Reviews Fludarabine


No reviews yet.

Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010





Other reviews about Fludarabine on wordpress

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On Monday I had noticed a slight swelling and tenderness in a lymph under my jaw. By Tuesday it was a little worse. On Wednesday morning it was […]


Fludarabine Compared With Chlorambucil As Primary Therapy For CLL
  by blackjava
By Lynn Haley Special to DG News VANCOUVER, CANADA -- March 18, 2001 -- Fludarabine has a greater response rate than chlorambucil for patients with chronic lymphocytic leukemia, as […]


Antisoma sells rights to oral fludarabine to sanofi-aventis
  by silico
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GlaxoSmithKline and Genmab A/S have announced the accelerated approval of Arzerra from the FDA for use in patients with chronic lymphocytic leukemia that is refractory to fludarabine and […]


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Trusting Evidence
  by colin perrott
WHEN CAN WE TRUST WHAT WE READ or are TOLD? The Cochrane Collaboration is a prestigious resource for reviews of clinical trials and statistical information. One Cochrane Review abstract […]


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When Denise was diagnosed with Chronic Lymphocytic Leukemia (CLL) in 2004, she was told the disease would progress slowly — she didn't need immediate treatment. But, instead of […]



Other reviews about Fludarabine on web:

Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine - Wikipedia, the free encyclopedia


Fludarabine is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as an antimetabolite. Fludara Fludarabine, Fludara - Chemotherapy Drugs, Chemo Drug Side Effects


Accurate, FDA approved Fludarabine information for healthcare professionals and patients - brought to you by Drugs.com. Fludarabine Official FDA information, side effects and uses.


Fludarabine Key Terms: Anemia , Chemotherapy , Deoxynucleic acid , Electrolytes , Food and Drug Administration , Gout , Intravenous , Neutropenia Fludarabine: Information from Answers.com


All about Fludarabine Tablets. View complete and up to date Fludarabine information - part of the Drugs.com trusted medication database. Fludarabine Tablets Facts and Comparisons at Drugs.com


Learn about the prescription medication Fludara (Fludarabine), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Fludara (Fludarabine) Drug Information: Uses, Side Effects, Drug ...


Mayo Clinic offers award-winning medical and health information and tools for healthy living. Fludarabine (Intravenous Route) - MayoClinic.com


CLL Topics - Patients dedicated to the fight against chronic lymphocytic leukemia - Therapies, Research and Patient Education CLL Topics: Fludarabine


Fludarabine is a cancer (antineoplastic) medication. Fludarabine interferes with the growth of cancer cells and slows their growth and spread in the body. Fludarabine


Revised: 01 Feb 2007 SYNONYM(S): 9-B-D-arabinofuranosyl-2-fluoroadenine 5’-monophosphate, 1 FAMP, 2,3 2-fluoro-ara-A Monophosphate, 3 2-fluoro-ara-AMP, 1,3 fludarabine phosphate, 1 NSC ... Fludarabine : BC Cancer Agency





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