Reviews Somatropin rDNA Origin


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Humatrope Drug Description
HUMATROPE®
[somatropin (rDNA ORIGIN)] for Injection, for Subcutaneous Use
DRUG DESCRIPTION



What are the possible side effects of somatropin?

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side...
Read All Potential Side Effects for Humatrope »




Humatrope (somatropin, rDNA origin, for injection) is a polypeptide hormone
of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia
coli that has been modified by the addition of the gene for human GH. The peptide
is comprised of 191 amino acid residues and has a molecular weight of about
22,125 daltons. The amino acid sequence of the peptide is identical to that
of human GH of pituitary origin.
Humatrope is a sterile, white, lyophilized powder intended for subcutaneous
or intramuscular administration after reconstitution to its liquid form. Humatrope
is a highly purified preparation. Phosphoric acid and/or sodium hydroxide may
have been added to adjust the pH. Reconstituted solutions have a pH of approximately
7.5. This product is oxygen sensitive.
Vial — Each vial of Humatrope contains 5 mg somatropin (15 IU or 225
nanomoles); 25 mg mannitol; 5 mg glycine; and 1.13 mg dibasic sodium phosphate.
Each vial is supplied in a combination package with an accompanying 5-mL vial
of diluting solution (diluent). The diluent contains Water for Injection with
0.3% metacresol as a preservative and 1.7% glycerin.
Cartridge — Cartridges of Humatrope contain either 6 mg (18 IU), 12
mg (36 IU), or 24 mg (72 IU) of somatropin. Each Humatrope cartridge contains
the following:




 
Cartridge


6 mg (gold)
12 mg (teal)
24 mg (purple)


Component


Somatropin
6 mg
12 mg
24 mg


Mannitol
18 mg
36 mg
72 mg


Glycine
6 mg
12 mg
24 mg


Dibasic sodium phosphate
1.36 mg
2.72 mg
5.43 mg



Each cartridge is supplied in a combination package with an accompanying syringe
containing approximately 3 mL of diluting solution (diluent). The diluent contains
Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, and
0.29% glycerin in the 6, 12, and 24 mg cartridges, respectively.
Last reviewed on RxList: 8/11/2010




Humatrope Drug Description
HUMATROPE®
[somatropin (rDNA ORIGIN)] for Injection, for Subcutaneous Use
DRUG DESCRIPTION



What are the possible side effects of somatropin?

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side...
Read All Potential Side Effects for Humatrope »




Humatrope (somatropin, rDNA origin, for injection) is a polypeptide hormone
of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia
coli that has been modified by the addition of the gene for human GH. The peptide
is comprised of 191 amino acid residues and has a molecular weight of about
22,125 daltons. The amino acid sequence of the peptide is identical to that
of human GH of pituitary origin.
Humatrope is a sterile, white, lyophilized powder intended for subcutaneous
or intramuscular administration after reconstitution to its liquid form. Humatrope
is a highly purified preparation. Phosphoric acid and/or sodium hydroxide may
have been added to adjust the pH. Reconstituted solutions have a pH of approximately
7.5. This product is oxygen sensitive.
Vial — Each vial of Humatrope contains 5 mg somatropin (15 IU or 225
nanomoles); 25 mg mannitol; 5 mg glycine; and 1.13 mg dibasic sodium phosphate.
Each vial is supplied in a combination package with an accompanying 5-mL vial
of diluting solution (diluent). The diluent contains Water for Injection with
0.3% metacresol as a preservative and 1.7% glycerin.
Cartridge — Cartridges of Humatrope contain either 6 mg (18 IU), 12
mg (36 IU), or 24 mg (72 IU) of somatropin. Each Humatrope cartridge contains
the following:




 
Cartridge


6 mg (gold)
12 mg (teal)
24 mg (purple)


Component


Somatropin
6 mg
12 mg
24 mg


Mannitol
18 mg
36 mg
72 mg


Glycine
6 mg
12 mg
24 mg


Dibasic sodium phosphate
1.36 mg
2.72 mg
5.43 mg



Each cartridge is supplied in a combination package with an accompanying syringe
containing approximately 3 mL of diluting solution (diluent). The diluent contains
Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, and
0.29% glycerin in the 6, 12, and 24 mg cartridges, respectively.
Last reviewed on RxList: 8/11/2010




Humatrope Drug Description
HUMATROPE®
[somatropin (rDNA ORIGIN)] for Injection, for Subcutaneous Use
DRUG DESCRIPTION



What are the possible side effects of somatropin?

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side...
Read All Potential Side Effects for Humatrope »




Humatrope (somatropin, rDNA origin, for injection) is a polypeptide hormone
of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia
coli that has been modified by the addition of the gene for human GH. The peptide
is comprised of 191 amino acid residues and has a molecular weight of about
22,125 daltons. The amino acid sequence of the peptide is identical to that
of human GH of pituitary origin.
Humatrope is a sterile, white, lyophilized powder intended for subcutaneous
or intramuscular administration after reconstitution to its liquid form. Humatrope
is a highly purified preparation. Phosphoric acid and/or sodium hydroxide may
have been added to adjust the pH. Reconstituted solutions have a pH of approximately
7.5. This product is oxygen sensitive.
Vial — Each vial of Humatrope contains 5 mg somatropin (15 IU or 225
nanomoles); 25 mg mannitol; 5 mg glycine; and 1.13 mg dibasic sodium phosphate.
Each vial is supplied in a combination package with an accompanying 5-mL vial
of diluting solution (diluent). The diluent contains Water for Injection with
0.3% metacresol as a preservative and 1.7% glycerin.
Cartridge — Cartridges of Humatrope contain either 6 mg (18 IU), 12
mg (36 IU), or 24 mg (72 IU) of somatropin. Each Humatrope cartridge contains
the following:




 
Cartridge


6 mg (gold)
12 mg (teal)
24 mg (purple)


Component


Somatropin
6 mg
12 mg
24 mg


Mannitol
18 mg
36 mg
72 mg


Glycine
6 mg
12 mg
24 mg


Dibasic sodium phosphate
1.36 mg
2.72 mg
5.43 mg



Each cartridge is supplied in a combination package with an accompanying syringe
containing approximately 3 mL of diluting solution (diluent). The diluent contains
Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, and
0.29% glycerin in the 6, 12, and 24 mg cartridges, respectively.
Last reviewed on RxList: 8/11/2010




Humatrope Drug Description
HUMATROPE®
[somatropin (rDNA ORIGIN)] for Injection, for Subcutaneous Use
DRUG DESCRIPTION



What are the possible side effects of somatropin?

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side...
Read All Potential Side Effects for Humatrope »




Humatrope (somatropin, rDNA origin, for injection) is a polypeptide hormone
of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia
coli that has been modified by the addition of the gene for human GH. The peptide
is comprised of 191 amino acid residues and has a molecular weight of about
22,125 daltons. The amino acid sequence of the peptide is identical to that
of human GH of pituitary origin.
Humatrope is a sterile, white, lyophilized powder intended for subcutaneous
or intramuscular administration after reconstitution to its liquid form. Humatrope
is a highly purified preparation. Phosphoric acid and/or sodium hydroxide may
have been added to adjust the pH. Reconstituted solutions have a pH of approximately
7.5. This product is oxygen sensitive.
Vial — Each vial of Humatrope contains 5 mg somatropin (15 IU or 225
nanomoles); 25 mg mannitol; 5 mg glycine; and 1.13 mg dibasic sodium phosphate.
Each vial is supplied in a combination package with an accompanying 5-mL vial
of diluting solution (diluent). The diluent contains Water for Injection with
0.3% metacresol as a preservative and 1.7% glycerin.
Cartridge — Cartridges of Humatrope contain either 6 mg (18 IU), 12
mg (36 IU), or 24 mg (72 IU) of somatropin. Each Humatrope cartridge contains
the following:




 
Cartridge


6 mg (gold)
12 mg (teal)
24 mg (purple)


Component


Somatropin
6 mg
12 mg
24 mg


Mannitol
18 mg
36 mg
72 mg


Glycine
6 mg
12 mg
24 mg


Dibasic sodium phosphate
1.36 mg
2.72 mg
5.43 mg



Each cartridge is supplied in a combination package with an accompanying syringe
containing approximately 3 mL of diluting solution (diluent). The diluent contains
Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, and
0.29% glycerin in the 6, 12, and 24 mg cartridges, respectively.
Last reviewed on RxList: 8/11/2010




Humatrope Drug Description
HUMATROPE®
[somatropin (rDNA ORIGIN)] for Injection, for Subcutaneous Use
DRUG DESCRIPTION



What are the possible side effects of somatropin?

If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side...
Read All Potential Side Effects for Humatrope »




Humatrope (somatropin, rDNA origin, for injection) is a polypeptide hormone
of recombinant DNA origin. Humatrope is synthesized in a strain of Escherichia
coli that has been modified by the addition of the gene for human GH. The peptide
is comprised of 191 amino acid residues and has a molecular weight of about
22,125 daltons. The amino acid sequence of the peptide is identical to that
of human GH of pituitary origin.
Humatrope is a sterile, white, lyophilized powder intended for subcutaneous
or intramuscular administration after reconstitution to its liquid form. Humatrope
is a highly purified preparation. Phosphoric acid and/or sodium hydroxide may
have been added to adjust the pH. Reconstituted solutions have a pH of approximately
7.5. This product is oxygen sensitive.
Vial — Each vial of Humatrope contains 5 mg somatropin (15 IU or 225
nanomoles); 25 mg mannitol; 5 mg glycine; and 1.13 mg dibasic sodium phosphate.
Each vial is supplied in a combination package with an accompanying 5-mL vial
of diluting solution (diluent). The diluent contains Water for Injection with
0.3% metacresol as a preservative and 1.7% glycerin.
Cartridge — Cartridges of Humatrope contain either 6 mg (18 IU), 12
mg (36 IU), or 24 mg (72 IU) of somatropin. Each Humatrope cartridge contains
the following:




 
Cartridge


6 mg (gold)
12 mg (teal)
24 mg (purple)


Component


Somatropin
6 mg
12 mg
24 mg


Mannitol
18 mg
36 mg
72 mg


Glycine
6 mg
12 mg
24 mg


Dibasic sodium phosphate
1.36 mg
2.72 mg
5.43 mg



Each cartridge is supplied in a combination package with an accompanying syringe
containing approximately 3 mL of diluting solution (diluent). The diluent contains
Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, and
0.29% glycerin in the 6, 12, and 24 mg cartridges, respectively.
Last reviewed on RxList: 8/11/2010





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