Reviews Morphine Sulfate


No reviews yet.

Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009





Other reviews about Morphine Sulfate on wordpress

Morphine Sulfate
  by gspbl20
Drug:  Morphine Sulfate Class:  Opioid Treatment for:  Analgesia for severe pain; acute pulmonary edema Primary Molecular Target:  Mu opioid receptors, mainly, but also Kappa and Delta receptors.  Mechanism of Action:  Morphine is […]


Drug Warning - Overdose Risk: Morphine Sulfate Lot Recalled
  by swallowed
BETHESDA, MD, 10 June 2008 — A single lot of morphine sulfate has been recalled because some of the tablets may contain twice the labeled level of the […]


MS CONTIN® (morphine sulfate) Controlled-Release
  by kanlayanee
[caption id="" align="alignnone" width="288" caption="MS CONTIN 15 MG TABLET SA"][/caption] Tablets 15 mg 30 mg 60 mg 100 mg* 200 mg* *100 mg and 200 mg are […]


ASHP News Article : FDA Backtracks on Oral Morphine Solution Ban
  by Christian Hartman
FDA Backtracks on Oral Morphine Solution Ban Kate Traynor BETHESDA, MD 10 April 2009—FDA announced yesterday that it will allow the continued manufacturing […]


NCLEX Practice Question of the Week
  by stereotypicalone
Here is the weekly question posted on the NCSBN Learning Extension: A nurse admits a clinet transferred from the emergency room (ER). The client, diagnosed with a myocardial infarction, […]


Book Trailer: Joshua Lyon's "PILL HEAD"
  by swallowed
_ NOTE: I am not paying WordPress for the "privilege" of embedding videos into my blog posts! (<— Rant over WP charging for video posts. —Ed.) It's not like […]


Morphine Sulfate Solution Approved
  by timeinctemp
TUESDAY, Jan. 26 (HealthDay News) — Morphine Sulfate Oral Solution has been approved by the U.S. Food and Drug Administration to treat acute and chronic pain. Sanctioned doses […]


Drug Information Update - FDA Approves Morphine Sulfate Oral Solution for Relief of Acute and Chronic Pain
  by neurologist
The Division of Drug Information (DDI) is CDER's focal point for public inquiries. We serve the public by providing information on human drug products and drug product regulation […]


Drug Information Update - FDA Approves Name Change for Heartburn Drug Kapidex
  by neurologist
The Division of Drug Information (DDI) is CDER's focal point for public inquiries. We serve the public by providing information on human drug products and drug product regulation […]


Cellino & Barnes - Morphine Sulfate Recall
  by cellinobarnes
A voluntary recall was issued today for one lot of Ethex Morphine Sulfate 60 mg Extended Release tablets. The manufacturer discovered that some pills sold since April 16, […]



Other reviews about Morphine Sulfate on web:

Morphine (pronounced /ˈmɔrfiːn/) (MS Contin, MSIR, Avinza, Kadian, Oramorph, Roxanol, Kapanol) is a potent opiate analgesic medication and is considered to be the ... Morphine - Wikipedia, the free encyclopedia


Comprehensive and trusted information about Morphine sulfate - plus advice on 24,000 other FDA approved drugs and medications from Drugs.com. Morphine sulfate patient advice including side effects


Learn about the prescription medication MS-Contin (Morphine Sulfate Controlled-Release), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. MS-Contin (Morphine Sulfate Controlled-Release) Drug Information ...


Morphine Sulfate professional patient advice. Specific and up to date information about Morphine Sulfate. Complete Morphine Sulfate information from Drugs.com


Drug details for Morphine sulfate. ... Morphine is available in oral preparations and as rectal suppositories. Morphine Sulfate Uses, Side Effects, and More


The following morphine conversion charts are used as an aid in the administration of morphine. The charts should be posted where medication is prepared for administration and ... Morphine Sulfate


Learn about the prescription medication Roxanol (Morphine Sulfate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Roxanol (Morphine Sulfate) Drug Information: Uses, Side Effects ...


Morphine Sulfate is a narcotic analgesic used to treat or prevent moderate to severe pain. Side effects and interactions are available at drugstore.com; plus get home delivery ... Morphine Sulfate - drugstore.com. Low prices, side effects ...


Morphine (MS Contin, Avinza, Oramorph SR, Kadian, Roxanol) morphine sulfate (sulphate) drug information, dosage, side effects, drug interactions, and warnings. Brand names ... Morphine Sulfate - Dosage - Side Effects - Drug Interactions ...


INDICATIONS AND USAGE. Morphine sulfate extended-release tablets are indicated for the relief of moderate to severe pain. Morphine - Indications and Dosage





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