Reviews Provocholine


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Provocholine Drug Description
PROVOCHOLINE®
(methacholine chloride)
POWDER FOR INHALATION
NOT FOR INJECTION

PROVOCHOLINE® (METHACHOLINE CHLORIDE POWDER FOR INHALATION) IS A BRONCHOCONSTRICTOR
AGENT FOR DIAGNOSTIC PURPOSES ONLY AND SHOULD NOT BE USED AS A THERAPEUTIC AGENT.
PROVOCHOLINE® INHALATION CHALLENGE SHOULD BE PERFORMED ONLY UNDER THE SUPERVISION
OF APHYSICIANTRAINED INAND THOROUGHLY FAMILIAR WITH ALL ASPECTS OF THE TECHNIQUE
OF METHACHOLINE CHALLENGE, ALL CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,
AND THE MANAGEMENT OF RESPIRATORY DISTRESS. EMERGENCY EQUIPMENT AND MEDICATION
SHOULD BE IMMEDIATELY AVAILABLE TO TREAT ACUTE RESPIRATORY DISTRESS.
PROVOCHOLINE® SHOULD BE ADMINISTERED ONLY BY INHALATION. SEVERE BRONCHOCONSTRICTION
AND REDUCTION IN RESPIRATORY FUNCTION CAN RESULT FROM THE ADMINISTRATION OF
PROVOCHOLlNE® . PATIENTS WITH SEVERE HYPERREACTIVITY OF THE AIRWAYS CAN
EXPERIENCE BRONCHOCONSTRICTION AT A DOSAGE AS LOW AS 0.025 MG/ML (0.125 CUMULATIVE
UNITS). IF SEVERE BRONCHOCONSTRICTION OCCURS, IT SHOULD BE REVERSED IMMEDIATELY
BY THE ADMINISTRATION OF A RAPID ACTING INHALED BRONCHODILATOR AGENT (BETAAGONIST).
BECAUSE OF THE POTENTIAL
FOR SEVERE BRONCHOCONSTRICTION, PROVOCHOLINE® CHALLENGE SHOULD NOT
BE PERFORMED IN ANY PATIENT WITH CLINICALLY APPARENT ASTHMA, WHEEZING, OR VERY
LOW BASELINE PULMONARY FUNCTION TESTS (e.g., FEV1 LESS THAN 1 TO 1.5 LITER OR
LESS THAN 70% OF THE PREDICTED VALUES). PLEASE CONSULT STANDARD NOMOGRAMS FOR
PREDICTED VALUES.1

DRUG DESCRIPTION
Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic
(cholinergic) bronchoconstrictor agent to be administered in solutiOn only,
by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine
chloride powder which is to be reconstituted with 0.9% sodium chloride injection
or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE
AND ADMINISTRATION for dilution procedures, concentrations and schedule
of administration.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium,
2-(acetyloxy)­N,N,N, - trimethyl,-chloride. It is a white to practically white
deliquescent compound, soluble in water. Methacholine chloride has an empirical
formula of C8H18CINO2, a calculated molecular
weight of 195.69, and the following structural formula:








REFERENCE
1. Morris JF, Koski WA, Johnson LC. Spirometric standards for
healthy non-smoking adults. Am Rev Resp Dis. Jan 1971; 103: 57-67.
Last reviewed on RxList: 9/25/2008




Provocholine Drug Description
PROVOCHOLINE®
(methacholine chloride)
POWDER FOR INHALATION
NOT FOR INJECTION

PROVOCHOLINE® (METHACHOLINE CHLORIDE POWDER FOR INHALATION) IS A BRONCHOCONSTRICTOR
AGENT FOR DIAGNOSTIC PURPOSES ONLY AND SHOULD NOT BE USED AS A THERAPEUTIC AGENT.
PROVOCHOLINE® INHALATION CHALLENGE SHOULD BE PERFORMED ONLY UNDER THE SUPERVISION
OF APHYSICIANTRAINED INAND THOROUGHLY FAMILIAR WITH ALL ASPECTS OF THE TECHNIQUE
OF METHACHOLINE CHALLENGE, ALL CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,
AND THE MANAGEMENT OF RESPIRATORY DISTRESS. EMERGENCY EQUIPMENT AND MEDICATION
SHOULD BE IMMEDIATELY AVAILABLE TO TREAT ACUTE RESPIRATORY DISTRESS.
PROVOCHOLINE® SHOULD BE ADMINISTERED ONLY BY INHALATION. SEVERE BRONCHOCONSTRICTION
AND REDUCTION IN RESPIRATORY FUNCTION CAN RESULT FROM THE ADMINISTRATION OF
PROVOCHOLlNE® . PATIENTS WITH SEVERE HYPERREACTIVITY OF THE AIRWAYS CAN
EXPERIENCE BRONCHOCONSTRICTION AT A DOSAGE AS LOW AS 0.025 MG/ML (0.125 CUMULATIVE
UNITS). IF SEVERE BRONCHOCONSTRICTION OCCURS, IT SHOULD BE REVERSED IMMEDIATELY
BY THE ADMINISTRATION OF A RAPID ACTING INHALED BRONCHODILATOR AGENT (BETAAGONIST).
BECAUSE OF THE POTENTIAL
FOR SEVERE BRONCHOCONSTRICTION, PROVOCHOLINE® CHALLENGE SHOULD NOT
BE PERFORMED IN ANY PATIENT WITH CLINICALLY APPARENT ASTHMA, WHEEZING, OR VERY
LOW BASELINE PULMONARY FUNCTION TESTS (e.g., FEV1 LESS THAN 1 TO 1.5 LITER OR
LESS THAN 70% OF THE PREDICTED VALUES). PLEASE CONSULT STANDARD NOMOGRAMS FOR
PREDICTED VALUES.1

DRUG DESCRIPTION
Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic
(cholinergic) bronchoconstrictor agent to be administered in solutiOn only,
by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine
chloride powder which is to be reconstituted with 0.9% sodium chloride injection
or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE
AND ADMINISTRATION for dilution procedures, concentrations and schedule
of administration.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium,
2-(acetyloxy)­N,N,N, - trimethyl,-chloride. It is a white to practically white
deliquescent compound, soluble in water. Methacholine chloride has an empirical
formula of C8H18CINO2, a calculated molecular
weight of 195.69, and the following structural formula:








REFERENCE
1. Morris JF, Koski WA, Johnson LC. Spirometric standards for
healthy non-smoking adults. Am Rev Resp Dis. Jan 1971; 103: 57-67.
Last reviewed on RxList: 9/25/2008




Provocholine Drug Description
PROVOCHOLINE®
(methacholine chloride)
POWDER FOR INHALATION
NOT FOR INJECTION

PROVOCHOLINE® (METHACHOLINE CHLORIDE POWDER FOR INHALATION) IS A BRONCHOCONSTRICTOR
AGENT FOR DIAGNOSTIC PURPOSES ONLY AND SHOULD NOT BE USED AS A THERAPEUTIC AGENT.
PROVOCHOLINE® INHALATION CHALLENGE SHOULD BE PERFORMED ONLY UNDER THE SUPERVISION
OF APHYSICIANTRAINED INAND THOROUGHLY FAMILIAR WITH ALL ASPECTS OF THE TECHNIQUE
OF METHACHOLINE CHALLENGE, ALL CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,
AND THE MANAGEMENT OF RESPIRATORY DISTRESS. EMERGENCY EQUIPMENT AND MEDICATION
SHOULD BE IMMEDIATELY AVAILABLE TO TREAT ACUTE RESPIRATORY DISTRESS.
PROVOCHOLINE® SHOULD BE ADMINISTERED ONLY BY INHALATION. SEVERE BRONCHOCONSTRICTION
AND REDUCTION IN RESPIRATORY FUNCTION CAN RESULT FROM THE ADMINISTRATION OF
PROVOCHOLlNE® . PATIENTS WITH SEVERE HYPERREACTIVITY OF THE AIRWAYS CAN
EXPERIENCE BRONCHOCONSTRICTION AT A DOSAGE AS LOW AS 0.025 MG/ML (0.125 CUMULATIVE
UNITS). IF SEVERE BRONCHOCONSTRICTION OCCURS, IT SHOULD BE REVERSED IMMEDIATELY
BY THE ADMINISTRATION OF A RAPID ACTING INHALED BRONCHODILATOR AGENT (BETAAGONIST).
BECAUSE OF THE POTENTIAL
FOR SEVERE BRONCHOCONSTRICTION, PROVOCHOLINE® CHALLENGE SHOULD NOT
BE PERFORMED IN ANY PATIENT WITH CLINICALLY APPARENT ASTHMA, WHEEZING, OR VERY
LOW BASELINE PULMONARY FUNCTION TESTS (e.g., FEV1 LESS THAN 1 TO 1.5 LITER OR
LESS THAN 70% OF THE PREDICTED VALUES). PLEASE CONSULT STANDARD NOMOGRAMS FOR
PREDICTED VALUES.1

DRUG DESCRIPTION
Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic
(cholinergic) bronchoconstrictor agent to be administered in solutiOn only,
by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine
chloride powder which is to be reconstituted with 0.9% sodium chloride injection
or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE
AND ADMINISTRATION for dilution procedures, concentrations and schedule
of administration.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium,
2-(acetyloxy)­N,N,N, - trimethyl,-chloride. It is a white to practically white
deliquescent compound, soluble in water. Methacholine chloride has an empirical
formula of C8H18CINO2, a calculated molecular
weight of 195.69, and the following structural formula:








REFERENCE
1. Morris JF, Koski WA, Johnson LC. Spirometric standards for
healthy non-smoking adults. Am Rev Resp Dis. Jan 1971; 103: 57-67.
Last reviewed on RxList: 9/25/2008




Provocholine Drug Description
PROVOCHOLINE®
(methacholine chloride)
POWDER FOR INHALATION
NOT FOR INJECTION

PROVOCHOLINE® (METHACHOLINE CHLORIDE POWDER FOR INHALATION) IS A BRONCHOCONSTRICTOR
AGENT FOR DIAGNOSTIC PURPOSES ONLY AND SHOULD NOT BE USED AS A THERAPEUTIC AGENT.
PROVOCHOLINE® INHALATION CHALLENGE SHOULD BE PERFORMED ONLY UNDER THE SUPERVISION
OF APHYSICIANTRAINED INAND THOROUGHLY FAMILIAR WITH ALL ASPECTS OF THE TECHNIQUE
OF METHACHOLINE CHALLENGE, ALL CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,
AND THE MANAGEMENT OF RESPIRATORY DISTRESS. EMERGENCY EQUIPMENT AND MEDICATION
SHOULD BE IMMEDIATELY AVAILABLE TO TREAT ACUTE RESPIRATORY DISTRESS.
PROVOCHOLINE® SHOULD BE ADMINISTERED ONLY BY INHALATION. SEVERE BRONCHOCONSTRICTION
AND REDUCTION IN RESPIRATORY FUNCTION CAN RESULT FROM THE ADMINISTRATION OF
PROVOCHOLlNE® . PATIENTS WITH SEVERE HYPERREACTIVITY OF THE AIRWAYS CAN
EXPERIENCE BRONCHOCONSTRICTION AT A DOSAGE AS LOW AS 0.025 MG/ML (0.125 CUMULATIVE
UNITS). IF SEVERE BRONCHOCONSTRICTION OCCURS, IT SHOULD BE REVERSED IMMEDIATELY
BY THE ADMINISTRATION OF A RAPID ACTING INHALED BRONCHODILATOR AGENT (BETAAGONIST).
BECAUSE OF THE POTENTIAL
FOR SEVERE BRONCHOCONSTRICTION, PROVOCHOLINE® CHALLENGE SHOULD NOT
BE PERFORMED IN ANY PATIENT WITH CLINICALLY APPARENT ASTHMA, WHEEZING, OR VERY
LOW BASELINE PULMONARY FUNCTION TESTS (e.g., FEV1 LESS THAN 1 TO 1.5 LITER OR
LESS THAN 70% OF THE PREDICTED VALUES). PLEASE CONSULT STANDARD NOMOGRAMS FOR
PREDICTED VALUES.1

DRUG DESCRIPTION
Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic
(cholinergic) bronchoconstrictor agent to be administered in solutiOn only,
by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine
chloride powder which is to be reconstituted with 0.9% sodium chloride injection
or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE
AND ADMINISTRATION for dilution procedures, concentrations and schedule
of administration.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium,
2-(acetyloxy)­N,N,N, - trimethyl,-chloride. It is a white to practically white
deliquescent compound, soluble in water. Methacholine chloride has an empirical
formula of C8H18CINO2, a calculated molecular
weight of 195.69, and the following structural formula:








REFERENCE
1. Morris JF, Koski WA, Johnson LC. Spirometric standards for
healthy non-smoking adults. Am Rev Resp Dis. Jan 1971; 103: 57-67.
Last reviewed on RxList: 9/25/2008




Provocholine Drug Description
PROVOCHOLINE®
(methacholine chloride)
POWDER FOR INHALATION
NOT FOR INJECTION

PROVOCHOLINE® (METHACHOLINE CHLORIDE POWDER FOR INHALATION) IS A BRONCHOCONSTRICTOR
AGENT FOR DIAGNOSTIC PURPOSES ONLY AND SHOULD NOT BE USED AS A THERAPEUTIC AGENT.
PROVOCHOLINE® INHALATION CHALLENGE SHOULD BE PERFORMED ONLY UNDER THE SUPERVISION
OF APHYSICIANTRAINED INAND THOROUGHLY FAMILIAR WITH ALL ASPECTS OF THE TECHNIQUE
OF METHACHOLINE CHALLENGE, ALL CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,
AND THE MANAGEMENT OF RESPIRATORY DISTRESS. EMERGENCY EQUIPMENT AND MEDICATION
SHOULD BE IMMEDIATELY AVAILABLE TO TREAT ACUTE RESPIRATORY DISTRESS.
PROVOCHOLINE® SHOULD BE ADMINISTERED ONLY BY INHALATION. SEVERE BRONCHOCONSTRICTION
AND REDUCTION IN RESPIRATORY FUNCTION CAN RESULT FROM THE ADMINISTRATION OF
PROVOCHOLlNE® . PATIENTS WITH SEVERE HYPERREACTIVITY OF THE AIRWAYS CAN
EXPERIENCE BRONCHOCONSTRICTION AT A DOSAGE AS LOW AS 0.025 MG/ML (0.125 CUMULATIVE
UNITS). IF SEVERE BRONCHOCONSTRICTION OCCURS, IT SHOULD BE REVERSED IMMEDIATELY
BY THE ADMINISTRATION OF A RAPID ACTING INHALED BRONCHODILATOR AGENT (BETAAGONIST).
BECAUSE OF THE POTENTIAL
FOR SEVERE BRONCHOCONSTRICTION, PROVOCHOLINE® CHALLENGE SHOULD NOT
BE PERFORMED IN ANY PATIENT WITH CLINICALLY APPARENT ASTHMA, WHEEZING, OR VERY
LOW BASELINE PULMONARY FUNCTION TESTS (e.g., FEV1 LESS THAN 1 TO 1.5 LITER OR
LESS THAN 70% OF THE PREDICTED VALUES). PLEASE CONSULT STANDARD NOMOGRAMS FOR
PREDICTED VALUES.1

DRUG DESCRIPTION
Provocholine® (methacholine chloride powder for inhalation) is a parasympathomimetic
(cholinergic) bronchoconstrictor agent to be administered in solutiOn only,
by inhalation, for diagnostic purposes. Each 20 mL vial contains 100 mg of methacholine
chloride powder which is to be reconstituted with 0.9% sodium chloride injection
or 0.9% sodium chloride injection containing 0.4% phenol (pH 7.0). See DOSAGE
AND ADMINISTRATION for dilution procedures, concentrations and schedule
of administration.
Chemically, methacholine chloride (the active ingredient) is 1-propanaminium,
2-(acetyloxy)­N,N,N, - trimethyl,-chloride. It is a white to practically white
deliquescent compound, soluble in water. Methacholine chloride has an empirical
formula of C8H18CINO2, a calculated molecular
weight of 195.69, and the following structural formula:








REFERENCE
1. Morris JF, Koski WA, Johnson LC. Spirometric standards for
healthy non-smoking adults. Am Rev Resp Dis. Jan 1971; 103: 57-67.
Last reviewed on RxList: 9/25/2008





Other reviews about Provocholine on web:

Provocholine (Methacholine Chloride) manufactured by Methapharm is indicated for the diagnosis of bronchial airway hyperreactivity in subjects who do not have clinically apparent ... Provocholine®--Methacholine Chloride Powder for Inhalation


Learn about the prescription medication Provocholine (Methacholine Chloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Provocholine (Methacholine Chloride) Drug Information: Uses, Side ...


Methacholine (Provocholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. Methacholine - Wikipedia, the free encyclopedia


All about Provocholine Solution. View complete and up to date Provocholine information - part of the Drugs.com trusted medication database. Provocholine Solution Facts and Comparisons at Drugs.com


Find patient medical information for Provocholine Inhl on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Provocholine Inhl : Uses, Side Effects, Interactions, Pictures ...


Consumer information about the medication METHACHOLINE - INHALATION (Provocholine), includes side effects, drug interactions, recommended dosages, and storage information. METHACHOLINE - INHALATION (Provocholine) side effects, medical ...


Provocholine Side Effects: cough, forced expiratory volume decreased, loss of consciousness. Provocholine Reports: patient, 39 years of age, weighting 232.. Page 1 Provocholine Side Effects


Provocholine (Methacholine Chloride) Side Effect Guide – warning symptoms, allergic reactions, precautions, drug interactions, overdose, missed dose, adverse effects and storage. Provocholine, Methacholine Chloride – Side effect guide, warning ...


methacholine [meth′äko′lēn] a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects. Provocholine - definition of Provocholine in the Medical ...


Read doctor-produced health and medical information written for you to make informed decisions about your health concerns. METHACHOLINE - INHALATION (Provocholine) side effects, medical ...





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