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Sporanox Drug Description

SPORANOX®
(itraconazole) Capsules

Congestive Heart Failure:
SPORANOX ® (itraconazole) Capsules should not be administered for the
treatment of onychomycosis in patients with evidence of ventricular dysfunction
such as congestive heart failure (CHF) or a history of CHF. If signs or
symptoms of congestive heart failure occur during administration of SPORANOX®
Capsules, discontinue administration. When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
(See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS,
PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing
Experience for more information.)
Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated SPORANOX®, a potent cytochrome
P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma concentrations
of drugs metabolized by this pathway. Serious cardiovascular events, including
QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest,
and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol
(levomethadyl), or quinidine, concomitantly with SPORANOX® and/or other
CYP3A4 inhibitors. See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS: DRUG INTERACTIONS for more information.

DRUG DESCRIPTION



What are the possible side effects of itraconazole (Sporanox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fever;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
problems with hearing;
numbness or tingly feeling;
pain or burning when you urinate; or
nausea, stomach...
Read All Potential Side Effects for Sporanox »




SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal
agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two
enantiomeric pairs), each possessing three chiral centers. It may be represented
by the following structural formula and nomenclature:








(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
mixture with (±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2-(2,4-dichlorophenyl)-2-(1H1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4triazolin-5-one
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
Itraconazole has a molecular formula of C35H38Cl2N8O4
and a molecular weight of 705.64. It is a white to slightly yellowish powder.
It is insoluble in water, very slightly soluble in alcohols, and freely soluble
in dichloromethane. It has a pKa of 3.70 (based on extrapolation of values obtained
from methanolic solutions) and a log (n-octanol/water) partition coefficient
of 5.66 at pH 8.1.
SPORANOX® Capsules contain 100 mg of itraconazole coated on sugar spheres.
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol
(PEG) 20,000, starch, sucrose, titanium dioxide, FD&C Blue No. 1, FD&C
Blue No. 2, D&C Red No. 22 and D&C Red No. 28.Last reviewed on RxList: 8/23/2010




Sporanox Drug Description

SPORANOX®
(itraconazole) Capsules

Congestive Heart Failure:
SPORANOX ® (itraconazole) Capsules should not be administered for the
treatment of onychomycosis in patients with evidence of ventricular dysfunction
such as congestive heart failure (CHF) or a history of CHF. If signs or
symptoms of congestive heart failure occur during administration of SPORANOX®
Capsules, discontinue administration. When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
(See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS,
PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing
Experience for more information.)
Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated SPORANOX®, a potent cytochrome
P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma concentrations
of drugs metabolized by this pathway. Serious cardiovascular events, including
QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest,
and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol
(levomethadyl), or quinidine, concomitantly with SPORANOX® and/or other
CYP3A4 inhibitors. See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS: DRUG INTERACTIONS for more information.

DRUG DESCRIPTION



What are the possible side effects of itraconazole (Sporanox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fever;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
problems with hearing;
numbness or tingly feeling;
pain or burning when you urinate; or
nausea, stomach...
Read All Potential Side Effects for Sporanox »




SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal
agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two
enantiomeric pairs), each possessing three chiral centers. It may be represented
by the following structural formula and nomenclature:








(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
mixture with (±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2-(2,4-dichlorophenyl)-2-(1H1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4triazolin-5-one
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
Itraconazole has a molecular formula of C35H38Cl2N8O4
and a molecular weight of 705.64. It is a white to slightly yellowish powder.
It is insoluble in water, very slightly soluble in alcohols, and freely soluble
in dichloromethane. It has a pKa of 3.70 (based on extrapolation of values obtained
from methanolic solutions) and a log (n-octanol/water) partition coefficient
of 5.66 at pH 8.1.
SPORANOX® Capsules contain 100 mg of itraconazole coated on sugar spheres.
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol
(PEG) 20,000, starch, sucrose, titanium dioxide, FD&C Blue No. 1, FD&C
Blue No. 2, D&C Red No. 22 and D&C Red No. 28.Last reviewed on RxList: 8/23/2010




Sporanox Drug Description

SPORANOX®
(itraconazole) Capsules

Congestive Heart Failure:
SPORANOX ® (itraconazole) Capsules should not be administered for the
treatment of onychomycosis in patients with evidence of ventricular dysfunction
such as congestive heart failure (CHF) or a history of CHF. If signs or
symptoms of congestive heart failure occur during administration of SPORANOX®
Capsules, discontinue administration. When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
(See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS,
PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing
Experience for more information.)
Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated SPORANOX®, a potent cytochrome
P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma concentrations
of drugs metabolized by this pathway. Serious cardiovascular events, including
QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest,
and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol
(levomethadyl), or quinidine, concomitantly with SPORANOX® and/or other
CYP3A4 inhibitors. See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS: DRUG INTERACTIONS for more information.

DRUG DESCRIPTION



What are the possible side effects of itraconazole (Sporanox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fever;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
problems with hearing;
numbness or tingly feeling;
pain or burning when you urinate; or
nausea, stomach...
Read All Potential Side Effects for Sporanox »




SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal
agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two
enantiomeric pairs), each possessing three chiral centers. It may be represented
by the following structural formula and nomenclature:








(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
mixture with (±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2-(2,4-dichlorophenyl)-2-(1H1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4triazolin-5-one
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
Itraconazole has a molecular formula of C35H38Cl2N8O4
and a molecular weight of 705.64. It is a white to slightly yellowish powder.
It is insoluble in water, very slightly soluble in alcohols, and freely soluble
in dichloromethane. It has a pKa of 3.70 (based on extrapolation of values obtained
from methanolic solutions) and a log (n-octanol/water) partition coefficient
of 5.66 at pH 8.1.
SPORANOX® Capsules contain 100 mg of itraconazole coated on sugar spheres.
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol
(PEG) 20,000, starch, sucrose, titanium dioxide, FD&C Blue No. 1, FD&C
Blue No. 2, D&C Red No. 22 and D&C Red No. 28.Last reviewed on RxList: 8/23/2010




Sporanox Drug Description

SPORANOX®
(itraconazole) Capsules

Congestive Heart Failure:
SPORANOX ® (itraconazole) Capsules should not be administered for the
treatment of onychomycosis in patients with evidence of ventricular dysfunction
such as congestive heart failure (CHF) or a history of CHF. If signs or
symptoms of congestive heart failure occur during administration of SPORANOX®
Capsules, discontinue administration. When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
(See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS,
PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing
Experience for more information.)
Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated SPORANOX®, a potent cytochrome
P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma concentrations
of drugs metabolized by this pathway. Serious cardiovascular events, including
QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest,
and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol
(levomethadyl), or quinidine, concomitantly with SPORANOX® and/or other
CYP3A4 inhibitors. See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS: DRUG INTERACTIONS for more information.

DRUG DESCRIPTION



What are the possible side effects of itraconazole (Sporanox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fever;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
problems with hearing;
numbness or tingly feeling;
pain or burning when you urinate; or
nausea, stomach...
Read All Potential Side Effects for Sporanox »




SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal
agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two
enantiomeric pairs), each possessing three chiral centers. It may be represented
by the following structural formula and nomenclature:








(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
mixture with (±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2-(2,4-dichlorophenyl)-2-(1H1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4triazolin-5-one
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
Itraconazole has a molecular formula of C35H38Cl2N8O4
and a molecular weight of 705.64. It is a white to slightly yellowish powder.
It is insoluble in water, very slightly soluble in alcohols, and freely soluble
in dichloromethane. It has a pKa of 3.70 (based on extrapolation of values obtained
from methanolic solutions) and a log (n-octanol/water) partition coefficient
of 5.66 at pH 8.1.
SPORANOX® Capsules contain 100 mg of itraconazole coated on sugar spheres.
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol
(PEG) 20,000, starch, sucrose, titanium dioxide, FD&C Blue No. 1, FD&C
Blue No. 2, D&C Red No. 22 and D&C Red No. 28.Last reviewed on RxList: 8/23/2010




Sporanox Drug Description

SPORANOX®
(itraconazole) Capsules

Congestive Heart Failure:
SPORANOX ® (itraconazole) Capsules should not be administered for the
treatment of onychomycosis in patients with evidence of ventricular dysfunction
such as congestive heart failure (CHF) or a history of CHF. If signs or
symptoms of congestive heart failure occur during administration of SPORANOX®
Capsules, discontinue administration. When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
(See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS,
PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing
Experience for more information.)
Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated SPORANOX®, a potent cytochrome
P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma concentrations
of drugs metabolized by this pathway. Serious cardiovascular events, including
QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest,
and/or sudden death have occurred in patients using cisapride, pimozide, levacetylmethadol
(levomethadyl), or quinidine, concomitantly with SPORANOX® and/or other
CYP3A4 inhibitors. See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS: DRUG INTERACTIONS for more information.

DRUG DESCRIPTION



What are the possible side effects of itraconazole (Sporanox)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

fever;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain;
problems with hearing;
numbness or tingly feeling;
pain or burning when you urinate; or
nausea, stomach...
Read All Potential Side Effects for Sporanox »




SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal
agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two
enantiomeric pairs), each possessing three chiral centers. It may be represented
by the following structural formula and nomenclature:








(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
mixture with (±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2-(2,4-dichlorophenyl)-2-(1H1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4triazolin-5-one
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one
Itraconazole has a molecular formula of C35H38Cl2N8O4
and a molecular weight of 705.64. It is a white to slightly yellowish powder.
It is insoluble in water, very slightly soluble in alcohols, and freely soluble
in dichloromethane. It has a pKa of 3.70 (based on extrapolation of values obtained
from methanolic solutions) and a log (n-octanol/water) partition coefficient
of 5.66 at pH 8.1.
SPORANOX® Capsules contain 100 mg of itraconazole coated on sugar spheres.
Inactive ingredients are hard gelatin capsule, hypromellose, polyethylene glycol
(PEG) 20,000, starch, sucrose, titanium dioxide, FD&C Blue No. 1, FD&C
Blue No. 2, D&C Red No. 22 and D&C Red No. 28.Last reviewed on RxList: 8/23/2010





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Other reviews about Sporanox on web:

Learn about the prescription medication Sporanox (Itraconazole Capsules), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Sporanox (Itraconazole Capsules) Drug Information: Uses, Side ...


Sporanox (itraconazole) is used to treat fungal infections of the lungs, mouth, throat, toenails and fingernails. Includes Sporanox side effects, interactions and indications. Sporanox Information from Drugs.com


Sporanox information from Drugs.com. Sporanox capsules are used to treat three types of serious fungal infection: blastomycosis, histoplasmosis, and aspergillosis. Sporanox patient advice including side effects


Itraconazole (marketed as Sporanox by Janssen Pharmaceutica), invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections. Itraconazole - Wikipedia, the free encyclopedia


Sporanox is an azole antifungal agent used to treat fungal infections. Side effects and interactions are available at drugstore.com; plus get home delivery from a trusted and ... Sporanox - drugstore.com. Low prices, side effects, interactions.


Emphasizes the medication itraconazole (Sporanox), a drug used for the treatment of fungal infections which are isolated to a small area of the body. itraconazole (Sporanox) - drug class, medical uses, medication ...


SPORANOX ® (itraconazole) Please see full US Prescribing Information, including Boxed Warning TYLENOL ® with Codeine (acetaminophen and codeine phosphate) Tablets CIII Ortho-McNeil®: Our Products


Learn about Sporanox from the publishers of the Physicians Desk Reference. Find prescription drug information resources including interactions, side effects, symptoms ... Sporanox | Prescription Drug Information, Side Effects | PDRHealth


Buy Sporanox (Itraconazole) from our Canadian Online Pharmacy by calling 1-877-888-3562. Fully licensed, fast delivery, free doctor consultation provided. Buy Sporanox (Itraconazole) Online Now


sporanox: noun: an oral antifungal drug (trade name Sporanox) taken for cases of fungal nail disease [syn: itraconazole] Sporanox | Define Sporanox at Dictionary.com





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