Reviews Polymyxin B Sulfate


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Polymyxin B Drug Description
POLYMYXIN B FOR INJECTION
500,000 Units
To reduce the development of drug-resistant bacteria and maintain the effectiveness
of polymyxin B and other antibacterial drugs, polymyxin B should be used only
to treat or prevent infections that are proven or strongly suspected to be caused
by bacteria.

WARNING
CAUTION: WHEN THIS DRUG IS GIVEN INTRAMUSCULARLY AND/OR INTRATHECALLY,
IT SHOULD BE GIVEN ONLY TO HOSPITALIZED PATIENTS, SO AS TO PROVIDE CONSTANT
SUPERVISION BY A PHYSICIAN.
RENAL FUNCTION SHOULD BE CAREFULLY DETERMINED AND PATIENTS WITH RENAL DAMAGE AND NITROGEN RETENTION SHOULD HAVE REDUCED DOSAGE. PATIENTS WITH NEPHROTOXICITY DUE TO POLYMYXIN B SULFATE USUALLY SHOW ALBUMINURIA, CELLULAR CASTS, AND AZOTEMIA. DIMINISHING URINE OUTPUT AND A RISING BUN ARE INDICATIONS FOR DISCONTINUING THERAPY WITH THIS DRUG.
NEUROTOXIC REACTIONS MAY BE MANIFESTED BY IRRITABILITY, WEAKNESS, DROWSINESS, ATAXIA, PERIORAL PARESTHESIA, NUMBNESS OF THE EXTREMITIES, AND BLURRING OF VISION. THESE ARE USUALLY ASSOCIATED WITH HIGH SERUM LEVELS FOUND IN PATIENTS WITH IMPAIRED RENAL FUNCTION AND/OR NEPHROTOXICITY.
THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOX-IC DRUGS
WITH POLYMYXIN B SULFATE, PARTICULARLY BACITRACIN, STREPTOMYCIN, NEOMYCIN, KANAMYCIN,
GENTAM-ICIN, TOBRAMYCIN, AMIKACIN, CEPHALORI-DINE, PAROMOMYCIN, VIOMYCIN, AND
COLISTIN SHOULD BE AVOIDED.
THE NEUROTOXICITY OF POLYMYXIN B SULFATE CAN RESULT IN RESPIRATORY PARALYSIS
FROM NEUROMUSCULAR BLOCKADE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER ANESTHESIA
AND/OR MUSCLE RELAXANTS.
USAGE IN PREGNANCY: THE SAFETY OF THIS DRUG IN HUMAN PREGNANCY HAS NOT
BEEN ESTABLISHED.

DRUG DESCRIPTION
Polymyxin B for Injection is one of a group of basic polypeptide antibiotics
derived from B polymyxa (B aerosporous). Polymyxin B sulfate is
the sulfate salt of Polymyxins B1 and B2,
which are produced by the growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B
units per mg, calculated on the anhydrous basis.The structural formulae are:








Each vial contains 500,000 polymyxin B units for parenteral or ophthalmic administration.
Polymyxin B forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.
In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B base.Each milligram of pure polymyxin B base is equivalent to 10,000 units of polymyxin B and each microgram of pure polymyxin B base is equivalent to 10 units of polymyxin B.
Aqueous solutions of polymyxin B sulfate may be stored up to 12 months without
significant loss of potency if kept under refrigeration.In the interest of safety,
solutions for parenteral use should be stored under refrigeration and any unused
portion should be discarded after 72 hours. Polymyxin B sulfate should not be
stored in alkaline solutions since they are less stable.Last reviewed on RxList: 9/10/2008




Polymyxin B Drug Description
POLYMYXIN B FOR INJECTION
500,000 Units
To reduce the development of drug-resistant bacteria and maintain the effectiveness
of polymyxin B and other antibacterial drugs, polymyxin B should be used only
to treat or prevent infections that are proven or strongly suspected to be caused
by bacteria.

WARNING
CAUTION: WHEN THIS DRUG IS GIVEN INTRAMUSCULARLY AND/OR INTRATHECALLY,
IT SHOULD BE GIVEN ONLY TO HOSPITALIZED PATIENTS, SO AS TO PROVIDE CONSTANT
SUPERVISION BY A PHYSICIAN.
RENAL FUNCTION SHOULD BE CAREFULLY DETERMINED AND PATIENTS WITH RENAL DAMAGE AND NITROGEN RETENTION SHOULD HAVE REDUCED DOSAGE. PATIENTS WITH NEPHROTOXICITY DUE TO POLYMYXIN B SULFATE USUALLY SHOW ALBUMINURIA, CELLULAR CASTS, AND AZOTEMIA. DIMINISHING URINE OUTPUT AND A RISING BUN ARE INDICATIONS FOR DISCONTINUING THERAPY WITH THIS DRUG.
NEUROTOXIC REACTIONS MAY BE MANIFESTED BY IRRITABILITY, WEAKNESS, DROWSINESS, ATAXIA, PERIORAL PARESTHESIA, NUMBNESS OF THE EXTREMITIES, AND BLURRING OF VISION. THESE ARE USUALLY ASSOCIATED WITH HIGH SERUM LEVELS FOUND IN PATIENTS WITH IMPAIRED RENAL FUNCTION AND/OR NEPHROTOXICITY.
THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOX-IC DRUGS
WITH POLYMYXIN B SULFATE, PARTICULARLY BACITRACIN, STREPTOMYCIN, NEOMYCIN, KANAMYCIN,
GENTAM-ICIN, TOBRAMYCIN, AMIKACIN, CEPHALORI-DINE, PAROMOMYCIN, VIOMYCIN, AND
COLISTIN SHOULD BE AVOIDED.
THE NEUROTOXICITY OF POLYMYXIN B SULFATE CAN RESULT IN RESPIRATORY PARALYSIS
FROM NEUROMUSCULAR BLOCKADE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER ANESTHESIA
AND/OR MUSCLE RELAXANTS.
USAGE IN PREGNANCY: THE SAFETY OF THIS DRUG IN HUMAN PREGNANCY HAS NOT
BEEN ESTABLISHED.

DRUG DESCRIPTION
Polymyxin B for Injection is one of a group of basic polypeptide antibiotics
derived from B polymyxa (B aerosporous). Polymyxin B sulfate is
the sulfate salt of Polymyxins B1 and B2,
which are produced by the growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B
units per mg, calculated on the anhydrous basis.The structural formulae are:








Each vial contains 500,000 polymyxin B units for parenteral or ophthalmic administration.
Polymyxin B forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.
In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B base.Each milligram of pure polymyxin B base is equivalent to 10,000 units of polymyxin B and each microgram of pure polymyxin B base is equivalent to 10 units of polymyxin B.
Aqueous solutions of polymyxin B sulfate may be stored up to 12 months without
significant loss of potency if kept under refrigeration.In the interest of safety,
solutions for parenteral use should be stored under refrigeration and any unused
portion should be discarded after 72 hours. Polymyxin B sulfate should not be
stored in alkaline solutions since they are less stable.Last reviewed on RxList: 9/10/2008




Polymyxin B Drug Description
POLYMYXIN B FOR INJECTION
500,000 Units
To reduce the development of drug-resistant bacteria and maintain the effectiveness
of polymyxin B and other antibacterial drugs, polymyxin B should be used only
to treat or prevent infections that are proven or strongly suspected to be caused
by bacteria.

WARNING
CAUTION: WHEN THIS DRUG IS GIVEN INTRAMUSCULARLY AND/OR INTRATHECALLY,
IT SHOULD BE GIVEN ONLY TO HOSPITALIZED PATIENTS, SO AS TO PROVIDE CONSTANT
SUPERVISION BY A PHYSICIAN.
RENAL FUNCTION SHOULD BE CAREFULLY DETERMINED AND PATIENTS WITH RENAL DAMAGE AND NITROGEN RETENTION SHOULD HAVE REDUCED DOSAGE. PATIENTS WITH NEPHROTOXICITY DUE TO POLYMYXIN B SULFATE USUALLY SHOW ALBUMINURIA, CELLULAR CASTS, AND AZOTEMIA. DIMINISHING URINE OUTPUT AND A RISING BUN ARE INDICATIONS FOR DISCONTINUING THERAPY WITH THIS DRUG.
NEUROTOXIC REACTIONS MAY BE MANIFESTED BY IRRITABILITY, WEAKNESS, DROWSINESS, ATAXIA, PERIORAL PARESTHESIA, NUMBNESS OF THE EXTREMITIES, AND BLURRING OF VISION. THESE ARE USUALLY ASSOCIATED WITH HIGH SERUM LEVELS FOUND IN PATIENTS WITH IMPAIRED RENAL FUNCTION AND/OR NEPHROTOXICITY.
THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOX-IC DRUGS
WITH POLYMYXIN B SULFATE, PARTICULARLY BACITRACIN, STREPTOMYCIN, NEOMYCIN, KANAMYCIN,
GENTAM-ICIN, TOBRAMYCIN, AMIKACIN, CEPHALORI-DINE, PAROMOMYCIN, VIOMYCIN, AND
COLISTIN SHOULD BE AVOIDED.
THE NEUROTOXICITY OF POLYMYXIN B SULFATE CAN RESULT IN RESPIRATORY PARALYSIS
FROM NEUROMUSCULAR BLOCKADE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER ANESTHESIA
AND/OR MUSCLE RELAXANTS.
USAGE IN PREGNANCY: THE SAFETY OF THIS DRUG IN HUMAN PREGNANCY HAS NOT
BEEN ESTABLISHED.

DRUG DESCRIPTION
Polymyxin B for Injection is one of a group of basic polypeptide antibiotics
derived from B polymyxa (B aerosporous). Polymyxin B sulfate is
the sulfate salt of Polymyxins B1 and B2,
which are produced by the growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B
units per mg, calculated on the anhydrous basis.The structural formulae are:








Each vial contains 500,000 polymyxin B units for parenteral or ophthalmic administration.
Polymyxin B forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.
In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B base.Each milligram of pure polymyxin B base is equivalent to 10,000 units of polymyxin B and each microgram of pure polymyxin B base is equivalent to 10 units of polymyxin B.
Aqueous solutions of polymyxin B sulfate may be stored up to 12 months without
significant loss of potency if kept under refrigeration.In the interest of safety,
solutions for parenteral use should be stored under refrigeration and any unused
portion should be discarded after 72 hours. Polymyxin B sulfate should not be
stored in alkaline solutions since they are less stable.Last reviewed on RxList: 9/10/2008




Polymyxin B Drug Description
POLYMYXIN B FOR INJECTION
500,000 Units
To reduce the development of drug-resistant bacteria and maintain the effectiveness
of polymyxin B and other antibacterial drugs, polymyxin B should be used only
to treat or prevent infections that are proven or strongly suspected to be caused
by bacteria.

WARNING
CAUTION: WHEN THIS DRUG IS GIVEN INTRAMUSCULARLY AND/OR INTRATHECALLY,
IT SHOULD BE GIVEN ONLY TO HOSPITALIZED PATIENTS, SO AS TO PROVIDE CONSTANT
SUPERVISION BY A PHYSICIAN.
RENAL FUNCTION SHOULD BE CAREFULLY DETERMINED AND PATIENTS WITH RENAL DAMAGE AND NITROGEN RETENTION SHOULD HAVE REDUCED DOSAGE. PATIENTS WITH NEPHROTOXICITY DUE TO POLYMYXIN B SULFATE USUALLY SHOW ALBUMINURIA, CELLULAR CASTS, AND AZOTEMIA. DIMINISHING URINE OUTPUT AND A RISING BUN ARE INDICATIONS FOR DISCONTINUING THERAPY WITH THIS DRUG.
NEUROTOXIC REACTIONS MAY BE MANIFESTED BY IRRITABILITY, WEAKNESS, DROWSINESS, ATAXIA, PERIORAL PARESTHESIA, NUMBNESS OF THE EXTREMITIES, AND BLURRING OF VISION. THESE ARE USUALLY ASSOCIATED WITH HIGH SERUM LEVELS FOUND IN PATIENTS WITH IMPAIRED RENAL FUNCTION AND/OR NEPHROTOXICITY.
THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOX-IC DRUGS
WITH POLYMYXIN B SULFATE, PARTICULARLY BACITRACIN, STREPTOMYCIN, NEOMYCIN, KANAMYCIN,
GENTAM-ICIN, TOBRAMYCIN, AMIKACIN, CEPHALORI-DINE, PAROMOMYCIN, VIOMYCIN, AND
COLISTIN SHOULD BE AVOIDED.
THE NEUROTOXICITY OF POLYMYXIN B SULFATE CAN RESULT IN RESPIRATORY PARALYSIS
FROM NEUROMUSCULAR BLOCKADE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER ANESTHESIA
AND/OR MUSCLE RELAXANTS.
USAGE IN PREGNANCY: THE SAFETY OF THIS DRUG IN HUMAN PREGNANCY HAS NOT
BEEN ESTABLISHED.

DRUG DESCRIPTION
Polymyxin B for Injection is one of a group of basic polypeptide antibiotics
derived from B polymyxa (B aerosporous). Polymyxin B sulfate is
the sulfate salt of Polymyxins B1 and B2,
which are produced by the growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B
units per mg, calculated on the anhydrous basis.The structural formulae are:








Each vial contains 500,000 polymyxin B units for parenteral or ophthalmic administration.
Polymyxin B forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.
In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B base.Each milligram of pure polymyxin B base is equivalent to 10,000 units of polymyxin B and each microgram of pure polymyxin B base is equivalent to 10 units of polymyxin B.
Aqueous solutions of polymyxin B sulfate may be stored up to 12 months without
significant loss of potency if kept under refrigeration.In the interest of safety,
solutions for parenteral use should be stored under refrigeration and any unused
portion should be discarded after 72 hours. Polymyxin B sulfate should not be
stored in alkaline solutions since they are less stable.Last reviewed on RxList: 9/10/2008




Polymyxin B Drug Description
POLYMYXIN B FOR INJECTION
500,000 Units
To reduce the development of drug-resistant bacteria and maintain the effectiveness
of polymyxin B and other antibacterial drugs, polymyxin B should be used only
to treat or prevent infections that are proven or strongly suspected to be caused
by bacteria.

WARNING
CAUTION: WHEN THIS DRUG IS GIVEN INTRAMUSCULARLY AND/OR INTRATHECALLY,
IT SHOULD BE GIVEN ONLY TO HOSPITALIZED PATIENTS, SO AS TO PROVIDE CONSTANT
SUPERVISION BY A PHYSICIAN.
RENAL FUNCTION SHOULD BE CAREFULLY DETERMINED AND PATIENTS WITH RENAL DAMAGE AND NITROGEN RETENTION SHOULD HAVE REDUCED DOSAGE. PATIENTS WITH NEPHROTOXICITY DUE TO POLYMYXIN B SULFATE USUALLY SHOW ALBUMINURIA, CELLULAR CASTS, AND AZOTEMIA. DIMINISHING URINE OUTPUT AND A RISING BUN ARE INDICATIONS FOR DISCONTINUING THERAPY WITH THIS DRUG.
NEUROTOXIC REACTIONS MAY BE MANIFESTED BY IRRITABILITY, WEAKNESS, DROWSINESS, ATAXIA, PERIORAL PARESTHESIA, NUMBNESS OF THE EXTREMITIES, AND BLURRING OF VISION. THESE ARE USUALLY ASSOCIATED WITH HIGH SERUM LEVELS FOUND IN PATIENTS WITH IMPAIRED RENAL FUNCTION AND/OR NEPHROTOXICITY.
THE CONCURRENT OR SEQUENTIAL USE OF OTHER NEUROTOXIC AND/OR NEPHROTOX-IC DRUGS
WITH POLYMYXIN B SULFATE, PARTICULARLY BACITRACIN, STREPTOMYCIN, NEOMYCIN, KANAMYCIN,
GENTAM-ICIN, TOBRAMYCIN, AMIKACIN, CEPHALORI-DINE, PAROMOMYCIN, VIOMYCIN, AND
COLISTIN SHOULD BE AVOIDED.
THE NEUROTOXICITY OF POLYMYXIN B SULFATE CAN RESULT IN RESPIRATORY PARALYSIS
FROM NEUROMUSCULAR BLOCKADE, ESPECIALLY WHEN THE DRUG IS GIVEN SOON AFTER ANESTHESIA
AND/OR MUSCLE RELAXANTS.
USAGE IN PREGNANCY: THE SAFETY OF THIS DRUG IN HUMAN PREGNANCY HAS NOT
BEEN ESTABLISHED.

DRUG DESCRIPTION
Polymyxin B for Injection is one of a group of basic polypeptide antibiotics
derived from B polymyxa (B aerosporous). Polymyxin B sulfate is
the sulfate salt of Polymyxins B1 and B2,
which are produced by the growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillacea).It has a potency of not less than 6000 polymyxin B
units per mg, calculated on the anhydrous basis.The structural formulae are:








Each vial contains 500,000 polymyxin B units for parenteral or ophthalmic administration.
Polymyxin B forInjection is in powder form suitable for preparation of sterile solutions for intramuscular, intravenous drip, intrathecal, or ophthalmic use.
In the medical literature, dosages have frequently been given in terms of equivalent weights of pure polymyxin B base.Each milligram of pure polymyxin B base is equivalent to 10,000 units of polymyxin B and each microgram of pure polymyxin B base is equivalent to 10 units of polymyxin B.
Aqueous solutions of polymyxin B sulfate may be stored up to 12 months without
significant loss of potency if kept under refrigeration.In the interest of safety,
solutions for parenteral use should be stored under refrigeration and any unused
portion should be discarded after 72 hours. Polymyxin B sulfate should not be
stored in alkaline solutions since they are less stable.Last reviewed on RxList: 9/10/2008





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Other reviews about Polymyxin B Sulfate on web:

Learn about the prescription medication Polymyxin B (Polymyxin B Sulfate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Polymyxin B (Polymyxin B Sulfate) Drug Information: Uses, Side ...


All about Polymyxin B Sulfate. View complete and up to date Polymyxin B Sulfate information - part of the Drugs.com trusted medication database. Polymyxin B Sulfate Facts and Comparisons at Drugs.com


Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. Polymyxins bind to the cell membrane and alter its structure making it more permeable. Polymyxin B - Wikipedia, the free encyclopedia


All about Polymyxin B Sulfate/Trimethoprim Solution. View complete and up to date Polymyxin B Sulfate/Trimethoprim information - part of the Drugs.com trusted medication database. Polymyxin B Sulfate/Trimethoprim Solution Facts and Comparisons at ...


Sterile. DESCRIPTION. POLYTRIM ® (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is a sterile antimicrobial solution for topical ophthalmic use. DailyMed: About DailyMed


Polymyxin B; Trimethoprim Brand names: Polytrim® Chemical formula: Español: Sulfato de Polimixina B; Sulfato de Trimetoprima, Solución para gotas Polymyxin B; Trimethoprim: Information from Answers.com


Comments: Polymyxin B sulfate-Trimethoprim is an ophthalmic preparation used to treat conjunctivitis due to susceptible organisms. Trimethoprim is active against most ... Polymyxin trimethoprim


Profession medical resources for "polymyxin b sulfate and trimethoprim" including "DailyMed: About DailyMed", "A Multicenter Comparison of Polymyxin B Sulfate/Trimethoprim ... polymyxin b sulfate and trimethoprim - Professional Medical ...


Consumer information about the medication POLYMYXIN B SULFATE - INJECTABLE (Polymyxin B Sulfate), includes side effects, drug interactions, recommended dosages, and storage ... POLYMYXIN B SULFATE - INJECTABLE (Polymyxin B Sulfate) side ...


Polymyxin B Sulfate Solution for injection To return to the main entry click here . What is this medicine? POLYMYXIN B (pol i MIX in B) is a Polymyxin B Sulfate Solution for injection: Information from ...





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