Reviews Pegaptanib Sodium


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Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009





Other reviews about Pegaptanib Sodium on wordpress

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On April 26 2010 Avecia Biotechnology Inc reached agreement with Pfizer Inc regarding the commercial supply of a key component of Macugen┬« (pegaptanib sodium injection), marketed in the […]


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Phase 3 Study Showed MACUGEN┬« Improved Vision Over Standard of Care in Patients with Diabetic Macular Edema Patients on MACUGEN Maintained and Expanded Vision Gains Over Two […]



Other reviews about Pegaptanib Sodium on web:

Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age-related macular degeneration (AMD). Pegaptanib - Wikipedia, the free encyclopedia


Learn about the prescription medication Macugen (Pegaptanib Sodium), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Macugen (Pegaptanib Sodium) Drug Information: Uses, Side Effects ...


In this web site, you will find information on an innovative treatment for wet AMD called MACUGEN (pegaptanib sodium injection). Macugen, An Exciting Treatment For AMD


B lueCross BlueShield of Tennessee Medical Policy Manual. Pegaptanib Sodium. DESCRIPTION. Pegaptanib sodium is a selective vascular endothelial growth factor (VEGF) antagonist. Pegaptanib Sodium


FDA Approves Macugen (Pegaptanib Sodium) for Treatment of Neovascular (Wet) Age-Related Macular Dege News - FDA Approves Macugen (Pegaptanib Sodium) for Treatment of ...


Pegaptanib Brand names: Macugen® Drug Forms: Pegaptanib Sodium Solution for injection (below) Pegaptanib intravitreal injection Español: Pegaptanib: Information from Answers.com


Disclaimer All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. pegaptanib sodium injection - definition of pegaptanib sodium ...


Buy Macugen (Pegaptanib Sodium) (Pfizer) from our Canadian Online Pharmacy by calling 1-877-888-3562. Fully licensed, fast delivery, free doctor consultation provided. Buy Macugen (Pegaptanib Sodium) (Pfizer) Online Now


The publication of the results of a phase 2 randomized trial of pegaptanib sodium for treatment of macular edema secondary to CRVO in April 2009 was the first randomized trial of ... Retinal Physician


Peer Reviewed Evaluating Retinal Thickness During Pegaptanib Sodium Therapy RICHARD B. ROSEN, MD, THOMAS O. MULDOON, MD, & PATRICIA GARCIA, MD Retinal Physician





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