Reviews Sitagliptin Metformin HCL


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Janumet Drug Description
JANUMET®
(sitagliptin/metformin HCl) Tablets

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare, but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive
heart failure.
The onset is often subtle, accompanied only by nonspecific symptoms such
as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific
abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, JANUMET should be discontinued and the patient
hospitalized immediately. [See WARNINGS AND PRECAUTIONS.]

DRUG DESCRIPTION



What are the possible side effects of metformin and sitagliptin (Janumet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
fever, chills, body aches, flu symptoms; or
a severe blistering, peeling, and red skin rash.

Less serious side effects...
Read All Potential Side Effects for Janumet »




JANUMET (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.
Sitagliptin
Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically
as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O
and a molecular weight of 523.32. The structural formula is:








Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.
Metformin hydrochloride
Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin hydrochloride is freely soluble
in water and is practically insoluble in acetone, ether, and chloroform. The
pKa of metformin is 12.4. The pH of a 1% aqueous solution
of metformin hydrochloride is 6.68. The structural formula is as shown:








JANUMET
JANUMET is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (JANUMET 50 mg/500 mg) or 1000 mg metformin hydrochloride (JANUMET 50 mg/1000 mg). Each film-coated tablet of JANUMET contains the following inactive ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide.
Last reviewed on RxList: 1/8/2010




Janumet Drug Description
JANUMET®
(sitagliptin/metformin HCl) Tablets

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare, but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive
heart failure.
The onset is often subtle, accompanied only by nonspecific symptoms such
as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific
abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, JANUMET should be discontinued and the patient
hospitalized immediately. [See WARNINGS AND PRECAUTIONS.]

DRUG DESCRIPTION



What are the possible side effects of metformin and sitagliptin (Janumet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
fever, chills, body aches, flu symptoms; or
a severe blistering, peeling, and red skin rash.

Less serious side effects...
Read All Potential Side Effects for Janumet »




JANUMET (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.
Sitagliptin
Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically
as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O
and a molecular weight of 523.32. The structural formula is:








Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.
Metformin hydrochloride
Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin hydrochloride is freely soluble
in water and is practically insoluble in acetone, ether, and chloroform. The
pKa of metformin is 12.4. The pH of a 1% aqueous solution
of metformin hydrochloride is 6.68. The structural formula is as shown:








JANUMET
JANUMET is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (JANUMET 50 mg/500 mg) or 1000 mg metformin hydrochloride (JANUMET 50 mg/1000 mg). Each film-coated tablet of JANUMET contains the following inactive ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide.
Last reviewed on RxList: 1/8/2010




Janumet Drug Description
JANUMET®
(sitagliptin/metformin HCl) Tablets

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare, but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive
heart failure.
The onset is often subtle, accompanied only by nonspecific symptoms such
as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific
abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, JANUMET should be discontinued and the patient
hospitalized immediately. [See WARNINGS AND PRECAUTIONS.]

DRUG DESCRIPTION



What are the possible side effects of metformin and sitagliptin (Janumet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
fever, chills, body aches, flu symptoms; or
a severe blistering, peeling, and red skin rash.

Less serious side effects...
Read All Potential Side Effects for Janumet »




JANUMET (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.
Sitagliptin
Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically
as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O
and a molecular weight of 523.32. The structural formula is:








Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.
Metformin hydrochloride
Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin hydrochloride is freely soluble
in water and is practically insoluble in acetone, ether, and chloroform. The
pKa of metformin is 12.4. The pH of a 1% aqueous solution
of metformin hydrochloride is 6.68. The structural formula is as shown:








JANUMET
JANUMET is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (JANUMET 50 mg/500 mg) or 1000 mg metformin hydrochloride (JANUMET 50 mg/1000 mg). Each film-coated tablet of JANUMET contains the following inactive ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide.
Last reviewed on RxList: 1/8/2010




Janumet Drug Description
JANUMET®
(sitagliptin/metformin HCl) Tablets

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare, but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive
heart failure.
The onset is often subtle, accompanied only by nonspecific symptoms such
as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific
abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, JANUMET should be discontinued and the patient
hospitalized immediately. [See WARNINGS AND PRECAUTIONS.]

DRUG DESCRIPTION



What are the possible side effects of metformin and sitagliptin (Janumet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
fever, chills, body aches, flu symptoms; or
a severe blistering, peeling, and red skin rash.

Less serious side effects...
Read All Potential Side Effects for Janumet »




JANUMET (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.
Sitagliptin
Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically
as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O
and a molecular weight of 523.32. The structural formula is:








Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.
Metformin hydrochloride
Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin hydrochloride is freely soluble
in water and is practically insoluble in acetone, ether, and chloroform. The
pKa of metformin is 12.4. The pH of a 1% aqueous solution
of metformin hydrochloride is 6.68. The structural formula is as shown:








JANUMET
JANUMET is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (JANUMET 50 mg/500 mg) or 1000 mg metformin hydrochloride (JANUMET 50 mg/1000 mg). Each film-coated tablet of JANUMET contains the following inactive ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide.
Last reviewed on RxList: 1/8/2010




Janumet Drug Description
JANUMET®
(sitagliptin/metformin HCl) Tablets

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare, but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive
heart failure.
The onset is often subtle, accompanied only by nonspecific symptoms such
as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific
abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, JANUMET should be discontinued and the patient
hospitalized immediately. [See WARNINGS AND PRECAUTIONS.]

DRUG DESCRIPTION



What are the possible side effects of metformin and sitagliptin (Janumet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
fever, chills, body aches, flu symptoms; or
a severe blistering, peeling, and red skin rash.

Less serious side effects...
Read All Potential Side Effects for Janumet »




JANUMET (sitagliptin/metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: sitagliptin and metformin hydrochloride.
Sitagliptin
Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically
as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5O•H3PO4•H2O
and a molecular weight of 523.32. The structural formula is:








Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl acetate.
Metformin hydrochloride
Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antihyperglycemic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•HCl
and a molecular weight of 165.63. Metformin hydrochloride is freely soluble
in water and is practically insoluble in acetone, ether, and chloroform. The
pKa of metformin is 12.4. The pH of a 1% aqueous solution
of metformin hydrochloride is 6.68. The structural formula is as shown:








JANUMET
JANUMET is available for oral administration as tablets containing 64.25 mg sitagliptin phosphate monohydrate and metformin hydrochloride equivalent to: 50 mg sitagliptin as free base and 500 mg metformin hydrochloride (JANUMET 50 mg/500 mg) or 1000 mg metformin hydrochloride (JANUMET 50 mg/1000 mg). Each film-coated tablet of JANUMET contains the following inactive ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide.
Last reviewed on RxList: 1/8/2010





Other reviews about Sitagliptin Metformin HCL on wordpress

FDA MedWatch - December 2009 Drug Safety Labeling Changes
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Other reviews about Sitagliptin Metformin HCL on web:

Learn about the prescription medication Janumet (Sitagliptin Metformin HCL), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Janumet (Sitagliptin Metformin HCL) Drug Information: Uses, Side ...


JANUMET is a powerful type 2 diabetes medicine that combines 2 prescription medicines, sitagliptin (JANUVIA テδづつョ) and metformin, and can lower blood sugar more than the most ... The Power of JANUMET


JANUMETテδ「テつテつ「 (sitagliptin/metformin HCl) Logo ... JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA テδづつョ) and metformin. JANUMET for Type 2 Diabetes


Merck & Co., Inc. announced today that the U.S. Food and Drug Administration (FDA) approved JANUMETテδ「テつテつ「. Please read the attached full Prescribing Information, including the ... FDA APPROVES JANUMET (SITAGLIPTIN/METFORMIN HCL)


Resources for You. Janumet (sitagliptin/metformin HCl) Tablets Prescribing Information and Patient Package Insert Jan 2008 -- Janumet (sitagliptin/metformin HCl) Tablets


Sitagliptin/Metformin Hydrochloride professional patient advice. Specific and up to date information about Sitagliptin/Metformin Hydrochloride. Complete Sitagliptin/Metformin Hydrochloride information from ...


JANUMET is indicated, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is ... A1C reduction information available at Janumet.com


Read the prescribing information for JANUMETテδづつョ (sitagliptin/metformin HCl) to learn how to administer the medication. Prescribing Information For JANUMETテδづつョ (sitagliptin/metformin HCl)


Janumet (sitagliptin/metformin HCl) tablets Drug Safety Labeling Changes December 2009 -MedWatch Janumet (sitagliptin/metformin HCl) tabletsテδづつ


No educational resources related to JANUMET テδづつョ (sitagliptin/metformin HCl) tablets are available at this time. You can request a number of complimentary resources, where available ... MerckProductServices - Pharmaceutical Products - JANUMET





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