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Optison Drug Description
OPTISON™
(perflutren protein-type A microspheres) Injectable Suspension, USP


WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes
OPTISON administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography, and cutaneous oxygen
saturation during and for at least 30 minutes after OPTISON administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
OPTISON™ (Perflutren Protein-Type A Microspheres Injectable Suspension, USP) is a sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren for contrast enhancement during the indicated ultrasound imaging procedures. The vial contains a clear liquid lower layer and a white upper layer that, after resuspension by gentle mixing, provides a homogeneous, opaque, milky-white suspension for intravenous injection.
Perflutren is chemically characterized as 1,1,1,2,2,3,3,3-perflutren with a
molecular weight of 188, an empirical formula of C3F8
and it has the following structural formula:








Each mL of OPTISON contains 5.0-8.0x108 protein-type A microspheres,
10 mg Albumin Human, USP, 0.22 ± 0.11mg/mL N-acetyltryptophan, and 0.12 mg caprylic0.11
acid in 0.9% aqueous sodium chloride. The headspace of the vial is filled with
perflutren gas. The pH is adjusted to 6.4-7.4. The protein in the microsphere
shell makes up approximately 5­7% (w/w) of the total protein in the liquid.
The microsphere particle size parameters are listed in Table 1.
Table 1: Microsphere Particle Size Parameters


Mean diameter (range)
3.0-4.5µm (max. 32.0µm)


Percent less than 10µm
95%


Last reviewed on RxList: 7/9/2008




Optison Drug Description
OPTISON™
(perflutren protein-type A microspheres) Injectable Suspension, USP


WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes
OPTISON administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography, and cutaneous oxygen
saturation during and for at least 30 minutes after OPTISON administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
OPTISON™ (Perflutren Protein-Type A Microspheres Injectable Suspension, USP) is a sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren for contrast enhancement during the indicated ultrasound imaging procedures. The vial contains a clear liquid lower layer and a white upper layer that, after resuspension by gentle mixing, provides a homogeneous, opaque, milky-white suspension for intravenous injection.
Perflutren is chemically characterized as 1,1,1,2,2,3,3,3-perflutren with a
molecular weight of 188, an empirical formula of C3F8
and it has the following structural formula:








Each mL of OPTISON contains 5.0-8.0x108 protein-type A microspheres,
10 mg Albumin Human, USP, 0.22 ± 0.11mg/mL N-acetyltryptophan, and 0.12 mg caprylic0.11
acid in 0.9% aqueous sodium chloride. The headspace of the vial is filled with
perflutren gas. The pH is adjusted to 6.4-7.4. The protein in the microsphere
shell makes up approximately 5­7% (w/w) of the total protein in the liquid.
The microsphere particle size parameters are listed in Table 1.
Table 1: Microsphere Particle Size Parameters


Mean diameter (range)
3.0-4.5µm (max. 32.0µm)


Percent less than 10µm
95%


Last reviewed on RxList: 7/9/2008




Optison Drug Description
OPTISON™
(perflutren protein-type A microspheres) Injectable Suspension, USP


WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes
OPTISON administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography, and cutaneous oxygen
saturation during and for at least 30 minutes after OPTISON administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
OPTISON™ (Perflutren Protein-Type A Microspheres Injectable Suspension, USP) is a sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren for contrast enhancement during the indicated ultrasound imaging procedures. The vial contains a clear liquid lower layer and a white upper layer that, after resuspension by gentle mixing, provides a homogeneous, opaque, milky-white suspension for intravenous injection.
Perflutren is chemically characterized as 1,1,1,2,2,3,3,3-perflutren with a
molecular weight of 188, an empirical formula of C3F8
and it has the following structural formula:








Each mL of OPTISON contains 5.0-8.0x108 protein-type A microspheres,
10 mg Albumin Human, USP, 0.22 ± 0.11mg/mL N-acetyltryptophan, and 0.12 mg caprylic0.11
acid in 0.9% aqueous sodium chloride. The headspace of the vial is filled with
perflutren gas. The pH is adjusted to 6.4-7.4. The protein in the microsphere
shell makes up approximately 5­7% (w/w) of the total protein in the liquid.
The microsphere particle size parameters are listed in Table 1.
Table 1: Microsphere Particle Size Parameters


Mean diameter (range)
3.0-4.5µm (max. 32.0µm)


Percent less than 10µm
95%


Last reviewed on RxList: 7/9/2008




Optison Drug Description
OPTISON™
(perflutren protein-type A microspheres) Injectable Suspension, USP


WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes
OPTISON administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography, and cutaneous oxygen
saturation during and for at least 30 minutes after OPTISON administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
OPTISON™ (Perflutren Protein-Type A Microspheres Injectable Suspension, USP) is a sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren for contrast enhancement during the indicated ultrasound imaging procedures. The vial contains a clear liquid lower layer and a white upper layer that, after resuspension by gentle mixing, provides a homogeneous, opaque, milky-white suspension for intravenous injection.
Perflutren is chemically characterized as 1,1,1,2,2,3,3,3-perflutren with a
molecular weight of 188, an empirical formula of C3F8
and it has the following structural formula:








Each mL of OPTISON contains 5.0-8.0x108 protein-type A microspheres,
10 mg Albumin Human, USP, 0.22 ± 0.11mg/mL N-acetyltryptophan, and 0.12 mg caprylic0.11
acid in 0.9% aqueous sodium chloride. The headspace of the vial is filled with
perflutren gas. The pH is adjusted to 6.4-7.4. The protein in the microsphere
shell makes up approximately 5­7% (w/w) of the total protein in the liquid.
The microsphere particle size parameters are listed in Table 1.
Table 1: Microsphere Particle Size Parameters


Mean diameter (range)
3.0-4.5µm (max. 32.0µm)


Percent less than 10µm
95%


Last reviewed on RxList: 7/9/2008




Optison Drug Description
OPTISON™
(perflutren protein-type A microspheres) Injectable Suspension, USP


WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes
OPTISON administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography, and cutaneous oxygen
saturation during and for at least 30 minutes after OPTISON administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
OPTISON™ (Perflutren Protein-Type A Microspheres Injectable Suspension, USP) is a sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren for contrast enhancement during the indicated ultrasound imaging procedures. The vial contains a clear liquid lower layer and a white upper layer that, after resuspension by gentle mixing, provides a homogeneous, opaque, milky-white suspension for intravenous injection.
Perflutren is chemically characterized as 1,1,1,2,2,3,3,3-perflutren with a
molecular weight of 188, an empirical formula of C3F8
and it has the following structural formula:








Each mL of OPTISON contains 5.0-8.0x108 protein-type A microspheres,
10 mg Albumin Human, USP, 0.22 ± 0.11mg/mL N-acetyltryptophan, and 0.12 mg caprylic0.11
acid in 0.9% aqueous sodium chloride. The headspace of the vial is filled with
perflutren gas. The pH is adjusted to 6.4-7.4. The protein in the microsphere
shell makes up approximately 5­7% (w/w) of the total protein in the liquid.
The microsphere particle size parameters are listed in Table 1.
Table 1: Microsphere Particle Size Parameters


Mean diameter (range)
3.0-4.5µm (max. 32.0µm)


Percent less than 10µm
95%


Last reviewed on RxList: 7/9/2008





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Learn about the prescription medication Optison (Perflutren Protein-Type A Microspheres), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling Optison (Perflutren Protein-Type A Microspheres) Drug Information ...


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