Reviews MDP Multidose Kit of Technetium Injection


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MDP Multidose Kit of Technetium Injection Drug Description
MDP Multidose Kit
for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
DRUG DESCRIPTION
Each kit contains 10 multidose reaction vials, each containing 10 mg of medronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29 mg), and 2 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours.1 The principal photon that is useful for detection and
imaging studies is listed in Table 1.
Table 1. Principal Radiation Emission Data1



Radiation
Mean %/Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5


1Kocher, David C, “Radioactive Decay Data Tables,”
DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 2. Radiation Attenuation of Lead (Pb) Shielding



Shield Thickness
(Pb) cm
Coefficient
of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
Table 3. Physical Decay Chart: Tc99m, half-life 6.02 hours



Hours
Fraction
Remaining
Hours
Fraction
Remaining


0*
1.000
5
0.562


1
0.891
6
0.501


2
0.794
8
0.398


3
0.708
10
0.316


4
0.631
12
0.251


*Calibration Time


Last reviewed on RxList: 10/3/2007




MDP Multidose Kit of Technetium Injection Drug Description
MDP Multidose Kit
for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
DRUG DESCRIPTION
Each kit contains 10 multidose reaction vials, each containing 10 mg of medronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29 mg), and 2 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours.1 The principal photon that is useful for detection and
imaging studies is listed in Table 1.
Table 1. Principal Radiation Emission Data1



Radiation
Mean %/Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5


1Kocher, David C, “Radioactive Decay Data Tables,”
DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 2. Radiation Attenuation of Lead (Pb) Shielding



Shield Thickness
(Pb) cm
Coefficient
of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
Table 3. Physical Decay Chart: Tc99m, half-life 6.02 hours



Hours
Fraction
Remaining
Hours
Fraction
Remaining


0*
1.000
5
0.562


1
0.891
6
0.501


2
0.794
8
0.398


3
0.708
10
0.316


4
0.631
12
0.251


*Calibration Time


Last reviewed on RxList: 10/3/2007




MDP Multidose Kit of Technetium Injection Drug Description
MDP Multidose Kit
for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
DRUG DESCRIPTION
Each kit contains 10 multidose reaction vials, each containing 10 mg of medronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29 mg), and 2 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours.1 The principal photon that is useful for detection and
imaging studies is listed in Table 1.
Table 1. Principal Radiation Emission Data1



Radiation
Mean %/Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5


1Kocher, David C, “Radioactive Decay Data Tables,”
DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 2. Radiation Attenuation of Lead (Pb) Shielding



Shield Thickness
(Pb) cm
Coefficient
of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
Table 3. Physical Decay Chart: Tc99m, half-life 6.02 hours



Hours
Fraction
Remaining
Hours
Fraction
Remaining


0*
1.000
5
0.562


1
0.891
6
0.501


2
0.794
8
0.398


3
0.708
10
0.316


4
0.631
12
0.251


*Calibration Time


Last reviewed on RxList: 10/3/2007




MDP Multidose Kit of Technetium Injection Drug Description
MDP Multidose Kit
for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
DRUG DESCRIPTION
Each kit contains 10 multidose reaction vials, each containing 10 mg of medronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29 mg), and 2 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours.1 The principal photon that is useful for detection and
imaging studies is listed in Table 1.
Table 1. Principal Radiation Emission Data1



Radiation
Mean %/Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5


1Kocher, David C, “Radioactive Decay Data Tables,”
DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 2. Radiation Attenuation of Lead (Pb) Shielding



Shield Thickness
(Pb) cm
Coefficient
of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
Table 3. Physical Decay Chart: Tc99m, half-life 6.02 hours



Hours
Fraction
Remaining
Hours
Fraction
Remaining


0*
1.000
5
0.562


1
0.891
6
0.501


2
0.794
8
0.398


3
0.708
10
0.316


4
0.631
12
0.251


*Calibration Time


Last reviewed on RxList: 10/3/2007




MDP Multidose Kit of Technetium Injection Drug Description
MDP Multidose Kit
for the Preparation of Technetium Tc99m Medronate Injection
DIAGNOSTIC - FOR INTRAVENOUS USE
DRUG DESCRIPTION
Each kit contains 10 multidose reaction vials, each containing 10 mg of medronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29 mg), and 2 mg ascorbic acid. The contents of the vial are sterile, pyrogen-free, lyophilized and sealed under nitrogen. The pH has been adjusted to 4.0-7.8 with hydrochloric acid and sodium hydroxide.
Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free sodium pertechnetate Tc99m injection. The product as supplied is sterile and pyrogen-free.
The precise structure of stannous technetium Tc99m medronate complex is unknown at this time.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours.1 The principal photon that is useful for detection and
imaging studies is listed in Table 1.
Table 1. Principal Radiation Emission Data1



Radiation
Mean %/Disintegration
Mean Energy (keV)


Gamma-2
89.07
140.5


1Kocher, David C, “Radioactive Decay Data Tables,”
DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 0.78 R/hr-mCi at 1 cm. The first half-value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 2. For example, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 2. Radiation Attenuation of Lead (Pb) Shielding



Shield Thickness
(Pb) cm
Coefficient
of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radionuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
Table 3. Physical Decay Chart: Tc99m, half-life 6.02 hours



Hours
Fraction
Remaining
Hours
Fraction
Remaining


0*
1.000
5
0.562


1
0.891
6
0.501


2
0.794
8
0.398


3
0.708
10
0.316


4
0.631
12
0.251


*Calibration Time


Last reviewed on RxList: 10/3/2007





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