Reviews Midazolam Injection


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Midazolam Injection Drug Description
Midazolam HCl
Injection

WARNING
Adult and Pediatrics
Intravenous midazolam has been associated with respiratory depression and
respiratory arrest, especially when used for sedation in noncritical care
settings. In some cases, where this was not recognized promptly and treated
effectively, death or hypoxic encephalopathy has resulted. Intravenous midazolam
should be used only in hospital or ambulatory care settings, including physicians'
and dental offices, that provide for continuous monitoring of respiratory
and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative
drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management
should be assured (see WARNINGS). For deeply
sedated pediatric patients, a dedicated individual, other than the practitioner
performing the procedure, should monitor the patient throughout the procedure.
The initial intravenous dose for sedation in adult patients may be as little
as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses
are necessary for older (over 60 years) or debilitated patients and in patients
receiving concomitant narcotics or other central nervous system (CNS) depressants.
The initial dose and all subsequent doses should always be titrated slowly;
administer over at least 2 minutes and allow an additional 2 or more minutes
to fully evaluate the sedative effect. The use of the 1 mg/mL formulation
or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate
slower injection. Doses of sedative medications in pediatric patients must
be calculated on a mg/kg basis, and initial doses and all subsequent doses
should always be titrated slowly. The initial pediatric dose of midazolam
for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see
DOSAGE AND ADMINISTRATION, PEDIATRIC PATIENTS
for complete dosing information).
Neonates
Midazolam should not be administered by rapid injection in the neonatal population.
Severe hypotension and seizures have been reported following rapid IV administration,
particularly with concomitant use of fentanyl (see DOSAGE
AND ADMINISTRATION, Usual Neonatal Dose for complete information).

DRUG DESCRIPTION
Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. Each mL contains midazolam hydrochloride equivalent to 1 mg or 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium with 1% benzyl alcohol as preservative, and sodium hydroxide and/or hydrochloric acid for pH adjustment. pH 2.9-3.7.
Midazolam is a white to light yellow crystalline compound, insoluble in water.
The hydrochloride salt of midazolam, which is formed in situ, is soluble
in aqueous solutions. Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-
imidazo[1,5-a] [1,4] benzodiazepine hydrochloride. Midazolam hydrochloride has
the molecular formula C18H13ClFN3•HCl, a calculated
molecular weight of 362.25 and the following structural formula:






Last reviewed on RxList: 1/4/2008




Midazolam Injection Drug Description
Midazolam HCl
Injection

WARNING
Adult and Pediatrics
Intravenous midazolam has been associated with respiratory depression and
respiratory arrest, especially when used for sedation in noncritical care
settings. In some cases, where this was not recognized promptly and treated
effectively, death or hypoxic encephalopathy has resulted. Intravenous midazolam
should be used only in hospital or ambulatory care settings, including physicians'
and dental offices, that provide for continuous monitoring of respiratory
and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative
drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management
should be assured (see WARNINGS). For deeply
sedated pediatric patients, a dedicated individual, other than the practitioner
performing the procedure, should monitor the patient throughout the procedure.
The initial intravenous dose for sedation in adult patients may be as little
as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses
are necessary for older (over 60 years) or debilitated patients and in patients
receiving concomitant narcotics or other central nervous system (CNS) depressants.
The initial dose and all subsequent doses should always be titrated slowly;
administer over at least 2 minutes and allow an additional 2 or more minutes
to fully evaluate the sedative effect. The use of the 1 mg/mL formulation
or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate
slower injection. Doses of sedative medications in pediatric patients must
be calculated on a mg/kg basis, and initial doses and all subsequent doses
should always be titrated slowly. The initial pediatric dose of midazolam
for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see
DOSAGE AND ADMINISTRATION, PEDIATRIC PATIENTS
for complete dosing information).
Neonates
Midazolam should not be administered by rapid injection in the neonatal population.
Severe hypotension and seizures have been reported following rapid IV administration,
particularly with concomitant use of fentanyl (see DOSAGE
AND ADMINISTRATION, Usual Neonatal Dose for complete information).

DRUG DESCRIPTION
Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. Each mL contains midazolam hydrochloride equivalent to 1 mg or 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium with 1% benzyl alcohol as preservative, and sodium hydroxide and/or hydrochloric acid for pH adjustment. pH 2.9-3.7.
Midazolam is a white to light yellow crystalline compound, insoluble in water.
The hydrochloride salt of midazolam, which is formed in situ, is soluble
in aqueous solutions. Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-
imidazo[1,5-a] [1,4] benzodiazepine hydrochloride. Midazolam hydrochloride has
the molecular formula C18H13ClFN3•HCl, a calculated
molecular weight of 362.25 and the following structural formula:






Last reviewed on RxList: 1/4/2008




Midazolam Injection Drug Description
Midazolam HCl
Injection

WARNING
Adult and Pediatrics
Intravenous midazolam has been associated with respiratory depression and
respiratory arrest, especially when used for sedation in noncritical care
settings. In some cases, where this was not recognized promptly and treated
effectively, death or hypoxic encephalopathy has resulted. Intravenous midazolam
should be used only in hospital or ambulatory care settings, including physicians'
and dental offices, that provide for continuous monitoring of respiratory
and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative
drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management
should be assured (see WARNINGS). For deeply
sedated pediatric patients, a dedicated individual, other than the practitioner
performing the procedure, should monitor the patient throughout the procedure.
The initial intravenous dose for sedation in adult patients may be as little
as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses
are necessary for older (over 60 years) or debilitated patients and in patients
receiving concomitant narcotics or other central nervous system (CNS) depressants.
The initial dose and all subsequent doses should always be titrated slowly;
administer over at least 2 minutes and allow an additional 2 or more minutes
to fully evaluate the sedative effect. The use of the 1 mg/mL formulation
or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate
slower injection. Doses of sedative medications in pediatric patients must
be calculated on a mg/kg basis, and initial doses and all subsequent doses
should always be titrated slowly. The initial pediatric dose of midazolam
for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see
DOSAGE AND ADMINISTRATION, PEDIATRIC PATIENTS
for complete dosing information).
Neonates
Midazolam should not be administered by rapid injection in the neonatal population.
Severe hypotension and seizures have been reported following rapid IV administration,
particularly with concomitant use of fentanyl (see DOSAGE
AND ADMINISTRATION, Usual Neonatal Dose for complete information).

DRUG DESCRIPTION
Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. Each mL contains midazolam hydrochloride equivalent to 1 mg or 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium with 1% benzyl alcohol as preservative, and sodium hydroxide and/or hydrochloric acid for pH adjustment. pH 2.9-3.7.
Midazolam is a white to light yellow crystalline compound, insoluble in water.
The hydrochloride salt of midazolam, which is formed in situ, is soluble
in aqueous solutions. Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-
imidazo[1,5-a] [1,4] benzodiazepine hydrochloride. Midazolam hydrochloride has
the molecular formula C18H13ClFN3•HCl, a calculated
molecular weight of 362.25 and the following structural formula:






Last reviewed on RxList: 1/4/2008




Midazolam Injection Drug Description
Midazolam HCl
Injection

WARNING
Adult and Pediatrics
Intravenous midazolam has been associated with respiratory depression and
respiratory arrest, especially when used for sedation in noncritical care
settings. In some cases, where this was not recognized promptly and treated
effectively, death or hypoxic encephalopathy has resulted. Intravenous midazolam
should be used only in hospital or ambulatory care settings, including physicians'
and dental offices, that provide for continuous monitoring of respiratory
and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative
drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management
should be assured (see WARNINGS). For deeply
sedated pediatric patients, a dedicated individual, other than the practitioner
performing the procedure, should monitor the patient throughout the procedure.
The initial intravenous dose for sedation in adult patients may be as little
as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses
are necessary for older (over 60 years) or debilitated patients and in patients
receiving concomitant narcotics or other central nervous system (CNS) depressants.
The initial dose and all subsequent doses should always be titrated slowly;
administer over at least 2 minutes and allow an additional 2 or more minutes
to fully evaluate the sedative effect. The use of the 1 mg/mL formulation
or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate
slower injection. Doses of sedative medications in pediatric patients must
be calculated on a mg/kg basis, and initial doses and all subsequent doses
should always be titrated slowly. The initial pediatric dose of midazolam
for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see
DOSAGE AND ADMINISTRATION, PEDIATRIC PATIENTS
for complete dosing information).
Neonates
Midazolam should not be administered by rapid injection in the neonatal population.
Severe hypotension and seizures have been reported following rapid IV administration,
particularly with concomitant use of fentanyl (see DOSAGE
AND ADMINISTRATION, Usual Neonatal Dose for complete information).

DRUG DESCRIPTION
Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. Each mL contains midazolam hydrochloride equivalent to 1 mg or 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium with 1% benzyl alcohol as preservative, and sodium hydroxide and/or hydrochloric acid for pH adjustment. pH 2.9-3.7.
Midazolam is a white to light yellow crystalline compound, insoluble in water.
The hydrochloride salt of midazolam, which is formed in situ, is soluble
in aqueous solutions. Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-
imidazo[1,5-a] [1,4] benzodiazepine hydrochloride. Midazolam hydrochloride has
the molecular formula C18H13ClFN3•HCl, a calculated
molecular weight of 362.25 and the following structural formula:






Last reviewed on RxList: 1/4/2008




Midazolam Injection Drug Description
Midazolam HCl
Injection

WARNING
Adult and Pediatrics
Intravenous midazolam has been associated with respiratory depression and
respiratory arrest, especially when used for sedation in noncritical care
settings. In some cases, where this was not recognized promptly and treated
effectively, death or hypoxic encephalopathy has resulted. Intravenous midazolam
should be used only in hospital or ambulatory care settings, including physicians'
and dental offices, that provide for continuous monitoring of respiratory
and cardiac function, ie, pulse oximetry. Immediate availability of resuscitative
drugs and age- and size-appropriate equipment for bag/valve/mask ventilation and intubation, and personnel trained in their use and skilled in airway management
should be assured (see WARNINGS). For deeply
sedated pediatric patients, a dedicated individual, other than the practitioner
performing the procedure, should monitor the patient throughout the procedure.
The initial intravenous dose for sedation in adult patients may be as little
as 1 mg, but should not exceed 2.5 mg in a normal healthy adult. Lower doses
are necessary for older (over 60 years) or debilitated patients and in patients
receiving concomitant narcotics or other central nervous system (CNS) depressants.
The initial dose and all subsequent doses should always be titrated slowly;
administer over at least 2 minutes and allow an additional 2 or more minutes
to fully evaluate the sedative effect. The use of the 1 mg/mL formulation
or dilution of the 1 mg/mL or 5 mg/mL formulation is recommended to facilitate
slower injection. Doses of sedative medications in pediatric patients must
be calculated on a mg/kg basis, and initial doses and all subsequent doses
should always be titrated slowly. The initial pediatric dose of midazolam
for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see
DOSAGE AND ADMINISTRATION, PEDIATRIC PATIENTS
for complete dosing information).
Neonates
Midazolam should not be administered by rapid injection in the neonatal population.
Severe hypotension and seizures have been reported following rapid IV administration,
particularly with concomitant use of fentanyl (see DOSAGE
AND ADMINISTRATION, Usual Neonatal Dose for complete information).

DRUG DESCRIPTION
Midazolam is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. Each mL contains midazolam hydrochloride equivalent to 1 mg or 5 mg midazolam compounded with 0.8% sodium chloride and 0.01% edetate disodium with 1% benzyl alcohol as preservative, and sodium hydroxide and/or hydrochloric acid for pH adjustment. pH 2.9-3.7.
Midazolam is a white to light yellow crystalline compound, insoluble in water.
The hydrochloride salt of midazolam, which is formed in situ, is soluble
in aqueous solutions. Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-
imidazo[1,5-a] [1,4] benzodiazepine hydrochloride. Midazolam hydrochloride has
the molecular formula C18H13ClFN3•HCl, a calculated
molecular weight of 362.25 and the following structural formula:






Last reviewed on RxList: 1/4/2008





Other reviews about Midazolam Injection on wordpress

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Found this article via reason's hit&run. Apparently, TN LEOs think themselves doctors and their counterpart and are administering meds that most people have to give consent […]


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CMR = Close Manual Reduction (of fractures) Here are the things u need to do prior, during and after CMR ;p So enjoy ^^ Consent (yeah, it's stil a procedure […]


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  by cafestocks
Pharmaceutical and biotechnology major Wockhardt has launched Midazolam injection in the United States. Wockhardt received this approval tram the United States Food & Drug Administration (US FDA) for […]


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  by headnecksurgery
Intravenous Sedative and Hypnotic Agents Drugs used to produce sedation and hypnosis belong almost exclusively to the categories of major or minor tranquilizers. They are commonly administered as premedicants […]


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Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained Bupropion ( Wellbutrin SR ) treatment.RATIONALE. Midazolam wellbutrin generic was administered to some animals to prevent […]


Nashville Police Use Sedatives On Public
  by narmer
Nashville Police Use Sedatives On Public Full story: www.bvblackspin.com Become too agitated on the streets of Nashville, Tenn., and police and paramedics may inject you with a drug that not […]


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COLUMBUS - Ohio yesterday announced it will become the first state in the nation to switch to a one-drug method of execution, essentially administering a […]


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on August 26, 2009 at 4:02am Official: Jacko death WAS homicide THE Los Angeles County coroner has ruled Michael Jackson's death WAS homicide, legal sources said tonight. The finding makes it […]


Use of midazolam in ED
  by drcd2009
USE OF IV MIDAZOLAM REQUIRES: 1. a designated person 2. use of pulse oximeter and blood pressure monitor 3. resuscitation trolley 4. ECG monitoring is recommended where possible, in patients receiving concomitant narcotics. CONSCIOUS SEDATION IN ADULT • […]


IM Midazolam for status epilepticus (0.2 mg/kg for children and 10 mg for adults)
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Meta-analysis of clinical studies of intramuscular (IM) or intranasal (IN) midazolam versus intravenous (IV) diazepam in patients who have SE demonstrates similar efficacy in terminating seizures within 10 […]



Other reviews about Midazolam Injection on web:

Consumer information about the medication MIDAZOLAM - INJECTION (Versed), includes side effects, drug interactions, recommended dosages, and storage information. Read more ... MIDAZOLAM - INJECTION (Versed) side effects, medical uses, and ...


Learn about the prescription medication Midazolam Injection (Midazolam), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Midazolam Injection (Midazolam) Drug Information: Uses, Side ...


Midazolam injection To return to the main entry click here . What is midazolam injection? MIDAZOLAM (Versed®) is a benzodiazepine Midazolam injection: Information from Answers.com


Accurate, FDA approved Midazolam Injection information for healthcare professionals and patients - brought to you by Drugs.com. Midazolam Injection Official FDA information, side effects and uses.


Midazolam injection may cause serious or life-threatening breathing problems such as shallow, slowed, or temporarily stopped breathing that may lead to permanent brain injury or ... Midazolam Injection: MedlinePlus Drug Information


Midazolam Brand names: Versed® Chemical formula: Drug Forms: Midazolam injection (below) Midazolam oral syrup Midazolam Hydrochloride Solution Midazolam: Definition from Answers.com


Read doctor-produced health and medical information written for you to make informed decisions about your health concerns. MIDAZOLAM - INJECTION (Versed) side effects, medical uses, and ...


Warnings: Oral route(Syrup) Midazolam has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. Midazolam (Injection route)


Learn all about Midazolam (Injection). Midazolam (MID-ay-zoe-lam) Is used before surgery or certain medical tests to make you sleepy, drowsy, or relaxed. Belongs to a class of ... Midazolam (Injection) - Drug Information


Mayo Clinic offers award-winning medical and health information and tools for healthy living. Midazolam (Injection Route) - MayoClinic.com





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