Reviews Poliovirus Vaccine Inactivated


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Ipol Drug Description
IPOL®
Poliovirus Vaccine Inactivated
DRUG DESCRIPTION



What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious...
Read All Potential Side Effects for Ipol »




IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is
a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2
(MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated
poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus
is individually grown in vero cells, a continuous line of monkey kidney cells
cultivated on microcarriers.1,2 The cells are grown in Eagle MEM
modified medium, supplemented with newborn calf serum tested for adventitious
agents prior to use, originated from countries free of bovine spongiform encephalopathy.
For viral growth the culture medium is replaced by M-199, without calf serum.
This culture technique and improvements in purification, concentration and standardization
of poliovirus antigen produce a more potent and consistent immunogenic vaccine
than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4
After clarification and filtration, viral suspensions are concentrated by ultrafiltration,
and purified by three liquid chromatography steps; one column of anion exchanger,
one column of gel filtration and again one column of anion exchanger. After
re-equilibration of the purified viral suspension, with Medium M-199 and adjustment
of the antigen titer, the monovalent viral suspensions are inactivated at +37°C
for at least 12 days with 1:4000 formalin.
Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen
units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type
3 poliovirus. For each lot of IPOL vaccine, D-antigen content is determined
in vitro using the D-antigen ELISA assay and immunogenicity is determined
by in vivo testing in animals. IPOL vaccine is produced from vaccine
concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol
and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin,
streptomycin and polymyxin B are used in vaccine production, and although purification
procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin
and 25 ng polymyxin B per dose may still be present. The residual calf serum
protein is less than 1 ppm in the final vaccine.
The vaccine is clear and colorless and should be administered intramuscularly
or subcutaneously.
REFERENCES
1. van Wezel AL, et al. Inactivated poliovirus vaccine: Current
production methods and new developments. Rev Infect Dis 6 (Suppl 2): S335-S340,
1984
2. Montagnon BJ, et al. Industrial scale production of inactivated
poliovirus vaccine prepared by culture of Vero cells on microcarrier. Rev Infect
Dis 6 (Suppl 2): S341-S344, 1984
3. McBean AM, et al. Serologic response to oral polio vaccine
and enhanced-potency inactivated polio vaccines. Am J Epidemiol 128: 615-628,
1988
4. Murdin AD, et al. Inactivated poliovirus vaccine: past and
present experience. Vaccine 8: 735-746, 1996Last reviewed on RxList: 2/20/2009




Ipol Drug Description
IPOL®
Poliovirus Vaccine Inactivated
DRUG DESCRIPTION



What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious...
Read All Potential Side Effects for Ipol »




IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is
a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2
(MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated
poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus
is individually grown in vero cells, a continuous line of monkey kidney cells
cultivated on microcarriers.1,2 The cells are grown in Eagle MEM
modified medium, supplemented with newborn calf serum tested for adventitious
agents prior to use, originated from countries free of bovine spongiform encephalopathy.
For viral growth the culture medium is replaced by M-199, without calf serum.
This culture technique and improvements in purification, concentration and standardization
of poliovirus antigen produce a more potent and consistent immunogenic vaccine
than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4
After clarification and filtration, viral suspensions are concentrated by ultrafiltration,
and purified by three liquid chromatography steps; one column of anion exchanger,
one column of gel filtration and again one column of anion exchanger. After
re-equilibration of the purified viral suspension, with Medium M-199 and adjustment
of the antigen titer, the monovalent viral suspensions are inactivated at +37°C
for at least 12 days with 1:4000 formalin.
Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen
units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type
3 poliovirus. For each lot of IPOL vaccine, D-antigen content is determined
in vitro using the D-antigen ELISA assay and immunogenicity is determined
by in vivo testing in animals. IPOL vaccine is produced from vaccine
concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol
and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin,
streptomycin and polymyxin B are used in vaccine production, and although purification
procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin
and 25 ng polymyxin B per dose may still be present. The residual calf serum
protein is less than 1 ppm in the final vaccine.
The vaccine is clear and colorless and should be administered intramuscularly
or subcutaneously.
REFERENCES
1. van Wezel AL, et al. Inactivated poliovirus vaccine: Current
production methods and new developments. Rev Infect Dis 6 (Suppl 2): S335-S340,
1984
2. Montagnon BJ, et al. Industrial scale production of inactivated
poliovirus vaccine prepared by culture of Vero cells on microcarrier. Rev Infect
Dis 6 (Suppl 2): S341-S344, 1984
3. McBean AM, et al. Serologic response to oral polio vaccine
and enhanced-potency inactivated polio vaccines. Am J Epidemiol 128: 615-628,
1988
4. Murdin AD, et al. Inactivated poliovirus vaccine: past and
present experience. Vaccine 8: 735-746, 1996Last reviewed on RxList: 2/20/2009




Ipol Drug Description
IPOL®
Poliovirus Vaccine Inactivated
DRUG DESCRIPTION



What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious...
Read All Potential Side Effects for Ipol »




IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is
a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2
(MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated
poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus
is individually grown in vero cells, a continuous line of monkey kidney cells
cultivated on microcarriers.1,2 The cells are grown in Eagle MEM
modified medium, supplemented with newborn calf serum tested for adventitious
agents prior to use, originated from countries free of bovine spongiform encephalopathy.
For viral growth the culture medium is replaced by M-199, without calf serum.
This culture technique and improvements in purification, concentration and standardization
of poliovirus antigen produce a more potent and consistent immunogenic vaccine
than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4
After clarification and filtration, viral suspensions are concentrated by ultrafiltration,
and purified by three liquid chromatography steps; one column of anion exchanger,
one column of gel filtration and again one column of anion exchanger. After
re-equilibration of the purified viral suspension, with Medium M-199 and adjustment
of the antigen titer, the monovalent viral suspensions are inactivated at +37°C
for at least 12 days with 1:4000 formalin.
Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen
units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type
3 poliovirus. For each lot of IPOL vaccine, D-antigen content is determined
in vitro using the D-antigen ELISA assay and immunogenicity is determined
by in vivo testing in animals. IPOL vaccine is produced from vaccine
concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol
and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin,
streptomycin and polymyxin B are used in vaccine production, and although purification
procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin
and 25 ng polymyxin B per dose may still be present. The residual calf serum
protein is less than 1 ppm in the final vaccine.
The vaccine is clear and colorless and should be administered intramuscularly
or subcutaneously.
REFERENCES
1. van Wezel AL, et al. Inactivated poliovirus vaccine: Current
production methods and new developments. Rev Infect Dis 6 (Suppl 2): S335-S340,
1984
2. Montagnon BJ, et al. Industrial scale production of inactivated
poliovirus vaccine prepared by culture of Vero cells on microcarrier. Rev Infect
Dis 6 (Suppl 2): S341-S344, 1984
3. McBean AM, et al. Serologic response to oral polio vaccine
and enhanced-potency inactivated polio vaccines. Am J Epidemiol 128: 615-628,
1988
4. Murdin AD, et al. Inactivated poliovirus vaccine: past and
present experience. Vaccine 8: 735-746, 1996Last reviewed on RxList: 2/20/2009




Ipol Drug Description
IPOL®
Poliovirus Vaccine Inactivated
DRUG DESCRIPTION



What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious...
Read All Potential Side Effects for Ipol »




IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is
a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2
(MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated
poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus
is individually grown in vero cells, a continuous line of monkey kidney cells
cultivated on microcarriers.1,2 The cells are grown in Eagle MEM
modified medium, supplemented with newborn calf serum tested for adventitious
agents prior to use, originated from countries free of bovine spongiform encephalopathy.
For viral growth the culture medium is replaced by M-199, without calf serum.
This culture technique and improvements in purification, concentration and standardization
of poliovirus antigen produce a more potent and consistent immunogenic vaccine
than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4
After clarification and filtration, viral suspensions are concentrated by ultrafiltration,
and purified by three liquid chromatography steps; one column of anion exchanger,
one column of gel filtration and again one column of anion exchanger. After
re-equilibration of the purified viral suspension, with Medium M-199 and adjustment
of the antigen titer, the monovalent viral suspensions are inactivated at +37°C
for at least 12 days with 1:4000 formalin.
Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen
units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type
3 poliovirus. For each lot of IPOL vaccine, D-antigen content is determined
in vitro using the D-antigen ELISA assay and immunogenicity is determined
by in vivo testing in animals. IPOL vaccine is produced from vaccine
concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol
and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin,
streptomycin and polymyxin B are used in vaccine production, and although purification
procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin
and 25 ng polymyxin B per dose may still be present. The residual calf serum
protein is less than 1 ppm in the final vaccine.
The vaccine is clear and colorless and should be administered intramuscularly
or subcutaneously.
REFERENCES
1. van Wezel AL, et al. Inactivated poliovirus vaccine: Current
production methods and new developments. Rev Infect Dis 6 (Suppl 2): S335-S340,
1984
2. Montagnon BJ, et al. Industrial scale production of inactivated
poliovirus vaccine prepared by culture of Vero cells on microcarrier. Rev Infect
Dis 6 (Suppl 2): S341-S344, 1984
3. McBean AM, et al. Serologic response to oral polio vaccine
and enhanced-potency inactivated polio vaccines. Am J Epidemiol 128: 615-628,
1988
4. Murdin AD, et al. Inactivated poliovirus vaccine: past and
present experience. Vaccine 8: 735-746, 1996Last reviewed on RxList: 2/20/2009




Ipol Drug Description
IPOL®
Poliovirus Vaccine Inactivated
DRUG DESCRIPTION



What are the possible side effects of polio vaccine (Ipol)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with polio vaccine is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious...
Read All Potential Side Effects for Ipol »




IPOL®, Poliovirus Vaccine Inactivated, produced by Sanofi Pasteur SA, is
a sterile suspension of three types of poliovirus: Type 1 (Mahoney), Type 2
(MEF-1), and Type 3 (Saukett). IPOL vaccine is a highly purified, inactivated
poliovirus vaccine with enhanced potency. Each of the three strains of poliovirus
is individually grown in vero cells, a continuous line of monkey kidney cells
cultivated on microcarriers.1,2 The cells are grown in Eagle MEM
modified medium, supplemented with newborn calf serum tested for adventitious
agents prior to use, originated from countries free of bovine spongiform encephalopathy.
For viral growth the culture medium is replaced by M-199, without calf serum.
This culture technique and improvements in purification, concentration and standardization
of poliovirus antigen produce a more potent and consistent immunogenic vaccine
than the inactivated poliovirus vaccine (IPV) available in the US prior to 1988.3,4
After clarification and filtration, viral suspensions are concentrated by ultrafiltration,
and purified by three liquid chromatography steps; one column of anion exchanger,
one column of gel filtration and again one column of anion exchanger. After
re-equilibration of the purified viral suspension, with Medium M-199 and adjustment
of the antigen titer, the monovalent viral suspensions are inactivated at +37°C
for at least 12 days with 1:4000 formalin.
Each dose (0.5 mL) of trivalent vaccine is formulated to contain 40 D antigen
units of Type 1, 8 D antigen units of Type 2, and 32 D antigen units of Type
3 poliovirus. For each lot of IPOL vaccine, D-antigen content is determined
in vitro using the D-antigen ELISA assay and immunogenicity is determined
by in vivo testing in animals. IPOL vaccine is produced from vaccine
concentrates diluted with M-199 medium. Also present are 0.5% of 2-phenoxyethanol
and a maximum of 0.02% of formaldehyde per dose as preservatives. Neomycin,
streptomycin and polymyxin B are used in vaccine production, and although purification
procedures eliminate measurable amounts, less than 5 ng neomycin, 200 ng streptomycin
and 25 ng polymyxin B per dose may still be present. The residual calf serum
protein is less than 1 ppm in the final vaccine.
The vaccine is clear and colorless and should be administered intramuscularly
or subcutaneously.
REFERENCES
1. van Wezel AL, et al. Inactivated poliovirus vaccine: Current
production methods and new developments. Rev Infect Dis 6 (Suppl 2): S335-S340,
1984
2. Montagnon BJ, et al. Industrial scale production of inactivated
poliovirus vaccine prepared by culture of Vero cells on microcarrier. Rev Infect
Dis 6 (Suppl 2): S341-S344, 1984
3. McBean AM, et al. Serologic response to oral polio vaccine
and enhanced-potency inactivated polio vaccines. Am J Epidemiol 128: 615-628,
1988
4. Murdin AD, et al. Inactivated poliovirus vaccine: past and
present experience. Vaccine 8: 735-746, 1996Last reviewed on RxList: 2/20/2009





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New England Journal of Medicine Volume 362 — June 24, 2010 — Number 25 http://content.nejm.org/current.shtml Original Articles Fractional Doses of Inactivated Poliovirus Vaccine in Oman A. J. Mohammed and Others [Free full-text] ABSTRACT Background We […]



Other reviews about Poliovirus Vaccine Inactivated on web:

What side effects may I notice from receiving Poliovirus Vaccine, Inactivated, IPV? Side effects that you should report to your prescriber or health care professional as soon as ... poliovirus vaccine: Definition from Answers.com


Poliovirus Vaccine, Inactivated, IPV To return to the main entry click here . What is Poliovirus Vaccine, Inactivated, IPV? INACTIVATED POLIOVIRUS Poliovirus Vaccine, Inactivated, IPV: Information from Answers.com


Two polio vaccines are used throughout the world to combat poliomyelitis (or polio). The first was developed by Jonas Salk and first tested in 1952. Polio vaccine - Wikipedia, the free encyclopedia


Four doses at two, four, and six to 18 months of age, and again between ages four to six years. Inactivated Poliovirus (IPV) Vaccine -- Childhood Immunizations ...


Inactivated Poliovirus Vaccine _____ [Back to Table of Contents] Enhanced Inactivated Poliovirus Vaccine (E-IPV)


Because of this risk, most parents prefer a vaccine schedule that starts with inactivated poliovirus vaccine (IPV), even though extra injections are required. Poliovirus Vaccine Options - January 1, 1999 - American Academy of ...


Poliovirus Vaccine, Inactivated (IPV) professional patient advice. Specific and up to date information about Poliovirus Vaccine, Inactivated (IPV). Complete Poliovirus Vaccine, Inactivated (IPV) information from ...


AHFS Detailed Monograph from Medscape Drug Reference ... Poliovirus vaccine inactivated (IPV) is an inactivated virus vaccine. IPV contains 3 strains of inactivated poliovirus (types 1 ... Poliovirus Vaccine, IPV SubQ: AHFS Detailed Monograph


1. General information Inactivated (Salk) poliovirus vaccine (IPV) was licensed in 1955 and was used extensively from that time until the early 1960s. Polio - Vaccine


Mayo Clinic offers award-winning medical and health information and tools for healthy living. Poliovirus Vaccine, Inactivated (Injection Route) - MayoClinic.com





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