Reviews Propoxyphene Napsylate and Acetaminophen


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Darvocet-N Drug Description
DARVOCET-N® 50 and DARVOCET-N® 100
(propoxyphene napsylate and acetaminophen) Tablets, USP

WARNINGS

There have been numerous cases of accidental and intentional overdose
with propoxyphene products either alone or in combination with other CNS depressants,
including alcohol. Fatalities within the first hour of overdosage are not
uncommon. Many of the propoxyphene related deaths have occurred in patients
with previous histories of emotional disturbances or suicidal ideation/attempts
and/or concomitant administration of sedatives, tranquilizers, muscle relaxants,
antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene
for patients who are suicidal or have a history of suicidal ideation.
The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors
(such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin,
nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin,
fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to
enhanced propoxyphene plasma levels. Patients receiving propoxyphene and
any CYP3A4 inhibitor should be carefully monitored for an extended period
of time and dosage adjustments should be made if warranted (see CLINICAL
PHARMACOLOGY - Drug Interactions, and WARNINGS,
PRECAUTIONS and DOSAGE
AND ADMINISTRATION for further information).


DRUG DESCRIPTION



What are the possible side effects of propoxyphene (Darvon, Darvon-N)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
feeling light-headed, fainting;
confusion, hallucinations, unusual thoughts or behavior;
seizure (convulsions); or
jaundice (yellowing of the skin or...
Read All Potential Side Effects for Darvocet-N »




Darvocet-N contains propoxyphene napsylate and acetaminophen.
Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a
bitter taste. It is very slightly soluble in water and soluble in methanol,
ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-α
phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate,
which can be represented by the accompanying structural formula. Its molecular
weight is 565.72.








Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows
more stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present in
65 mg (172.9 µmol) of propoxyphene hydrochloride.








Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic
and antipyretic which occurs as a white, odorless, crystalline powder, possessing
a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2
and the molecular weight is 151.17. It may be represented by the following structural
formula:
Each tablet of Darvocet-N 50 contains 50 mg (88.4 µmol) propoxyphene napsylate and 325 mg (2,150 µmol) acetaminophen.
Each tablet of Darvocet-N 100 contains 100 mg (176.8 µmol) propoxyphene napsylate and 650 mg (4,300 µmol) acetaminophen.
Each tablet also contains amberlite, cellulose, F D & C Yellow No. 6, magnesium stearate, stearic acid, titanium dioxide, and other inactive ingredients.Last reviewed on RxList: 10/9/2009




Darvocet-N Drug Description
DARVOCET-N® 50 and DARVOCET-N® 100
(propoxyphene napsylate and acetaminophen) Tablets, USP

WARNINGS

There have been numerous cases of accidental and intentional overdose
with propoxyphene products either alone or in combination with other CNS depressants,
including alcohol. Fatalities within the first hour of overdosage are not
uncommon. Many of the propoxyphene related deaths have occurred in patients
with previous histories of emotional disturbances or suicidal ideation/attempts
and/or concomitant administration of sedatives, tranquilizers, muscle relaxants,
antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene
for patients who are suicidal or have a history of suicidal ideation.
The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors
(such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin,
nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin,
fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to
enhanced propoxyphene plasma levels. Patients receiving propoxyphene and
any CYP3A4 inhibitor should be carefully monitored for an extended period
of time and dosage adjustments should be made if warranted (see CLINICAL
PHARMACOLOGY - Drug Interactions, and WARNINGS,
PRECAUTIONS and DOSAGE
AND ADMINISTRATION for further information).


DRUG DESCRIPTION



What are the possible side effects of propoxyphene (Darvon, Darvon-N)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
feeling light-headed, fainting;
confusion, hallucinations, unusual thoughts or behavior;
seizure (convulsions); or
jaundice (yellowing of the skin or...
Read All Potential Side Effects for Darvocet-N »




Darvocet-N contains propoxyphene napsylate and acetaminophen.
Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a
bitter taste. It is very slightly soluble in water and soluble in methanol,
ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-α
phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate,
which can be represented by the accompanying structural formula. Its molecular
weight is 565.72.








Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows
more stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present in
65 mg (172.9 µmol) of propoxyphene hydrochloride.








Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic
and antipyretic which occurs as a white, odorless, crystalline powder, possessing
a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2
and the molecular weight is 151.17. It may be represented by the following structural
formula:
Each tablet of Darvocet-N 50 contains 50 mg (88.4 µmol) propoxyphene napsylate and 325 mg (2,150 µmol) acetaminophen.
Each tablet of Darvocet-N 100 contains 100 mg (176.8 µmol) propoxyphene napsylate and 650 mg (4,300 µmol) acetaminophen.
Each tablet also contains amberlite, cellulose, F D & C Yellow No. 6, magnesium stearate, stearic acid, titanium dioxide, and other inactive ingredients.Last reviewed on RxList: 10/9/2009




Darvocet-N Drug Description
DARVOCET-N® 50 and DARVOCET-N® 100
(propoxyphene napsylate and acetaminophen) Tablets, USP

WARNINGS

There have been numerous cases of accidental and intentional overdose
with propoxyphene products either alone or in combination with other CNS depressants,
including alcohol. Fatalities within the first hour of overdosage are not
uncommon. Many of the propoxyphene related deaths have occurred in patients
with previous histories of emotional disturbances or suicidal ideation/attempts
and/or concomitant administration of sedatives, tranquilizers, muscle relaxants,
antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene
for patients who are suicidal or have a history of suicidal ideation.
The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors
(such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin,
nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin,
fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to
enhanced propoxyphene plasma levels. Patients receiving propoxyphene and
any CYP3A4 inhibitor should be carefully monitored for an extended period
of time and dosage adjustments should be made if warranted (see CLINICAL
PHARMACOLOGY - Drug Interactions, and WARNINGS,
PRECAUTIONS and DOSAGE
AND ADMINISTRATION for further information).


DRUG DESCRIPTION



What are the possible side effects of propoxyphene (Darvon, Darvon-N)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
feeling light-headed, fainting;
confusion, hallucinations, unusual thoughts or behavior;
seizure (convulsions); or
jaundice (yellowing of the skin or...
Read All Potential Side Effects for Darvocet-N »




Darvocet-N contains propoxyphene napsylate and acetaminophen.
Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a
bitter taste. It is very slightly soluble in water and soluble in methanol,
ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-α
phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate,
which can be represented by the accompanying structural formula. Its molecular
weight is 565.72.








Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows
more stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present in
65 mg (172.9 µmol) of propoxyphene hydrochloride.








Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic
and antipyretic which occurs as a white, odorless, crystalline powder, possessing
a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2
and the molecular weight is 151.17. It may be represented by the following structural
formula:
Each tablet of Darvocet-N 50 contains 50 mg (88.4 µmol) propoxyphene napsylate and 325 mg (2,150 µmol) acetaminophen.
Each tablet of Darvocet-N 100 contains 100 mg (176.8 µmol) propoxyphene napsylate and 650 mg (4,300 µmol) acetaminophen.
Each tablet also contains amberlite, cellulose, F D & C Yellow No. 6, magnesium stearate, stearic acid, titanium dioxide, and other inactive ingredients.Last reviewed on RxList: 10/9/2009




Darvocet-N Drug Description
DARVOCET-N® 50 and DARVOCET-N® 100
(propoxyphene napsylate and acetaminophen) Tablets, USP

WARNINGS

There have been numerous cases of accidental and intentional overdose
with propoxyphene products either alone or in combination with other CNS depressants,
including alcohol. Fatalities within the first hour of overdosage are not
uncommon. Many of the propoxyphene related deaths have occurred in patients
with previous histories of emotional disturbances or suicidal ideation/attempts
and/or concomitant administration of sedatives, tranquilizers, muscle relaxants,
antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene
for patients who are suicidal or have a history of suicidal ideation.
The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors
(such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin,
nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin,
fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to
enhanced propoxyphene plasma levels. Patients receiving propoxyphene and
any CYP3A4 inhibitor should be carefully monitored for an extended period
of time and dosage adjustments should be made if warranted (see CLINICAL
PHARMACOLOGY - Drug Interactions, and WARNINGS,
PRECAUTIONS and DOSAGE
AND ADMINISTRATION for further information).


DRUG DESCRIPTION



What are the possible side effects of propoxyphene (Darvon, Darvon-N)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
feeling light-headed, fainting;
confusion, hallucinations, unusual thoughts or behavior;
seizure (convulsions); or
jaundice (yellowing of the skin or...
Read All Potential Side Effects for Darvocet-N »




Darvocet-N contains propoxyphene napsylate and acetaminophen.
Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a
bitter taste. It is very slightly soluble in water and soluble in methanol,
ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-α
phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate,
which can be represented by the accompanying structural formula. Its molecular
weight is 565.72.








Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows
more stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present in
65 mg (172.9 µmol) of propoxyphene hydrochloride.








Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic
and antipyretic which occurs as a white, odorless, crystalline powder, possessing
a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2
and the molecular weight is 151.17. It may be represented by the following structural
formula:
Each tablet of Darvocet-N 50 contains 50 mg (88.4 µmol) propoxyphene napsylate and 325 mg (2,150 µmol) acetaminophen.
Each tablet of Darvocet-N 100 contains 100 mg (176.8 µmol) propoxyphene napsylate and 650 mg (4,300 µmol) acetaminophen.
Each tablet also contains amberlite, cellulose, F D & C Yellow No. 6, magnesium stearate, stearic acid, titanium dioxide, and other inactive ingredients.Last reviewed on RxList: 10/9/2009




Darvocet-N Drug Description
DARVOCET-N® 50 and DARVOCET-N® 100
(propoxyphene napsylate and acetaminophen) Tablets, USP

WARNINGS

There have been numerous cases of accidental and intentional overdose
with propoxyphene products either alone or in combination with other CNS depressants,
including alcohol. Fatalities within the first hour of overdosage are not
uncommon. Many of the propoxyphene related deaths have occurred in patients
with previous histories of emotional disturbances or suicidal ideation/attempts
and/or concomitant administration of sedatives, tranquilizers, muscle relaxants,
antidepressants, or other CNS-depressant drugs. Do not prescribe propoxyphene
for patients who are suicidal or have a history of suicidal ideation.
The metabolism of propoxyphene may be altered by strong CYP3A4 inhibitors
(such as ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin,
nelfinavir, nefazadone, amiodarone, amprenavir, aprepitant, diltiazem, erythromycin,
fluconazole, fosamprenavir, grapefruit juice, and verapamil) leading to
enhanced propoxyphene plasma levels. Patients receiving propoxyphene and
any CYP3A4 inhibitor should be carefully monitored for an extended period
of time and dosage adjustments should be made if warranted (see CLINICAL
PHARMACOLOGY - Drug Interactions, and WARNINGS,
PRECAUTIONS and DOSAGE
AND ADMINISTRATION for further information).


DRUG DESCRIPTION



What are the possible side effects of propoxyphene (Darvon, Darvon-N)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
feeling light-headed, fainting;
confusion, hallucinations, unusual thoughts or behavior;
seizure (convulsions); or
jaundice (yellowing of the skin or...
Read All Potential Side Effects for Darvocet-N »




Darvocet-N contains propoxyphene napsylate and acetaminophen.
Propoxyphene Napsylate, USP is an odorless, white crystalline powder with a
bitter taste. It is very slightly soluble in water and soluble in methanol,
ethanol, chloroform, and acetone. Chemically, it is (αS,1R)-α-[2-(Dimethylamino)-1-methylethyl]-α
phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate,
which can be represented by the accompanying structural formula. Its molecular
weight is 565.72.








Propoxyphene napsylate differs from propoxyphene hydrochloride in that it allows
more stable liquid dosage forms and tablet formulations. Because of differences
in molecular weight, a dose of 100 mg (176.8 µmol) of propoxyphene napsylate
is required to supply an amount of propoxyphene equivalent to that present in
65 mg (172.9 µmol) of propoxyphene hydrochloride.








Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic
and antipyretic which occurs as a white, odorless, crystalline powder, possessing
a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2
and the molecular weight is 151.17. It may be represented by the following structural
formula:
Each tablet of Darvocet-N 50 contains 50 mg (88.4 µmol) propoxyphene napsylate and 325 mg (2,150 µmol) acetaminophen.
Each tablet of Darvocet-N 100 contains 100 mg (176.8 µmol) propoxyphene napsylate and 650 mg (4,300 µmol) acetaminophen.
Each tablet also contains amberlite, cellulose, F D & C Yellow No. 6, magnesium stearate, stearic acid, titanium dioxide, and other inactive ingredients.Last reviewed on RxList: 10/9/2009





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Other reviews about Propoxyphene Napsylate and Acetaminophen on web:

Consumer information about the medication PROPOXYPHENE NAPSYLATE WITH ACETAMINOPHEN - ORAL (Darvocet A500, Darvocet-N), includes side effects, drug interactions, recommended ... PROPOXYPHENE NAPSYLATE WITH ACETAMINOPHEN - ORAL (Darvocet A500 ...


Comprehensive and trusted information about Propoxyphene napsylate, Acetaminophen - plus advice on 24,000 other FDA approved drugs and medications from Drugs.com. Propoxyphene napsylate, Acetaminophen patient advice including ...


Acetaminophen; Propoxyphene Napsylate (Darvoc. What is it? Darvocet is an opioid analgesic used to treat mild to moderate pain. FDA approved: Before 1982 Arthritis Insight-Acetaminophen; Propoxyphene


Propoxyphene/Acetaminophen professional patient advice. Specific and up to date ... - Tablets 65 mg propoxyphene hydrochloride/650 mg acetaminophen. Propoxyphene Napsylate ... Complete Propoxyphene/Acetaminophen information from Drugs.com


propoxyphene napsylate/acetaminophen pharmacology, dosing, interactions, and patient education at Epocrates Online, the leading provider of drug and disease decision support tools. propoxyphene napsylate/acetaminophen Pharmacology - Epocrates Online


propoxyphene napsylate/acetaminophen manufacturer/pricing, dosing, interactions, and patient education at Epocrates Online, the leading provider of drug and disease decision ... propoxyphene napsylate/acetaminophen Manufacturer/Pricing ...


The information on this page is seed content provided by an organization. Please help improve this Article by adding to it. If you are a physician or PhD, learn how to edit. If you ... Clinical:Propoxyphene and acetaminophen (propoxyphene napsylate ...


Propoxyphene Napsylate and Acetaminophen (Propoxyphene / Acetaminophen) - Drug Info, Side Effects, Research, Clinical Trials Propoxyphene Napsylate and Acetaminophen (Propoxyphene ...


Learn about the prescription medication Darvocet-N (Propoxyphene Napsylate and Acetaminophen), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Darvocet-N (Propoxyphene Napsylate and Acetaminophen) Drug ...


Overview Darvocet-N 100 is a popular pain reliever containing propoxyphene and acetaminophen. Propoxyphene, a mild synthetic analgesic, is almost as effective as codeine. In ... Propoxyphene napsylate and acetaminophen Side Effects - The People ...





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