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Elitek Drug Description
ELITEK
(rasburicase) Powder for Solution, for Intravenous Infusion

WARNING: ANAPHYLAXIS, HEMOLYSIS, METHEMOGLOBINEMIA, AND INTERFERENCE
WITH URIC ACID MEASUREMENTS Anaphylaxis
Elitek® can cause severe hypersensitivity reactions including anaphylaxis.
Immediately and permanently discontinue Elitek in patients who experience
a serious hypersensitivity reaction [see CONTRAINDICATIONS,
WARNINGS AND PRECAUTIONS, ADVERSE
REACTIONS].
Hemolysis
Do not administer Elitek to patients with glucose-6-phosphate dehydrogenase
(G6PD) deficiency. Immediately and permanently discontinue Elitek in patients
developing hemolysis. Screen patients at higher risk for G6PD deficiency (e.g.,
patients of African or Mediterranean ancestry) prior to starting Elitek [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Methemoglobinemia
Elitek can result in methemoglobinemia in some patients. Immediately and
permanently discontinue Elitek in patients developing methemoglobinemia [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Interference with Uric Acid Measurements
Elitek enzymatically degrades uric acid in blood samples left at room temperature.
Collect blood samples in pre-chilled tubes containing heparin and immediately
immerse and maintain sample in an ice water bath. Assay plasma samples within
4 hours of collection [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of rasburicase (Elitek)?

In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience:

...
Read All Potential Side Effects for Elitek »




Elitek (rasburicase) is a recombinant urate-oxidase produced by a genetically
modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase
was cloned from a strain of Aspergillus flavus.
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Elitek 1.5 mg presentation contains 1.5 mg rasburicase, 10.6 mg mannitol, 15.9 mg L-alanine, between 12.6 and 14.3 mg of dibasic sodium phosphate (lyophilized powder), and a diluent (1 mL Water for Injection, USP, and 1 mg Poloxamer 188).
Elitek 7.5 mg presentation contains 7.5 mg of rasburicase, 53 mg mannitol, 79.5 mg L-alanine, and between 63 and 71.5 mg dibasic sodium phosphate (lyophilized powder) and a diluent (5 mL Water for Injection, USP, and 5 mg Poloxamer 188).
Last reviewed on RxList: 11/2/2009




Elitek Drug Description
ELITEK
(rasburicase) Powder for Solution, for Intravenous Infusion

WARNING: ANAPHYLAXIS, HEMOLYSIS, METHEMOGLOBINEMIA, AND INTERFERENCE
WITH URIC ACID MEASUREMENTS Anaphylaxis
Elitek® can cause severe hypersensitivity reactions including anaphylaxis.
Immediately and permanently discontinue Elitek in patients who experience
a serious hypersensitivity reaction [see CONTRAINDICATIONS,
WARNINGS AND PRECAUTIONS, ADVERSE
REACTIONS].
Hemolysis
Do not administer Elitek to patients with glucose-6-phosphate dehydrogenase
(G6PD) deficiency. Immediately and permanently discontinue Elitek in patients
developing hemolysis. Screen patients at higher risk for G6PD deficiency (e.g.,
patients of African or Mediterranean ancestry) prior to starting Elitek [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Methemoglobinemia
Elitek can result in methemoglobinemia in some patients. Immediately and
permanently discontinue Elitek in patients developing methemoglobinemia [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Interference with Uric Acid Measurements
Elitek enzymatically degrades uric acid in blood samples left at room temperature.
Collect blood samples in pre-chilled tubes containing heparin and immediately
immerse and maintain sample in an ice water bath. Assay plasma samples within
4 hours of collection [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of rasburicase (Elitek)?

In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience:

...
Read All Potential Side Effects for Elitek »




Elitek (rasburicase) is a recombinant urate-oxidase produced by a genetically
modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase
was cloned from a strain of Aspergillus flavus.
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Elitek 1.5 mg presentation contains 1.5 mg rasburicase, 10.6 mg mannitol, 15.9 mg L-alanine, between 12.6 and 14.3 mg of dibasic sodium phosphate (lyophilized powder), and a diluent (1 mL Water for Injection, USP, and 1 mg Poloxamer 188).
Elitek 7.5 mg presentation contains 7.5 mg of rasburicase, 53 mg mannitol, 79.5 mg L-alanine, and between 63 and 71.5 mg dibasic sodium phosphate (lyophilized powder) and a diluent (5 mL Water for Injection, USP, and 5 mg Poloxamer 188).
Last reviewed on RxList: 11/2/2009




Elitek Drug Description
ELITEK
(rasburicase) Powder for Solution, for Intravenous Infusion

WARNING: ANAPHYLAXIS, HEMOLYSIS, METHEMOGLOBINEMIA, AND INTERFERENCE
WITH URIC ACID MEASUREMENTS Anaphylaxis
Elitek® can cause severe hypersensitivity reactions including anaphylaxis.
Immediately and permanently discontinue Elitek in patients who experience
a serious hypersensitivity reaction [see CONTRAINDICATIONS,
WARNINGS AND PRECAUTIONS, ADVERSE
REACTIONS].
Hemolysis
Do not administer Elitek to patients with glucose-6-phosphate dehydrogenase
(G6PD) deficiency. Immediately and permanently discontinue Elitek in patients
developing hemolysis. Screen patients at higher risk for G6PD deficiency (e.g.,
patients of African or Mediterranean ancestry) prior to starting Elitek [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Methemoglobinemia
Elitek can result in methemoglobinemia in some patients. Immediately and
permanently discontinue Elitek in patients developing methemoglobinemia [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Interference with Uric Acid Measurements
Elitek enzymatically degrades uric acid in blood samples left at room temperature.
Collect blood samples in pre-chilled tubes containing heparin and immediately
immerse and maintain sample in an ice water bath. Assay plasma samples within
4 hours of collection [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of rasburicase (Elitek)?

In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience:

...
Read All Potential Side Effects for Elitek »




Elitek (rasburicase) is a recombinant urate-oxidase produced by a genetically
modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase
was cloned from a strain of Aspergillus flavus.
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Elitek 1.5 mg presentation contains 1.5 mg rasburicase, 10.6 mg mannitol, 15.9 mg L-alanine, between 12.6 and 14.3 mg of dibasic sodium phosphate (lyophilized powder), and a diluent (1 mL Water for Injection, USP, and 1 mg Poloxamer 188).
Elitek 7.5 mg presentation contains 7.5 mg of rasburicase, 53 mg mannitol, 79.5 mg L-alanine, and between 63 and 71.5 mg dibasic sodium phosphate (lyophilized powder) and a diluent (5 mL Water for Injection, USP, and 5 mg Poloxamer 188).
Last reviewed on RxList: 11/2/2009




Elitek Drug Description
ELITEK
(rasburicase) Powder for Solution, for Intravenous Infusion

WARNING: ANAPHYLAXIS, HEMOLYSIS, METHEMOGLOBINEMIA, AND INTERFERENCE
WITH URIC ACID MEASUREMENTS Anaphylaxis
Elitek® can cause severe hypersensitivity reactions including anaphylaxis.
Immediately and permanently discontinue Elitek in patients who experience
a serious hypersensitivity reaction [see CONTRAINDICATIONS,
WARNINGS AND PRECAUTIONS, ADVERSE
REACTIONS].
Hemolysis
Do not administer Elitek to patients with glucose-6-phosphate dehydrogenase
(G6PD) deficiency. Immediately and permanently discontinue Elitek in patients
developing hemolysis. Screen patients at higher risk for G6PD deficiency (e.g.,
patients of African or Mediterranean ancestry) prior to starting Elitek [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Methemoglobinemia
Elitek can result in methemoglobinemia in some patients. Immediately and
permanently discontinue Elitek in patients developing methemoglobinemia [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Interference with Uric Acid Measurements
Elitek enzymatically degrades uric acid in blood samples left at room temperature.
Collect blood samples in pre-chilled tubes containing heparin and immediately
immerse and maintain sample in an ice water bath. Assay plasma samples within
4 hours of collection [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of rasburicase (Elitek)?

In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience:

...
Read All Potential Side Effects for Elitek »




Elitek (rasburicase) is a recombinant urate-oxidase produced by a genetically
modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase
was cloned from a strain of Aspergillus flavus.
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Elitek 1.5 mg presentation contains 1.5 mg rasburicase, 10.6 mg mannitol, 15.9 mg L-alanine, between 12.6 and 14.3 mg of dibasic sodium phosphate (lyophilized powder), and a diluent (1 mL Water for Injection, USP, and 1 mg Poloxamer 188).
Elitek 7.5 mg presentation contains 7.5 mg of rasburicase, 53 mg mannitol, 79.5 mg L-alanine, and between 63 and 71.5 mg dibasic sodium phosphate (lyophilized powder) and a diluent (5 mL Water for Injection, USP, and 5 mg Poloxamer 188).
Last reviewed on RxList: 11/2/2009




Elitek Drug Description
ELITEK
(rasburicase) Powder for Solution, for Intravenous Infusion

WARNING: ANAPHYLAXIS, HEMOLYSIS, METHEMOGLOBINEMIA, AND INTERFERENCE
WITH URIC ACID MEASUREMENTS Anaphylaxis
Elitek® can cause severe hypersensitivity reactions including anaphylaxis.
Immediately and permanently discontinue Elitek in patients who experience
a serious hypersensitivity reaction [see CONTRAINDICATIONS,
WARNINGS AND PRECAUTIONS, ADVERSE
REACTIONS].
Hemolysis
Do not administer Elitek to patients with glucose-6-phosphate dehydrogenase
(G6PD) deficiency. Immediately and permanently discontinue Elitek in patients
developing hemolysis. Screen patients at higher risk for G6PD deficiency (e.g.,
patients of African or Mediterranean ancestry) prior to starting Elitek [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Methemoglobinemia
Elitek can result in methemoglobinemia in some patients. Immediately and
permanently discontinue Elitek in patients developing methemoglobinemia [see
CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS].
Interference with Uric Acid Measurements
Elitek enzymatically degrades uric acid in blood samples left at room temperature.
Collect blood samples in pre-chilled tubes containing heparin and immediately
immerse and maintain sample in an ice water bath. Assay plasma samples within
4 hours of collection [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION



What are the possible side effects of rasburicase (Elitek)?

In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience:

...
Read All Potential Side Effects for Elitek »




Elitek (rasburicase) is a recombinant urate-oxidase produced by a genetically
modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase
was cloned from a strain of Aspergillus flavus.
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
Elitek 1.5 mg presentation contains 1.5 mg rasburicase, 10.6 mg mannitol, 15.9 mg L-alanine, between 12.6 and 14.3 mg of dibasic sodium phosphate (lyophilized powder), and a diluent (1 mL Water for Injection, USP, and 1 mg Poloxamer 188).
Elitek 7.5 mg presentation contains 7.5 mg of rasburicase, 53 mg mannitol, 79.5 mg L-alanine, and between 63 and 71.5 mg dibasic sodium phosphate (lyophilized powder) and a diluent (5 mL Water for Injection, USP, and 5 mg Poloxamer 188).
Last reviewed on RxList: 11/2/2009





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Other reviews about Rasburicase on web:

Rasburicase (brand names: Elitek in the US, and Fasturtec in Europe ) is a recombinant version of a urate oxidase enzyme that occurs in many mammals but not in humans. Rasburicase - Wikipedia, the free encyclopedia


Rasburicase Brand names: Elitek® Drug Forms: Rasburicase Injection (below) Rasburicase Solution for injection Español: Inyección de rasburicasa Rasburicase: Information from Answers.com


All about Rasburicase. View complete and up to date Rasburicase information - part of the Drugs.com trusted medication database. Rasburicase Facts and Comparisons at Drugs.com


Learn about the prescription medication Elitek (Rasburicase), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Elitek (Rasburicase) Drug Information: Uses, Side Effects, Drug ...


1 From the Department of Pharmacy Services, Baylor University Medical Center, Dallas, Texas. Rasburicase (Elitek): a novel agent for tumor lysis syndrome


Physician reviewed rasburicase patient information - includes rasburicase description, dosage and directions. rasburicase medical facts from Drugs.com


rasburicase, an antineoplastic antimetabolite used to reduce uric acid levels in children with leukemia or lymphoma and in chemotherapy patients with solid tumor malignancies. rasburicase - definition of rasburicase in the Medical dictionary ...


This information has been developed and provided by an independent third-party source. Merck & Co., Inc. does not endorse and is not responsible for the accuracy of the content, or ... Rasburicase: Drug Information Provided by Lexi-Comp: Merck Manual ...


Consumer information about the medication RASBURICASE - INJECTION (Elitek), includes side effects, drug interactions, recommended dosages, and storage information. Read more ... RASBURICASE - INJECTION (Elitek) side effects, medical uses, and ...


What is Rasburicase? Rasburicase increases the rate at which uric acid is broken down in the body. Rasburicase is used to treat increased levels of uric acid caused by the breakdown ... Rasburicase - Drugs & Treatments - Revolution Health





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