylene microporous membrane,
and (4) a peripheral layer of acrylic adhesive surrounding the central, active
drug delivery area of the system. Prior to opening of the system and application
to the skin, the central delivery surface of the system is sealed with a peelable
laminate disc (5) composed of a five-layer laminate containing polyester/polyesterurethane
adhesive/aluminum foil/ polyester-urethane adhesive/polyethylene. The disc is
attached to and removed with the release liner (6), a silicone-coated polyester
film, which is removed before the system can be used.







Figure 1: System Schematic
The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.Last reviewed on RxList: 7/15/2008




Androderm Drug Description
Androderm®
(testosterone) Transdermal System
Controlled Delivery for Once-Daily Application
DRUG DESCRIPTION



What are the possible side effects of testosterone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using testosterone topical and call your doctor at once if you have any of these serious side effects:

burn-like blistering of the skin where the transdermal patch is worn;
skin irritation with patch-wearing that does not get better with time;
problems with urination;
swelling of your...
Read All Potential Side Effects for Androderm »




Androderm (testosterone transdermal system) provides continuous delivery of
testosterone (the primary endogenous androgen) for 24 hours following application
to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms).
Two strengths of Androderm are available which deliver in vivo
2.5 mg or 5 mg of testosterone per day across skin of average permeability.
Androderm has a central drug delivery reservoir surrounded by a peripheral
adhesive area. The Androderm 2.5 mg system has a total contact surface
area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir
containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The
Androderm 5 mg system has a total contact surface area of 44 cm2
with a 15 cm2 central drug delivery reservoir containing 24.3 mg
testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white,
or creamy white crystalline powder or crystals chemically described as 17β-hydroxyandrost-4-en-3-one.







C19H28O2        mw
288.43
The Androderm systems have six components as shown in Figure 1. Proceeding
from the top toward the surface attached to the skin, the system is composed
of (1) metallized polyester/Surlyn®* (ethylene-methacrylic acid copolymer)/ethylene
vinyl acetate backing film with alcohol resistant ink, (2) a drug reservoir
of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, methyl
laurate, sodium hydroxide NF, to adjust pH, and purified water USP, gelled with
carbomer copolymer Type B NF, (3) a permeable polyethylene microporous membrane,
and (4) a peripheral layer of acrylic adhesive surrounding the central, active
drug delivery area of the system. Prior to opening of the system and application
to the skin, the central delivery surface of the system is sealed with a peelable
laminate disc (5) composed of a five-layer laminate containing polyester/polyesterurethane
adhesive/aluminum foil/ polyester-urethane adhesive/polyethylene. The disc is
attached to and removed with the release liner (6), a silicone-coated polyester
film, which is removed before the system can be used.







Figure 1: System Schematic
The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.Last reviewed on RxList: 7/15/2008




Androderm Drug Description
Androderm®
(testosterone) Transdermal System
Controlled Delivery for Once-Daily Application
DRUG DESCRIPTION



What are the possible side effects of testosterone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using testosterone topical and call your doctor at once if you have any of these serious side effects:

burn-like blistering of the skin where the transdermal patch is worn;
skin irritation with patch-wearing that does not get better with time;
problems with urination;
swelling of your...
Read All Potential Side Effects for Androderm »




Androderm (testosterone transdermal system) provides continuous delivery of
testosterone (the primary endogenous androgen) for 24 hours following application
to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms).
Two strengths of Androderm are available which deliver in vivo
2.5 mg or 5 mg of testosterone per day across skin of average permeability.
Androderm has a central drug delivery reservoir surrounded by a peripheral
adhesive area. The Androderm 2.5 mg system has a total contact surface
area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir
containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The
Androderm 5 mg system has a total contact surface area of 44 cm2
with a 15 cm2 central drug delivery reservoir containing 24.3 mg
testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white,
or creamy white crystalline powder or crystals chemically described as 17β-hydroxyandrost-4-en-3-one.







C19H28O2        mw
288.43
The Androderm systems have six components as shown in Figure 1. Proceeding
from the top toward the surface attached to the skin, the system is composed
of (1) metallized polyester/Surlyn®* (ethylene-methacrylic acid copolymer)/ethylene
vinyl acetate backing film with alcohol resistant ink, (2) a drug reservoir
of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, methyl
laurate, sodium hydroxide NF, to adjust pH, and purified water USP, gelled with
carbomer copolymer Type B NF, (3) a permeable polyethylene microporous membrane,
and (4) a peripheral layer of acrylic adhesive surrounding the central, active
drug delivery area of the system. Prior to opening of the system and application
to the skin, the central delivery surface of the system is sealed with a peelable
laminate disc (5) composed of a five-layer laminate containing polyester/polyesterurethane
adhesive/aluminum foil/ polyester-urethane adhesive/polyethylene. The disc is
attached to and removed with the release liner (6), a silicone-coated polyester
film, which is removed before the system can be used.







Figure 1: System Schematic
The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.Last reviewed on RxList: 7/15/2008




Androderm Drug Description
Androderm®
(testosterone) Transdermal System
Controlled Delivery for Once-Daily Application
DRUG DESCRIPTION



What are the possible side effects of testosterone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using testosterone topical and call your doctor at once if you have any of these serious side effects:

burn-like blistering of the skin where the transdermal patch is worn;
skin irritation with patch-wearing that does not get better with time;
problems with urination;
swelling of your...
Read All Potential Side Effects for Androderm »




Androderm (testosterone transdermal system) provides continuous delivery of
testosterone (the primary endogenous androgen) for 24 hours following application
to intact, non-scrotal skin (e.g., back, abdomen, thighs, upper arms).
Two strengths of Androderm are available which deliver in vivo
2.5 mg or 5 mg of testosterone per day across skin of average permeability.
Androderm has a central drug delivery reservoir surrounded by a peripheral
adhesive area. The Androderm 2.5 mg system has a total contact surface
area of 37 cm2 with a 7.5 cm2 central drug delivery reservoir
containing 12.2 mg testosterone USP, dissolved in an alcohol-based gel. The
Androderm 5 mg system has a total contact surface area of 44 cm2
with a 15 cm2 central drug delivery reservoir containing 24.3 mg
testosterone USP, dissolved in an alcohol-based gel. Testosterone USP is a white,
or creamy white crystalline powder or crystals chemically described as 17β-hydroxyandrost-4-en-3-one.







C19H28O2        mw
288.43
The Androderm systems have six components as shown in Figure 1. Proceeding
from the top toward the surface attached to the skin, the system is composed
of (1) metallized polyester/Surlyn®* (ethylene-methacrylic acid copolymer)/ethylene
vinyl acetate backing film with alcohol resistant ink, (2) a drug reservoir
of testosterone USP, alcohol USP, glycerin USP, glycerol monooleate, methyl
laurate, sodium hydroxide NF, to adjust pH, and purified water USP, gelled with
carbomer copolymer Type B NF, (3) a permeable polyethylene microporous membrane,
and (4) a peripheral layer of acrylic adhesive surrounding the central, active
drug delivery area of the system. Prior to opening of the system and application
to the skin, the central delivery surface of the system is sealed with a peelable
laminate disc (5) composed of a five-layer laminate containing polyester/polyesterurethane
adhesive/aluminum foil/ polyester-urethane adhesive/polyethylene. The disc is
attached to and removed with the release liner (6), a silicone-coated polyester
film, which is removed before the system can be used.







Figure 1: System Schematic
The active ingredient in the system is testosterone. The remaining components of the system are pharmacologically inactive.Last reviewed on RxList: 7/15/2008





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Other reviews about Testosterone Transdermal System on web:

Androderm is a convenient, once-daily skin patch, called a transdermal delivery system, which delivers consistent, controlled concentrations of testosterone through the skin. Androderm: Testosterone Transdermal System


Learn about the prescription medication Androderm (Testosterone Transdermal System), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Androderm (Testosterone Transdermal System) Drug Information: Uses ...


Arver S, Dobs AS, Meikle AW, et al. Long-term efficacy and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men. Transdermal Testosterone (Androgel) Profile


Drug information and side-effects for Androderm (Testosterone Transdermal System) Androderm (Testosterone Transdermal System) - Drug information ...


Testosterone (teh-STAHS-tuh-RONE) Testosterone Androderm; Transdermal system ; 5 mg/24 hr, 44 cm 2 surface area, 24.3 mg total testosterone; Transdermal system Testosterone


: In a randomized trial, 97% of patients achieved physiological testosterone concentrations with the buccal system and tolerated it well. Buccal Testosterone Delivery System Better Than Transdermal


In the first protocol, it was shown that peak levels of testosterone were achieved three to eight hours after scrotal application of a transdermal therapeutic system containing 5, 10 ... JAMA -- Abstract: Testosterone Replacement With Transdermal ...


Other parameters in the study such as adverse effects of testosterone administered through injection and transdermal system on the liver, prostate, lipid profile and hematocrit ... Benefits of Transdermal Testosterone


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Pre-IND Meeting for TDS Testosterone: Transdermal Announces Successful Delivery of Diazepam Through ... is a patented physio-chemical and mathematical process for designing a system ... Welcome to TransDermal





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