Reviews Histrelin Acetate Subcutaneous Implant


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Supprelin LA Drug Description
Supprelin LA
(histrelin acetate) Subcutaneous Implant
DRUG DESCRIPTION



What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding...
Read All Potential Side Effects for Supprelin LA »




Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic
nonapeptide analog of the naturally occurring gonadotropin releasing hormone
(GnRH) that possesses a greater potency than the natural sequence hormone. The
chemical name of histrelin acetate is:
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline
Nethylamide, acetate salt.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and
its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also
chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
diacetate. The chemical structure of the free base (histrelin) is represented
below in Figure 1.
Figure 1. Structure of histrelin







The Supprelin LA implant looks like a small thin flexible tube. The sterile
implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable,
3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).
Figure 2. Histrelin Implant diagram (not to scale)







The drug core also contains the inactive ingredient stearic acid NF. The hydrogel
reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl
methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16,
and Triton X-100. Each hydrated implant is packaged in a glass vial containing
2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate
release of the drug upon insertion. The 3.5 mL Type I clear glass vial with
the implant is closed with a pre-treated grey Teflon coated stopper and sealed
with an aluminum crimp seal.
A single use sterile insertion tool (Trocar) is to be used with Supprelin LA.
The insertion tool is enclosed in a sterile bag as part of the implantation
kit.Last reviewed on RxList: 8/5/2008




Supprelin LA Drug Description
Supprelin LA
(histrelin acetate) Subcutaneous Implant
DRUG DESCRIPTION



What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding...
Read All Potential Side Effects for Supprelin LA »




Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic
nonapeptide analog of the naturally occurring gonadotropin releasing hormone
(GnRH) that possesses a greater potency than the natural sequence hormone. The
chemical name of histrelin acetate is:
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline
Nethylamide, acetate salt.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and
its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also
chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
diacetate. The chemical structure of the free base (histrelin) is represented
below in Figure 1.
Figure 1. Structure of histrelin







The Supprelin LA implant looks like a small thin flexible tube. The sterile
implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable,
3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).
Figure 2. Histrelin Implant diagram (not to scale)







The drug core also contains the inactive ingredient stearic acid NF. The hydrogel
reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl
methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16,
and Triton X-100. Each hydrated implant is packaged in a glass vial containing
2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate
release of the drug upon insertion. The 3.5 mL Type I clear glass vial with
the implant is closed with a pre-treated grey Teflon coated stopper and sealed
with an aluminum crimp seal.
A single use sterile insertion tool (Trocar) is to be used with Supprelin LA.
The insertion tool is enclosed in a sterile bag as part of the implantation
kit.Last reviewed on RxList: 8/5/2008




Supprelin LA Drug Description
Supprelin LA
(histrelin acetate) Subcutaneous Implant
DRUG DESCRIPTION



What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding...
Read All Potential Side Effects for Supprelin LA »




Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic
nonapeptide analog of the naturally occurring gonadotropin releasing hormone
(GnRH) that possesses a greater potency than the natural sequence hormone. The
chemical name of histrelin acetate is:
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline
Nethylamide, acetate salt.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and
its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also
chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
diacetate. The chemical structure of the free base (histrelin) is represented
below in Figure 1.
Figure 1. Structure of histrelin







The Supprelin LA implant looks like a small thin flexible tube. The sterile
implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable,
3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).
Figure 2. Histrelin Implant diagram (not to scale)







The drug core also contains the inactive ingredient stearic acid NF. The hydrogel
reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl
methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16,
and Triton X-100. Each hydrated implant is packaged in a glass vial containing
2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate
release of the drug upon insertion. The 3.5 mL Type I clear glass vial with
the implant is closed with a pre-treated grey Teflon coated stopper and sealed
with an aluminum crimp seal.
A single use sterile insertion tool (Trocar) is to be used with Supprelin LA.
The insertion tool is enclosed in a sterile bag as part of the implantation
kit.Last reviewed on RxList: 8/5/2008




Supprelin LA Drug Description
Supprelin LA
(histrelin acetate) Subcutaneous Implant
DRUG DESCRIPTION



What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding...
Read All Potential Side Effects for Supprelin LA »




Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic
nonapeptide analog of the naturally occurring gonadotropin releasing hormone
(GnRH) that possesses a greater potency than the natural sequence hormone. The
chemical name of histrelin acetate is:
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline
Nethylamide, acetate salt.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and
its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also
chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
diacetate. The chemical structure of the free base (histrelin) is represented
below in Figure 1.
Figure 1. Structure of histrelin







The Supprelin LA implant looks like a small thin flexible tube. The sterile
implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable,
3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).
Figure 2. Histrelin Implant diagram (not to scale)







The drug core also contains the inactive ingredient stearic acid NF. The hydrogel
reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl
methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16,
and Triton X-100. Each hydrated implant is packaged in a glass vial containing
2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate
release of the drug upon insertion. The 3.5 mL Type I clear glass vial with
the implant is closed with a pre-treated grey Teflon coated stopper and sealed
with an aluminum crimp seal.
A single use sterile insertion tool (Trocar) is to be used with Supprelin LA.
The insertion tool is enclosed in a sterile bag as part of the implantation
kit.Last reviewed on RxList: 8/5/2008




Supprelin LA Drug Description
Supprelin LA
(histrelin acetate) Subcutaneous Implant
DRUG DESCRIPTION



What are the possible side effects of histrelin (Supprelin LA, Vantas)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating more or less than usual, or not at all;
fast or pounding...
Read All Potential Side Effects for Supprelin LA »




Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic
nonapeptide analog of the naturally occurring gonadotropin releasing hormone
(GnRH) that possesses a greater potency than the natural sequence hormone. The
chemical name of histrelin acetate is:
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline
Nethylamide, acetate salt.
The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and
its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also
chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-Lseryl- L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
diacetate. The chemical structure of the free base (histrelin) is represented
below in Figure 1.
Figure 1. Structure of histrelin







The Supprelin LA implant looks like a small thin flexible tube. The sterile
implant consists of a 50-mg histrelin acetate drug core inside a non-biodegradable,
3.5 cm by 3 mm, cylindrical hydrogel reservoir (Figure 2).
Figure 2. Histrelin Implant diagram (not to scale)







The drug core also contains the inactive ingredient stearic acid NF. The hydrogel
reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl
methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16,
and Triton X-100. Each hydrated implant is packaged in a glass vial containing
2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate
release of the drug upon insertion. The 3.5 mL Type I clear glass vial with
the implant is closed with a pre-treated grey Teflon coated stopper and sealed
with an aluminum crimp seal.
A single use sterile insertion tool (Trocar) is to be used with Supprelin LA.
The insertion tool is enclosed in a sterile bag as part of the implantation
kit.Last reviewed on RxList: 8/5/2008





Other reviews about Histrelin Acetate Subcutaneous Implant on web:

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with ... A 12-month subcutaneous implant (Supprelin LA) for central precocious puberty (CPP) was ... Histrelin - Wikipedia, the free encyclopedia


Histrelin acetate (Subcutaneous route) ... After the implant is put in place, you or your child should keep the arm clean ... Histrelin acetate (Subcutaneous route)


Histrelin Acetate professional patient advice. Specific and up to date information about ... Apparent Cl after a 50 mg subcutaneous implant is approximately 174 mL/min. Complete Histrelin Acetate information from Drugs.com


Learn about the prescription medication Supprelin LA (Histrelin Acetate Subcutaneous Implant), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Supprelin LA (Histrelin Acetate Subcutaneous Implant) Drug ...


... reservoir drug delivery system designed to deliver histrelin continuously for 12 months upon subcutaneous implantation. The Vantas implant contains 50 mg of histrelin acetate. Vantas (Histrelin Implant) - Drug Info, Side Effects, Research ...


Supprelin® LA (histrelin acetate) subcutaneous implant label. Retrieved April 17, 2009 from http://www.fda.gov/cder/foi/appletter/2008/022058s003ltr.pdf. Histrelin Acetate Implant


Supprelin LA (histrelin acetate) subcutaneous implant Initial U.S. Approval: 2007-----INDICATIONS AND USAGE-----Supprelin LA is a gonadotropin ... HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not ...


Histrelin acetate is not active when given orally. PHARMACOKINETICS Absorption: Following subcutaneous insertion of one Vantas (histrelin implant) 50 mg implant in advanced prostate ... Vantas™ ( histrelin implant ) PACKAGE INSERT


histrelin acetate (Subcutaneous route) Commonly used brand name(s): In the ... at regular visits to ensure histrelin implant is in place and functioning in your body. histrelin acetate may ... histrelin acetate Subcutaneous consumer information from Drugs.com


Histrelin acetate is not active when given orally. PHARMACOKINETICS. Absorption: Following subcutaneous insertion of one Vantas (histrelin implant) 50 mg implant in advanced prostate ... Vantas (Histrelin Implant) - Description and Clinical Pharmacology





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