Reviews Technetium Tc99m sestamibi


No reviews yet.

Miraluma Drug Description
Miraluma®*
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time



*Cardiolite® and Miraluma® are different names for the same drug.Last reviewed on RxList: 3/9/2009




Miraluma Drug Description
Miraluma®*
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time



*Cardiolite® and Miraluma® are different names for the same drug.Last reviewed on RxList: 3/9/2009




Miraluma Drug Description
Miraluma®*
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time



*Cardiolite® and Miraluma® are different names for the same drug.Last reviewed on RxList: 3/9/2009




Miraluma Drug Description
Miraluma®*
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time



*Cardiolite® and Miraluma® are different names for the same drug.Last reviewed on RxList: 3/9/2009




Miraluma Drug Description
Miraluma®*
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time



*Cardiolite® and Miraluma® are different names for the same drug.Last reviewed on RxList: 3/9/2009





Other reviews about Technetium Tc99m sestamibi on web:

Technetium (99m Tc) sestamibi (trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex of the radioisotope technetium-99m ... Technetium (99mTc) sestamibi - Wikipedia, the free encyclopedia


Learn about the prescription medication Miraluma (Technetium Tc99m sestamibi), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Miraluma (Technetium Tc99m sestamibi) Drug Information: Uses, Side ...


Technetium-99m is a metastable nuclear isomer of technetium-99, symbolized as 99m Tc. ... the radiopharmaceuticals 99m Tc-tetrofosmin (Myoview ®, GE Healthcare) or 99m Tc-sestamibi ... Technetium-99m - Wikipedia, the free encyclopedia


Science Central - 4538615 - Manufactured by Bristol-Myers Squibb Medical Imaging, Inc. Cardiolite (Technetium Tc99m Sestamibi) - Manufactured by Bristol ...


T5-B001 May 2003 513121-0503 331 Treble Cove Road N. Billerica, Massachusetts 01862 USA CARDIOLITE ® Kit for the Preparation of Technetium Tc99m Sestamibi for Injection FOR ... Kit for the Preparation of Technetium Tc99m Sestamibi for Injection


Definition and other additional information on Technetium tc 99m sestamibi from Biology-Online.org dictionary. Technetium tc 99m sestamibi - definition from Biology-Online.org


Kit for the Preparation of Technetium Tc99m Sestamibi Injection _____ _____ FOR DIAGNOSTIC USE ... Kit for the Preparation of Technetium Tc99m Sestamibi Injection


* The Referenced Listed Drug (RLD) for the generic Pharmalucence Technetium Tc99m Sestamibi Kit is Cardiolite®, a registered trademark of Lantheus Medical Imaging, Inc. pharmalucence (2010) - nuclear medicine docs ::..


The radiochemical purity was determined by the following method. 2.4 Determination of Radiochemical Purity in Technetium Tc99m Sestamibi 1. Obtain a Baker-Flex Aluminum Oxide coated ... CARDIOLITE®





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