Reviews Itraconazole Injection


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Sporanox Injection Drug Description
SPORANOX®
(itraconazole) Injection


Congestive Heart Failure: When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
If signs or symptoms of congestive heart failure occur during administration
of SPORANOX® (itraconazole) Injection, continued SPORANOX® use should
be reassessed. (See CLINICAL PHARMACOLOGY:
Special Populations, CONTRAINDICATIONS,
WARNINGS, PRECAUTIONS: DRUG
INTERACTIONS and ADVERSE REACTIONS:
Post-marketing Experience for more information.) Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated. SPORANOX®, a potent
cytochrome P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma
concentrations of drugs metabolized by this pathway. Serious cardiovascular
events, including QT prolongation, torsades de pointes, ventricular tachycardia,
cardiac arrest, and/or sudden death have occurred in patients using cisapride,
pimozide, levacetylmethadol (levomethadyl), or quinidine concomitantly with
SPORANOX® and/or other CYP3A4 inhibitors. (See CONTRAINDICATIONS,
WARNINGS, and PRECAUTIONS: DRUG
INTERACTIONS for more information.)

DRUG DESCRIPTION
For intravenous infusion (NOT FOR IV BOLUS INJECTION)
SPORANOX® is the brand name for itraconazole, a synthetic
triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four
diastereomers (two enantiomeric pairs), each possessing three chiral centers.
It may be represented by the following structural formula and nomenclature:









(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2
1,2,4-triazolin-5-one mixture with
(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
Itraconazole has a molecular formula of C35H38Cl2N8O4 and a
molecular weight of 705.64. It is a white to slightly yellowish powder. It is
insoluble in water, very slightly soluble in alcohols, and freely soluble in
dichloromethane. It has a pKa of  3.70 (based on extrapolation of values
obtained from methanolic solutions) and a log (n-octanol/water) partition
coefficient of 5.66 at pH 8.1.
SPORANOX® (itraconazole) Injection is a sterile pyrogen-free
clear, colorless to slightly yellow solution for intravenous infusion. Each mL
contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin
(400 mg) as a molecular inclusion complex, with 3.8 μL hydrochloric acid,
25 μL propylene glycol, and sodium hydroxide for pH adjustment to 4.5, in
water for injection. SPORANOX® Injection is packaged in 25 mL colorless glass
ampules, containing 250 mg of itraconazole, contents of which are diluted in 50
mL 0.9% Sodium Chloride Injection, USP (Normal Saline) prior to infusion. When
properly administered, contents of one ampule will supply 200 mg of
itraconazole.Last reviewed on RxList: 5/18/2009




Sporanox Injection Drug Description
SPORANOX®
(itraconazole) Injection


Congestive Heart Failure: When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
If signs or symptoms of congestive heart failure occur during administration
of SPORANOX® (itraconazole) Injection, continued SPORANOX® use should
be reassessed. (See CLINICAL PHARMACOLOGY:
Special Populations, CONTRAINDICATIONS,
WARNINGS, PRECAUTIONS: DRUG
INTERACTIONS and ADVERSE REACTIONS:
Post-marketing Experience for more information.) Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated. SPORANOX®, a potent
cytochrome P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma
concentrations of drugs metabolized by this pathway. Serious cardiovascular
events, including QT prolongation, torsades de pointes, ventricular tachycardia,
cardiac arrest, and/or sudden death have occurred in patients using cisapride,
pimozide, levacetylmethadol (levomethadyl), or quinidine concomitantly with
SPORANOX® and/or other CYP3A4 inhibitors. (See CONTRAINDICATIONS,
WARNINGS, and PRECAUTIONS: DRUG
INTERACTIONS for more information.)

DRUG DESCRIPTION
For intravenous infusion (NOT FOR IV BOLUS INJECTION)
SPORANOX® is the brand name for itraconazole, a synthetic
triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four
diastereomers (two enantiomeric pairs), each possessing three chiral centers.
It may be represented by the following structural formula and nomenclature:









(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2
1,2,4-triazolin-5-one mixture with
(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
Itraconazole has a molecular formula of C35H38Cl2N8O4 and a
molecular weight of 705.64. It is a white to slightly yellowish powder. It is
insoluble in water, very slightly soluble in alcohols, and freely soluble in
dichloromethane. It has a pKa of  3.70 (based on extrapolation of values
obtained from methanolic solutions) and a log (n-octanol/water) partition
coefficient of 5.66 at pH 8.1.
SPORANOX® (itraconazole) Injection is a sterile pyrogen-free
clear, colorless to slightly yellow solution for intravenous infusion. Each mL
contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin
(400 mg) as a molecular inclusion complex, with 3.8 μL hydrochloric acid,
25 μL propylene glycol, and sodium hydroxide for pH adjustment to 4.5, in
water for injection. SPORANOX® Injection is packaged in 25 mL colorless glass
ampules, containing 250 mg of itraconazole, contents of which are diluted in 50
mL 0.9% Sodium Chloride Injection, USP (Normal Saline) prior to infusion. When
properly administered, contents of one ampule will supply 200 mg of
itraconazole.Last reviewed on RxList: 5/18/2009




Sporanox Injection Drug Description
SPORANOX®
(itraconazole) Injection


Congestive Heart Failure: When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
If signs or symptoms of congestive heart failure occur during administration
of SPORANOX® (itraconazole) Injection, continued SPORANOX® use should
be reassessed. (See CLINICAL PHARMACOLOGY:
Special Populations, CONTRAINDICATIONS,
WARNINGS, PRECAUTIONS: DRUG
INTERACTIONS and ADVERSE REACTIONS:
Post-marketing Experience for more information.) Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated. SPORANOX®, a potent
cytochrome P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma
concentrations of drugs metabolized by this pathway. Serious cardiovascular
events, including QT prolongation, torsades de pointes, ventricular tachycardia,
cardiac arrest, and/or sudden death have occurred in patients using cisapride,
pimozide, levacetylmethadol (levomethadyl), or quinidine concomitantly with
SPORANOX® and/or other CYP3A4 inhibitors. (See CONTRAINDICATIONS,
WARNINGS, and PRECAUTIONS: DRUG
INTERACTIONS for more information.)

DRUG DESCRIPTION
For intravenous infusion (NOT FOR IV BOLUS INJECTION)
SPORANOX® is the brand name for itraconazole, a synthetic
triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four
diastereomers (two enantiomeric pairs), each possessing three chiral centers.
It may be represented by the following structural formula and nomenclature:









(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2
1,2,4-triazolin-5-one mixture with
(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
Itraconazole has a molecular formula of C35H38Cl2N8O4 and a
molecular weight of 705.64. It is a white to slightly yellowish powder. It is
insoluble in water, very slightly soluble in alcohols, and freely soluble in
dichloromethane. It has a pKa of  3.70 (based on extrapolation of values
obtained from methanolic solutions) and a log (n-octanol/water) partition
coefficient of 5.66 at pH 8.1.
SPORANOX® (itraconazole) Injection is a sterile pyrogen-free
clear, colorless to slightly yellow solution for intravenous infusion. Each mL
contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin
(400 mg) as a molecular inclusion complex, with 3.8 μL hydrochloric acid,
25 μL propylene glycol, and sodium hydroxide for pH adjustment to 4.5, in
water for injection. SPORANOX® Injection is packaged in 25 mL colorless glass
ampules, containing 250 mg of itraconazole, contents of which are diluted in 50
mL 0.9% Sodium Chloride Injection, USP (Normal Saline) prior to infusion. When
properly administered, contents of one ampule will supply 200 mg of
itraconazole.Last reviewed on RxList: 5/18/2009




Sporanox Injection Drug Description
SPORANOX®
(itraconazole) Injection


Congestive Heart Failure: When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
If signs or symptoms of congestive heart failure occur during administration
of SPORANOX® (itraconazole) Injection, continued SPORANOX® use should
be reassessed. (See CLINICAL PHARMACOLOGY:
Special Populations, CONTRAINDICATIONS,
WARNINGS, PRECAUTIONS: DRUG
INTERACTIONS and ADVERSE REACTIONS:
Post-marketing Experience for more information.) Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated. SPORANOX®, a potent
cytochrome P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma
concentrations of drugs metabolized by this pathway. Serious cardiovascular
events, including QT prolongation, torsades de pointes, ventricular tachycardia,
cardiac arrest, and/or sudden death have occurred in patients using cisapride,
pimozide, levacetylmethadol (levomethadyl), or quinidine concomitantly with
SPORANOX® and/or other CYP3A4 inhibitors. (See CONTRAINDICATIONS,
WARNINGS, and PRECAUTIONS: DRUG
INTERACTIONS for more information.)

DRUG DESCRIPTION
For intravenous infusion (NOT FOR IV BOLUS INJECTION)
SPORANOX® is the brand name for itraconazole, a synthetic
triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four
diastereomers (two enantiomeric pairs), each possessing three chiral centers.
It may be represented by the following structural formula and nomenclature:









(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2
1,2,4-triazolin-5-one mixture with
(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
Itraconazole has a molecular formula of C35H38Cl2N8O4 and a
molecular weight of 705.64. It is a white to slightly yellowish powder. It is
insoluble in water, very slightly soluble in alcohols, and freely soluble in
dichloromethane. It has a pKa of  3.70 (based on extrapolation of values
obtained from methanolic solutions) and a log (n-octanol/water) partition
coefficient of 5.66 at pH 8.1.
SPORANOX® (itraconazole) Injection is a sterile pyrogen-free
clear, colorless to slightly yellow solution for intravenous infusion. Each mL
contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin
(400 mg) as a molecular inclusion complex, with 3.8 μL hydrochloric acid,
25 μL propylene glycol, and sodium hydroxide for pH adjustment to 4.5, in
water for injection. SPORANOX® Injection is packaged in 25 mL colorless glass
ampules, containing 250 mg of itraconazole, contents of which are diluted in 50
mL 0.9% Sodium Chloride Injection, USP (Normal Saline) prior to infusion. When
properly administered, contents of one ampule will supply 200 mg of
itraconazole.Last reviewed on RxList: 5/18/2009




Sporanox Injection Drug Description
SPORANOX®
(itraconazole) Injection


Congestive Heart Failure: When itraconazole was administered intravenously
to dogs and healthy human volunteers, negative inotropic effects were seen.
If signs or symptoms of congestive heart failure occur during administration
of SPORANOX® (itraconazole) Injection, continued SPORANOX® use should
be reassessed. (See CLINICAL PHARMACOLOGY:
Special Populations, CONTRAINDICATIONS,
WARNINGS, PRECAUTIONS: DRUG
INTERACTIONS and ADVERSE REACTIONS:
Post-marketing Experience for more information.) Drug Interactions: Coadministration of cisapride, pimozide, quinidine, dofetilide,
or levacetylmethadol (levomethadyl) with SPORANOX® (itraconazole) Capsules,
Injection or Oral Solution is contraindicated. SPORANOX®, a potent
cytochrome P450 3A4 isoenzyme system (CYP3A4) inhibitor, may increase plasma
concentrations of drugs metabolized by this pathway. Serious cardiovascular
events, including QT prolongation, torsades de pointes, ventricular tachycardia,
cardiac arrest, and/or sudden death have occurred in patients using cisapride,
pimozide, levacetylmethadol (levomethadyl), or quinidine concomitantly with
SPORANOX® and/or other CYP3A4 inhibitors. (See CONTRAINDICATIONS,
WARNINGS, and PRECAUTIONS: DRUG
INTERACTIONS for more information.)

DRUG DESCRIPTION
For intravenous infusion (NOT FOR IV BOLUS INJECTION)
SPORANOX® is the brand name for itraconazole, a synthetic
triazole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four
diastereomers (two enantiomeric pairs), each possessing three chiral centers.
It may be represented by the following structural formula and nomenclature:









(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2
1,2,4-triazolin-5-one mixture with
(±)-1-[(R*)-sec-butyl]-4-[p-[4-[p-[[(2S*,4R*)-2(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
or
(±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-
Δ2-1,2,4-triazolin-5-one.
Itraconazole has a molecular formula of C35H38Cl2N8O4 and a
molecular weight of 705.64. It is a white to slightly yellowish powder. It is
insoluble in water, very slightly soluble in alcohols, and freely soluble in
dichloromethane. It has a pKa of  3.70 (based on extrapolation of values
obtained from methanolic solutions) and a log (n-octanol/water) partition
coefficient of 5.66 at pH 8.1.
SPORANOX® (itraconazole) Injection is a sterile pyrogen-free
clear, colorless to slightly yellow solution for intravenous infusion. Each mL
contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin
(400 mg) as a molecular inclusion complex, with 3.8 μL hydrochloric acid,
25 μL propylene glycol, and sodium hydroxide for pH adjustment to 4.5, in
water for injection. SPORANOX® Injection is packaged in 25 mL colorless glass
ampules, containing 250 mg of itraconazole, contents of which are diluted in 50
mL 0.9% Sodium Chloride Injection, USP (Normal Saline) prior to infusion. When
properly administered, contents of one ampule will supply 200 mg of
itraconazole.Last reviewed on RxList: 5/18/2009





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Other reviews about Itraconazole Injection on web:

Learn about the prescription medication Sporanox Injection (Itraconazole Injection), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling. Sporanox Injection (Itraconazole Injection) Drug Information: Uses ...


You should not receive itraconazole if you are taking an ergot medicine such as ... Make sure you understand all instructions before giving yourself an injection. Kelsey-Seybold Clinic - Welcome


You should not receive itraconazole if you are taking an ergot medicine such as ... Make sure you understand all instructions before giving yourself an injection. Health Library


Itraconazole Injection. 17 October 2007. Products Affected - Description. Sporanox Injection (NDC 50458-0298-01), Ortho Biotech. Reason for the Shortage Bulletin


Learn all about Itraconazole (Injection). Treats fungal infections. This medicine is an antifungal antibiotic. The manufacturer stopped making this medicine in late 2007. This ... Itraconazole (Injection) - Drug Information


SPORANOX ® (itraconazole) INJECTION Congestive Heart Failure: When itraconazole was administered intravenously to dogs and healthy human volunteers, negative inotropic effects were seen SPORANOX (itraconazole) Injection


Itraconazole capsules (below) Itraconazole Oral capsule; Itraconazole Oral solution; Itraconazole Solution for injection; Español: Cápsulas de itraconazol itraconazole: Definition from Answers.com


BOX WARNING. Congestive Heart Failure: When itraconazole was administered intravenously to dogs and healthy human volunteers, negative inotropic effects were seen. Sporanox Injection (Itraconazole Injection) - Drug Info, Side ...


Treats fungal infections. This medicine is an antifungal antibiotic. The manufacturer stopped making this medicine in late 2007. This decision was not due to safety problems. Allina Hospitals & Clinics - Itraconazole (Injection)


Overview Introduction Brand Name(s) When This Medicine Should Not Be Used How to Use This Medicine How to Store and Dispose of This Medicine Drugs and Foods to Avoid Warnings ... Itraconazole (Injection)





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