Reviews Mecasermin Rinfabate [rDNA origin] Injection


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Iplex Drug Description
IPLEX™
(mecasermin rinfabate [rDNA origin]) Injection
DRUG DESCRIPTION



What are the possible side effects of mecasermin rinfabate (iPlex)?

Stop using mecasermin rinfabate and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Mecasermin rinfabate may cause a temporary increase in pressure within the brain. Symptoms include pain behind the eyes, and nausea with vomiting. Call your doctor at once if your child has a headache with vomiting.
Mecasermin rinfabate may cause a bone problem called "slipped capital...
Read All Potential Side Effects for Iplex »




IPLEX™ (mecasermin rinfabate [rDNA origin] injection) is an aqueous solution
for injection containing a binary protein complex of human insulin-like growth
factor-1 (rhIGF-1) and human insulin-like growth factor-binding protein-3 (rhIGFBP-3),
both produced by recombinant DNA technology.
rhIGF-1 and rhIGFBP-3 are produced by two separate E. coli strains:
one containing the human gene for insulin-like growth factor-1 (IGF-1), the
other containing the human gene for insulin-like growth factor-binding protein-3
(IGFBP-3). IGF-1 consists of 70 amino acids in a single chain with three intramolecular
disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence
of the rhIGF-1 protein is identical to that of endogenous human IGF-1. IGFBP-3
consists of 264 amino acid residues with a molecular weight of 28,732 daltons.
The amino acid sequence of the rhIGFBP-3 protein is identical to that of endogenous
human IGFBP-3. Endogenous IGFBP-3 contains 18 cysteine residues that are all
paired in disulfide bonds to form the biologically active molecule, but the
pairings have not been fully elucidated. The rhIGF-1 and rhIGFBP-3 proteins
are complexed in a 1:1 molar ratio for formation of mecasermin rinfabate with
a molecular weight of 36,381 daltons. IGFBP-3 from human plasma is glycosylated,
whereas rhIGFBP-3 produced in E. coli is non-glycosylated. Glycosylated
and non-glycosylated IGFBP-3 bind IGF-1 with similar affinities.
Primary structures for rhIGF-1/rhIGFBP-3:
Recombinant human insulin growth factor-1 ( rhIGF-1)







Recombinant human insulin growth factor binding protein-3 (rhIGFBP-3)








IPLEX is prepared to a final concentration of 36 mg/0.6 mL in 50 mM sodium
acetate and 105 mM sodium chloride with a final pH of 5.5. IPLEX is for subcutaneous
injection only and is a preservative-free, sterile, clear, colorless-to-slightly-yellow
liquid.Last reviewed on RxList: 3/2/2009




Iplex Drug Description
IPLEX™
(mecasermin rinfabate [rDNA origin]) Injection
DRUG DESCRIPTION



What are the possible side effects of mecasermin rinfabate (iPlex)?

Stop using mecasermin rinfabate and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Mecasermin rinfabate may cause a temporary increase in pressure within the brain. Symptoms include pain behind the eyes, and nausea with vomiting. Call your doctor at once if your child has a headache with vomiting.
Mecasermin rinfabate may cause a bone problem called "slipped capital...
Read All Potential Side Effects for Iplex »




IPLEX™ (mecasermin rinfabate [rDNA origin] injection) is an aqueous solution
for injection containing a binary protein complex of human insulin-like growth
factor-1 (rhIGF-1) and human insulin-like growth factor-binding protein-3 (rhIGFBP-3),
both produced by recombinant DNA technology.
rhIGF-1 and rhIGFBP-3 are produced by two separate E. coli strains:
one containing the human gene for insulin-like growth factor-1 (IGF-1), the
other containing the human gene for insulin-like growth factor-binding protein-3
(IGFBP-3). IGF-1 consists of 70 amino acids in a single chain with three intramolecular
disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence
of the rhIGF-1 protein is identical to that of endogenous human IGF-1. IGFBP-3
consists of 264 amino acid residues with a molecular weight of 28,732 daltons.
The amino acid sequence of the rhIGFBP-3 protein is identical to that of endogenous
human IGFBP-3. Endogenous IGFBP-3 contains 18 cysteine residues that are all
paired in disulfide bonds to form the biologically active molecule, but the
pairings have not been fully elucidated. The rhIGF-1 and rhIGFBP-3 proteins
are complexed in a 1:1 molar ratio for formation of mecasermin rinfabate with
a molecular weight of 36,381 daltons. IGFBP-3 from human plasma is glycosylated,
whereas rhIGFBP-3 produced in E. coli is non-glycosylated. Glycosylated
and non-glycosylated IGFBP-3 bind IGF-1 with similar affinities.
Primary structures for rhIGF-1/rhIGFBP-3:
Recombinant human insulin growth factor-1 ( rhIGF-1)







Recombinant human insulin growth factor binding protein-3 (rhIGFBP-3)








IPLEX is prepared to a final concentration of 36 mg/0.6 mL in 50 mM sodium
acetate and 105 mM sodium chloride with a final pH of 5.5. IPLEX is for subcutaneous
injection only and is a preservative-free, sterile, clear, colorless-to-slightly-yellow
liquid.Last reviewed on RxList: 3/2/2009




Iplex Drug Description
IPLEX™
(mecasermin rinfabate [rDNA origin]) Injection
DRUG DESCRIPTION



What are the possible side effects of mecasermin rinfabate (iPlex)?

Stop using mecasermin rinfabate and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Mecasermin rinfabate may cause a temporary increase in pressure within the brain. Symptoms include pain behind the eyes, and nausea with vomiting. Call your doctor at once if your child has a headache with vomiting.
Mecasermin rinfabate may cause a bone problem called "slipped capital...
Read All Potential Side Effects for Iplex »




IPLEX™ (mecasermin rinfabate [rDNA origin] injection) is an aqueous solution
for injection containing a binary protein complex of human insulin-like growth
factor-1 (rhIGF-1) and human insulin-like growth factor-binding protein-3 (rhIGFBP-3),
both produced by recombinant DNA technology.
rhIGF-1 and rhIGFBP-3 are produced by two separate E. coli strains:
one containing the human gene for insulin-like growth factor-1 (IGF-1), the
other containing the human gene for insulin-like growth factor-binding protein-3
(IGFBP-3). IGF-1 consists of 70 amino acids in a single chain with three intramolecular
disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence
of the rhIGF-1 protein is identical to that of endogenous human IGF-1. IGFBP-3
consists of 264 amino acid residues with a molecular weight of 28,732 daltons.
The amino acid sequence of the rhIGFBP-3 protein is identical to that of endogenous
human IGFBP-3. Endogenous IGFBP-3 contains 18 cysteine residues that are all
paired in disulfide bonds to form the biologically active molecule, but the
pairings have not been fully elucidated. The rhIGF-1 and rhIGFBP-3 proteins
are complexed in a 1:1 molar ratio for formation of mecasermin rinfabate with
a molecular weight of 36,381 daltons. IGFBP-3 from human plasma is glycosylated,
whereas rhIGFBP-3 produced in E. coli is non-glycosylated. Glycosylated
and non-glycosylated IGFBP-3 bind IGF-1 with similar affinities.
Primary structures for rhIGF-1/rhIGFBP-3:
Recombinant human insulin growth factor-1 ( rhIGF-1)







Recombinant human insulin growth factor binding protein-3 (rhIGFBP-3)








IPLEX is prepared to a final concentration of 36 mg/0.6 mL in 50 mM sodium
acetate and 105 mM sodium chloride with a final pH of 5.5. IPLEX is for subcutaneous
injection only and is a preservative-free, sterile, clear, colorless-to-slightly-yellow
liquid.Last reviewed on RxList: 3/2/2009




Iplex Drug Description
IPLEX™
(mecasermin rinfabate [rDNA origin]) Injection
DRUG DESCRIPTION



What are the possible side effects of mecasermin rinfabate (iPlex)?

Stop using mecasermin rinfabate and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Mecasermin rinfabate may cause a temporary increase in pressure within the brain. Symptoms include pain behind the eyes, and nausea with vomiting. Call your doctor at once if your child has a headache with vomiting.
Mecasermin rinfabate may cause a bone problem called "slipped capital...
Read All Potential Side Effects for Iplex »




IPLEX™ (mecasermin rinfabate [rDNA origin] injection) is an aqueous solution
for injection containing a binary protein complex of human insulin-like growth
factor-1 (rhIGF-1) and human insulin-like growth factor-binding protein-3 (rhIGFBP-3),
both produced by recombinant DNA technology.
rhIGF-1 and rhIGFBP-3 are produced by two separate E. coli strains:
one containing the human gene for insulin-like growth factor-1 (IGF-1), the
other containing the human gene for insulin-like growth factor-binding protein-3
(IGFBP-3). IGF-1 consists of 70 amino acids in a single chain with three intramolecular
disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence
of the rhIGF-1 protein is identical to that of endogenous human IGF-1. IGFBP-3
consists of 264 amino acid residues with a molecular weight of 28,732 daltons.
The amino acid sequence of the rhIGFBP-3 protein is identical to that of endogenous
human IGFBP-3. Endogenous IGFBP-3 contains 18 cysteine residues that are all
paired in disulfide bonds to form the biologically active molecule, but the
pairings have not been fully elucidated. The rhIGF-1 and rhIGFBP-3 proteins
are complexed in a 1:1 molar ratio for formation of mecasermin rinfabate with
a molecular weight of 36,381 daltons. IGFBP-3 from human plasma is glycosylated,
whereas rhIGFBP-3 produced in E. coli is non-glycosylated. Glycosylated
and non-glycosylated IGFBP-3 bind IGF-1 with similar affinities.
Primary structures for rhIGF-1/rhIGFBP-3:
Recombinant human insulin growth factor-1 ( rhIGF-1)







Recombinant human insulin growth factor binding protein-3 (rhIGFBP-3)








IPLEX is prepared to a final concentration of 36 mg/0.6 mL in 50 mM sodium
acetate and 105 mM sodium chloride with a final pH of 5.5. IPLEX is for subcutaneous
injection only and is a preservative-free, sterile, clear, colorless-to-slightly-yellow
liquid.Last reviewed on RxList: 3/2/2009




Iplex Drug Description
IPLEX™
(mecasermin rinfabate [rDNA origin]) Injection
DRUG DESCRIPTION



What are the possible side effects of mecasermin rinfabate (iPlex)?

Stop using mecasermin rinfabate and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Mecasermin rinfabate may cause a temporary increase in pressure within the brain. Symptoms include pain behind the eyes, and nausea with vomiting. Call your doctor at once if your child has a headache with vomiting.
Mecasermin rinfabate may cause a bone problem called "slipped capital...
Read All Potential Side Effects for Iplex »




IPLEX™ (mecasermin rinfabate [rDNA origin] injection) is an aqueous solution
for injection containing a binary protein complex of human insulin-like growth
factor-1 (rhIGF-1) and human insulin-like growth factor-binding protein-3 (rhIGFBP-3),
both produced by recombinant DNA technology.
rhIGF-1 and rhIGFBP-3 are produced by two separate E. coli strains:
one containing the human gene for insulin-like growth factor-1 (IGF-1), the
other containing the human gene for insulin-like growth factor-binding protein-3
(IGFBP-3). IGF-1 consists of 70 amino acids in a single chain with three intramolecular
disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence
of the rhIGF-1 protein is identical to that of endogenous human IGF-1. IGFBP-3
consists of 264 amino acid residues with a molecular weight of 28,732 daltons.
The amino acid sequence of the rhIGFBP-3 protein is identical to that of endogenous
human IGFBP-3. Endogenous IGFBP-3 contains 18 cysteine residues that are all
paired in disulfide bonds to form the biologically active molecule, but the
pairings have not been fully elucidated. The rhIGF-1 and rhIGFBP-3 proteins
are complexed in a 1:1 molar ratio for formation of mecasermin rinfabate with
a molecular weight of 36,381 daltons. IGFBP-3 from human plasma is glycosylated,
whereas rhIGFBP-3 produced in E. coli is non-glycosylated. Glycosylated
and non-glycosylated IGFBP-3 bind IGF-1 with similar affinities.
Primary structures for rhIGF-1/rhIGFBP-3:
Recombinant human insulin growth factor-1 ( rhIGF-1)







Recombinant human insulin growth factor binding protein-3 (rhIGFBP-3)








IPLEX is prepared to a final concentration of 36 mg/0.6 mL in 50 mM sodium
acetate and 105 mM sodium chloride with a final pH of 5.5. IPLEX is for subcutaneous
injection only and is a preservative-free, sterile, clear, colorless-to-slightly-yellow
liquid.Last reviewed on RxList: 3/2/2009





Other reviews about Mecasermin Rinfabate [rDNA origin] Injection on web:

Mecasermin rinfabate injection To return to the main entry click here . What is Mecasermin rinfabate injection? MECASERMIN RINFABATE (IPLEX™) is Mecasermin rinfabate injection: Information from Answers.com


Mecasermin rinfabate (trade name IPLEX) is a drug consisting of recombinant Insulin-like growth ... is studying the safety and tolerability of once-daily, subcutaneous injection of ... Mecasermin rinfabate - Wikipedia, the free encyclopedia


Learn about the prescription medication Iplex (Mecasermin Rinfabate [rDNA origin] Injection), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Iplex (Mecasermin Rinfabate [rDNA origin] Injection) Drug ...


Mecasermin rinfabate Brand names: Iplex™ Drug Forms: Mecasermin rinfabate injection (below) Mecasermin rinfabate (E Mecasermin rinfabate: Information from Answers.com


Wait until the child has eaten and 20 minutes have passed before giving the mecasermin rinfabate injection. Mecasermin rinfabate may lower blood sugar levels if it is used without ... mecasermin rinfabate Information - Drugs and Treatments - MedHelp


Do not give a mecasermin rinfabate injection if the child does not eat a meal or snack within 20 minutes before or after the injection. Mecasermin rinfabate may lower blood sugar ... mecasermin rinfabate medical facts from Drugs.com


Insmed, Inc (NASDAQ: INSM) today provided an update on the launch of IPLEX (mecasermin rinfabate (rDNA origin) injection) and the Company's payer ... Mecasermin


Iplex.(New & Approved)(mecasermin rinfabate) ... find Pediatric News articles. div id="be-doc-text" Iplex (mecasermin rinfabate [rDNA origin] injection, Insmed Inc.)The Food and ... Iplex.(New & Approved)(mecasermin rinfabate) - Pediatric News ...


Do not use the medicine if the meal or snack is not eaten for any reason. Wait until the child has eaten and 20 minutes have passed before giving the mecasermin rinfabate injection. mecasermin rinfabate - Caring4Cancer


Do not use the medicine if the meal or snack is not eaten for any reason. Wait until the child has eaten and 20 minutes have passed before giving the mecasermin rinfabate injection Health: mecasermin rinfabate; Mecasermin rinfabate may cause a ...





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