Reviews Lotronex


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Lotronex Drug Description
LOTRONEX®
(alosetron hydrochloride) Tablets

WARNING
Infrequent but serious gastrointestinal adverse events have been reported
with the use of LOTRONEX. These events, including ischemic colitis and serious
complications of constipation, have resulted in hospitalization, and rarely,
blood transfusion, surgery, and death.

The Prescribing Program for LOTRONEX™ was implemented to help reduce
risks of serious gastrointestinal adverse events. Only physicians who have
enrolled in based on their understanding of the benefits and risks, should
prescribe LOTRONEX (see PRECAUTIONS: Prescribing
Program for LOTRONEX).
LOTRONEX is indicated only for women with severe diarrhea-predominant
IBS who have not responded adequately to conventional therapy (see INDICATIONS
AND USAGE). Before receiving the initial prescription for LOTRONEX, the
patient must read and sign the Patient-Physician Agreement for LOTRONEX (see
PRECAUTIONS: Information for Patients).
LOTRONEX should be discontinued immediately in patients who develop constipation
or symptoms of ischemic colitis. Patients should immediately report constipation
or symptoms of ischemic colitis to their physician. LOTRONEX should not be
resumed in patients who develop ischemic colitis. Patients who have constipation
should immediately contact their physician if the constipation does not resolve
after LOTRONEX is discontinued. Patients with resolved constipation should
resume LOTRONEX only on the advice of their treating physician.


DRUG DESCRIPTION



What are the possible side effects of alosetron (Lotronex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking alosetron and call your doctor right away if you have any of these serious side effects:

new or worsening stomach pain;
bleeding from your rectum or blood in your stools; or
fast or uneven heartbeats.

Less serious side effects may include:

mild stomach discomfort,...
Read All Potential Side Effects for Lotronex »




The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl),
a potent and selective antagonist of the serotonin 5-HT3 receptor
type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one,
monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl,
representing a molecular weight of 330.8. Alosetron is a white to beige solid
that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid,
0.3 mg/mL in pH 6 phosphate buffer, and < 0.1 mg/mL in pH 8 phosphate buffer.
The chemical structure of alosetron is:








LOTRONEX Tablets are supplied for oral administration as 0.5-mg (white) and
1-mg (blue) tablets. The 0.5-mg tablet contains 0.562 mg alosetron HCl equivalent
to 0.5 mg alosetron and the 1-mg tablet contains 1.124 mg alosetron HCl equivalent
to 1 mg of alosetron. Each tablet also contains the inactive ingredients: lactose
(anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized
starch. The white film-coat for the 0.5-mg tablet contains hypromellose, titanium
dioxide, and triacetin. The blue film-coat for the 1-mg tablet contains hypromellose,
titanium dioxide, triacetin, and indigo carmine.Last reviewed on RxList: 5/16/2008




Lotronex Drug Description
LOTRONEX®
(alosetron hydrochloride) Tablets

WARNING
Infrequent but serious gastrointestinal adverse events have been reported
with the use of LOTRONEX. These events, including ischemic colitis and serious
complications of constipation, have resulted in hospitalization, and rarely,
blood transfusion, surgery, and death.

The Prescribing Program for LOTRONEX™ was implemented to help reduce
risks of serious gastrointestinal adverse events. Only physicians who have
enrolled in based on their understanding of the benefits and risks, should
prescribe LOTRONEX (see PRECAUTIONS: Prescribing
Program for LOTRONEX).
LOTRONEX is indicated only for women with severe diarrhea-predominant
IBS who have not responded adequately to conventional therapy (see INDICATIONS
AND USAGE). Before receiving the initial prescription for LOTRONEX, the
patient must read and sign the Patient-Physician Agreement for LOTRONEX (see
PRECAUTIONS: Information for Patients).
LOTRONEX should be discontinued immediately in patients who develop constipation
or symptoms of ischemic colitis. Patients should immediately report constipation
or symptoms of ischemic colitis to their physician. LOTRONEX should not be
resumed in patients who develop ischemic colitis. Patients who have constipation
should immediately contact their physician if the constipation does not resolve
after LOTRONEX is discontinued. Patients with resolved constipation should
resume LOTRONEX only on the advice of their treating physician.


DRUG DESCRIPTION



What are the possible side effects of alosetron (Lotronex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking alosetron and call your doctor right away if you have any of these serious side effects:

new or worsening stomach pain;
bleeding from your rectum or blood in your stools; or
fast or uneven heartbeats.

Less serious side effects may include:

mild stomach discomfort,...
Read All Potential Side Effects for Lotronex »




The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl),
a potent and selective antagonist of the serotonin 5-HT3 receptor
type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one,
monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl,
representing a molecular weight of 330.8. Alosetron is a white to beige solid
that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid,
0.3 mg/mL in pH 6 phosphate buffer, and < 0.1 mg/mL in pH 8 phosphate buffer.
The chemical structure of alosetron is:








LOTRONEX Tablets are supplied for oral administration as 0.5-mg (white) and
1-mg (blue) tablets. The 0.5-mg tablet contains 0.562 mg alosetron HCl equivalent
to 0.5 mg alosetron and the 1-mg tablet contains 1.124 mg alosetron HCl equivalent
to 1 mg of alosetron. Each tablet also contains the inactive ingredients: lactose
(anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized
starch. The white film-coat for the 0.5-mg tablet contains hypromellose, titanium
dioxide, and triacetin. The blue film-coat for the 1-mg tablet contains hypromellose,
titanium dioxide, triacetin, and indigo carmine.Last reviewed on RxList: 5/16/2008




Lotronex Drug Description
LOTRONEX®
(alosetron hydrochloride) Tablets

WARNING
Infrequent but serious gastrointestinal adverse events have been reported
with the use of LOTRONEX. These events, including ischemic colitis and serious
complications of constipation, have resulted in hospitalization, and rarely,
blood transfusion, surgery, and death.

The Prescribing Program for LOTRONEX™ was implemented to help reduce
risks of serious gastrointestinal adverse events. Only physicians who have
enrolled in based on their understanding of the benefits and risks, should
prescribe LOTRONEX (see PRECAUTIONS: Prescribing
Program for LOTRONEX).
LOTRONEX is indicated only for women with severe diarrhea-predominant
IBS who have not responded adequately to conventional therapy (see INDICATIONS
AND USAGE). Before receiving the initial prescription for LOTRONEX, the
patient must read and sign the Patient-Physician Agreement for LOTRONEX (see
PRECAUTIONS: Information for Patients).
LOTRONEX should be discontinued immediately in patients who develop constipation
or symptoms of ischemic colitis. Patients should immediately report constipation
or symptoms of ischemic colitis to their physician. LOTRONEX should not be
resumed in patients who develop ischemic colitis. Patients who have constipation
should immediately contact their physician if the constipation does not resolve
after LOTRONEX is discontinued. Patients with resolved constipation should
resume LOTRONEX only on the advice of their treating physician.


DRUG DESCRIPTION



What are the possible side effects of alosetron (Lotronex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking alosetron and call your doctor right away if you have any of these serious side effects:

new or worsening stomach pain;
bleeding from your rectum or blood in your stools; or
fast or uneven heartbeats.

Less serious side effects may include:

mild stomach discomfort,...
Read All Potential Side Effects for Lotronex »




The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl),
a potent and selective antagonist of the serotonin 5-HT3 receptor
type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one,
monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl,
representing a molecular weight of 330.8. Alosetron is a white to beige solid
that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid,
0.3 mg/mL in pH 6 phosphate buffer, and < 0.1 mg/mL in pH 8 phosphate buffer.
The chemical structure of alosetron is:








LOTRONEX Tablets are supplied for oral administration as 0.5-mg (white) and
1-mg (blue) tablets. The 0.5-mg tablet contains 0.562 mg alosetron HCl equivalent
to 0.5 mg alosetron and the 1-mg tablet contains 1.124 mg alosetron HCl equivalent
to 1 mg of alosetron. Each tablet also contains the inactive ingredients: lactose
(anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized
starch. The white film-coat for the 0.5-mg tablet contains hypromellose, titanium
dioxide, and triacetin. The blue film-coat for the 1-mg tablet contains hypromellose,
titanium dioxide, triacetin, and indigo carmine.Last reviewed on RxList: 5/16/2008




Lotronex Drug Description
LOTRONEX®
(alosetron hydrochloride) Tablets

WARNING
Infrequent but serious gastrointestinal adverse events have been reported
with the use of LOTRONEX. These events, including ischemic colitis and serious
complications of constipation, have resulted in hospitalization, and rarely,
blood transfusion, surgery, and death.

The Prescribing Program for LOTRONEX™ was implemented to help reduce
risks of serious gastrointestinal adverse events. Only physicians who have
enrolled in based on their understanding of the benefits and risks, should
prescribe LOTRONEX (see PRECAUTIONS: Prescribing
Program for LOTRONEX).
LOTRONEX is indicated only for women with severe diarrhea-predominant
IBS who have not responded adequately to conventional therapy (see INDICATIONS
AND USAGE). Before receiving the initial prescription for LOTRONEX, the
patient must read and sign the Patient-Physician Agreement for LOTRONEX (see
PRECAUTIONS: Information for Patients).
LOTRONEX should be discontinued immediately in patients who develop constipation
or symptoms of ischemic colitis. Patients should immediately report constipation
or symptoms of ischemic colitis to their physician. LOTRONEX should not be
resumed in patients who develop ischemic colitis. Patients who have constipation
should immediately contact their physician if the constipation does not resolve
after LOTRONEX is discontinued. Patients with resolved constipation should
resume LOTRONEX only on the advice of their treating physician.


DRUG DESCRIPTION



What are the possible side effects of alosetron (Lotronex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking alosetron and call your doctor right away if you have any of these serious side effects:

new or worsening stomach pain;
bleeding from your rectum or blood in your stools; or
fast or uneven heartbeats.

Less serious side effects may include:

mild stomach discomfort,...
Read All Potential Side Effects for Lotronex »




The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl),
a potent and selective antagonist of the serotonin 5-HT3 receptor
type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one,
monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl,
representing a molecular weight of 330.8. Alosetron is a white to beige solid
that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid,
0.3 mg/mL in pH 6 phosphate buffer, and < 0.1 mg/mL in pH 8 phosphate buffer.
The chemical structure of alosetron is:








LOTRONEX Tablets are supplied for oral administration as 0.5-mg (white) and
1-mg (blue) tablets. The 0.5-mg tablet contains 0.562 mg alosetron HCl equivalent
to 0.5 mg alosetron and the 1-mg tablet contains 1.124 mg alosetron HCl equivalent
to 1 mg of alosetron. Each tablet also contains the inactive ingredients: lactose
(anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized
starch. The white film-coat for the 0.5-mg tablet contains hypromellose, titanium
dioxide, and triacetin. The blue film-coat for the 1-mg tablet contains hypromellose,
titanium dioxide, triacetin, and indigo carmine.Last reviewed on RxList: 5/16/2008




Lotronex Drug Description
LOTRONEX®
(alosetron hydrochloride) Tablets

WARNING
Infrequent but serious gastrointestinal adverse events have been reported
with the use of LOTRONEX. These events, including ischemic colitis and serious
complications of constipation, have resulted in hospitalization, and rarely,
blood transfusion, surgery, and death.

The Prescribing Program for LOTRONEX™ was implemented to help reduce
risks of serious gastrointestinal adverse events. Only physicians who have
enrolled in based on their understanding of the benefits and risks, should
prescribe LOTRONEX (see PRECAUTIONS: Prescribing
Program for LOTRONEX).
LOTRONEX is indicated only for women with severe diarrhea-predominant
IBS who have not responded adequately to conventional therapy (see INDICATIONS
AND USAGE). Before receiving the initial prescription for LOTRONEX, the
patient must read and sign the Patient-Physician Agreement for LOTRONEX (see
PRECAUTIONS: Information for Patients).
LOTRONEX should be discontinued immediately in patients who develop constipation
or symptoms of ischemic colitis. Patients should immediately report constipation
or symptoms of ischemic colitis to their physician. LOTRONEX should not be
resumed in patients who develop ischemic colitis. Patients who have constipation
should immediately contact their physician if the constipation does not resolve
after LOTRONEX is discontinued. Patients with resolved constipation should
resume LOTRONEX only on the advice of their treating physician.


DRUG DESCRIPTION



What are the possible side effects of alosetron (Lotronex)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking alosetron and call your doctor right away if you have any of these serious side effects:

new or worsening stomach pain;
bleeding from your rectum or blood in your stools; or
fast or uneven heartbeats.

Less serious side effects may include:

mild stomach discomfort,...
Read All Potential Side Effects for Lotronex »




The active ingredient in LOTRONEX Tablets is alosetron hydrochloride (HCl),
a potent and selective antagonist of the serotonin 5-HT3 receptor
type. Chemically, alosetron is designated as 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one,
monohydrochloride. Alosetron is achiral and has the empirical formula: C17H18N4O•HCl,
representing a molecular weight of 330.8. Alosetron is a white to beige solid
that has a solubility of 61 mg/mL in water, 42 mg/mL in 0.1M hydrochloric acid,
0.3 mg/mL in pH 6 phosphate buffer, and < 0.1 mg/mL in pH 8 phosphate buffer.
The chemical structure of alosetron is:








LOTRONEX Tablets are supplied for oral administration as 0.5-mg (white) and
1-mg (blue) tablets. The 0.5-mg tablet contains 0.562 mg alosetron HCl equivalent
to 0.5 mg alosetron and the 1-mg tablet contains 1.124 mg alosetron HCl equivalent
to 1 mg of alosetron. Each tablet also contains the inactive ingredients: lactose
(anhydrous), magnesium stearate, microcrystalline cellulose, and pregelatinized
starch. The white film-coat for the 0.5-mg tablet contains hypromellose, titanium
dioxide, and triacetin. The blue film-coat for the 1-mg tablet contains hypromellose,
titanium dioxide, triacetin, and indigo carmine.Last reviewed on RxList: 5/16/2008





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Other reviews about Lotronex on web:

Lotronex is a medication that treats pain, urgency and frequency of bowel movements in women with severe diarrhea-predominant irritable bowel syndrome, IBS. Lotronex may reduce ... Lotronex.com | IBS medication for women with IBS-D symptoms


Accurate, FDA approved Lotronex information for healthcare professionals and patients - brought to you by Drugs.com. Lotronex Official FDA information, side effects and uses.


Learn about the prescription medication Lotronex (Alosetron Hydrochloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Lotronex (Alosetron Hydrochloride) Drug Information: Uses, Side ...


Alosetron (initial brand name: Lotronex; originator: GSK) is a 5-HT 3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. Alosetron - Wikipedia, the free encyclopedia


Lotronex is a medication that treats pain, urgency and frequency of bowel movements in women with severe diarrhea-predominant irritable bowel syndrome, IBS. Lotronex may reduce ... Lotronex.com | Lotronex is a medication for women with IBS-D


Lotronex (alosetron) is used to treat severe, chronic irritable bowel syndrome (IBS) in women. Includes Lotronex side effects, interactions and indications. Lotronex Information from Drugs.com


Read reviews of Lotronex for IBS, written by irritable bowel syndrome sufferers. Lotronex


Lotronex is a selective serotonin antagonist used to treat severe cases of irritable bowel syndrome (IBS) in women who have diarrhea as the main symptom. Side effects and ... Lotronex - drugstore.com. Low prices, side effects, interactions.


Answers to frequently asked questions about the drug Lotronex, used to treat Irritable Bowel Syndrome. Lotronex Frequently Asked Questions


Lotronex® is a prescription drug designed to treat the side effects of irritable bowel syndrome, including diarrhea and constipation. Consult a Lotronex® attorney to learn more ... Defective Drugs - Lotronex® Lawsuits - Side Effects and FDA Recall





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