Reviews Teniposide


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Vumon Drug Description
VUMON®
(teniposide) Injection
Formerly: VUMON® (teniposide) For Injection Concentrate

WARNING
VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to VUMON. Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

DRUG DESCRIPTION



What are the possible side effects of teniposide (Vumon)?

If you experience any of the following serious side effects from teniposide, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection).

Other, less serious side effects may...
Read All Potential Side Effects for Vumon »




VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion. VUMON is available in 50 mg (5 mL) ampules. Each mL contains 10 mg teniposide, 30 mg benzyl alcohol, 60 mg N,N-dimethylacetamide, 500 mg purified Cremophor® EL (polyoxyethylated castor oil)*, and 42.7% (v/v) dehydrated alcohol. The pH of the clear solution is adjusted to approximately 5 with maleic acid.
Teniposide is a semisynthetic derivative of podophyllotoxin. The chemical name for teniposide is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)-2-thenylidene-β-D-glucopyranoside]. Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring.
Teniposide has the following structural formula:








Teniposide is a white to off-white crystalline powder with the empirical formula
C32H32O13S and a molecular weight of 656.66.
It is a lipophilic compound with a partition coefficient value (octanol/water)
of approximately 100. Teniposide is insoluble in water and ether. It is slightly
soluble in methanol and very soluble in acetone and dimethylformamide.
*Cremophor® EL is the registered trademark of BASF Aktiengesellschaft.
Cremophor® EL is further purified by a Bristol-Myers Squibb Company proprietary process before use.Last reviewed on RxList: 6/29/2009




Vumon Drug Description
VUMON®
(teniposide) Injection
Formerly: VUMON® (teniposide) For Injection Concentrate

WARNING
VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to VUMON. Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

DRUG DESCRIPTION



What are the possible side effects of teniposide (Vumon)?

If you experience any of the following serious side effects from teniposide, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection).

Other, less serious side effects may...
Read All Potential Side Effects for Vumon »




VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion. VUMON is available in 50 mg (5 mL) ampules. Each mL contains 10 mg teniposide, 30 mg benzyl alcohol, 60 mg N,N-dimethylacetamide, 500 mg purified Cremophor® EL (polyoxyethylated castor oil)*, and 42.7% (v/v) dehydrated alcohol. The pH of the clear solution is adjusted to approximately 5 with maleic acid.
Teniposide is a semisynthetic derivative of podophyllotoxin. The chemical name for teniposide is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)-2-thenylidene-β-D-glucopyranoside]. Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring.
Teniposide has the following structural formula:








Teniposide is a white to off-white crystalline powder with the empirical formula
C32H32O13S and a molecular weight of 656.66.
It is a lipophilic compound with a partition coefficient value (octanol/water)
of approximately 100. Teniposide is insoluble in water and ether. It is slightly
soluble in methanol and very soluble in acetone and dimethylformamide.
*Cremophor® EL is the registered trademark of BASF Aktiengesellschaft.
Cremophor® EL is further purified by a Bristol-Myers Squibb Company proprietary process before use.Last reviewed on RxList: 6/29/2009




Vumon Drug Description
VUMON®
(teniposide) Injection
Formerly: VUMON® (teniposide) For Injection Concentrate

WARNING
VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to VUMON. Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

DRUG DESCRIPTION



What are the possible side effects of teniposide (Vumon)?

If you experience any of the following serious side effects from teniposide, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection).

Other, less serious side effects may...
Read All Potential Side Effects for Vumon »




VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion. VUMON is available in 50 mg (5 mL) ampules. Each mL contains 10 mg teniposide, 30 mg benzyl alcohol, 60 mg N,N-dimethylacetamide, 500 mg purified Cremophor® EL (polyoxyethylated castor oil)*, and 42.7% (v/v) dehydrated alcohol. The pH of the clear solution is adjusted to approximately 5 with maleic acid.
Teniposide is a semisynthetic derivative of podophyllotoxin. The chemical name for teniposide is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)-2-thenylidene-β-D-glucopyranoside]. Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring.
Teniposide has the following structural formula:








Teniposide is a white to off-white crystalline powder with the empirical formula
C32H32O13S and a molecular weight of 656.66.
It is a lipophilic compound with a partition coefficient value (octanol/water)
of approximately 100. Teniposide is insoluble in water and ether. It is slightly
soluble in methanol and very soluble in acetone and dimethylformamide.
*Cremophor® EL is the registered trademark of BASF Aktiengesellschaft.
Cremophor® EL is further purified by a Bristol-Myers Squibb Company proprietary process before use.Last reviewed on RxList: 6/29/2009




Vumon Drug Description
VUMON®
(teniposide) Injection
Formerly: VUMON® (teniposide) For Injection Concentrate

WARNING
VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to VUMON. Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

DRUG DESCRIPTION



What are the possible side effects of teniposide (Vumon)?

If you experience any of the following serious side effects from teniposide, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection).

Other, less serious side effects may...
Read All Potential Side Effects for Vumon »




VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion. VUMON is available in 50 mg (5 mL) ampules. Each mL contains 10 mg teniposide, 30 mg benzyl alcohol, 60 mg N,N-dimethylacetamide, 500 mg purified Cremophor® EL (polyoxyethylated castor oil)*, and 42.7% (v/v) dehydrated alcohol. The pH of the clear solution is adjusted to approximately 5 with maleic acid.
Teniposide is a semisynthetic derivative of podophyllotoxin. The chemical name for teniposide is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)-2-thenylidene-β-D-glucopyranoside]. Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring.
Teniposide has the following structural formula:








Teniposide is a white to off-white crystalline powder with the empirical formula
C32H32O13S and a molecular weight of 656.66.
It is a lipophilic compound with a partition coefficient value (octanol/water)
of approximately 100. Teniposide is insoluble in water and ether. It is slightly
soluble in methanol and very soluble in acetone and dimethylformamide.
*Cremophor® EL is the registered trademark of BASF Aktiengesellschaft.
Cremophor® EL is further purified by a Bristol-Myers Squibb Company proprietary process before use.Last reviewed on RxList: 6/29/2009




Vumon Drug Description
VUMON®
(teniposide) Injection
Formerly: VUMON® (teniposide) For Injection Concentrate

WARNING
VUMON (teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
Severe myelosuppression with resulting infection or bleeding may occur. Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to VUMON. Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

DRUG DESCRIPTION



What are the possible side effects of teniposide (Vumon)?

If you experience any of the following serious side effects from teniposide, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection).

Other, less serious side effects may...
Read All Potential Side Effects for Vumon »




VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion. VUMON is available in 50 mg (5 mL) ampules. Each mL contains 10 mg teniposide, 30 mg benzyl alcohol, 60 mg N,N-dimethylacetamide, 500 mg purified Cremophor® EL (polyoxyethylated castor oil)*, and 42.7% (v/v) dehydrated alcohol. The pH of the clear solution is adjusted to approximately 5 with maleic acid.
Teniposide is a semisynthetic derivative of podophyllotoxin. The chemical name for teniposide is 4′-demethylepipodophyllotoxin 9-[4,6-0-(R)-2-thenylidene-β-D-glucopyranoside]. Teniposide differs from etoposide, another podophyllotoxin derivative, by the substitution of a thenylidene group on the glucopyranoside ring.
Teniposide has the following structural formula:








Teniposide is a white to off-white crystalline powder with the empirical formula
C32H32O13S and a molecular weight of 656.66.
It is a lipophilic compound with a partition coefficient value (octanol/water)
of approximately 100. Teniposide is insoluble in water and ether. It is slightly
soluble in methanol and very soluble in acetone and dimethylformamide.
*Cremophor® EL is the registered trademark of BASF Aktiengesellschaft.
Cremophor® EL is further purified by a Bristol-Myers Squibb Company proprietary process before use.Last reviewed on RxList: 6/29/2009





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Other reviews about Teniposide on web:

Teniposide (Vumon, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as ... Teniposide - Wikipedia, the free encyclopedia


Teniposide Key Terms: Anemia , Chemotherapy , Refractory cancer , DNA , Food and Drug Administration , Induction therapy , Intravenous Teniposide: Information from Answers.com


All about Teniposide. View complete and up to date Teniposide information - part of the Drugs.com trusted medication database. Teniposide Facts and Comparisons at Drugs.com


Learn about the prescription medication Vumon (Teniposide), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Vumon (Teniposide) Drug Information: Uses, Side Effects, Drug ...


Physician reviewed teniposide patient information - includes teniposide description, dosage and directions. teniposide medical facts from Drugs.com


Teniposide is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as an topoisomerase II inhibitor. Vumon, VM-26 Teniposide, Vumon, VM-26 - Chemotherapy Drugs, Chemo Drug Side Effects


Information for patients in English and Spanish. Teniposide: MedlinePlus Drug Information


teniposide /ten·i·po·side/ (ten-ĭ-po´sīd) a semisynthetic antineoplastic used in the treatment of neuroblastoma, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia. teniposide - definition of teniposide in the Medical dictionary ...


Resource URI: http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00444 Teniposide | D2R Server publishing the DrugBank Database


Mayo Clinic offers award-winning medical and health information and tools for healthy living. Teniposide (Intravenous Route) - MayoClinic.com





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