Reviews Melphalan


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Alkeran Drug Description
ALKERAN®
(melphalan) Tablets

WARNING
ALKERAN (melphalan) should be administered under the supervision of a qualified
physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan
is leukemogenic in humans.
Melphalan produces chromosomal aberrations in vitro and in vivo
and, therefore, should be considered potentially mutagenic in humans.

DRUG DESCRIPTION



What are the possible side effects of melphalan (Alkeran, Alkeran I.V.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
...
Read All Potential Side Effects for Alkeran »




ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating agent which is active against selective
human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine.
The molecular formula is C13H18Cl2N2O2
and the molecular weight is 305.20. The structural formula is:








Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.
Melphalan is practically insoluble in water and has a pKa1 of ~2.5.
ALKERAN (melphalan) is available in tablet form for oral administration. Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Last reviewed on RxList: 6/20/2008




Alkeran Drug Description
ALKERAN®
(melphalan) Tablets

WARNING
ALKERAN (melphalan) should be administered under the supervision of a qualified
physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan
is leukemogenic in humans.
Melphalan produces chromosomal aberrations in vitro and in vivo
and, therefore, should be considered potentially mutagenic in humans.

DRUG DESCRIPTION



What are the possible side effects of melphalan (Alkeran, Alkeran I.V.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
...
Read All Potential Side Effects for Alkeran »




ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating agent which is active against selective
human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine.
The molecular formula is C13H18Cl2N2O2
and the molecular weight is 305.20. The structural formula is:








Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.
Melphalan is practically insoluble in water and has a pKa1 of ~2.5.
ALKERAN (melphalan) is available in tablet form for oral administration. Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Last reviewed on RxList: 6/20/2008




Alkeran Drug Description
ALKERAN®
(melphalan) Tablets

WARNING
ALKERAN (melphalan) should be administered under the supervision of a qualified
physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan
is leukemogenic in humans.
Melphalan produces chromosomal aberrations in vitro and in vivo
and, therefore, should be considered potentially mutagenic in humans.

DRUG DESCRIPTION



What are the possible side effects of melphalan (Alkeran, Alkeran I.V.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
...
Read All Potential Side Effects for Alkeran »




ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating agent which is active against selective
human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine.
The molecular formula is C13H18Cl2N2O2
and the molecular weight is 305.20. The structural formula is:








Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.
Melphalan is practically insoluble in water and has a pKa1 of ~2.5.
ALKERAN (melphalan) is available in tablet form for oral administration. Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Last reviewed on RxList: 6/20/2008




Alkeran Drug Description
ALKERAN®
(melphalan) Tablets

WARNING
ALKERAN (melphalan) should be administered under the supervision of a qualified
physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan
is leukemogenic in humans.
Melphalan produces chromosomal aberrations in vitro and in vivo
and, therefore, should be considered potentially mutagenic in humans.

DRUG DESCRIPTION



What are the possible side effects of melphalan (Alkeran, Alkeran I.V.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
...
Read All Potential Side Effects for Alkeran »




ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating agent which is active against selective
human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine.
The molecular formula is C13H18Cl2N2O2
and the molecular weight is 305.20. The structural formula is:








Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.
Melphalan is practically insoluble in water and has a pKa1 of ~2.5.
ALKERAN (melphalan) is available in tablet form for oral administration. Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Last reviewed on RxList: 6/20/2008




Alkeran Drug Description
ALKERAN®
(melphalan) Tablets

WARNING
ALKERAN (melphalan) should be administered under the supervision of a qualified
physician experienced in the use of cancer chemotherapeutic agents. Severe bone marrow suppression with resulting infection or bleeding may occur. Melphalan
is leukemogenic in humans.
Melphalan produces chromosomal aberrations in vitro and in vivo
and, therefore, should be considered potentially mutagenic in humans.

DRUG DESCRIPTION



What are the possible side effects of melphalan (Alkeran, Alkeran I.V.)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
...
Read All Potential Side Effects for Alkeran »




ALKERAN (melphalan), also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating agent which is active against selective
human neoplastic diseases. It is known chemically as 4-[bis(2-chloroethyl)amino]-L-phenylalanine.
The molecular formula is C13H18Cl2N2O2
and the molecular weight is 305.20. The structural formula is:








Melphalan is the active L-isomer of the compound and was first synthesized in 1953 by Bergel and Stock; the D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.
Melphalan is practically insoluble in water and has a pKa1 of ~2.5.
ALKERAN (melphalan) is available in tablet form for oral administration. Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide.
Last reviewed on RxList: 6/20/2008





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Other reviews about Melphalan on web:

Melphalan hydrochloride (trade name Alkeran) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (C n H 2n+1) to DNA Melphalan - Wikipedia, the free encyclopedia


Melphalan is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as an alkylating agent. Alkeran, L-PAM, L-Sarcolysin, Phenylalanine ... Melphalan, Megace Alkeran - Chemotherapy Drugs, Chemo Drug Side ...


melphalan n trade name: Alkeran; drug class: antineoplastic; action: responsible for cross-linking DNA strands, which leads to cell death; uses: melphalan: Definition from Answers.com


Melphalan Key Terms: Antineoplastic . Definition Melphalan is an anticancer ( antineoplastic ) agent Melphalan: Definition from Answers.com


Consumer information about the medication MELPHALAN - ORAL (Alkeran), includes side effects, drug interactions, recommended dosages, and storage information. Read more about ... MELPHALAN - ORAL (Alkeran) side effects, medical uses, and drug ...


All about Melphalan. View complete and up to date Melphalan information - part of the Drugs.com trusted medication database. Melphalan Facts and Comparisons at Drugs.com


Physician reviewed melphalan patient information - includes melphalan description, dosage and directions. melphalan medical facts from Drugs.com


Learn about the prescription medication Alkeran (Melphalan), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Alkeran (Melphalan) Drug Information: Uses, Side Effects, Drug ...


melphalan /mel·pha·lan/ (mel´fah-lan) a cytotoxic alkylating agent derived from mechlorethamine, used as an antineoplastic. melphalan [mel′fəlan] melphalan - definition of melphalan in the Medical dictionary - by ...


Features information about dosage, usage, side effects, and warnings. Melphalan: MedlinePlus Drug Information





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