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NeoTect Drug Description
NEOTECT®
Kit for the Preparation of Technetium Tc 99m Depreotide Injection
DRUG DESCRIPTION
NeoTect® (Kit for the Preparation of Technetium Tc 99m Depreotide Injection)
is intended for use in the preparation of Technetium Tc 99m Depreotide, a diagnostic
radiopharmaceutical to be used by intravenous injection. Each vial contains
a sterile, non-pyrogenic lyophilized mixture of 47 µg of Depreotide,
75 mg of sodium glucoheptonate dihydrate, 50 µg of stannous chloride
dihydrate (with a minimum stannous tin content of 20 µg), 100 µg
edetate disodium dihydrate, 10 mg of sodium iodide, and sufficient sodium hydroxide
or hydrochloric acid for adjustment to pH 7.4 prior to lyophilization. The lyophilized
powder is sealed under a nitrogen atmosphere with a rubber closure. The product
contains no antimicrobial preservative.
Chemical Name:
Cyclo (L- homocysteinyl-N- methyl- L-phenylalanyl- L-tyrosyl- D-tryptophyl-
L-lysyl-L- valyl), (1→1')-sulfide with 3-[(mercaptoacetyl)amino]-L-alanyl-L-
lysyl- L-cysteinyl- L- lysinamide
The structural formula of Depreotide is:








When sterile, non-pyrogenic Sodium Pertechnetate Tc 99m Injection, in 0.9% Sodium Chloride Injection, U.S.P., is added to the vial, a Technetium Tc 99m complex of Depreotide is formed.
Physical Charateristics
Technetium Tc 99m decays by isomeric transition with a physical half- life of 6.02 hours. The photon that is useful for imaging studies is listed in Table 1.
Table 1. Principal radiation emission data for Technetium
Tc 99m



Radiation
Mean Percent per Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5



External radiation
The specific gamma-ray constant for Technetium Tc 99m is 5.4 microcoulombs/kg·MBq·hour (0.78 R/mCi·hour) at 1 cm. The first half- value thickness of lead for Technetium Tc 99m is 0.17 mm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of lead is shown in Table 2. For example, the use of a 0.25 cm thickness of lead will decrease the external radiation exposure by a factor of 1,000.
Table 2. Radiation attenuation by lead shielding.



Lead Shield Thickness (cm)
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractio ns that remain at selected intervals relative to the time of calibration are shown in Table 3.
Table 3. Physical decay chart: Technetium Tc 99m half- life
6.02 hours.



Hours
Fraction Remaining
Hours
Fraction Remaining


0
1.000
7
0.447


1
0.891
8
0.398


2
0.794
9
0.355


3
0.708
10
0.316


4
0.631
11
0.282


5
0.562
12
0.251


6
0.501
--
--


Last reviewed on RxList: 12/1/2008




NeoTect Drug Description
NEOTECT®
Kit for the Preparation of Technetium Tc 99m Depreotide Injection
DRUG DESCRIPTION
NeoTect® (Kit for the Preparation of Technetium Tc 99m Depreotide Injection)
is intended for use in the preparation of Technetium Tc 99m Depreotide, a diagnostic
radiopharmaceutical to be used by intravenous injection. Each vial contains
a sterile, non-pyrogenic lyophilized mixture of 47 µg of Depreotide,
75 mg of sodium glucoheptonate dihydrate, 50 µg of stannous chloride
dihydrate (with a minimum stannous tin content of 20 µg), 100 µg
edetate disodium dihydrate, 10 mg of sodium iodide, and sufficient sodium hydroxide
or hydrochloric acid for adjustment to pH 7.4 prior to lyophilization. The lyophilized
powder is sealed under a nitrogen atmosphere with a rubber closure. The product
contains no antimicrobial preservative.
Chemical Name:
Cyclo (L- homocysteinyl-N- methyl- L-phenylalanyl- L-tyrosyl- D-tryptophyl-
L-lysyl-L- valyl), (1→1')-sulfide with 3-[(mercaptoacetyl)amino]-L-alanyl-L-
lysyl- L-cysteinyl- L- lysinamide
The structural formula of Depreotide is:








When sterile, non-pyrogenic Sodium Pertechnetate Tc 99m Injection, in 0.9% Sodium Chloride Injection, U.S.P., is added to the vial, a Technetium Tc 99m complex of Depreotide is formed.
Physical Charateristics
Technetium Tc 99m decays by isomeric transition with a physical half- life of 6.02 hours. The photon that is useful for imaging studies is listed in Table 1.
Table 1. Principal radiation emission data for Technetium
Tc 99m



Radiation
Mean Percent per Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5



External radiation
The specific gamma-ray constant for Technetium Tc 99m is 5.4 microcoulombs/kg·MBq·hour (0.78 R/mCi·hour) at 1 cm. The first half- value thickness of lead for Technetium Tc 99m is 0.17 mm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of lead is shown in Table 2. For example, the use of a 0.25 cm thickness of lead will decrease the external radiation exposure by a factor of 1,000.
Table 2. Radiation attenuation by lead shielding.



Lead Shield Thickness (cm)
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractio ns that remain at selected intervals relative to the time of calibration are shown in Table 3.
Table 3. Physical decay chart: Technetium Tc 99m half- life
6.02 hours.



Hours
Fraction Remaining
Hours
Fraction Remaining


0
1.000
7
0.447


1
0.891
8
0.398


2
0.794
9
0.355


3
0.708
10
0.316


4
0.631
11
0.282


5
0.562
12
0.251


6
0.501
--
--


Last reviewed on RxList: 12/1/2008




NeoTect Drug Description
NEOTECT®
Kit for the Preparation of Technetium Tc 99m Depreotide Injection
DRUG DESCRIPTION
NeoTect® (Kit for the Preparation of Technetium Tc 99m Depreotide Injection)
is intended for use in the preparation of Technetium Tc 99m Depreotide, a diagnostic
radiopharmaceutical to be used by intravenous injection. Each vial contains
a sterile, non-pyrogenic lyophilized mixture of 47 µg of Depreotide,
75 mg of sodium glucoheptonate dihydrate, 50 µg of stannous chloride
dihydrate (with a minimum stannous tin content of 20 µg), 100 µg
edetate disodium dihydrate, 10 mg of sodium iodide, and sufficient sodium hydroxide
or hydrochloric acid for adjustment to pH 7.4 prior to lyophilization. The lyophilized
powder is sealed under a nitrogen atmosphere with a rubber closure. The product
contains no antimicrobial preservative.
Chemical Name:
Cyclo (L- homocysteinyl-N- methyl- L-phenylalanyl- L-tyrosyl- D-tryptophyl-
L-lysyl-L- valyl), (1→1')-sulfide with 3-[(mercaptoacetyl)amino]-L-alanyl-L-
lysyl- L-cysteinyl- L- lysinamide
The structural formula of Depreotide is:








When sterile, non-pyrogenic Sodium Pertechnetate Tc 99m Injection, in 0.9% Sodium Chloride Injection, U.S.P., is added to the vial, a Technetium Tc 99m complex of Depreotide is formed.
Physical Charateristics
Technetium Tc 99m decays by isomeric transition with a physical half- life of 6.02 hours. The photon that is useful for imaging studies is listed in Table 1.
Table 1. Principal radiation emission data for Technetium
Tc 99m



Radiation
Mean Percent per Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5



External radiation
The specific gamma-ray constant for Technetium Tc 99m is 5.4 microcoulombs/kg·MBq·hour (0.78 R/mCi·hour) at 1 cm. The first half- value thickness of lead for Technetium Tc 99m is 0.17 mm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of lead is shown in Table 2. For example, the use of a 0.25 cm thickness of lead will decrease the external radiation exposure by a factor of 1,000.
Table 2. Radiation attenuation by lead shielding.



Lead Shield Thickness (cm)
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractio ns that remain at selected intervals relative to the time of calibration are shown in Table 3.
Table 3. Physical decay chart: Technetium Tc 99m half- life
6.02 hours.



Hours
Fraction Remaining
Hours
Fraction Remaining


0
1.000
7
0.447


1
0.891
8
0.398


2
0.794
9
0.355


3
0.708
10
0.316


4
0.631
11
0.282


5
0.562
12
0.251


6
0.501
--
--


Last reviewed on RxList: 12/1/2008




NeoTect Drug Description
NEOTECT®
Kit for the Preparation of Technetium Tc 99m Depreotide Injection
DRUG DESCRIPTION
NeoTect® (Kit for the Preparation of Technetium Tc 99m Depreotide Injection)
is intended for use in the preparation of Technetium Tc 99m Depreotide, a diagnostic
radiopharmaceutical to be used by intravenous injection. Each vial contains
a sterile, non-pyrogenic lyophilized mixture of 47 µg of Depreotide,
75 mg of sodium glucoheptonate dihydrate, 50 µg of stannous chloride
dihydrate (with a minimum stannous tin content of 20 µg), 100 µg
edetate disodium dihydrate, 10 mg of sodium iodide, and sufficient sodium hydroxide
or hydrochloric acid for adjustment to pH 7.4 prior to lyophilization. The lyophilized
powder is sealed under a nitrogen atmosphere with a rubber closure. The product
contains no antimicrobial preservative.
Chemical Name:
Cyclo (L- homocysteinyl-N- methyl- L-phenylalanyl- L-tyrosyl- D-tryptophyl-
L-lysyl-L- valyl), (1→1')-sulfide with 3-[(mercaptoacetyl)amino]-L-alanyl-L-
lysyl- L-cysteinyl- L- lysinamide
The structural formula of Depreotide is:








When sterile, non-pyrogenic Sodium Pertechnetate Tc 99m Injection, in 0.9% Sodium Chloride Injection, U.S.P., is added to the vial, a Technetium Tc 99m complex of Depreotide is formed.
Physical Charateristics
Technetium Tc 99m decays by isomeric transition with a physical half- life of 6.02 hours. The photon that is useful for imaging studies is listed in Table 1.
Table 1. Principal radiation emission data for Technetium
Tc 99m



Radiation
Mean Percent per Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5



External radiation
The specific gamma-ray constant for Technetium Tc 99m is 5.4 microcoulombs/kg·MBq·hour (0.78 R/mCi·hour) at 1 cm. The first half- value thickness of lead for Technetium Tc 99m is 0.17 mm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of lead is shown in Table 2. For example, the use of a 0.25 cm thickness of lead will decrease the external radiation exposure by a factor of 1,000.
Table 2. Radiation attenuation by lead shielding.



Lead Shield Thickness (cm)
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractio ns that remain at selected intervals relative to the time of calibration are shown in Table 3.
Table 3. Physical decay chart: Technetium Tc 99m half- life
6.02 hours.



Hours
Fraction Remaining
Hours
Fraction Remaining


0
1.000
7
0.447


1
0.891
8
0.398


2
0.794
9
0.355


3
0.708
10
0.316


4
0.631
11
0.282


5
0.562
12
0.251


6
0.501
--
--


Last reviewed on RxList: 12/1/2008




NeoTect Drug Description
NEOTECT®
Kit for the Preparation of Technetium Tc 99m Depreotide Injection
DRUG DESCRIPTION
NeoTect® (Kit for the Preparation of Technetium Tc 99m Depreotide Injection)
is intended for use in the preparation of Technetium Tc 99m Depreotide, a diagnostic
radiopharmaceutical to be used by intravenous injection. Each vial contains
a sterile, non-pyrogenic lyophilized mixture of 47 µg of Depreotide,
75 mg of sodium glucoheptonate dihydrate, 50 µg of stannous chloride
dihydrate (with a minimum stannous tin content of 20 µg), 100 µg
edetate disodium dihydrate, 10 mg of sodium iodide, and sufficient sodium hydroxide
or hydrochloric acid for adjustment to pH 7.4 prior to lyophilization. The lyophilized
powder is sealed under a nitrogen atmosphere with a rubber closure. The product
contains no antimicrobial preservative.
Chemical Name:
Cyclo (L- homocysteinyl-N- methyl- L-phenylalanyl- L-tyrosyl- D-tryptophyl-
L-lysyl-L- valyl), (1→1')-sulfide with 3-[(mercaptoacetyl)amino]-L-alanyl-L-
lysyl- L-cysteinyl- L- lysinamide
The structural formula of Depreotide is:








When sterile, non-pyrogenic Sodium Pertechnetate Tc 99m Injection, in 0.9% Sodium Chloride Injection, U.S.P., is added to the vial, a Technetium Tc 99m complex of Depreotide is formed.
Physical Charateristics
Technetium Tc 99m decays by isomeric transition with a physical half- life of 6.02 hours. The photon that is useful for imaging studies is listed in Table 1.
Table 1. Principal radiation emission data for Technetium
Tc 99m



Radiation
Mean Percent per Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5



External radiation
The specific gamma-ray constant for Technetium Tc 99m is 5.4 microcoulombs/kg·MBq·hour (0.78 R/mCi·hour) at 1 cm. The first half- value thickness of lead for Technetium Tc 99m is 0.17 mm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of lead is shown in Table 2. For example, the use of a 0.25 cm thickness of lead will decrease the external radiation exposure by a factor of 1,000.
Table 2. Radiation attenuation by lead shielding.



Lead Shield Thickness (cm)
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractio ns that remain at selected intervals relative to the time of calibration are shown in Table 3.
Table 3. Physical decay chart: Technetium Tc 99m half- life
6.02 hours.



Hours
Fraction Remaining
Hours
Fraction Remaining


0
1.000
7
0.447


1
0.891
8
0.398


2
0.794
9
0.355


3
0.708
10
0.316


4
0.631
11
0.282


5
0.562
12
0.251


6
0.501
--
--


Last reviewed on RxList: 12/1/2008





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Learn about the prescription medication NeoTect (Technetium Tc 99m Depreotide Injection), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling NeoTect (Technetium Tc 99m Depreotide Injection) Drug Information ...


Neotect Kit and Technetium Tc 99M Depreotide Information. News and Information on Neotect Kit, Attorneys and Lawyers at LegalView.info Neotect Kit and Technetium Tc 99M Depreotide - Attorney, Lawsuit ...


Consumer information and patient comments on perscription drugs ... We currently have info on 350 drugs Users have posted 4369 comments NeoTect - The Internet Drug Database


NeoTect This page contains recent news articles, when available, and an overview of NeoTect but does not offer medical advice. You should contact your physician with regard to any ... NeoTect


altdrug.com is a drug database offering info on medications of all types, pharmacies, and other medicine resources. neotect kit > drug info > drug database prescription information ...


NeoTect Kit: Brand Name: NeoTect Kit: Active Ingredient: Technetium Tc 99m Depreotide Injection: Strength(s): Depreotide containing approximately 15-20 mCi of Technetium Tc 99m and ... NeoTect Kit Consumer Information


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Get the latest drug information for NeoTect Kit including its side effects, interactions, warnings, overdose, and patient info from eDrugSearch.com NeoTect Kit Drug Information by eDrugSearch


Information on NeoTect side effects, warnings and interactions. ... NeoTect Kit® Brand Name: NeoTect Kit® Active Ingredient: Technetium Tc 99m Depreotide Injection NeoTect Side Effects, Warnings and Interactions


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