Reviews Succinylcholine Chloride


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Anectine Drug Description
ANECTINE®
(succinylcholine chloride) Injection, USP

WARNING
RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed
by ventricular dysrhythmias, cardiac arrest, and death after the administration
of succinylcholine to apparently healthy children who were subsequently found
to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular
dystrophy.
This syndrome often presents as peaked T-waves and sudden cardiac arrest within
minutes after the administration of the drug in healthy appearing children (usually,
but not exclusively, males, and most frequently 8 years of age or younger).
There have also been reports in adolescents.
Therefore, when a healthy appearing infant or child develops cardiac arrest
soon after administration of succinylcholine not felt to be due to inadequate
ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia
should be instituted. This should include administration of intravenous calcium,
bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful.
However, extraordinary and prolonged resuscitative efforts have resulted in
successful resuscitation in some reported cases. In addition, in the presence
of signs of malignant hyperthermia, appropriate treatment should be instituted
concurrently.
Since there may be no signs or symptoms to alert the practitioner to which
patients are at risk, it is recommended that the use of succinylcholine in children
should be reserved for emergency intubation or instances where immediate securing
of the airway is necessary, e.g., laryngospasm, difficult airway, full stomach,
or for intramuscular use when a suitable vein is inaccessible (see PRECAUTIONS:
Pediatric Use and DOSAGE AND ADMINISTRATION).

This drug should be used only by individuals familiar with its actions,
characteristics, and hazards.
DRUG DESCRIPTION
ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type,
skeletal muscle relaxant for intravenous (IV) administration.
Succinylcholine chloride is a white, odorless, slightly bitter powder and very
soluble in water. The drug is unstable in alkaline solutions but relatively
stable in acid solutions, depending upon the concentration of the solution and
the storage temperature. Solutions of succinylcholine chloride should be stored
under refrigeration to preserve potency. ANECTINE Injection is a sterile nonpyrogenic
solution for IV injection, containing 20 mg succinylcholine chloride in each
mL and made isotonic with sodium chloride. The pH is adjusted to 3.5 with hydrochloric
acid.
Methylparaben (0.1%) is added as a preservative.
The chemical name for succinylcholine chloride is 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]
dichloride, and the structural formula is:







Last reviewed on RxList: 6/3/2008




Anectine Drug Description
ANECTINE®
(succinylcholine chloride) Injection, USP

WARNING
RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed
by ventricular dysrhythmias, cardiac arrest, and death after the administration
of succinylcholine to apparently healthy children who were subsequently found
to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular
dystrophy.
This syndrome often presents as peaked T-waves and sudden cardiac arrest within
minutes after the administration of the drug in healthy appearing children (usually,
but not exclusively, males, and most frequently 8 years of age or younger).
There have also been reports in adolescents.
Therefore, when a healthy appearing infant or child develops cardiac arrest
soon after administration of succinylcholine not felt to be due to inadequate
ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia
should be instituted. This should include administration of intravenous calcium,
bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful.
However, extraordinary and prolonged resuscitative efforts have resulted in
successful resuscitation in some reported cases. In addition, in the presence
of signs of malignant hyperthermia, appropriate treatment should be instituted
concurrently.
Since there may be no signs or symptoms to alert the practitioner to which
patients are at risk, it is recommended that the use of succinylcholine in children
should be reserved for emergency intubation or instances where immediate securing
of the airway is necessary, e.g., laryngospasm, difficult airway, full stomach,
or for intramuscular use when a suitable vein is inaccessible (see PRECAUTIONS:
Pediatric Use and DOSAGE AND ADMINISTRATION).

This drug should be used only by individuals familiar with its actions,
characteristics, and hazards.
DRUG DESCRIPTION
ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type,
skeletal muscle relaxant for intravenous (IV) administration.
Succinylcholine chloride is a white, odorless, slightly bitter powder and very
soluble in water. The drug is unstable in alkaline solutions but relatively
stable in acid solutions, depending upon the concentration of the solution and
the storage temperature. Solutions of succinylcholine chloride should be stored
under refrigeration to preserve potency. ANECTINE Injection is a sterile nonpyrogenic
solution for IV injection, containing 20 mg succinylcholine chloride in each
mL and made isotonic with sodium chloride. The pH is adjusted to 3.5 with hydrochloric
acid.
Methylparaben (0.1%) is added as a preservative.
The chemical name for succinylcholine chloride is 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]
dichloride, and the structural formula is:







Last reviewed on RxList: 6/3/2008




Anectine Drug Description
ANECTINE®
(succinylcholine chloride) Injection, USP

WARNING
RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed
by ventricular dysrhythmias, cardiac arrest, and death after the administration
of succinylcholine to apparently healthy children who were subsequently found
to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular
dystrophy.
This syndrome often presents as peaked T-waves and sudden cardiac arrest within
minutes after the administration of the drug in healthy appearing children (usually,
but not exclusively, males, and most frequently 8 years of age or younger).
There have also been reports in adolescents.
Therefore, when a healthy appearing infant or child develops cardiac arrest
soon after administration of succinylcholine not felt to be due to inadequate
ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia
should be instituted. This should include administration of intravenous calcium,
bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful.
However, extraordinary and prolonged resuscitative efforts have resulted in
successful resuscitation in some reported cases. In addition, in the presence
of signs of malignant hyperthermia, appropriate treatment should be instituted
concurrently.
Since there may be no signs or symptoms to alert the practitioner to which
patients are at risk, it is recommended that the use of succinylcholine in children
should be reserved for emergency intubation or instances where immediate securing
of the airway is necessary, e.g., laryngospasm, difficult airway, full stomach,
or for intramuscular use when a suitable vein is inaccessible (see PRECAUTIONS:
Pediatric Use and DOSAGE AND ADMINISTRATION).

This drug should be used only by individuals familiar with its actions,
characteristics, and hazards.
DRUG DESCRIPTION
ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type,
skeletal muscle relaxant for intravenous (IV) administration.
Succinylcholine chloride is a white, odorless, slightly bitter powder and very
soluble in water. The drug is unstable in alkaline solutions but relatively
stable in acid solutions, depending upon the concentration of the solution and
the storage temperature. Solutions of succinylcholine chloride should be stored
under refrigeration to preserve potency. ANECTINE Injection is a sterile nonpyrogenic
solution for IV injection, containing 20 mg succinylcholine chloride in each
mL and made isotonic with sodium chloride. The pH is adjusted to 3.5 with hydrochloric
acid.
Methylparaben (0.1%) is added as a preservative.
The chemical name for succinylcholine chloride is 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]
dichloride, and the structural formula is:







Last reviewed on RxList: 6/3/2008




Anectine Drug Description
ANECTINE®
(succinylcholine chloride) Injection, USP

WARNING
RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed
by ventricular dysrhythmias, cardiac arrest, and death after the administration
of succinylcholine to apparently healthy children who were subsequently found
to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular
dystrophy.
This syndrome often presents as peaked T-waves and sudden cardiac arrest within
minutes after the administration of the drug in healthy appearing children (usually,
but not exclusively, males, and most frequently 8 years of age or younger).
There have also been reports in adolescents.
Therefore, when a healthy appearing infant or child develops cardiac arrest
soon after administration of succinylcholine not felt to be due to inadequate
ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia
should be instituted. This should include administration of intravenous calcium,
bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful.
However, extraordinary and prolonged resuscitative efforts have resulted in
successful resuscitation in some reported cases. In addition, in the presence
of signs of malignant hyperthermia, appropriate treatment should be instituted
concurrently.
Since there may be no signs or symptoms to alert the practitioner to which
patients are at risk, it is recommended that the use of succinylcholine in children
should be reserved for emergency intubation or instances where immediate securing
of the airway is necessary, e.g., laryngospasm, difficult airway, full stomach,
or for intramuscular use when a suitable vein is inaccessible (see PRECAUTIONS:
Pediatric Use and DOSAGE AND ADMINISTRATION).

This drug should be used only by individuals familiar with its actions,
characteristics, and hazards.
DRUG DESCRIPTION
ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type,
skeletal muscle relaxant for intravenous (IV) administration.
Succinylcholine chloride is a white, odorless, slightly bitter powder and very
soluble in water. The drug is unstable in alkaline solutions but relatively
stable in acid solutions, depending upon the concentration of the solution and
the storage temperature. Solutions of succinylcholine chloride should be stored
under refrigeration to preserve potency. ANECTINE Injection is a sterile nonpyrogenic
solution for IV injection, containing 20 mg succinylcholine chloride in each
mL and made isotonic with sodium chloride. The pH is adjusted to 3.5 with hydrochloric
acid.
Methylparaben (0.1%) is added as a preservative.
The chemical name for succinylcholine chloride is 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]
dichloride, and the structural formula is:







Last reviewed on RxList: 6/3/2008




Anectine Drug Description
ANECTINE®
(succinylcholine chloride) Injection, USP

WARNING
RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS
There have been rare reports of acute rhabdomyolysis with hyperkalemia followed
by ventricular dysrhythmias, cardiac arrest, and death after the administration
of succinylcholine to apparently healthy children who were subsequently found
to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular
dystrophy.
This syndrome often presents as peaked T-waves and sudden cardiac arrest within
minutes after the administration of the drug in healthy appearing children (usually,
but not exclusively, males, and most frequently 8 years of age or younger).
There have also been reports in adolescents.
Therefore, when a healthy appearing infant or child develops cardiac arrest
soon after administration of succinylcholine not felt to be due to inadequate
ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia
should be instituted. This should include administration of intravenous calcium,
bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful.
However, extraordinary and prolonged resuscitative efforts have resulted in
successful resuscitation in some reported cases. In addition, in the presence
of signs of malignant hyperthermia, appropriate treatment should be instituted
concurrently.
Since there may be no signs or symptoms to alert the practitioner to which
patients are at risk, it is recommended that the use of succinylcholine in children
should be reserved for emergency intubation or instances where immediate securing
of the airway is necessary, e.g., laryngospasm, difficult airway, full stomach,
or for intramuscular use when a suitable vein is inaccessible (see PRECAUTIONS:
Pediatric Use and DOSAGE AND ADMINISTRATION).

This drug should be used only by individuals familiar with its actions,
characteristics, and hazards.
DRUG DESCRIPTION
ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type,
skeletal muscle relaxant for intravenous (IV) administration.
Succinylcholine chloride is a white, odorless, slightly bitter powder and very
soluble in water. The drug is unstable in alkaline solutions but relatively
stable in acid solutions, depending upon the concentration of the solution and
the storage temperature. Solutions of succinylcholine chloride should be stored
under refrigeration to preserve potency. ANECTINE Injection is a sterile nonpyrogenic
solution for IV injection, containing 20 mg succinylcholine chloride in each
mL and made isotonic with sodium chloride. The pH is adjusted to 3.5 with hydrochloric
acid.
Methylparaben (0.1%) is added as a preservative.
The chemical name for succinylcholine chloride is 2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]
dichloride, and the structural formula is:







Last reviewed on RxList: 6/3/2008





Other reviews about Succinylcholine Chloride on wordpress

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  by lmu2010
I have been asked the MOA of propofol and what channel it works on (chloride) MOA of Succinylcholine and how it increases potassium.  If succs is given how much […]


SOME CONSIDERATIONS FOR THE USE OF DRUGS FOR ENDOTRACHEAL INTUBATION
  by clinicalpediatric
  The choice of drugs for control of the airway should address two concerns: adequate sedation/analgesia for laryngoscopy and appropriate selection of a muscle relaxant, if indicated. A patient […]


Frequently Used Emergency Drugs
  by clinicalpediatric
  Adenosine Albuterol Atropine Bicarbonate Calcium chloride Calcium gluconate Charcoal Dexamethasone Diazepam Diazoxide Digibind Diphenhydramine Dopamine Dobutamine Epinephrine Fentanyl Fosphenytoin Glucagon Glucose Haloperidol Insulin Ipecac Kayexalate Ketamine Lidocaine Lorazepam Mannitol Meperidine Methylprednisolone Midazolam Morphine sulfate Naloxone Nitroprusside Oxygen Pancuronium Phenobarbital Phenylephrine Phenytoin Procainamide Propranolol Prostaglandin E Rocuronium Succinylcholine Thiopental Vecuronium 2 of 11     DRUGS FOR PEDIATRIC EMERGENCIES Albuterol Indication: Status asthmaticus, bronchospasm Dosage: 0.1 to 0.15 mg/kg by nebulization. Repeat as needed. Note: 0.02 to 0.03 mL/kg of 5 […]


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  by coptermedic
From Medgadget (the post includes a cool video demo): Deep Pocket Series just released a new helper iPhone application to help you calculate medicine dosages quickly. The Stat Meds […]


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  by Amy Philo
From: Leonard Roy Frank January 7, 2010 To: Food and Drug Administration Dockets Management Branch (HFA-305) 5630 Fishers LaneRoom 1061 Rockville, MD  20852 Docket Number FDA-2009-N-0392 To whom it may concern: As a survivor […]


Succinylcholine: Is It the Perfect Murder Weapon? Not Exactly.
  by D.P. Lyle, MD
Succinylcholine, SUX for short, is a neuromuscular paralytic drug. This means that it works at the junction of the nerves and muscles and causes muscular paralysis. It paralyzes […]


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Lethal drug killed Hamas commander: Police Amira Abdullah, Khaleej Times, Feb 28 2010 According to Dubai Police, the operatives involved in the murder of killing of Hamas commander Mabhouh used […]


Hamas Leader Was 'Drugged And Suffocated'
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[  Succinylcholine is NOT a sedative.  It is a muscle relaxer used to induce paralysis, so the victim can die awake, while his lungs refuse […]


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10 LC 21 0617S The House Committee on Science and Technology offers the following substitute to HB 788: A BILL TO BE ENTITLED AN ACT To amend Article 1 of Chapter 11 […]



Other reviews about Succinylcholine Chloride on web:

Suxamethonium, also known as succinylcholine, is a paralytic drug used to induce muscle relaxation and short term paralysis, usually to make endotracheal intubation possible. Suxamethonium chloride - Wikipedia, the free encyclopedia


Learn about the prescription medication Anectine (Succinylcholine Chloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Anectine (Succinylcholine Chloride) Drug Information: Uses, Side ...


Succinylcholine Chloride. The Elephant Formulary © 2003-06 Susan K. Mikota DVM and Donald C. Plumb, Pharm.D. Published by Elephant Care International - www.elephantcare.org Succinylcholine Chloride


Succinylcholine chloride breaks down quickly into chemicals that are normally found in human tissue. succinylcholine chloride - definition of succinylcholine chloride ...


WARNING. RISK OF CARDIAC ARREST FROM HYPERKALEMIC. RHABDOMYOLYSIS. There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular ... QUELICIN®SUCCINYLCHOLINE CHLORIDE INJECTION, USP


succinylcholine chloride ( ¦səksənəl′kō′lēn ′klör′īd ) ( organic chemistry ) [Cl(CH 3 ) 3 N-(CH 2 ) 2 OOCH 2 ] 2 2H 2 O Water-soluble white succinylcholine chloride: Definition from Answers.com


Sota Omoigui's Anesthesia Drug Handbook 3rd Edition: : Succinylcholine Chloride MedicineHouse.com


AHFS Detailed Monograph from Medscape Drug Reference ... Monograph - Succinylcholine Chloride. Class: NEUROMUSCULAR BLOCKING AGENTS(12:20.20) - See Related General Statement Succinylcholine Chloride Injection: AHFS Detailed Monograph


Succinylcholine Chloride Drug Information from Drugs.com. Includes Succinylcholine Chloride side effects, interactions and indications. Succinylcholine Chloride Drug Information, Professional


ANECTINE (succinylcholine chloride) is an ultra short-acting depolarizing-type, skeletal muscle relaxant for intravenous (IV) administration. ... Anectine (Succinylcholine) - Drug Info, Side Effects, Research ...





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