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Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009




Macugen Drug Description
MACUGEN®
(pegaptanib sodium) Injection
DRUG DESCRIPTION



What are the possible side effects of pegaptanib (Macugen)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

eye pain, redness, or irritation;
drainage or discharge from your eyes;
feeling that your eyes are more sensitive to light; or
trouble seeing, or other vision changes.

Other less serious side effects are more...
Read All Potential Side Effects for Macugen »




MACUGEN® (pegaptanib sodium injection) is a sterile, aqueous solution containing
pegaptanib sodium for intravitreous injection. Macugen is supplied in a single-dose,
pre-filled syringe and is formulated as a 3.47 mg/mL solution, measured as the
free acid form of the oligonucleotide. The active ingredient is 0.3 mg of the
free acid form of the oligonucleotide without polyethylene glycol, in a nominal
volume of 90 ┬ÁL. This dose is equivalent to 1.6 mg of pegaptanib sodium (pegylated
oligonucleotide) or 0.32 mg when expressed as the sodium salt form of the oligonucleotide
moiety. The product is a sterile, clear, preservative-free solution containing
sodium chloride, monobasic sodium phosphate monohydrate, dibasic sodium phosphate
heptahydrate, hydrochloric acid, and/or sodium hydroxide to adjust the pH and
water for injection.
Pegaptanib sodium is a covalent conjugate of an oligonucleotide of twenty-eight
nucleotides in length that terminates in a pentylamino linker, to which two
20-kilodalton monomethoxy polyethylene glycol (PEG) units are covalently attached
via the two amino groups on a lysine residue.
Pegaptanib sodium is represented by the following structural formula:








Where R is








and n is approximately 450.
The chemical name for pegaptanib sodium is as follows: RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'→3')-dT),
5'-ester with α,α'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[ω-methoxypoly(oxy-1,2-ethanediyl)],
sodium salt.
The molecular formula for pegaptanib sodium is C294H342F13N107Na28O188P28[C2H4O]n
(where n is approximately 900) and the molecular weight is approximately 50
kilodaltons.
Macugen is formulated to have an osmolality of 280-360 mOsm/Kg, and a pH of
6-7.Last reviewed on RxList: 1/30/2009





Other reviews about Macugen on wordpress

News
  by hopeforvision
┬á ┬á┬á ┬á ┬á 01-19-2006, Good vibes: tuning into a career dream, by Adrian Chamberlain 01-17-2006, Clinical Trial on Gene Therapy for Macular Degeneration Published in Human Gene Therapy 01-16-2006, Legally blind man has […]


ARC Study
  by associatedretina
┬áARC STUDY PARTICIPATION Sponsor: Eyetech Pharmaceuticals Inc. Co-Developer: Pfizer, Inc. EOP1013:A Phase 2/3 Randomized, Controlled, Double-Masked, Multi-Center, Comparative Dose-Finding Trial, in Parallel Groups, to Compare the Safety and Efficacy of […]


3 Commercialized Products & Census!
  by ymrforrest
Vexed question: What take care of ZostaVax┬«, Kineret┬« and Macugen┬« labor inflooding commonÔÇŽDealing: It are integral FDA endorsed sovereign-adit-elegance commercialized products originating for Academia as to Colorado illuminate […]


3 Commercialized Products & Census!
  by ymrforrest
Vexed question: What take care of ZostaVax┬«, Kineret┬« and Macugen┬« labor inflooding commonÔÇŽDealing: It are integral FDA endorsed sovereign-adit-elegance commercialized products originating for Academia as to Colorado illuminate […]


Partnering profiles: Pfizer
  by silico
How many partners does Pfizer have? In common with other pharmaceutical companies Pfizer does not disclose the exact number of partners it has but in its 2005 financial results […]


Coming to your doctor's office: rationing
  by christopherfountain
Yesterday's WSJ has an interesting look at Britain's health care system and the rationing that, of necessity, takes place.┬áLots of horror stories, which make a nice accompaniment to […]


About Me
  by Mike Hart
Mike is a senior executive in the biotechnology industry.┬á After working for several electronics companies in Silicon Valley during the 1980s, Mike became CFO of NeXstar Pharmaceuticals in […]


Cancer Research leads to AMD Treatment.
  by lvatug
Linda Fugate writes in the EmpowHer blog: Cancer research has opened a new avenue of treatment options for neovascular eye conditions, including age-related macular degeneration and diabetic retinopathy. The […]


Manufacturing agreement between Avecia Biotechnology and Pfizer
  by silico
On April 26 2010 Avecia Biotechnology Inc reached agreement with Pfizer Inc regarding the commercial supply of a key component of Macugen┬« (pegaptanib sodium injection), marketed in the […]


Results of Phase 3 Macugen Study
  by lvatug
Phase 3 Study Showed MACUGEN┬« Improved Vision Over Standard of Care in Patients with Diabetic Macular Edema Patients on MACUGEN Maintained and Expanded Vision Gains Over Two […]



Other reviews about Macugen on web:

Macugen ® , an exciting treatment for AMD. ... he product information in this site is intended only for residents of the United States. Macugen, An Exciting Treatment For AMD


Macugen (pegaptanib) is used to treat age-related macular degeneration (AMD). Includes Macugen side effects, interactions and indications. Macugen (pegaptanib) Information from Drugs.com


Description of Macugen ® , an exciting AMD treatment. ... (pegaptanib sodium injection) In December 2004, MACUGEN became the first ... MACUGEN: Macular Degeneration Treatment for Wet Macular ...


Learn about the prescription medication Macugen (Pegaptanib Sodium), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Macugen (Pegaptanib Sodium) Drug Information: Uses, Side Effects ...


Macugen is a medicine that is prescribed to treat age-related wet macular degeneration. This eMedTV Web page explains how Macugen can help slow down vision loss, offers dosing ... Macugen


Pegaptanib sodium injection (brand name Macugen) is an anti-angiogenic medicine for the treatment of neovascular (wet) age-related macular degeneration (AMD). Pegaptanib - Wikipedia, the free encyclopedia


All about Macugen. View complete and up to date Macugen information - part of the Drugs.com trusted medication database. Macugen Facts and Comparisons at Drugs.com


Macugen, an exciting treatment for AMD. Macugen Global Search


The AMDF is a 501(c)(3) non-profit, publicly supported organization. Contributions are tax deductible. AMDF: American Macular Degeneration Foundation - Macugen


Macugen is injected into the cavity of the eye (vitreous) by an ophthalmologist and is slowly absorbed into the bloodstream. The injection is given every 6 weeks for one year. Information About Macugen The New Drug That Helps Protect Against AMD





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