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Prefest Drug Description
PREFEST™
(estradiol/norgestimate) Tablets

WARNING
Estrogens and progestins should not be used for the prevention of cardiovascular
disease. (See WARNINGS, Cardiovascular disorders.)
The Women's Health Initiative (WHI) study reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein
thrombosis in postmenopausal women (50 to 79 years of age) during 5 years
of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone
acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
increased risk of developing probable dementia in postmenopausal women 65
years of age or older during 4 years of treatment with oral conjugated estrogens
plus medroxyprogesterone acetate relative to placebo. It is unknown whether
this finding applies to younger postmenopausal women or to women taking estrogen
alone therapy. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION



What are the possible side effects of estradiol and norgestimate (Prefest)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision,...
Read All Potential Side Effects for Prefest »




The PREFEST regimen provides for a single oral tablet to be taken once daily. The pink tablet containing 1.0 mg estradiol is taken on days one through three of therapy; the white tablet containing 1.0 mg estradiol and 0.09 mg norgestimate is taken on days four through six of therapy. This pattern is then repeated continuously to produce the constant estrogen/intermittent progestogen regimen of PREFEST.
The estrogenic component of PREFEST is estradiol, USP. It is a white, crystalline
solid, chemically described as estra-1,3,5(10)-triene-3,17β-diol. It has
an empirical formula of C18H24O2 and molecular
weight of 272.39. The structural formula is:








The progestational component of PREFEST is micronized norgestimate, a white
powder which is chemically described as 18,19-dinor-17-pregn-4-en-20-yn-3-one,
17-(acetyloxy)-13-ethyl-,oxime,(17α)-(+)-. It has an empirical formula
of C23H31NO3 and a molecular weight of 369.50.
The structural formula is:








Each tablet for oral administration contains 1.0 mg estradiol alone or 1.0 mg estradiol and 0.09 mg of norgestimate, and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, magnesium stearate, ferric oxide red, and lactose monohydrate.
Last reviewed on RxList: 3/4/2009




Prefest Drug Description
PREFEST™
(estradiol/norgestimate) Tablets

WARNING
Estrogens and progestins should not be used for the prevention of cardiovascular
disease. (See WARNINGS, Cardiovascular disorders.)
The Women's Health Initiative (WHI) study reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein
thrombosis in postmenopausal women (50 to 79 years of age) during 5 years
of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone
acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
increased risk of developing probable dementia in postmenopausal women 65
years of age or older during 4 years of treatment with oral conjugated estrogens
plus medroxyprogesterone acetate relative to placebo. It is unknown whether
this finding applies to younger postmenopausal women or to women taking estrogen
alone therapy. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION



What are the possible side effects of estradiol and norgestimate (Prefest)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision,...
Read All Potential Side Effects for Prefest »




The PREFEST regimen provides for a single oral tablet to be taken once daily. The pink tablet containing 1.0 mg estradiol is taken on days one through three of therapy; the white tablet containing 1.0 mg estradiol and 0.09 mg norgestimate is taken on days four through six of therapy. This pattern is then repeated continuously to produce the constant estrogen/intermittent progestogen regimen of PREFEST.
The estrogenic component of PREFEST is estradiol, USP. It is a white, crystalline
solid, chemically described as estra-1,3,5(10)-triene-3,17β-diol. It has
an empirical formula of C18H24O2 and molecular
weight of 272.39. The structural formula is:








The progestational component of PREFEST is micronized norgestimate, a white
powder which is chemically described as 18,19-dinor-17-pregn-4-en-20-yn-3-one,
17-(acetyloxy)-13-ethyl-,oxime,(17α)-(+)-. It has an empirical formula
of C23H31NO3 and a molecular weight of 369.50.
The structural formula is:








Each tablet for oral administration contains 1.0 mg estradiol alone or 1.0 mg estradiol and 0.09 mg of norgestimate, and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, magnesium stearate, ferric oxide red, and lactose monohydrate.
Last reviewed on RxList: 3/4/2009




Prefest Drug Description
PREFEST™
(estradiol/norgestimate) Tablets

WARNING
Estrogens and progestins should not be used for the prevention of cardiovascular
disease. (See WARNINGS, Cardiovascular disorders.)
The Women's Health Initiative (WHI) study reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein
thrombosis in postmenopausal women (50 to 79 years of age) during 5 years
of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone
acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
increased risk of developing probable dementia in postmenopausal women 65
years of age or older during 4 years of treatment with oral conjugated estrogens
plus medroxyprogesterone acetate relative to placebo. It is unknown whether
this finding applies to younger postmenopausal women or to women taking estrogen
alone therapy. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION



What are the possible side effects of estradiol and norgestimate (Prefest)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision,...
Read All Potential Side Effects for Prefest »




The PREFEST regimen provides for a single oral tablet to be taken once daily. The pink tablet containing 1.0 mg estradiol is taken on days one through three of therapy; the white tablet containing 1.0 mg estradiol and 0.09 mg norgestimate is taken on days four through six of therapy. This pattern is then repeated continuously to produce the constant estrogen/intermittent progestogen regimen of PREFEST.
The estrogenic component of PREFEST is estradiol, USP. It is a white, crystalline
solid, chemically described as estra-1,3,5(10)-triene-3,17β-diol. It has
an empirical formula of C18H24O2 and molecular
weight of 272.39. The structural formula is:








The progestational component of PREFEST is micronized norgestimate, a white
powder which is chemically described as 18,19-dinor-17-pregn-4-en-20-yn-3-one,
17-(acetyloxy)-13-ethyl-,oxime,(17α)-(+)-. It has an empirical formula
of C23H31NO3 and a molecular weight of 369.50.
The structural formula is:








Each tablet for oral administration contains 1.0 mg estradiol alone or 1.0 mg estradiol and 0.09 mg of norgestimate, and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, magnesium stearate, ferric oxide red, and lactose monohydrate.
Last reviewed on RxList: 3/4/2009




Prefest Drug Description
PREFEST™
(estradiol/norgestimate) Tablets

WARNING
Estrogens and progestins should not be used for the prevention of cardiovascular
disease. (See WARNINGS, Cardiovascular disorders.)
The Women's Health Initiative (WHI) study reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein
thrombosis in postmenopausal women (50 to 79 years of age) during 5 years
of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone
acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
increased risk of developing probable dementia in postmenopausal women 65
years of age or older during 4 years of treatment with oral conjugated estrogens
plus medroxyprogesterone acetate relative to placebo. It is unknown whether
this finding applies to younger postmenopausal women or to women taking estrogen
alone therapy. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION



What are the possible side effects of estradiol and norgestimate (Prefest)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision,...
Read All Potential Side Effects for Prefest »




The PREFEST regimen provides for a single oral tablet to be taken once daily. The pink tablet containing 1.0 mg estradiol is taken on days one through three of therapy; the white tablet containing 1.0 mg estradiol and 0.09 mg norgestimate is taken on days four through six of therapy. This pattern is then repeated continuously to produce the constant estrogen/intermittent progestogen regimen of PREFEST.
The estrogenic component of PREFEST is estradiol, USP. It is a white, crystalline
solid, chemically described as estra-1,3,5(10)-triene-3,17β-diol. It has
an empirical formula of C18H24O2 and molecular
weight of 272.39. The structural formula is:








The progestational component of PREFEST is micronized norgestimate, a white
powder which is chemically described as 18,19-dinor-17-pregn-4-en-20-yn-3-one,
17-(acetyloxy)-13-ethyl-,oxime,(17α)-(+)-. It has an empirical formula
of C23H31NO3 and a molecular weight of 369.50.
The structural formula is:








Each tablet for oral administration contains 1.0 mg estradiol alone or 1.0 mg estradiol and 0.09 mg of norgestimate, and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, magnesium stearate, ferric oxide red, and lactose monohydrate.
Last reviewed on RxList: 3/4/2009




Prefest Drug Description
PREFEST™
(estradiol/norgestimate) Tablets

WARNING
Estrogens and progestins should not be used for the prevention of cardiovascular
disease. (See WARNINGS, Cardiovascular disorders.)
The Women's Health Initiative (WHI) study reported increased risks of myocardial
infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein
thrombosis in postmenopausal women (50 to 79 years of age) during 5 years
of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone
acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported
increased risk of developing probable dementia in postmenopausal women 65
years of age or older during 4 years of treatment with oral conjugated estrogens
plus medroxyprogesterone acetate relative to placebo. It is unknown whether
this finding applies to younger postmenopausal women or to women taking estrogen
alone therapy. (See CLINICAL PHARMACOLOGY, Clinical
Studies.)
Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

DRUG DESCRIPTION



What are the possible side effects of estradiol and norgestimate (Prefest)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision,...
Read All Potential Side Effects for Prefest »




The PREFEST regimen provides for a single oral tablet to be taken once daily. The pink tablet containing 1.0 mg estradiol is taken on days one through three of therapy; the white tablet containing 1.0 mg estradiol and 0.09 mg norgestimate is taken on days four through six of therapy. This pattern is then repeated continuously to produce the constant estrogen/intermittent progestogen regimen of PREFEST.
The estrogenic component of PREFEST is estradiol, USP. It is a white, crystalline
solid, chemically described as estra-1,3,5(10)-triene-3,17β-diol. It has
an empirical formula of C18H24O2 and molecular
weight of 272.39. The structural formula is:








The progestational component of PREFEST is micronized norgestimate, a white
powder which is chemically described as 18,19-dinor-17-pregn-4-en-20-yn-3-one,
17-(acetyloxy)-13-ethyl-,oxime,(17α)-(+)-. It has an empirical formula
of C23H31NO3 and a molecular weight of 369.50.
The structural formula is:








Each tablet for oral administration contains 1.0 mg estradiol alone or 1.0 mg estradiol and 0.09 mg of norgestimate, and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, magnesium stearate, ferric oxide red, and lactose monohydrate.
Last reviewed on RxList: 3/4/2009





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Other reviews about Prefest on web:

Learn about the prescription medication Prefest (Estradiol, Norgestimate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Prefest (Estradiol, Norgestimate) Drug Information: Uses, Side ...


All about Prefest Tablets. View complete and up to date Prefest information - part of the Drugs.com trusted medication database. Prefest Tablets Facts and Comparisons at Drugs.com


Accurate, FDA approved Prefest information for healthcare professionals and patients - brought to you by Drugs.com. Prefest Official FDA information, side effects and uses.


Prefest is a combination of hormones (estrogen and progestin) used to treat menopausal symptoms (e. Side effects and interactions are available at drugstore.com; plus get home ... Prefest - drugstore.com. Low prices, side effects, interactions.


Find patient medical information for Prefest Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Prefest Oral : Uses, Side Effects, Interactions, Pictures ...


If you or a loved one took Ortho-Prefest and suffered side effects, please fill out the form at the right for a free lawsuit case evaluation by a qualified drug side effects ... Ortho Prefest HRT Side Effects Injury Lawyer


FDA Approves Ortho-Prefest For Menopause Symptoms RARITAN, N.J. -- October 26, 1999 -- The U.S. Food and Drug Administration has approved Ortho-Prefest™ (17(beta)-estradiol ... FDA Approves Ortho-Prefest For Menopause Symptoms


PREFEST (Estradiol, Norgestimate) drug information for Menopausal disorders, Osteoporosis~estrogens from MPR including side effects, drug interactions, dosing, contraindications ... PREFEST (Estradiol, Norgestimate) drug information from MPR


Prefest - Estradiol is a female sex hormone that is involved in the development and maintenance of the female reproductive system. - Do not use this medication if you have any of ... Prefest - Side Effects, Dosage, Interactions - Drugs ...


Estradiol is a female sex hormone that is involved in the development and maintenance of the female reproductive system. Prefest Information - Drugs and Treatments - MedHelp





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