Reviews Diphtheria CRM197 Protein Conjugate


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HibTITER Drug Description
HibTITER®
(Diphtheria CRM197Protein Conjugate) Haemophilus b Conjugate
Vaccine
DRUG DESCRIPTION



What are the possible side effects of this vaccine (Hibtiter)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with haemophilus B is much more dangerous to your child's health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.
Get emergency medical help if your child has any of...
Read All Potential Side Effects for HibTITER »




Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate)
HibTITER is a sterile solution of a conjugate of oligosaccharides of the capsular
antigen of Haemophilus influenzae type b (Haemophilus b) and diphtheria
CRM197 protein (CRM197) dissolved in 0.9% sodium chloride.
The oligosaccharides are derived from highly purified capsular polysaccharide,
polyribosylribitol phosphate, isolated from Haemophilus b strain Eagan grown
in a chemically defined medium (a mixture of mineral salts, amino acids, and
cofactors). The oligosaccharides are purified and sized by diafiltrations through
a series of ultrafiltration membranes, and coupled by reductive amination directly
to highly purified CRM197.1,2 CRM197 is a nontoxic
variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae
C7 (β197) grown in a casamino acids and yeast extract-based medium that
is ultrafiltered before use. CRM197 is purified through ultrafiltration,
ammonium sulfate precipitation, and ion-exchange chromatography to high purity.
The conjugate is purified to remove unreacted protein, oligosaccharides, and
reagents; sterilized by filtration; and filled into vials. HibTITER is intended
for intramuscular use.
The vaccine is a clear, colorless solution. Each single dose of 0.5 mL is formulated
to contain 10 µg of purified Haemophilus b saccharide and approximately
25 µg of CRM197 protein. The potency of HibTITER is determined
by chemical assay for polyribosylribitol.
REFERENCES
1. United States Patent Number 4,902,506 by Anderson PW, Eby filed May 5, 1986
issued February 20, 1990.
2. Seid RC Jr, Boykins RA, Liu DF, et al. Chemical evidence for covalent linkage
of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae
type b disease. Glycoconjugate J. 1989;6:489-498.Last reviewed on RxList: 3/9/2009




HibTITER Drug Description
HibTITER®
(Diphtheria CRM197Protein Conjugate) Haemophilus b Conjugate
Vaccine
DRUG DESCRIPTION



What are the possible side effects of this vaccine (Hibtiter)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with haemophilus B is much more dangerous to your child's health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.
Get emergency medical help if your child has any of...
Read All Potential Side Effects for HibTITER »




Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate)
HibTITER is a sterile solution of a conjugate of oligosaccharides of the capsular
antigen of Haemophilus influenzae type b (Haemophilus b) and diphtheria
CRM197 protein (CRM197) dissolved in 0.9% sodium chloride.
The oligosaccharides are derived from highly purified capsular polysaccharide,
polyribosylribitol phosphate, isolated from Haemophilus b strain Eagan grown
in a chemically defined medium (a mixture of mineral salts, amino acids, and
cofactors). The oligosaccharides are purified and sized by diafiltrations through
a series of ultrafiltration membranes, and coupled by reductive amination directly
to highly purified CRM197.1,2 CRM197 is a nontoxic
variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae
C7 (β197) grown in a casamino acids and yeast extract-based medium that
is ultrafiltered before use. CRM197 is purified through ultrafiltration,
ammonium sulfate precipitation, and ion-exchange chromatography to high purity.
The conjugate is purified to remove unreacted protein, oligosaccharides, and
reagents; sterilized by filtration; and filled into vials. HibTITER is intended
for intramuscular use.
The vaccine is a clear, colorless solution. Each single dose of 0.5 mL is formulated
to contain 10 µg of purified Haemophilus b saccharide and approximately
25 µg of CRM197 protein. The potency of HibTITER is determined
by chemical assay for polyribosylribitol.
REFERENCES
1. United States Patent Number 4,902,506 by Anderson PW, Eby filed May 5, 1986
issued February 20, 1990.
2. Seid RC Jr, Boykins RA, Liu DF, et al. Chemical evidence for covalent linkage
of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae
type b disease. Glycoconjugate J. 1989;6:489-498.Last reviewed on RxList: 3/9/2009




HibTITER Drug Description
HibTITER®
(Diphtheria CRM197Protein Conjugate) Haemophilus b Conjugate
Vaccine
DRUG DESCRIPTION



What are the possible side effects of this vaccine (Hibtiter)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with haemophilus B is much more dangerous to your child's health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.
Get emergency medical help if your child has any of...
Read All Potential Side Effects for HibTITER »




Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate)
HibTITER is a sterile solution of a conjugate of oligosaccharides of the capsular
antigen of Haemophilus influenzae type b (Haemophilus b) and diphtheria
CRM197 protein (CRM197) dissolved in 0.9% sodium chloride.
The oligosaccharides are derived from highly purified capsular polysaccharide,
polyribosylribitol phosphate, isolated from Haemophilus b strain Eagan grown
in a chemically defined medium (a mixture of mineral salts, amino acids, and
cofactors). The oligosaccharides are purified and sized by diafiltrations through
a series of ultrafiltration membranes, and coupled by reductive amination directly
to highly purified CRM197.1,2 CRM197 is a nontoxic
variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae
C7 (β197) grown in a casamino acids and yeast extract-based medium that
is ultrafiltered before use. CRM197 is purified through ultrafiltration,
ammonium sulfate precipitation, and ion-exchange chromatography to high purity.
The conjugate is purified to remove unreacted protein, oligosaccharides, and
reagents; sterilized by filtration; and filled into vials. HibTITER is intended
for intramuscular use.
The vaccine is a clear, colorless solution. Each single dose of 0.5 mL is formulated
to contain 10 µg of purified Haemophilus b saccharide and approximately
25 µg of CRM197 protein. The potency of HibTITER is determined
by chemical assay for polyribosylribitol.
REFERENCES
1. United States Patent Number 4,902,506 by Anderson PW, Eby filed May 5, 1986
issued February 20, 1990.
2. Seid RC Jr, Boykins RA, Liu DF, et al. Chemical evidence for covalent linkage
of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae
type b disease. Glycoconjugate J. 1989;6:489-498.Last reviewed on RxList: 3/9/2009




HibTITER Drug Description
HibTITER®
(Diphtheria CRM197Protein Conjugate) Haemophilus b Conjugate
Vaccine
DRUG DESCRIPTION



What are the possible side effects of this vaccine (Hibtiter)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with haemophilus B is much more dangerous to your child's health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.
Get emergency medical help if your child has any of...
Read All Potential Side Effects for HibTITER »




Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate)
HibTITER is a sterile solution of a conjugate of oligosaccharides of the capsular
antigen of Haemophilus influenzae type b (Haemophilus b) and diphtheria
CRM197 protein (CRM197) dissolved in 0.9% sodium chloride.
The oligosaccharides are derived from highly purified capsular polysaccharide,
polyribosylribitol phosphate, isolated from Haemophilus b strain Eagan grown
in a chemically defined medium (a mixture of mineral salts, amino acids, and
cofactors). The oligosaccharides are purified and sized by diafiltrations through
a series of ultrafiltration membranes, and coupled by reductive amination directly
to highly purified CRM197.1,2 CRM197 is a nontoxic
variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae
C7 (β197) grown in a casamino acids and yeast extract-based medium that
is ultrafiltered before use. CRM197 is purified through ultrafiltration,
ammonium sulfate precipitation, and ion-exchange chromatography to high purity.
The conjugate is purified to remove unreacted protein, oligosaccharides, and
reagents; sterilized by filtration; and filled into vials. HibTITER is intended
for intramuscular use.
The vaccine is a clear, colorless solution. Each single dose of 0.5 mL is formulated
to contain 10 µg of purified Haemophilus b saccharide and approximately
25 µg of CRM197 protein. The potency of HibTITER is determined
by chemical assay for polyribosylribitol.
REFERENCES
1. United States Patent Number 4,902,506 by Anderson PW, Eby filed May 5, 1986
issued February 20, 1990.
2. Seid RC Jr, Boykins RA, Liu DF, et al. Chemical evidence for covalent linkage
of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae
type b disease. Glycoconjugate J. 1989;6:489-498.Last reviewed on RxList: 3/9/2009




HibTITER Drug Description
HibTITER®
(Diphtheria CRM197Protein Conjugate) Haemophilus b Conjugate
Vaccine
DRUG DESCRIPTION



What are the possible side effects of this vaccine (Hibtiter)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.
Becoming infected with haemophilus B is much more dangerous to your child's health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.
Get emergency medical help if your child has any of...
Read All Potential Side Effects for HibTITER »




Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate)
HibTITER is a sterile solution of a conjugate of oligosaccharides of the capsular
antigen of Haemophilus influenzae type b (Haemophilus b) and diphtheria
CRM197 protein (CRM197) dissolved in 0.9% sodium chloride.
The oligosaccharides are derived from highly purified capsular polysaccharide,
polyribosylribitol phosphate, isolated from Haemophilus b strain Eagan grown
in a chemically defined medium (a mixture of mineral salts, amino acids, and
cofactors). The oligosaccharides are purified and sized by diafiltrations through
a series of ultrafiltration membranes, and coupled by reductive amination directly
to highly purified CRM197.1,2 CRM197 is a nontoxic
variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae
C7 (β197) grown in a casamino acids and yeast extract-based medium that
is ultrafiltered before use. CRM197 is purified through ultrafiltration,
ammonium sulfate precipitation, and ion-exchange chromatography to high purity.
The conjugate is purified to remove unreacted protein, oligosaccharides, and
reagents; sterilized by filtration; and filled into vials. HibTITER is intended
for intramuscular use.
The vaccine is a clear, colorless solution. Each single dose of 0.5 mL is formulated
to contain 10 µg of purified Haemophilus b saccharide and approximately
25 µg of CRM197 protein. The potency of HibTITER is determined
by chemical assay for polyribosylribitol.
REFERENCES
1. United States Patent Number 4,902,506 by Anderson PW, Eby filed May 5, 1986
issued February 20, 1990.
2. Seid RC Jr, Boykins RA, Liu DF, et al. Chemical evidence for covalent linkage
of a semi-synthetic glycoconjugate vaccine for Haemophilus influenzae
type b disease. Glycoconjugate J. 1989;6:489-498.Last reviewed on RxList: 3/9/2009





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Other reviews about Diphtheria CRM197 Protein Conjugate on web:

Learn about the prescription medication HibTITER (Diphtheria CRM197 Protein Conjugate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. HibTITER (Diphtheria CRM197 Protein Conjugate) Drug Information ...


1 HAEMOPHILUS b CONJUGATE VACCINE (Diphtheria CRM 197 Protein Conjugate) HibTITER ® Rx only DESCRIPTION Haemophilus b Conjugate Vaccine (Diphtheria CRM 197 Protein Conjugate ... HAEMOPHILUS b CONJUGATE VACCINE(Diphtheria CRM197 Protein ...


Haemophilus B Conjugate Vaccine (Diphtheria CRM197 Protein) Solution for injection To return to the main entry click here Haemophilus B Conjugate Vaccine (Diphtheria CRM197 Protein) So ...


Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM 197 Protein) - Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 ...


Pneumococcal 7-valent Conjugate Vaccine Clinical Review - Prevnar (PDF - 1300KB) Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) Clinical Review (PDF ... Prevnar


Learn about HibTITER (Diphtheria CRM197 Protein Conjugate) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList HibTITER (Diphtheria CRM197 Protein Conjugate) Patient Drug ...


Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) Suspension for injection To return to the main entry click here Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Pro ...


Haemophilus B Conjugate Vaccine (Diphtheria CRM197 Protein) Solution for injection What is this medicine? HAEMOPHILUS INFLUENZAE TYPE B CONJUGATE VACCINE is used to prevent ... Haemophilus influenzae type b Conjugate Vaccine


Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM 197 Protein) Prevnar ® FOR PEDIATRIC USE ONLY Rx only For Intramuscular Injection Only DESCRIPTION ® Pneumococcal 7-valent Conjugate ... Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein)


General Background Pharmacology Prevnar 13, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein) is a sterile suspension of saccharides of the capsular antigens of ... CIGNA PHARMACY COVERAGE POLICY





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