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Rifamate Drug Description
RIFAMATE®
(rifampin and isoniazid) Capsules USP

WARNING
Severe and sometimes fatal hepatitis associated with isoniazid therapy may
occur and may develop even after many months of treatment. The risk of developing
hepatitis is age related. Approximate case rates by age are: 0 per 1,000 for
persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age
group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for
persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years
of age. The risk of hepatitis is increased with daily consumption of alcohol.
Precise data to provide a fatality rate for isoniazid-related hepatitis is not
available; however, in a U.S. Public Health Service Surveillance Study of 13,838
persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.

Therefore, patients given isoniazid should be carefully monitored and interviewed
at monthly intervals. Serum transaminase concentration becomes elevated in about
10-20 percent of patients, usually during the first few months of therapy, but
it can occur at any time. Usually enzyme levels return to normal despite continuance
of drug, but in some cases progressive liver dysfunction occurs. Patients should
be instructed to report immediately any of the prodromal symptoms of hepatitis,
such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these
symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid
should be discontinued promptly, since continued use of the drug in these cases
has been reported to cause a more severe form of liver damage.
Patients with tuberculosis should be given appropriate treatment with alternative
drugs. If isoniazid must be reinstituted, it should be reinstituted only after
symptoms and laboratory abnormalities have cleared. The drug should be restarted
in very small and gradually increasing doses and should be withdrawn immediately
if there is any indication of recurrent liver involvement. Treatment should
be deferred in persons with acute hepatic diseases.

DRUG DESCRIPTION



What are the possible side effects of isoniazid and rifampin (Rifamate)?

If you experience any of the following serious side effects, stop taking isoniazid and rifampin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
excessive tiredness or weakness;
nausea, vomiting, diarrhea, or loss of appetite;
yellow skin or eyes;
unusual bruising or bleeding;
dark...
Read All Potential Side Effects for Rifamate »




RIFAMATE is a combination capsule containing 300 mg rifampin and 150 mg isoniazid.
The capsules also contain as inactive ingredients: colloidal silicon dioxide,
FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, sodium
starch glycolate, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical
name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or
white crystals or as a white, crystalline powder that is water soluble, odorless,
and slowly affected by exposure to air and light.Last reviewed on RxList: 2/24/2009




Rifamate Drug Description
RIFAMATE®
(rifampin and isoniazid) Capsules USP

WARNING
Severe and sometimes fatal hepatitis associated with isoniazid therapy may
occur and may develop even after many months of treatment. The risk of developing
hepatitis is age related. Approximate case rates by age are: 0 per 1,000 for
persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age
group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for
persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years
of age. The risk of hepatitis is increased with daily consumption of alcohol.
Precise data to provide a fatality rate for isoniazid-related hepatitis is not
available; however, in a U.S. Public Health Service Surveillance Study of 13,838
persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.

Therefore, patients given isoniazid should be carefully monitored and interviewed
at monthly intervals. Serum transaminase concentration becomes elevated in about
10-20 percent of patients, usually during the first few months of therapy, but
it can occur at any time. Usually enzyme levels return to normal despite continuance
of drug, but in some cases progressive liver dysfunction occurs. Patients should
be instructed to report immediately any of the prodromal symptoms of hepatitis,
such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these
symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid
should be discontinued promptly, since continued use of the drug in these cases
has been reported to cause a more severe form of liver damage.
Patients with tuberculosis should be given appropriate treatment with alternative
drugs. If isoniazid must be reinstituted, it should be reinstituted only after
symptoms and laboratory abnormalities have cleared. The drug should be restarted
in very small and gradually increasing doses and should be withdrawn immediately
if there is any indication of recurrent liver involvement. Treatment should
be deferred in persons with acute hepatic diseases.

DRUG DESCRIPTION



What are the possible side effects of isoniazid and rifampin (Rifamate)?

If you experience any of the following serious side effects, stop taking isoniazid and rifampin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
excessive tiredness or weakness;
nausea, vomiting, diarrhea, or loss of appetite;
yellow skin or eyes;
unusual bruising or bleeding;
dark...
Read All Potential Side Effects for Rifamate »




RIFAMATE is a combination capsule containing 300 mg rifampin and 150 mg isoniazid.
The capsules also contain as inactive ingredients: colloidal silicon dioxide,
FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, sodium
starch glycolate, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical
name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or
white crystals or as a white, crystalline powder that is water soluble, odorless,
and slowly affected by exposure to air and light.Last reviewed on RxList: 2/24/2009




Rifamate Drug Description
RIFAMATE®
(rifampin and isoniazid) Capsules USP

WARNING
Severe and sometimes fatal hepatitis associated with isoniazid therapy may
occur and may develop even after many months of treatment. The risk of developing
hepatitis is age related. Approximate case rates by age are: 0 per 1,000 for
persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age
group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for
persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years
of age. The risk of hepatitis is increased with daily consumption of alcohol.
Precise data to provide a fatality rate for isoniazid-related hepatitis is not
available; however, in a U.S. Public Health Service Surveillance Study of 13,838
persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.

Therefore, patients given isoniazid should be carefully monitored and interviewed
at monthly intervals. Serum transaminase concentration becomes elevated in about
10-20 percent of patients, usually during the first few months of therapy, but
it can occur at any time. Usually enzyme levels return to normal despite continuance
of drug, but in some cases progressive liver dysfunction occurs. Patients should
be instructed to report immediately any of the prodromal symptoms of hepatitis,
such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these
symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid
should be discontinued promptly, since continued use of the drug in these cases
has been reported to cause a more severe form of liver damage.
Patients with tuberculosis should be given appropriate treatment with alternative
drugs. If isoniazid must be reinstituted, it should be reinstituted only after
symptoms and laboratory abnormalities have cleared. The drug should be restarted
in very small and gradually increasing doses and should be withdrawn immediately
if there is any indication of recurrent liver involvement. Treatment should
be deferred in persons with acute hepatic diseases.

DRUG DESCRIPTION



What are the possible side effects of isoniazid and rifampin (Rifamate)?

If you experience any of the following serious side effects, stop taking isoniazid and rifampin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
excessive tiredness or weakness;
nausea, vomiting, diarrhea, or loss of appetite;
yellow skin or eyes;
unusual bruising or bleeding;
dark...
Read All Potential Side Effects for Rifamate »




RIFAMATE is a combination capsule containing 300 mg rifampin and 150 mg isoniazid.
The capsules also contain as inactive ingredients: colloidal silicon dioxide,
FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, sodium
starch glycolate, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical
name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or
white crystals or as a white, crystalline powder that is water soluble, odorless,
and slowly affected by exposure to air and light.Last reviewed on RxList: 2/24/2009




Rifamate Drug Description
RIFAMATE®
(rifampin and isoniazid) Capsules USP

WARNING
Severe and sometimes fatal hepatitis associated with isoniazid therapy may
occur and may develop even after many months of treatment. The risk of developing
hepatitis is age related. Approximate case rates by age are: 0 per 1,000 for
persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age
group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for
persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years
of age. The risk of hepatitis is increased with daily consumption of alcohol.
Precise data to provide a fatality rate for isoniazid-related hepatitis is not
available; however, in a U.S. Public Health Service Surveillance Study of 13,838
persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.

Therefore, patients given isoniazid should be carefully monitored and interviewed
at monthly intervals. Serum transaminase concentration becomes elevated in about
10-20 percent of patients, usually during the first few months of therapy, but
it can occur at any time. Usually enzyme levels return to normal despite continuance
of drug, but in some cases progressive liver dysfunction occurs. Patients should
be instructed to report immediately any of the prodromal symptoms of hepatitis,
such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these
symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid
should be discontinued promptly, since continued use of the drug in these cases
has been reported to cause a more severe form of liver damage.
Patients with tuberculosis should be given appropriate treatment with alternative
drugs. If isoniazid must be reinstituted, it should be reinstituted only after
symptoms and laboratory abnormalities have cleared. The drug should be restarted
in very small and gradually increasing doses and should be withdrawn immediately
if there is any indication of recurrent liver involvement. Treatment should
be deferred in persons with acute hepatic diseases.

DRUG DESCRIPTION



What are the possible side effects of isoniazid and rifampin (Rifamate)?

If you experience any of the following serious side effects, stop taking isoniazid and rifampin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
excessive tiredness or weakness;
nausea, vomiting, diarrhea, or loss of appetite;
yellow skin or eyes;
unusual bruising or bleeding;
dark...
Read All Potential Side Effects for Rifamate »




RIFAMATE is a combination capsule containing 300 mg rifampin and 150 mg isoniazid.
The capsules also contain as inactive ingredients: colloidal silicon dioxide,
FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, sodium
starch glycolate, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical
name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or
white crystals or as a white, crystalline powder that is water soluble, odorless,
and slowly affected by exposure to air and light.Last reviewed on RxList: 2/24/2009




Rifamate Drug Description
RIFAMATE®
(rifampin and isoniazid) Capsules USP

WARNING
Severe and sometimes fatal hepatitis associated with isoniazid therapy may
occur and may develop even after many months of treatment. The risk of developing
hepatitis is age related. Approximate case rates by age are: 0 per 1,000 for
persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age
group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for
persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years
of age. The risk of hepatitis is increased with daily consumption of alcohol.
Precise data to provide a fatality rate for isoniazid-related hepatitis is not
available; however, in a U.S. Public Health Service Surveillance Study of 13,838
persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.

Therefore, patients given isoniazid should be carefully monitored and interviewed
at monthly intervals. Serum transaminase concentration becomes elevated in about
10-20 percent of patients, usually during the first few months of therapy, but
it can occur at any time. Usually enzyme levels return to normal despite continuance
of drug, but in some cases progressive liver dysfunction occurs. Patients should
be instructed to report immediately any of the prodromal symptoms of hepatitis,
such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. If these
symptoms appear or if signs suggestive of hepatic damage are detected, isoniazid
should be discontinued promptly, since continued use of the drug in these cases
has been reported to cause a more severe form of liver damage.
Patients with tuberculosis should be given appropriate treatment with alternative
drugs. If isoniazid must be reinstituted, it should be reinstituted only after
symptoms and laboratory abnormalities have cleared. The drug should be restarted
in very small and gradually increasing doses and should be withdrawn immediately
if there is any indication of recurrent liver involvement. Treatment should
be deferred in persons with acute hepatic diseases.

DRUG DESCRIPTION



What are the possible side effects of isoniazid and rifampin (Rifamate)?

If you experience any of the following serious side effects, stop taking isoniazid and rifampin and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
excessive tiredness or weakness;
nausea, vomiting, diarrhea, or loss of appetite;
yellow skin or eyes;
unusual bruising or bleeding;
dark...
Read All Potential Side Effects for Rifamate »




RIFAMATE is a combination capsule containing 300 mg rifampin and 150 mg isoniazid.
The capsules also contain as inactive ingredients: colloidal silicon dioxide,
FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, sodium
starch glycolate, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical
name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or
white crystals or as a white, crystalline powder that is water soluble, odorless,
and slowly affected by exposure to air and light.Last reviewed on RxList: 2/24/2009





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Other reviews about Rifamate on web:

All about Rifamate Capsules. View complete and up to date Rifamate information - part of the Drugs.com trusted medication database. Rifamate Capsules Facts and Comparisons at Drugs.com


Learn about the prescription medication Rifamate (Rifampin and Isoniazid), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Rifamate (Rifampin and Isoniazid) Drug Information: Uses, Side ...


Rifamate patient information. Detailed drug information for the consumer, includes dosage, Rifamate side effects and more. Rifamate consumer information from Drugs.com


What is Rifamate? Rifamate is a combination of two antibacterial medicines (rifampin, isoniazid), which helps in treating the tuberculosis infection caused by TB bacteria. Rifamate - Kosmix : Reference, Videos, Images, News, Shopping and ...


What is Rifamate (Isoniazid Rifampin)? Isoniazid and rifampin are antibiotics. They prevent tuberculous bacteria from multiplying in your body. Rifamate - Drugs & Treatments - Revolution Health


Find patient medical information for Rifamate Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Rifamate Oral : Uses, Side Effects, Interactions, Pictures ...


Rifamate is an antibacterial combination used to treat tuberculosis (TB). Side effects and interactions are available at drugstore.com; plus get home delivery from a trusted and ... Rifamate - drugstore.com. Low prices, side effects, interactions.


Partner With Us : Partnering with us is easy. Simply fill out the form on this page to be added to our growing directory of partners. Copy the link code provided below to include on ... Rifamate Resource Site


Learn about Rifamate (Rifampin and Isoniazid) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Rifamate (Rifampin and Isoniazid) Patient Drug Information and ...


Description. Rifampin and isoniazid (rif-AM-pin and eye-soe-NYE-a-zid) is a combination antibiotic and anti-infective medicine. This combination medication is used to treat ... Rifamate Resource Site





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