Reviews Pazopanib Tablets


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Votrient Drug Description
VOTRIENT
(pazopanib) Tablets

WARNING: HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor
hepatic function and interrupt, reduce, or discontinue dosing as recommended.
[See WARNINGS AND
PRECAUTIONS.]

DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented
as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
monohydrochloride. It has the molecular formula C21H23N7O2S•HCl
and a molecular weight of 473.99. Pazopanib hydrochloride has the following
chemical structure:








Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate,
microcrystalline cellulose, povidone, sodium starch glycolate. Coating:
Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol
400 (PEG 400), polysorbate 80, titanium dioxide.
Last reviewed on RxList: 6/1/2010




Votrient Drug Description
VOTRIENT
(pazopanib) Tablets

WARNING: HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor
hepatic function and interrupt, reduce, or discontinue dosing as recommended.
[See WARNINGS AND
PRECAUTIONS.]

DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented
as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
monohydrochloride. It has the molecular formula C21H23N7O2S•HCl
and a molecular weight of 473.99. Pazopanib hydrochloride has the following
chemical structure:








Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate,
microcrystalline cellulose, povidone, sodium starch glycolate. Coating:
Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol
400 (PEG 400), polysorbate 80, titanium dioxide.
Last reviewed on RxList: 6/1/2010




Votrient Drug Description
VOTRIENT
(pazopanib) Tablets

WARNING: HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor
hepatic function and interrupt, reduce, or discontinue dosing as recommended.
[See WARNINGS AND
PRECAUTIONS.]

DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented
as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
monohydrochloride. It has the molecular formula C21H23N7O2S•HCl
and a molecular weight of 473.99. Pazopanib hydrochloride has the following
chemical structure:








Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate,
microcrystalline cellulose, povidone, sodium starch glycolate. Coating:
Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol
400 (PEG 400), polysorbate 80, titanium dioxide.
Last reviewed on RxList: 6/1/2010




Votrient Drug Description
VOTRIENT
(pazopanib) Tablets

WARNING: HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor
hepatic function and interrupt, reduce, or discontinue dosing as recommended.
[See WARNINGS AND
PRECAUTIONS.]

DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented
as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
monohydrochloride. It has the molecular formula C21H23N7O2S•HCl
and a molecular weight of 473.99. Pazopanib hydrochloride has the following
chemical structure:








Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate,
microcrystalline cellulose, povidone, sodium starch glycolate. Coating:
Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol
400 (PEG 400), polysorbate 80, titanium dioxide.
Last reviewed on RxList: 6/1/2010




Votrient Drug Description
VOTRIENT
(pazopanib) Tablets

WARNING: HEPATOTOXICITY
Severe and fatal hepatotoxicity has been observed in clinical studies. Monitor
hepatic function and interrupt, reduce, or discontinue dosing as recommended.
[See WARNINGS AND
PRECAUTIONS.]

DRUG DESCRIPTION
VOTRIENT (pazopanib) is a tyrosine kinase inhibitor (TKI). Pazopanib is presented
as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
monohydrochloride. It has the molecular formula C21H23N7O2S•HCl
and a molecular weight of 473.99. Pazopanib hydrochloride has the following
chemical structure:








Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.
Tablets of VOTRIENT are for oral administration. Each 200 mg tablet of VOTRIENT contains 216.7 mg of pazopanib hydrochloride, equivalent to 200 mg of pazopanib free base.
The inactive ingredients of VOTRIENT are: Tablet Core: Magnesium stearate,
microcrystalline cellulose, povidone, sodium starch glycolate. Coating:
Gray film-coat: Hypromellose, iron oxide black, macrogol/polyethylene glycol
400 (PEG 400), polysorbate 80, titanium dioxide.
Last reviewed on RxList: 6/1/2010





Other reviews about Pazopanib Tablets on wordpress

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For A Mere $140(!), You Too Can Watch A Grainy, Low-Res Webcast of the ODAC Meeting on Monday
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Other reviews about Pazopanib Tablets on web:

Learn about the prescription medication Votrient (Pazopanib Tablets), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Votrient (Pazopanib Tablets) Drug Information: Uses, Side Effects ...


On October 19, 2009, the Food and Drug Administration (FDA) granted approval to pazopanib hydrochloride tablets (Votrient™, made by GlaxoSmithKline) for the treatment of patients ... FDA Approval for Pazopanib Hydrochloride - National Cancer Institute


Pazopanib On October 19, 2009, the U. S. Food and Drug Administration granted approval to pazopanib tablets (VOTRIENT, GlaxoSmithKline) for the treatment of patients with ... Pazopanib


FDA approved pazopanib tablets (VOTRIENT) for the treatment of patients with advanced renal cell carcinoma - ASCO - The American Society of Clinical Oncology (ASCO) is the ... FDA approved pazopanib tablets (VOTRIENT) for the treatment of ...


There 372 was no consistent increase in AUC or C max at pazopanib doses above 800 mg. 373 Administration of a single pazopanib 400 mg crushed tablet increased AUC (0-72) by 46% 374 and C ... HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not ...


2 Key NDA Information Submission: Dec. 18, 2008 Product Information: Pazopanib, a new tyrosine kinase inhibitor, targets VEGFR, PDGFR and c-Kit tyrosine kinases. NDA 22465: VOTRIENT™ (pazopanib) Tablets Applicant: GlaxoSmithKline


On October 19, 2009, the U. S. Food and Drug Administration granted approval to pazopanib tablets (VotrientTM, GlaxoSmithKline) for the treatment of patients with advanced renal ... FDA Approves Pazopanib Tablets for Patients With Advanced Renal ...


: The FDA has approved pazopanib tablets for the treatment of patients with advanced renal cell carcinoma. FDA Approves Pazopanib for Kidney Cancer


The FDA has approved Votrient (pazopanib tablets, from GlaxoSmithKline), an angiogenesis inhibitor, for the treatment of advanced renal cell carcinoma (RCC). Votrient approved for advanced renal cell cancer - MPR


tell your doctor and pharmacist if you are allergic to pazopanib, any other medications, or any of the ingredients in pazopanib tablets. Ask your pharmacist or check the Medication ... Pazopanib: MedlinePlus Drug Information





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