Reviews Fludara


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Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010




Fludara Drug Description
Fludara®
(fludarabine phosphate) for Injection

WARNING
FLUDARA FOR INJECTION should be administered under the supervision of a qualified
physician experienced in the use of antineoplastic therapy. FLUDARA FOR INJECTION
can severely suppress bone marrow function. When used at high doses in doseranging
studies in patients with acute leukemia, FLUDARA FOR INJECTION was associated
with severe neurologic effects, including blindness, coma, and death. This severe
central nervous system toxicity occurred in 36% of patients treated with doses
approximately four times greater (96 mg/m²/day for 5-7 days) than the recommended
dose. Similar severe central nervous system toxicity, including coma, seizures,
agitation and confusion, has been reported in patients treated at doses in the
range of the dose recommended for chronic lymphocytic leukemia.
Instances of life-threatening and sometimes fatal autoimmune phenomena such
as hemolytic anemia, autoimmune thrombocytopenia/thrombocytopenic purpura (ITP),
Evans syndrome, and acquired hemophilia have been reported to occur after one
or more cycles of treatment with FLUDARA FOR INJECTION. Patients undergoing
treatment with FLUDARA FOR INJECTION should be evaluated and closely monitored
for hemolysis.
In a clinical investigation using FLUDARA FOR INJECTION in combination with
pentostatin (deoxycoformycin) for the treatment of refractory chronic lymphocytic
leukemia (CLL), there was an unacceptably high incidence of fatal pulmonary
toxicity. Therefore, the use of FLUDARA FOR INJECTION in combination with pentostatin
is not recommended.

DRUG DESCRIPTION



What are the possible side effects of fludarabine (Fludara)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness;
pale or yellowed skin, dark colored urine;
...
Read All Potential Side Effects for Fludara »




FLUDARA FOR INJECTION contains fludarabine phosphate, a fluorinated nucleotide
analog of the antiviral agent vidarabine, 9-p-D-arabinofuranosyladenine (ara-A)
that is relatively resistant to deamination by adenosine deaminase. Each vial
of sterile lyophilized solid cake contains 50 mg of the active ingredient fludarabine
phosphate, 50 mg of mannitol, and sodium hydroxide to adjust pH to 7.7. The
pH range for the final product is 7.2-8.2. Reconstitution with 2 mL of Sterile
Water for Injection, USP, results in a solution containing 25 mg/mL of fludarabine
phosphate intended for intravenous administration.
The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-
0-D-arabino-furanosyl) (2-fluoro-ara-AMP). The molecular formula of fludarabine
phosphate is C10H13FN5O7P (MW 365.2)
and the structure is:







Last reviewed on RxList: 8/18/2010





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Other reviews about Fludara on web:

Accurate, FDA approved Fludara information for healthcare professionals and patients - brought to you by Drugs.com. Fludara Official FDA information, side effects and uses.


Learn about the prescription medication Fludara (Fludarabine), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Fludara (Fludarabine) Drug Information: Uses, Side Effects, Drug ...


Fludara is the trade name for Fludarabine. Fludara is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as an antimetabolite. Fludara, Fludarabine - Chemotherapy Drugs, Chemo Drug Side Effects


Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine - Wikipedia, the free encyclopedia


Fludara (fludarabine) patient information. Detailed drug information for the consumer, includes dosage, Fludara side effects and more. Fludara consumer information from Drugs.com


Consumer information about the medication FLUDARABINE - INJECTION (Fludara), includes side effects, drug interactions, recommended dosages, and storage information. Read more ... FLUDARABINE - INJECTION (Fludara) side effects, medical uses, and ...


Buy Fludara (Fludrabine) from our Canadian Online Pharmacy by calling 1-877-888-3562. Fully licensed, fast delivery, free doctor consultation provided. Buy Fludara (Fludrabine) Online Now


Find patient medical information for Fludara IV on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Fludara IV : Uses, Side Effects, Interactions, Pictures, Warnings ...


Fludara (fludarabine) is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine is a purine analog, and can b... Fludara: 16 user reviews - DailyStrength


1 Fludara ® 1 (fludarabine phosphate) 2 FOR INJECTION 3 FOR INTRAVENOUS USE ONLY 4 Rx Only 5 WARNING: FLUDARA FOR INJECTION should be administered under the supervision of a 6 ... Fludara USPI 21009





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