Reviews Midazolam Hcl Syrup


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Midazolam Hydrochloride Syrup Drug Description
Midazolam Hydrochloride Syrup
(generic formulation)

Midazolam HCI syrup has been associated with respiratory depression and respiratory
arrest, especially when used for sedation in noncritical care settings. Midazolam
HCI syrup has been associated with reports of respiratory depression, airway obstruction, desaturation, hypoxia, and apnea, most often when used concomitantly with other central nervous system depressants (eg, opioids). Midazolam HCI syrup should be used only in hospital or ambulatory care settings, including physicians'
and dentists' offices, THAT CAN PROVIDE FOR CONTINUOUS MONITORING OF RESPIRATORY
AND CARDIAC FUNCTION. IMMEDIATE AVAILABILITY OF RESUSCITATIVE DRUGS AND AGE-AND
SIZE- APPROPRIATE EQUIPMENT FOR VENTILATION AND INTUBATION, AND PERSONNEL TRAINED IN THEIR USE AND SKILLED IN AIRWAY MANAGEMENT SHOULD BE ASSURED (see WARNINGS).
For deeply sedated patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure.

DRUG DESCRIPTION
Midazolam is a benzodiazepine available as midazolam HCI syrup for oral administration.
Midazolam, a white to light yellow crystalline compound, is insoluble in water,
but can be solubilized in aqueous solutions by formation of the hydrochloride
salt in situ under acidic conditions. Chemically, midazolam HCI is 8-chloro-6-(2-fluo-rophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]
benzodiazepine hydrochloride.Midazolam hydrochloride has the molecular formula
C18H13CIFN3•HCI, a calculated molecular
weight of 362.25 and the following structural formula:








Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam
compounded with artificial bitterness modifier, citric acid anhydrous, D&C
Red #33, edetate disodium, glycerin, mixed fruit flavor, sodium benzoate, sodium
citrate, sorbitol, and water; the pH is adjusted to 2.8 - 3.6 with hydrochloric
acid.
Under the acidic conditions required to solubilize midazolam in the syrup,
midazolam is present as an equilibrium mixture (shown below) of the closed ring
form shown above and an open-ring structure formed by the acid-catalyzed ring
opening of the 4,5-double bond of the diazepine ring.The amount of open-ring
form is dependent upon the pH of the solution.At the specified pH of the syrup,
the solution may contain up to about 40% of the open-ring compound.At the physiologic
conditions under which the product is absorbed (pH of 5 to 8) into the systemic
circulation, any open-ring form present reverts to the physiologically active,
lipophilic, closed-ring form (midazolam) and is absorbed as such.








 
The following chart plots the percentage of midazolam present as the open-ring
form as a function of pH in aqueous solutions.As indicated in the graph, the
amount of open-ring compound present in solution is sensitive to changes in
pH over the pH range specified for the product: 2.8 to 3.6.Above pH 5, at least
99% of the mixture is present in the closed-ring form.
pH Dependence of Open-ring Form in Water






Last reviewed on RxList: 6/25/2008




Midazolam Hydrochloride Syrup Drug Description
Midazolam Hydrochloride Syrup
(generic formulation)

Midazolam HCI syrup has been associated with respiratory depression and respiratory
arrest, especially when used for sedation in noncritical care settings. Midazolam
HCI syrup has been associated with reports of respiratory depression, airway obstruction, desaturation, hypoxia, and apnea, most often when used concomitantly with other central nervous system depressants (eg, opioids). Midazolam HCI syrup should be used only in hospital or ambulatory care settings, including physicians'
and dentists' offices, THAT CAN PROVIDE FOR CONTINUOUS MONITORING OF RESPIRATORY
AND CARDIAC FUNCTION. IMMEDIATE AVAILABILITY OF RESUSCITATIVE DRUGS AND AGE-AND
SIZE- APPROPRIATE EQUIPMENT FOR VENTILATION AND INTUBATION, AND PERSONNEL TRAINED IN THEIR USE AND SKILLED IN AIRWAY MANAGEMENT SHOULD BE ASSURED (see WARNINGS).
For deeply sedated patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure.

DRUG DESCRIPTION
Midazolam is a benzodiazepine available as midazolam HCI syrup for oral administration.
Midazolam, a white to light yellow crystalline compound, is insoluble in water,
but can be solubilized in aqueous solutions by formation of the hydrochloride
salt in situ under acidic conditions. Chemically, midazolam HCI is 8-chloro-6-(2-fluo-rophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]
benzodiazepine hydrochloride.Midazolam hydrochloride has the molecular formula
C18H13CIFN3•HCI, a calculated molecular
weight of 362.25 and the following structural formula:








Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam
compounded with artificial bitterness modifier, citric acid anhydrous, D&C
Red #33, edetate disodium, glycerin, mixed fruit flavor, sodium benzoate, sodium
citrate, sorbitol, and water; the pH is adjusted to 2.8 - 3.6 with hydrochloric
acid.
Under the acidic conditions required to solubilize midazolam in the syrup,
midazolam is present as an equilibrium mixture (shown below) of the closed ring
form shown above and an open-ring structure formed by the acid-catalyzed ring
opening of the 4,5-double bond of the diazepine ring.The amount of open-ring
form is dependent upon the pH of the solution.At the specified pH of the syrup,
the solution may contain up to about 40% of the open-ring compound.At the physiologic
conditions under which the product is absorbed (pH of 5 to 8) into the systemic
circulation, any open-ring form present reverts to the physiologically active,
lipophilic, closed-ring form (midazolam) and is absorbed as such.








 
The following chart plots the percentage of midazolam present as the open-ring
form as a function of pH in aqueous solutions.As indicated in the graph, the
amount of open-ring compound present in solution is sensitive to changes in
pH over the pH range specified for the product: 2.8 to 3.6.Above pH 5, at least
99% of the mixture is present in the closed-ring form.
pH Dependence of Open-ring Form in Water






Last reviewed on RxList: 6/25/2008




Midazolam Hydrochloride Syrup Drug Description
Midazolam Hydrochloride Syrup
(generic formulation)

Midazolam HCI syrup has been associated with respiratory depression and respiratory
arrest, especially when used for sedation in noncritical care settings. Midazolam
HCI syrup has been associated with reports of respiratory depression, airway obstruction, desaturation, hypoxia, and apnea, most often when used concomitantly with other central nervous system depressants (eg, opioids). Midazolam HCI syrup should be used only in hospital or ambulatory care settings, including physicians'
and dentists' offices, THAT CAN PROVIDE FOR CONTINUOUS MONITORING OF RESPIRATORY
AND CARDIAC FUNCTION. IMMEDIATE AVAILABILITY OF RESUSCITATIVE DRUGS AND AGE-AND
SIZE- APPROPRIATE EQUIPMENT FOR VENTILATION AND INTUBATION, AND PERSONNEL TRAINED IN THEIR USE AND SKILLED IN AIRWAY MANAGEMENT SHOULD BE ASSURED (see WARNINGS).
For deeply sedated patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure.

DRUG DESCRIPTION
Midazolam is a benzodiazepine available as midazolam HCI syrup for oral administration.
Midazolam, a white to light yellow crystalline compound, is insoluble in water,
but can be solubilized in aqueous solutions by formation of the hydrochloride
salt in situ under acidic conditions. Chemically, midazolam HCI is 8-chloro-6-(2-fluo-rophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]
benzodiazepine hydrochloride.Midazolam hydrochloride has the molecular formula
C18H13CIFN3•HCI, a calculated molecular
weight of 362.25 and the following structural formula:








Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam
compounded with artificial bitterness modifier, citric acid anhydrous, D&C
Red #33, edetate disodium, glycerin, mixed fruit flavor, sodium benzoate, sodium
citrate, sorbitol, and water; the pH is adjusted to 2.8 - 3.6 with hydrochloric
acid.
Under the acidic conditions required to solubilize midazolam in the syrup,
midazolam is present as an equilibrium mixture (shown below) of the closed ring
form shown above and an open-ring structure formed by the acid-catalyzed ring
opening of the 4,5-double bond of the diazepine ring.The amount of open-ring
form is dependent upon the pH of the solution.At the specified pH of the syrup,
the solution may contain up to about 40% of the open-ring compound.At the physiologic
conditions under which the product is absorbed (pH of 5 to 8) into the systemic
circulation, any open-ring form present reverts to the physiologically active,
lipophilic, closed-ring form (midazolam) and is absorbed as such.








 
The following chart plots the percentage of midazolam present as the open-ring
form as a function of pH in aqueous solutions.As indicated in the graph, the
amount of open-ring compound present in solution is sensitive to changes in
pH over the pH range specified for the product: 2.8 to 3.6.Above pH 5, at least
99% of the mixture is present in the closed-ring form.
pH Dependence of Open-ring Form in Water






Last reviewed on RxList: 6/25/2008




Midazolam Hydrochloride Syrup Drug Description
Midazolam Hydrochloride Syrup
(generic formulation)

Midazolam HCI syrup has been associated with respiratory depression and respiratory
arrest, especially when used for sedation in noncritical care settings. Midazolam
HCI syrup has been associated with reports of respiratory depression, airway obstruction, desaturation, hypoxia, and apnea, most often when used concomitantly with other central nervous system depressants (eg, opioids). Midazolam HCI syrup should be used only in hospital or ambulatory care settings, including physicians'
and dentists' offices, THAT CAN PROVIDE FOR CONTINUOUS MONITORING OF RESPIRATORY
AND CARDIAC FUNCTION. IMMEDIATE AVAILABILITY OF RESUSCITATIVE DRUGS AND AGE-AND
SIZE- APPROPRIATE EQUIPMENT FOR VENTILATION AND INTUBATION, AND PERSONNEL TRAINED IN THEIR USE AND SKILLED IN AIRWAY MANAGEMENT SHOULD BE ASSURED (see WARNINGS).
For deeply sedated patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure.

DRUG DESCRIPTION
Midazolam is a benzodiazepine available as midazolam HCI syrup for oral administration.
Midazolam, a white to light yellow crystalline compound, is insoluble in water,
but can be solubilized in aqueous solutions by formation of the hydrochloride
salt in situ under acidic conditions. Chemically, midazolam HCI is 8-chloro-6-(2-fluo-rophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]
benzodiazepine hydrochloride.Midazolam hydrochloride has the molecular formula
C18H13CIFN3•HCI, a calculated molecular
weight of 362.25 and the following structural formula:








Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam
compounded with artificial bitterness modifier, citric acid anhydrous, D&C
Red #33, edetate disodium, glycerin, mixed fruit flavor, sodium benzoate, sodium
citrate, sorbitol, and water; the pH is adjusted to 2.8 - 3.6 with hydrochloric
acid.
Under the acidic conditions required to solubilize midazolam in the syrup,
midazolam is present as an equilibrium mixture (shown below) of the closed ring
form shown above and an open-ring structure formed by the acid-catalyzed ring
opening of the 4,5-double bond of the diazepine ring.The amount of open-ring
form is dependent upon the pH of the solution.At the specified pH of the syrup,
the solution may contain up to about 40% of the open-ring compound.At the physiologic
conditions under which the product is absorbed (pH of 5 to 8) into the systemic
circulation, any open-ring form present reverts to the physiologically active,
lipophilic, closed-ring form (midazolam) and is absorbed as such.








 
The following chart plots the percentage of midazolam present as the open-ring
form as a function of pH in aqueous solutions.As indicated in the graph, the
amount of open-ring compound present in solution is sensitive to changes in
pH over the pH range specified for the product: 2.8 to 3.6.Above pH 5, at least
99% of the mixture is present in the closed-ring form.
pH Dependence of Open-ring Form in Water






Last reviewed on RxList: 6/25/2008




Midazolam Hydrochloride Syrup Drug Description
Midazolam Hydrochloride Syrup
(generic formulation)

Midazolam HCI syrup has been associated with respiratory depression and respiratory
arrest, especially when used for sedation in noncritical care settings. Midazolam
HCI syrup has been associated with reports of respiratory depression, airway obstruction, desaturation, hypoxia, and apnea, most often when used concomitantly with other central nervous system depressants (eg, opioids). Midazolam HCI syrup should be used only in hospital or ambulatory care settings, including physicians'
and dentists' offices, THAT CAN PROVIDE FOR CONTINUOUS MONITORING OF RESPIRATORY
AND CARDIAC FUNCTION. IMMEDIATE AVAILABILITY OF RESUSCITATIVE DRUGS AND AGE-AND
SIZE- APPROPRIATE EQUIPMENT FOR VENTILATION AND INTUBATION, AND PERSONNEL TRAINED IN THEIR USE AND SKILLED IN AIRWAY MANAGEMENT SHOULD BE ASSURED (see WARNINGS).
For deeply sedated patients, a dedicated individual, other than the practitioner performing the procedure, should monitor the patient throughout the procedure.

DRUG DESCRIPTION
Midazolam is a benzodiazepine available as midazolam HCI syrup for oral administration.
Midazolam, a white to light yellow crystalline compound, is insoluble in water,
but can be solubilized in aqueous solutions by formation of the hydrochloride
salt in situ under acidic conditions. Chemically, midazolam HCI is 8-chloro-6-(2-fluo-rophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]
benzodiazepine hydrochloride.Midazolam hydrochloride has the molecular formula
C18H13CIFN3•HCI, a calculated molecular
weight of 362.25 and the following structural formula:








Each mL of the syrup contains midazolam hydrochloride equivalent to 2 mg midazolam
compounded with artificial bitterness modifier, citric acid anhydrous, D&C
Red #33, edetate disodium, glycerin, mixed fruit flavor, sodium benzoate, sodium
citrate, sorbitol, and water; the pH is adjusted to 2.8 - 3.6 with hydrochloric
acid.
Under the acidic conditions required to solubilize midazolam in the syrup,
midazolam is present as an equilibrium mixture (shown below) of the closed ring
form shown above and an open-ring structure formed by the acid-catalyzed ring
opening of the 4,5-double bond of the diazepine ring.The amount of open-ring
form is dependent upon the pH of the solution.At the specified pH of the syrup,
the solution may contain up to about 40% of the open-ring compound.At the physiologic
conditions under which the product is absorbed (pH of 5 to 8) into the systemic
circulation, any open-ring form present reverts to the physiologically active,
lipophilic, closed-ring form (midazolam) and is absorbed as such.








 
The following chart plots the percentage of midazolam present as the open-ring
form as a function of pH in aqueous solutions.As indicated in the graph, the
amount of open-ring compound present in solution is sensitive to changes in
pH over the pH range specified for the product: 2.8 to 3.6.Above pH 5, at least
99% of the mixture is present in the closed-ring form.
pH Dependence of Open-ring Form in Water






Last reviewed on RxList: 6/25/2008





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Other reviews about Midazolam Hcl Syrup on web:

If midazolam HCl syrup will be administered in combination with other anesthetic drugs or drugs which depress the central nervous system, patients must be monitored by persons ... Midazolam Syrup Official FDA information, side effects and uses.


Learn about the prescription medication Midazolam Hydrochloride Syrup (Midazolam Hcl Syrup), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Midazolam Hydrochloride Syrup (Midazolam Hcl Syrup) Drug ...


If midazolam HCl syrup will be administered in combination with other anesthetic drugs or drugs which depress the central nervous system, patients must be monitored by persons ... MIDAZOLAM HYDROCHLORIDE SYRUP


Midazolam Hcl Syrup Dosage - Free tips, articles, expert advice, videos, communities and more. Midazolam Hcl Syrup Dosage - Wellsphere


Roche Laboratories is conducting a voluntary Class I drug recall of 118 mL (2mg/mL) bottle, lots U0009-50 and U0010-50, because of the potential presence of a crystalline ... FDA Alert: Versed Syrup (midazolam HCl) CIV


Roche Laboratories is conducting a voluntary Class I drug recall of 118 mL (2mg/mL) bottle, lots U0009-50 and U0010-50, because of the potential presence of a crystalline ... Versed Syrup (midazolam HCl) CIV


INDICATIONS AND USAGE: Midazolam HCl syrup is indicated for use in pediatric patients for sedation, anxiolysis and amnesia prior to diagnostic, therapeutic or endoscopic procedures ... Midazolam - Indications and Dosage


Midazolam HCl syrup has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. Midazolam - Drug Info, Side Effects, Research, Clinical Trials


midazolam HclMidazolam Syrup - OralVersed ... White spots on back of throat from smoking weed? first time smoking weed and mouth was extrememly dry then the next day i found ... midazolam HclMidazolam Syrup - Oral - Drug Information and Side ...


midazolam - Oral Syrup (mid-aze-oh-lam) Common Brand Name(s): Versed Warning: Use Of Midazolam ... Available Midazolam Hcl Coupons - Beta MIDAZOLAM HCL Patient Assistance Program





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