Reviews Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution


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Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25° (C=1, water) = ~ -17°.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (­11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25° (C=1, water) = ~ -17°.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (­11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25° (C=1, water) = ~ -17°.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (­11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25° (C=1, water) = ~ -17°.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (­11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25° (C=1, water) = ~ -17°.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (­11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010





Other reviews about Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution on web:

Learn about the prescription medication Cosopt (Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution), drug uses, dosage, side effects, drug interactions, warnings ... Cosopt (Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic ...


COSOPT® (dorzolamide hydrochloride-timolol maleate ophthalmic solution) 9711305 2 Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. COSOPT® (dorzolamide hydrochloride-timolol maleate ophthalmic ...


Dorzolamide Hydrochloride, Timolol Maleate Ophthalmic drops, solution To return to the main entry click here Dorzolamide Hydrochloride, Timolol Maleate Ophthalmic drops, s ...


Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck's Cosopt ® and is indicated for the treatment of glaucoma. Glaucoma - Tentative Approval For Dorzolamide Hydrochloride With ...


Dorzolamide Hydrochloride/Timolol Maleate professional patient advice. ... - Solution 2% dorzolamide, 0.5% timolol. Cosopt ... Although not reported with ophthalmic use of dorzolamide ... Complete Dorzolamide Hydrochloride/Timolol Maleate information ...


In an increasingly competitive market environment, Apotex continually strives to introduce quality, affordable medicines to consumers. Dorzolamide Hydrochloride/Timolol Maleate Ophthalmic Solution, 22 ...


DORZOLAMIDE HYDROCHLORIDE-TIMOLOL MALEATE OPHTHALMIC SOLUTION Sterile Ophthalmic Solution DESCRIPTION Dorzolamide hydrochloride-timolol maleate ophthalmic solution is the combination of ... DORZOLAMIDE HYDROCHLORIDE- TIMOLOL MALEATE OPHTHALMIC SOLUTION


Dorzolamide Hydrochloride - Timolol Maleate Ophthalmic Solution: Strength: 2% dorzolamide equivalent/ 0.5% timolol equivalent Brand Name: COSOPT® (Dorzolamide Hydrochloride - Timolol ... Untitled Page


Resources for You. Cosopt (dorzolamide hydrochloride-timolol maleate ophthalmic solution) Prescribing Information Oct 2008 -- Cosopt (dorzolamide hydrochloride-timolol maleate ophthalmic ...


This could contaminate the solution. If ... If you are nursing, use of Dorzolamide hydrochloride, Timolol maleate is ... Email me about dorzolamide/timolol ophthalmic: Dorzolamide hydrochloride, Timolol maleate patient advice ...





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