Reviews Repaglinide and Metformin HCl Tablets


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Prandimet Drug Description
PrandiMet®
(repaglinide and metformin HCl) Tablets.

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic impairment, renal impairment, and acute congestive
heart failure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific
symptoms such as malaise, myalgias, respiratory distress, increasing somnolence,
and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, PrandiMet should be discontinued and the patient
hospitalized immediately [See WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain;
sudden numbness or weakness, especially on one side of the body; or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side...
Read All Potential Side Effects for Prandimet »




PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin HCl has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.
Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl)
amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea
insulin secretagogues. Repaglinide is a white to off-white powder with molecular
formula C27H36N2O4 and a molecular
weight of 452.6 with the structural formula as shown below. Repaglinide is freely
soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and
the pKa in amine is 6.0.
Structural formula of Repaglinide







Metformin HCl (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not
chemically or pharmacologically related to any other classes of oral antihyperglycemic
agents. Metformin HCl is a white to off-white crystalline compound with a molecular
formula of C4H11N5•HCl and a molecular weight
of 165.63. Metformin HCl is freely soluble in water and is practically insoluble
in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH
of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of
metformin HCl is:
Structural formula of Metformin HCl







PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.
Last reviewed on RxList: 6/25/2010




Prandimet Drug Description
PrandiMet®
(repaglinide and metformin HCl) Tablets.

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic impairment, renal impairment, and acute congestive
heart failure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific
symptoms such as malaise, myalgias, respiratory distress, increasing somnolence,
and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, PrandiMet should be discontinued and the patient
hospitalized immediately [See WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain;
sudden numbness or weakness, especially on one side of the body; or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side...
Read All Potential Side Effects for Prandimet »




PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin HCl has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.
Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl)
amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea
insulin secretagogues. Repaglinide is a white to off-white powder with molecular
formula C27H36N2O4 and a molecular
weight of 452.6 with the structural formula as shown below. Repaglinide is freely
soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and
the pKa in amine is 6.0.
Structural formula of Repaglinide







Metformin HCl (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not
chemically or pharmacologically related to any other classes of oral antihyperglycemic
agents. Metformin HCl is a white to off-white crystalline compound with a molecular
formula of C4H11N5•HCl and a molecular weight
of 165.63. Metformin HCl is freely soluble in water and is practically insoluble
in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH
of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of
metformin HCl is:
Structural formula of Metformin HCl







PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.
Last reviewed on RxList: 6/25/2010




Prandimet Drug Description
PrandiMet®
(repaglinide and metformin HCl) Tablets.

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic impairment, renal impairment, and acute congestive
heart failure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific
symptoms such as malaise, myalgias, respiratory distress, increasing somnolence,
and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, PrandiMet should be discontinued and the patient
hospitalized immediately [See WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain;
sudden numbness or weakness, especially on one side of the body; or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side...
Read All Potential Side Effects for Prandimet »




PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin HCl has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.
Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl)
amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea
insulin secretagogues. Repaglinide is a white to off-white powder with molecular
formula C27H36N2O4 and a molecular
weight of 452.6 with the structural formula as shown below. Repaglinide is freely
soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and
the pKa in amine is 6.0.
Structural formula of Repaglinide







Metformin HCl (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not
chemically or pharmacologically related to any other classes of oral antihyperglycemic
agents. Metformin HCl is a white to off-white crystalline compound with a molecular
formula of C4H11N5•HCl and a molecular weight
of 165.63. Metformin HCl is freely soluble in water and is practically insoluble
in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH
of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of
metformin HCl is:
Structural formula of Metformin HCl







PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.
Last reviewed on RxList: 6/25/2010




Prandimet Drug Description
PrandiMet®
(repaglinide and metformin HCl) Tablets.

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic impairment, renal impairment, and acute congestive
heart failure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific
symptoms such as malaise, myalgias, respiratory distress, increasing somnolence,
and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, PrandiMet should be discontinued and the patient
hospitalized immediately [See WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain;
sudden numbness or weakness, especially on one side of the body; or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side...
Read All Potential Side Effects for Prandimet »




PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin HCl has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.
Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl)
amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea
insulin secretagogues. Repaglinide is a white to off-white powder with molecular
formula C27H36N2O4 and a molecular
weight of 452.6 with the structural formula as shown below. Repaglinide is freely
soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and
the pKa in amine is 6.0.
Structural formula of Repaglinide







Metformin HCl (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not
chemically or pharmacologically related to any other classes of oral antihyperglycemic
agents. Metformin HCl is a white to off-white crystalline compound with a molecular
formula of C4H11N5•HCl and a molecular weight
of 165.63. Metformin HCl is freely soluble in water and is practically insoluble
in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH
of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of
metformin HCl is:
Structural formula of Metformin HCl







PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.
Last reviewed on RxList: 6/25/2010




Prandimet Drug Description
PrandiMet®
(repaglinide and metformin HCl) Tablets.

WARNING: LACTIC ACIDOSIS
Lactic acidosis is a rare but serious complication that can occur due to
metformin accumulation. The risk increases with conditions such as sepsis, dehydration,
excess alcohol intake, hepatic impairment, renal impairment, and acute congestive
heart failure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific
symptoms such as malaise, myalgias, respiratory distress, increasing somnolence,
and nonspecific abdominal distress.
Laboratory abnormalities include low pH, increased anion gap and elevated
blood lactate.
If acidosis is suspected, PrandiMet should be discontinued and the patient
hospitalized immediately [See WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain;
sudden numbness or weakness, especially on one side of the body; or
stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side...
Read All Potential Side Effects for Prandimet »




PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin HCl has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.
Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl)
amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea
insulin secretagogues. Repaglinide is a white to off-white powder with molecular
formula C27H36N2O4 and a molecular
weight of 452.6 with the structural formula as shown below. Repaglinide is freely
soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and
the pKa in amine is 6.0.
Structural formula of Repaglinide







Metformin HCl (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not
chemically or pharmacologically related to any other classes of oral antihyperglycemic
agents. Metformin HCl is a white to off-white crystalline compound with a molecular
formula of C4H11N5•HCl and a molecular weight
of 165.63. Metformin HCl is freely soluble in water and is practically insoluble
in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH
of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of
metformin HCl is:
Structural formula of Metformin HCl







PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.
Last reviewed on RxList: 6/25/2010





Other reviews about Repaglinide and Metformin HCl Tablets on wordpress

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Other reviews about Repaglinide and Metformin HCl Tablets on web:

Learn about the prescription medication Prandimet (Repaglinide and Metformin HCl Tablets), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Prandimet (Repaglinide and Metformin HCl Tablets) Drug Information ...


HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use PrandiMet safely and effectively. See full prescribing information for ... PrandiMetテδ「テつテつ「 (repaglinide and metformin HCl) Tablets


Novo Nordisk and Sciele Pharma, Inc., a Shionogi Company, announced the availability of PrandiMetテδづつョ (repaglinide and metformin HCl) tablets, the first and only fixed-dose ... PrandiMet(R), First Repaglinide And Metformin HCl Fixed Dose ...


PrandiMet (repaglinide/metformin HCl fixed-dose combination) tablet Drug Safety Labeling Changes May 2010 PrandiMet (repaglinide/metformin HCl fixed-dose combination) tablet


PRINCETON, N.J. & ATLANTA -- Novo Nordisk and Sciele Pharma, Inc., a Shionogi Company, today announced the availability of PrandiMet([R]) (repaglinide and metformin HCl) tablets ... PrandiMetテδづつョ, First Repaglinide and Metformin HCl Fixed Dose ...


Learn about Prandimet (Repaglinide and Metformin HCl Tablets) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Prandimet (Repaglinide and Metformin HCl Tablets) Patient Drug ...


... HCl) tablets, the first and only fixed-dose combination of the short-acting secretagogue repaglinide (also known as Prandin テδづつョ) and insulin sensitizer metformin HCl ... PrandiMet , First Repaglinide and Metformin HCl Fixed Dose ...


PrandiMetテδづつョ, First Repaglinide and Metformin HCl Fixed Dose Combination Therapy ... today announced the availability of PrandiMetテδづつョ (repaglinide and metformin HCl) tablets ... PrandiMetテδづつョ, First Repaglinide and Metformin HCl Fixed Dose ...


... and metformin HCl) tablets, the first and only fixed-dose combination of the short-acting secretagogue repaglinide (also known as Prandinテδづつョ) and insulin sensitizer metformin HCl ... Novo Nordisk MediaRoom - Latest News


Pharmacy & Therapeutics - September 2008 - (Page 551) Pharmaceutical Approval Update Repaglinide Plus Metformin HCl Tablets (PrandiMet) Manufacturer: Novo Nordisk, Inc ... Pharmacy & Therapeutics - September 2008 - (551)





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