Reviews Premarin Injection


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Premarin Injection Drug Description
Premarin®Intravenous
(conjugated estrogens, USP) for Injection
Specially prepared for Intravenous & Intramuscular use

WARNINGS
ENDOMETRIAL CANCER
Adequate diagnostic measures, including endometrial sampling when indicated,
should be undertaken to rule out malignancy in all cases of undiagnosed persistent
or recurring abnormal vaginal bleeding. (See WARNINGS,
Malignant neoplasms, Endometrial cancer.)
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention
of cardiovascular disease or dementia. (See Clinical
Studies and WARNINGS, Cardiovascular
disorders and Dementia.)
The estrogen alone substudy of the Women's Health Initiative< (WHI) reported
increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal
women (50 to 79 years of age) during 6.8 years and 7.1 years, respectively,
of treatment with daily oral conjugated estrogens (CE 0.625 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders.)
The estrogen plus progestin substudy of WHI reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal
women (50 to 79 years of age) during 5.6 years of treatment with daily CE
0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders and Malignant neoplasms, Breast cancer.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
an increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 5.2 years of treatment with daily CE 0.625
mg alone and during 4 years of treatment with daily CE 0.625 mg combined with
MPA 2.5 mg, relative to placebo. It is unknown whether this finding applies
to younger postmenopausal women. (See Clinical
Studies and WARNINGS, Dementia and
PRECAUTIONS, Geriatric Use.)
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA and other combinations and dosage forms of estrogens and progestins. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION
Premarin® Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin.
Each Secule® vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
Last reviewed on RxList: 8/21/2008




Premarin Injection Drug Description
Premarin®Intravenous
(conjugated estrogens, USP) for Injection
Specially prepared for Intravenous & Intramuscular use

WARNINGS
ENDOMETRIAL CANCER
Adequate diagnostic measures, including endometrial sampling when indicated,
should be undertaken to rule out malignancy in all cases of undiagnosed persistent
or recurring abnormal vaginal bleeding. (See WARNINGS,
Malignant neoplasms, Endometrial cancer.)
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention
of cardiovascular disease or dementia. (See Clinical
Studies and WARNINGS, Cardiovascular
disorders and Dementia.)
The estrogen alone substudy of the Women's Health Initiative< (WHI) reported
increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal
women (50 to 79 years of age) during 6.8 years and 7.1 years, respectively,
of treatment with daily oral conjugated estrogens (CE 0.625 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders.)
The estrogen plus progestin substudy of WHI reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal
women (50 to 79 years of age) during 5.6 years of treatment with daily CE
0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders and Malignant neoplasms, Breast cancer.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
an increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 5.2 years of treatment with daily CE 0.625
mg alone and during 4 years of treatment with daily CE 0.625 mg combined with
MPA 2.5 mg, relative to placebo. It is unknown whether this finding applies
to younger postmenopausal women. (See Clinical
Studies and WARNINGS, Dementia and
PRECAUTIONS, Geriatric Use.)
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA and other combinations and dosage forms of estrogens and progestins. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION
Premarin® Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin.
Each Secule® vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
Last reviewed on RxList: 8/21/2008




Premarin Injection Drug Description
Premarin®Intravenous
(conjugated estrogens, USP) for Injection
Specially prepared for Intravenous & Intramuscular use

WARNINGS
ENDOMETRIAL CANCER
Adequate diagnostic measures, including endometrial sampling when indicated,
should be undertaken to rule out malignancy in all cases of undiagnosed persistent
or recurring abnormal vaginal bleeding. (See WARNINGS,
Malignant neoplasms, Endometrial cancer.)
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention
of cardiovascular disease or dementia. (See Clinical
Studies and WARNINGS, Cardiovascular
disorders and Dementia.)
The estrogen alone substudy of the Women's Health Initiative< (WHI) reported
increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal
women (50 to 79 years of age) during 6.8 years and 7.1 years, respectively,
of treatment with daily oral conjugated estrogens (CE 0.625 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders.)
The estrogen plus progestin substudy of WHI reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal
women (50 to 79 years of age) during 5.6 years of treatment with daily CE
0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders and Malignant neoplasms, Breast cancer.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
an increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 5.2 years of treatment with daily CE 0.625
mg alone and during 4 years of treatment with daily CE 0.625 mg combined with
MPA 2.5 mg, relative to placebo. It is unknown whether this finding applies
to younger postmenopausal women. (See Clinical
Studies and WARNINGS, Dementia and
PRECAUTIONS, Geriatric Use.)
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA and other combinations and dosage forms of estrogens and progestins. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION
Premarin® Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin.
Each Secule® vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
Last reviewed on RxList: 8/21/2008




Premarin Injection Drug Description
Premarin®Intravenous
(conjugated estrogens, USP) for Injection
Specially prepared for Intravenous & Intramuscular use

WARNINGS
ENDOMETRIAL CANCER
Adequate diagnostic measures, including endometrial sampling when indicated,
should be undertaken to rule out malignancy in all cases of undiagnosed persistent
or recurring abnormal vaginal bleeding. (See WARNINGS,
Malignant neoplasms, Endometrial cancer.)
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention
of cardiovascular disease or dementia. (See Clinical
Studies and WARNINGS, Cardiovascular
disorders and Dementia.)
The estrogen alone substudy of the Women's Health Initiative< (WHI) reported
increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal
women (50 to 79 years of age) during 6.8 years and 7.1 years, respectively,
of treatment with daily oral conjugated estrogens (CE 0.625 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders.)
The estrogen plus progestin substudy of WHI reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal
women (50 to 79 years of age) during 5.6 years of treatment with daily CE
0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders and Malignant neoplasms, Breast cancer.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
an increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 5.2 years of treatment with daily CE 0.625
mg alone and during 4 years of treatment with daily CE 0.625 mg combined with
MPA 2.5 mg, relative to placebo. It is unknown whether this finding applies
to younger postmenopausal women. (See Clinical
Studies and WARNINGS, Dementia and
PRECAUTIONS, Geriatric Use.)
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA and other combinations and dosage forms of estrogens and progestins. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION
Premarin® Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin.
Each Secule® vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
Last reviewed on RxList: 8/21/2008




Premarin Injection Drug Description
Premarin®Intravenous
(conjugated estrogens, USP) for Injection
Specially prepared for Intravenous & Intramuscular use

WARNINGS
ENDOMETRIAL CANCER
Adequate diagnostic measures, including endometrial sampling when indicated,
should be undertaken to rule out malignancy in all cases of undiagnosed persistent
or recurring abnormal vaginal bleeding. (See WARNINGS,
Malignant neoplasms, Endometrial cancer.)
CARDIOVASCULAR AND OTHER RISKS
Estrogens with or without progestins should not be used for the prevention
of cardiovascular disease or dementia. (See Clinical
Studies and WARNINGS, Cardiovascular
disorders and Dementia.)
The estrogen alone substudy of the Women's Health Initiative< (WHI) reported
increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal
women (50 to 79 years of age) during 6.8 years and 7.1 years, respectively,
of treatment with daily oral conjugated estrogens (CE 0.625 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders.)
The estrogen plus progestin substudy of WHI reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and DVT in postmenopausal
women (50 to 79 years of age) during 5.6 years of treatment with daily CE
0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative
to placebo. (See Clinical Studies and WARNINGS,
Cardiovascular disorders and Malignant neoplasms, Breast cancer.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
an increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 5.2 years of treatment with daily CE 0.625
mg alone and during 4 years of treatment with daily CE 0.625 mg combined with
MPA 2.5 mg, relative to placebo. It is unknown whether this finding applies
to younger postmenopausal women. (See Clinical
Studies and WARNINGS, Dementia and
PRECAUTIONS, Geriatric Use.)
In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA and other combinations and dosage forms of estrogens and progestins. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION
Premarin® Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17β-dihydroequilin.
Each Secule® vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
Last reviewed on RxList: 8/21/2008





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Other reviews about Premarin Injection on web:

Learn about the prescription medication Premarin Injection (Conjugated Estrogens for Injection), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Premarin Injection (Conjugated Estrogens for Injection) Drug ...


Accurate, FDA approved Premarin Injection information for healthcare professionals and patients - brought to you by Drugs.com. Premarin Injection Official FDA information, side effects and uses.


An extra patient leaflet is available with Premarin. Talk to your pharmacist if you have questions about this information. Premarin is usually given as an injection at your doctor's ... Premarin Facts and Comparisons at Drugs.com


Premarin / PMU: a look at the real facts of the PREMARINE. Premarin (Premarine) ERT/HRT & PMU Farms Controversy: Page 1


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TTO RECONSTITUTE: Reconstitute Premarin® Intravenous with 5 mL of Sterile Water for Injection, USP. Introduce the sterile diluent slowly against the side of SECULE ... conjugated estrogens (Premarin ®)- Intravenous (IV) Dilution


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