Reviews Pioglitazone Hydrochloride


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Actos Drug Description
ACTOS®
(pioglitazone hydrochloride) Tablets

WARNING
CONGESTIVE HEART FAILURE

Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart
failure in some patients (see WARNINGS). After initiation of ACTOS,
and after dose increases, observe patients carefully for signs and symptoms
of heart failure (including excessive, rapid weight gain, dyspnea, and/or
edema). If these signs and symptoms develop, the heart failure should be
managed according to the current standards of care. Furthermore, discontinuation
or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established NYHA Class III or IV heart
failure is contraindicated (see CONTRAINDICATIONS
and WARNINGS).


DRUG DESCRIPTION



What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
chest pain, general ill feeling;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools,...
Read All Potential Side Effects for Actos »




ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose
tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control
while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the α-glucosidase inhibitors. The molecule contains one asymmetric
carbon, and the compound is synthesized and used as the racemic mixture. The
two enantiomers of pioglitazone interconvert in vivo. No differences were
found in the pharmacologic activity between the two enantiomers. The
structural formula is as shown:








Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide,
slightly soluble in anhydrous ethanol, very slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
carboxymethylcellulose calcium NF, and magnesium stearate NF.Last reviewed on RxList: 9/28/2009




Actos Drug Description
ACTOS®
(pioglitazone hydrochloride) Tablets

WARNING
CONGESTIVE HEART FAILURE

Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart
failure in some patients (see WARNINGS). After initiation of ACTOS,
and after dose increases, observe patients carefully for signs and symptoms
of heart failure (including excessive, rapid weight gain, dyspnea, and/or
edema). If these signs and symptoms develop, the heart failure should be
managed according to the current standards of care. Furthermore, discontinuation
or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established NYHA Class III or IV heart
failure is contraindicated (see CONTRAINDICATIONS
and WARNINGS).


DRUG DESCRIPTION



What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
chest pain, general ill feeling;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools,...
Read All Potential Side Effects for Actos »




ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose
tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control
while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the α-glucosidase inhibitors. The molecule contains one asymmetric
carbon, and the compound is synthesized and used as the racemic mixture. The
two enantiomers of pioglitazone interconvert in vivo. No differences were
found in the pharmacologic activity between the two enantiomers. The
structural formula is as shown:








Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide,
slightly soluble in anhydrous ethanol, very slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
carboxymethylcellulose calcium NF, and magnesium stearate NF.Last reviewed on RxList: 9/28/2009




Actos Drug Description
ACTOS®
(pioglitazone hydrochloride) Tablets

WARNING
CONGESTIVE HEART FAILURE

Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart
failure in some patients (see WARNINGS). After initiation of ACTOS,
and after dose increases, observe patients carefully for signs and symptoms
of heart failure (including excessive, rapid weight gain, dyspnea, and/or
edema). If these signs and symptoms develop, the heart failure should be
managed according to the current standards of care. Furthermore, discontinuation
or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established NYHA Class III or IV heart
failure is contraindicated (see CONTRAINDICATIONS
and WARNINGS).


DRUG DESCRIPTION



What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
chest pain, general ill feeling;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools,...
Read All Potential Side Effects for Actos »




ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose
tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control
while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the α-glucosidase inhibitors. The molecule contains one asymmetric
carbon, and the compound is synthesized and used as the racemic mixture. The
two enantiomers of pioglitazone interconvert in vivo. No differences were
found in the pharmacologic activity between the two enantiomers. The
structural formula is as shown:








Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide,
slightly soluble in anhydrous ethanol, very slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
carboxymethylcellulose calcium NF, and magnesium stearate NF.Last reviewed on RxList: 9/28/2009




Actos Drug Description
ACTOS®
(pioglitazone hydrochloride) Tablets

WARNING
CONGESTIVE HEART FAILURE

Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart
failure in some patients (see WARNINGS). After initiation of ACTOS,
and after dose increases, observe patients carefully for signs and symptoms
of heart failure (including excessive, rapid weight gain, dyspnea, and/or
edema). If these signs and symptoms develop, the heart failure should be
managed according to the current standards of care. Furthermore, discontinuation
or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established NYHA Class III or IV heart
failure is contraindicated (see CONTRAINDICATIONS
and WARNINGS).


DRUG DESCRIPTION



What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
chest pain, general ill feeling;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools,...
Read All Potential Side Effects for Actos »




ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose
tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control
while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the α-glucosidase inhibitors. The molecule contains one asymmetric
carbon, and the compound is synthesized and used as the racemic mixture. The
two enantiomers of pioglitazone interconvert in vivo. No differences were
found in the pharmacologic activity between the two enantiomers. The
structural formula is as shown:








Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide,
slightly soluble in anhydrous ethanol, very slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
carboxymethylcellulose calcium NF, and magnesium stearate NF.Last reviewed on RxList: 9/28/2009




Actos Drug Description
ACTOS®
(pioglitazone hydrochloride) Tablets

WARNING
CONGESTIVE HEART FAILURE

Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart
failure in some patients (see WARNINGS). After initiation of ACTOS,
and after dose increases, observe patients carefully for signs and symptoms
of heart failure (including excessive, rapid weight gain, dyspnea, and/or
edema). If these signs and symptoms develop, the heart failure should be
managed according to the current standards of care. Furthermore, discontinuation
or dose reduction of ACTOS must be considered.
ACTOS is not recommended in patients with symptomatic heart failure.
Initiation of ACTOS in patients with established NYHA Class III or IV heart
failure is contraindicated (see CONTRAINDICATIONS
and WARNINGS).


DRUG DESCRIPTION



What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

feeling short of breath, even with mild exertion;
swelling or rapid weight gain;
chest pain, general ill feeling;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools,...
Read All Potential Side Effects for Actos »




ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose
tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control
while reducing circulating insulin levels.
Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidinedione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the α-glucosidase inhibitors. The molecule contains one asymmetric
carbon, and the compound is synthesized and used as the racemic mixture. The
two enantiomers of pioglitazone interconvert in vivo. No differences were
found in the pharmacologic activity between the two enantiomers. The
structural formula is as shown:








Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide,
slightly soluble in anhydrous ethanol, very slightly soluble in acetone and
acetonitrile, practically insoluble in water, and insoluble in ether.
ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
carboxymethylcellulose calcium NF, and magnesium stearate NF.Last reviewed on RxList: 9/28/2009





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[caption id="" align="alignleft" width="221" caption=" Actos "][/caption] WARNING: CONGESTIVE HEART FAILURE Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients (see WARNINGS). […]


Updated Labelling For Diabetes Drug Actos And Risk Of Heart Failure, Canada
  by healtherm2
Health Canada is informing diabetic patients taking Actos (the brand name for the prescription drug pioglitazone hydrochloride) of recent changes to the prescribing information for this product. […]


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  by health61
To compare the role of glibenclamide and pioglitazone drugs in type 11 non- insulin dependent diabetes mellitus patients. Introduction:- Diabetes comes from the greek word for ‘SIPHON" which one is […]


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Earlier this week, I posted about the link between TZDs, a drug used to treat type 2 diabetes, and increased risk of osteoporosis. Well that's not all […]


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Ranbaxy Laboratories Ltd has entered into an agreement with the Japanese drug maker Takeda Pharmaceuticals for ending the patent litigation regarding diabetic drug Actos. Takeda has granted Ranbaxy,a non-exclusive […]


To Compare the Role of Glibenclamide and Pioglitazone Drugs
  by allweightdiet
To compare the role of glibenclamide and pioglitazone drugs in type 11 non- insulin dependent diabetes mellitus patients. Introduction:- Diabetes comes from the greek word for […]


FDA schedules Avandia advisory panel for July 13-14
  by Larry Husten
The FDA has definitely scheduled the much-anticipated Avandia (rosiglitazone) advisory panel for July 13-14 in Gaithersburg, MD. The notification appears in the Federal Register. [Update: click here for […]


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The notice below of the “Two Studies Suggest Diabetes Drug Avandia Increases Risk of Heart Problems” is a further substantiation of our evidence-based review of the BARI2 trial.  […]



Other reviews about Pioglitazone Hydrochloride on web:

Learn about the prescription medication Actos (Pioglitazone Hydrochloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Actos (Pioglitazone Hydrochloride) Drug Information: Uses, Side ...


Pioglitazone is a prescription drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action. Pioglitazone is marketed as trademarks Actos in the ... Pioglitazone - Wikipedia, the free encyclopedia


Comprehensive and trusted information about Pioglitazone hydrochloride - plus advice on 24,000 other FDA approved drugs and medications from Drugs.com. Pioglitazone hydrochloride patient advice including side effects


Pioglitazone HCI. Provides product information, diet plans, physical activity information, and prescribing information. ACTOS, A Type 2 Diabetes Treatment


Pioglitazone Hydrochloride Review And Information ! ... Click on the image below to Buy Pioglitazone Hydrochloride Online ! Pioglitazone Hydrochloride Review


Pioglitazone Hydrochloride/Metformin Hydrochloride professional patient advice. Specific and up to date information about Pioglitazone Hydrochloride/Metformin Hydrochloride. Complete Pioglitazone Hydrochloride/Metformin Hydrochloride ...


Pioglitazone Hydrochloride Oral tablet To return to the main entry click here . What is this medicine? PIOGLITAZONE (pye oh GLI ta zone) helps to Pioglitazone Hydrochloride Oral tablet: Information from Answers.com


There are two enantiomers of pioglitazone but no differences were found in their activities. Thus, the racemic mixture is used in the pharmacologic. The hydrochloride salt of ... PIOGLITAZONE HCl


chemBlink provides information about Pioglitazone hydrochloride, [5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione hydrochloride, CAS #: 112529-15-4. Pioglitazone hydrochloride, [5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy ...


Our local sales offices provide full information on our product, regulatory compliance and documentation on Pioglitazone Hydrochloride. Contact us today for further inquiries and ... Pioglitazone HCl - Teva API





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