Reviews Droperidol


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Inapsine Drug Description
INAPSINE®
(droperidol) Injection
For intravenous or intramuscular use only

WARNING
Cases of QT prolongation and/or torsade de pointes have been reported in
patients receiving Inapsine at doses at or below recommended doses. Some cases
have occurred in patients with no known risk factors for QT prolongation and
some cases have been fatal.
Due to its potential for serious proarrhythmic effects and death, INAPSINE
should be reserved for use in the treatment of patients who fail to show an
acceptable response to other adequate treatments, either because of insufficient
effectiveness or the inability to achieve an effective dose due to intolerable
adverse effects from those drugs (see WARNINGS,
ADVERSE REACTIONS, CONTRAINDICATIONS,
and PRECAUTIONS).
Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with INAPSINE. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of INAPSINE to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, INAPSINE should NOT be administered. For patients in whom the potential benefit of INAPSINE treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.
INAPSINE is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome.
INAPSINE should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.

DRUG DESCRIPTION



What are the possible side effects of droperidol (Inapsine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:

feeling like you might pass out;
dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;
chest tightness and trouble breathing;
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
...
Read All Potential Side Effects for Inapsine »




INAPSINE contains droperidol, a neuroleptic (tranquilizer) agent. Inapsine
(droperidol) Injection is available in ampoules and vials. Each milliliter contains
2.5 mg of droperidol in an aqueous solution adjusted to pH 3.4 ± 0.4 with lactic
acid. Droperidol is chemically identified as 1-(1-[3-(p-fluorobenzoyl) propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
with a molecular weight of 379.43. The structural formula of droperidol is:








Molecular formula: C22H22FN3O2,
partition coefficient in n-octanol: water: 3.46, pKa: 7.46
INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection.Last reviewed on RxList: 6/5/2008




Inapsine Drug Description
INAPSINE®
(droperidol) Injection
For intravenous or intramuscular use only

WARNING
Cases of QT prolongation and/or torsade de pointes have been reported in
patients receiving Inapsine at doses at or below recommended doses. Some cases
have occurred in patients with no known risk factors for QT prolongation and
some cases have been fatal.
Due to its potential for serious proarrhythmic effects and death, INAPSINE
should be reserved for use in the treatment of patients who fail to show an
acceptable response to other adequate treatments, either because of insufficient
effectiveness or the inability to achieve an effective dose due to intolerable
adverse effects from those drugs (see WARNINGS,
ADVERSE REACTIONS, CONTRAINDICATIONS,
and PRECAUTIONS).
Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with INAPSINE. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of INAPSINE to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, INAPSINE should NOT be administered. For patients in whom the potential benefit of INAPSINE treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.
INAPSINE is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome.
INAPSINE should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.

DRUG DESCRIPTION



What are the possible side effects of droperidol (Inapsine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:

feeling like you might pass out;
dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;
chest tightness and trouble breathing;
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
...
Read All Potential Side Effects for Inapsine »




INAPSINE contains droperidol, a neuroleptic (tranquilizer) agent. Inapsine
(droperidol) Injection is available in ampoules and vials. Each milliliter contains
2.5 mg of droperidol in an aqueous solution adjusted to pH 3.4 ± 0.4 with lactic
acid. Droperidol is chemically identified as 1-(1-[3-(p-fluorobenzoyl) propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
with a molecular weight of 379.43. The structural formula of droperidol is:








Molecular formula: C22H22FN3O2,
partition coefficient in n-octanol: water: 3.46, pKa: 7.46
INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection.Last reviewed on RxList: 6/5/2008




Inapsine Drug Description
INAPSINE®
(droperidol) Injection
For intravenous or intramuscular use only

WARNING
Cases of QT prolongation and/or torsade de pointes have been reported in
patients receiving Inapsine at doses at or below recommended doses. Some cases
have occurred in patients with no known risk factors for QT prolongation and
some cases have been fatal.
Due to its potential for serious proarrhythmic effects and death, INAPSINE
should be reserved for use in the treatment of patients who fail to show an
acceptable response to other adequate treatments, either because of insufficient
effectiveness or the inability to achieve an effective dose due to intolerable
adverse effects from those drugs (see WARNINGS,
ADVERSE REACTIONS, CONTRAINDICATIONS,
and PRECAUTIONS).
Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with INAPSINE. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of INAPSINE to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, INAPSINE should NOT be administered. For patients in whom the potential benefit of INAPSINE treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.
INAPSINE is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome.
INAPSINE should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.

DRUG DESCRIPTION



What are the possible side effects of droperidol (Inapsine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:

feeling like you might pass out;
dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;
chest tightness and trouble breathing;
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
...
Read All Potential Side Effects for Inapsine »




INAPSINE contains droperidol, a neuroleptic (tranquilizer) agent. Inapsine
(droperidol) Injection is available in ampoules and vials. Each milliliter contains
2.5 mg of droperidol in an aqueous solution adjusted to pH 3.4 ± 0.4 with lactic
acid. Droperidol is chemically identified as 1-(1-[3-(p-fluorobenzoyl) propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
with a molecular weight of 379.43. The structural formula of droperidol is:








Molecular formula: C22H22FN3O2,
partition coefficient in n-octanol: water: 3.46, pKa: 7.46
INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection.Last reviewed on RxList: 6/5/2008




Inapsine Drug Description
INAPSINE®
(droperidol) Injection
For intravenous or intramuscular use only

WARNING
Cases of QT prolongation and/or torsade de pointes have been reported in
patients receiving Inapsine at doses at or below recommended doses. Some cases
have occurred in patients with no known risk factors for QT prolongation and
some cases have been fatal.
Due to its potential for serious proarrhythmic effects and death, INAPSINE
should be reserved for use in the treatment of patients who fail to show an
acceptable response to other adequate treatments, either because of insufficient
effectiveness or the inability to achieve an effective dose due to intolerable
adverse effects from those drugs (see WARNINGS,
ADVERSE REACTIONS, CONTRAINDICATIONS,
and PRECAUTIONS).
Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with INAPSINE. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of INAPSINE to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, INAPSINE should NOT be administered. For patients in whom the potential benefit of INAPSINE treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.
INAPSINE is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome.
INAPSINE should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.

DRUG DESCRIPTION



What are the possible side effects of droperidol (Inapsine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:

feeling like you might pass out;
dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;
chest tightness and trouble breathing;
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
...
Read All Potential Side Effects for Inapsine »




INAPSINE contains droperidol, a neuroleptic (tranquilizer) agent. Inapsine
(droperidol) Injection is available in ampoules and vials. Each milliliter contains
2.5 mg of droperidol in an aqueous solution adjusted to pH 3.4 ± 0.4 with lactic
acid. Droperidol is chemically identified as 1-(1-[3-(p-fluorobenzoyl) propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
with a molecular weight of 379.43. The structural formula of droperidol is:








Molecular formula: C22H22FN3O2,
partition coefficient in n-octanol: water: 3.46, pKa: 7.46
INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection.Last reviewed on RxList: 6/5/2008




Inapsine Drug Description
INAPSINE®
(droperidol) Injection
For intravenous or intramuscular use only

WARNING
Cases of QT prolongation and/or torsade de pointes have been reported in
patients receiving Inapsine at doses at or below recommended doses. Some cases
have occurred in patients with no known risk factors for QT prolongation and
some cases have been fatal.
Due to its potential for serious proarrhythmic effects and death, INAPSINE
should be reserved for use in the treatment of patients who fail to show an
acceptable response to other adequate treatments, either because of insufficient
effectiveness or the inability to achieve an effective dose due to intolerable
adverse effects from those drugs (see WARNINGS,
ADVERSE REACTIONS, CONTRAINDICATIONS,
and PRECAUTIONS).
Cases of QT prolongation and serious arrhythmias (e.g., torsade de pointes) have been reported in patients treated with INAPSINE. Based on these reports, all patients should undergo a 12-lead ECG prior to administration of INAPSINE to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. If there is a prolonged QT interval, INAPSINE should NOT be administered. For patients in whom the potential benefit of INAPSINE treatment is felt to outweigh the risks of potentially serious arrhythmias, ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias.
INAPSINE is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome.
INAPSINE should be administered with extreme caution to patients who may be at risk for development of prolonged QT syndrome (e.g., congestive heart failure, bradycardia, use of a diuretic, cardiac hypertrophy, hypokalemia, hypomagnesemia, or administration of other drugs known to increase the QT interval). Other risk factors may include age over 65 years, alcohol abuse, and use of agents such as benzodiazepines, volatile anesthetics, and IV opiates. Droperidol should be initiated at a low dose and adjusted upward, with caution, as needed to achieve the desired effect.

DRUG DESCRIPTION



What are the possible side effects of droperidol (Inapsine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:

feeling like you might pass out;
dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;
chest tightness and trouble breathing;
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
...
Read All Potential Side Effects for Inapsine »




INAPSINE contains droperidol, a neuroleptic (tranquilizer) agent. Inapsine
(droperidol) Injection is available in ampoules and vials. Each milliliter contains
2.5 mg of droperidol in an aqueous solution adjusted to pH 3.4 ± 0.4 with lactic
acid. Droperidol is chemically identified as 1-(1-[3-(p-fluorobenzoyl) propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
with a molecular weight of 379.43. The structural formula of droperidol is:








Molecular formula: C22H22FN3O2,
partition coefficient in n-octanol: water: 3.46, pKa: 7.46
INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection.Last reviewed on RxList: 6/5/2008





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Other reviews about Droperidol on web:

Droperidol (Droleptan, Dridol, Inapsine) is an antidopaminergic drug used as an antiemetic and antipsychotic. Droperidol is also often used for neuroleptanalgesic anesthesia and ... Droperidol - Wikipedia, the free encyclopedia


Accurate, FDA approved Droperidol information for healthcare professionals and patients - brought to you by Drugs.com. Droperidol Official FDA information, side effects and uses.


Consumer information about the medication DROPERIDOL INJECTION (Inapsine), includes side effects, drug interactions, recommended dosages, and storage information. Read more about ... DROPERIDOL INJECTION (Inapsine) side effects, medical uses, and ...


Learn about the prescription medication Inapsine (Droperidol), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Inapsine (Droperidol) Drug Information: Uses, Side Effects, Drug ...


All about Droperidol. View complete and up to date Droperidol information - part of the Drugs.com trusted medication database. Droperidol Facts and Comparisons at Drugs.com


droperidol A tranquilizer of the butyrophenone series, used as a narcoleptic preanesthetic and, in combination with fentanyl citrate, as a Droperidol: Definition from Answers.com


droperidol /dro·per·i·dol/ (dro-per´ĭ-dol) a tranquilizer of the butyrophenone series, used as a preanesthetic and anesthesia adjunct, as a postoperative antiemetic, and to ... droperidol - definition of droperidol in the Medical dictionary ...


droperidol n A butyrophenone drug used in neuroleptanalgesia and preanesthetic medication. droperidol: Definition from Answers.com


PRO: The Food and Drug Administration black box warning on droperidol is not justified. Anesth Analg 2008;106:1414–7 Another viewpoint is the black box warning is justified. Dropiderol in Endoscopic Sedation (Inapsine®) | SedationFacts.org


–noun Pharmacology. a phenothiazine, C 22 H 22 FN 3 O 2, used as an anesthetic or antiemetic, or for emergency control of severe behavioral disturbance. Droperidol | Define Droperidol at Dictionary.com





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