Reviews Dexrazoxane for Injection, Intravenous Infusion Only


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Totect Drug Description
Totect® Kit
(dexrazoxane) for Injection, for Intravenous Infusion Only
DRUG DESCRIPTION



What are the possible side effects of dexrazoxane (Totect, Zinecard)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:

fever, chills, body aches, flu symptoms;
easy bruising or bleeding, weakness; or
white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

hair loss;
...
Read All Potential Side Effects for Totect »




Totect® (dexrazoxane) for injection is a sterile, pyrogen-free lyophilizate intended for intravenous (IV) administration. Totect®
is packaged as a kit for single patient use. Each kit contains 10 vials of
Totect® (dexrazoxane for injection) 500 mg and 10 vials of 50 mL diluent, which
provides a complete three day treatment
Chemically, dexrazoxane is
2,6-piperazinedione,4,4'-(1-methyl-1,2ethanediyl)bis-,(S)- or
(S)-(+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. The following diagram shows
the chemical structure:








The molecular formula is C11H16N4O4;
the molecular weight is 268.3. Dexrazoxane is a white to off-white powder, with
a melting point of 194 ± 3 °C. It is soluble in dioxane and 0.1 N HCl,
sparingly soluble in water, tetrahydrofuran, citrate buffer at pH 4.0,
phosphate buffer at pH 7.0, and borate-potassium chloride sodium hydroxide
buffer at pH 9.0. The acid dissociation constants, pKa, are 2.5 (for the
tertiary piperazine nitrogen) and 9.7 (for the nitrogen imide). Log P is
-2.135.
The finished product is supplied in a sterile form for
intravenous infusion only following mixing and diluting.
Each kit contains twenty 50 mL Type I glass vials. Ten vials
each contains dexrazoxane hydrochloride equivalent to 500 mg dexrazoxane and 10
vials each contains diluent (0.167M Sodium Lactate Injection, USP). Each vial
of dexrazoxane for injection is closed with an aluminum flip-off cap covered
with a dark red overcap. Each vial of diluent is closed with an aluminum
flip-off cap covered with a white overcap.
When reconstituted as directed, the admixture contains dexrazoxane and the
following excipients: hydrochloric acid, sodium lactate, water for injection,
sodium hydroxide and lactic acid [see DOSAGE AND
ADMINISTRATION]. The admixture should be further diluted in 0.9 % NaCl
prior to administration to patients.
Last reviewed on RxList: 9/30/2009




Totect Drug Description
Totect® Kit
(dexrazoxane) for Injection, for Intravenous Infusion Only
DRUG DESCRIPTION



What are the possible side effects of dexrazoxane (Totect, Zinecard)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:

fever, chills, body aches, flu symptoms;
easy bruising or bleeding, weakness; or
white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

hair loss;
...
Read All Potential Side Effects for Totect »




Totect® (dexrazoxane) for injection is a sterile, pyrogen-free lyophilizate intended for intravenous (IV) administration. Totect®
is packaged as a kit for single patient use. Each kit contains 10 vials of
Totect® (dexrazoxane for injection) 500 mg and 10 vials of 50 mL diluent, which
provides a complete three day treatment
Chemically, dexrazoxane is
2,6-piperazinedione,4,4'-(1-methyl-1,2ethanediyl)bis-,(S)- or
(S)-(+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. The following diagram shows
the chemical structure:








The molecular formula is C11H16N4O4;
the molecular weight is 268.3. Dexrazoxane is a white to off-white powder, with
a melting point of 194 ± 3 °C. It is soluble in dioxane and 0.1 N HCl,
sparingly soluble in water, tetrahydrofuran, citrate buffer at pH 4.0,
phosphate buffer at pH 7.0, and borate-potassium chloride sodium hydroxide
buffer at pH 9.0. The acid dissociation constants, pKa, are 2.5 (for the
tertiary piperazine nitrogen) and 9.7 (for the nitrogen imide). Log P is
-2.135.
The finished product is supplied in a sterile form for
intravenous infusion only following mixing and diluting.
Each kit contains twenty 50 mL Type I glass vials. Ten vials
each contains dexrazoxane hydrochloride equivalent to 500 mg dexrazoxane and 10
vials each contains diluent (0.167M Sodium Lactate Injection, USP). Each vial
of dexrazoxane for injection is closed with an aluminum flip-off cap covered
with a dark red overcap. Each vial of diluent is closed with an aluminum
flip-off cap covered with a white overcap.
When reconstituted as directed, the admixture contains dexrazoxane and the
following excipients: hydrochloric acid, sodium lactate, water for injection,
sodium hydroxide and lactic acid [see DOSAGE AND
ADMINISTRATION]. The admixture should be further diluted in 0.9 % NaCl
prior to administration to patients.
Last reviewed on RxList: 9/30/2009




Totect Drug Description
Totect® Kit
(dexrazoxane) for Injection, for Intravenous Infusion Only
DRUG DESCRIPTION



What are the possible side effects of dexrazoxane (Totect, Zinecard)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:

fever, chills, body aches, flu symptoms;
easy bruising or bleeding, weakness; or
white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

hair loss;
...
Read All Potential Side Effects for Totect »




Totect® (dexrazoxane) for injection is a sterile, pyrogen-free lyophilizate intended for intravenous (IV) administration. Totect®
is packaged as a kit for single patient use. Each kit contains 10 vials of
Totect® (dexrazoxane for injection) 500 mg and 10 vials of 50 mL diluent, which
provides a complete three day treatment
Chemically, dexrazoxane is
2,6-piperazinedione,4,4'-(1-methyl-1,2ethanediyl)bis-,(S)- or
(S)-(+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. The following diagram shows
the chemical structure:








The molecular formula is C11H16N4O4;
the molecular weight is 268.3. Dexrazoxane is a white to off-white powder, with
a melting point of 194 ± 3 °C. It is soluble in dioxane and 0.1 N HCl,
sparingly soluble in water, tetrahydrofuran, citrate buffer at pH 4.0,
phosphate buffer at pH 7.0, and borate-potassium chloride sodium hydroxide
buffer at pH 9.0. The acid dissociation constants, pKa, are 2.5 (for the
tertiary piperazine nitrogen) and 9.7 (for the nitrogen imide). Log P is
-2.135.
The finished product is supplied in a sterile form for
intravenous infusion only following mixing and diluting.
Each kit contains twenty 50 mL Type I glass vials. Ten vials
each contains dexrazoxane hydrochloride equivalent to 500 mg dexrazoxane and 10
vials each contains diluent (0.167M Sodium Lactate Injection, USP). Each vial
of dexrazoxane for injection is closed with an aluminum flip-off cap covered
with a dark red overcap. Each vial of diluent is closed with an aluminum
flip-off cap covered with a white overcap.
When reconstituted as directed, the admixture contains dexrazoxane and the
following excipients: hydrochloric acid, sodium lactate, water for injection,
sodium hydroxide and lactic acid [see DOSAGE AND
ADMINISTRATION]. The admixture should be further diluted in 0.9 % NaCl
prior to administration to patients.
Last reviewed on RxList: 9/30/2009




Totect Drug Description
Totect® Kit
(dexrazoxane) for Injection, for Intravenous Infusion Only
DRUG DESCRIPTION



What are the possible side effects of dexrazoxane (Totect, Zinecard)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:

fever, chills, body aches, flu symptoms;
easy bruising or bleeding, weakness; or
white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

hair loss;
...
Read All Potential Side Effects for Totect »




Totect® (dexrazoxane) for injection is a sterile, pyrogen-free lyophilizate intended for intravenous (IV) administration. Totect®
is packaged as a kit for single patient use. Each kit contains 10 vials of
Totect® (dexrazoxane for injection) 500 mg and 10 vials of 50 mL diluent, which
provides a complete three day treatment
Chemically, dexrazoxane is
2,6-piperazinedione,4,4'-(1-methyl-1,2ethanediyl)bis-,(S)- or
(S)-(+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. The following diagram shows
the chemical structure:








The molecular formula is C11H16N4O4;
the molecular weight is 268.3. Dexrazoxane is a white to off-white powder, with
a melting point of 194 ± 3 °C. It is soluble in dioxane and 0.1 N HCl,
sparingly soluble in water, tetrahydrofuran, citrate buffer at pH 4.0,
phosphate buffer at pH 7.0, and borate-potassium chloride sodium hydroxide
buffer at pH 9.0. The acid dissociation constants, pKa, are 2.5 (for the
tertiary piperazine nitrogen) and 9.7 (for the nitrogen imide). Log P is
-2.135.
The finished product is supplied in a sterile form for
intravenous infusion only following mixing and diluting.
Each kit contains twenty 50 mL Type I glass vials. Ten vials
each contains dexrazoxane hydrochloride equivalent to 500 mg dexrazoxane and 10
vials each contains diluent (0.167M Sodium Lactate Injection, USP). Each vial
of dexrazoxane for injection is closed with an aluminum flip-off cap covered
with a dark red overcap. Each vial of diluent is closed with an aluminum
flip-off cap covered with a white overcap.
When reconstituted as directed, the admixture contains dexrazoxane and the
following excipients: hydrochloric acid, sodium lactate, water for injection,
sodium hydroxide and lactic acid [see DOSAGE AND
ADMINISTRATION]. The admixture should be further diluted in 0.9 % NaCl
prior to administration to patients.
Last reviewed on RxList: 9/30/2009




Totect Drug Description
Totect® Kit
(dexrazoxane) for Injection, for Intravenous Infusion Only
DRUG DESCRIPTION



What are the possible side effects of dexrazoxane (Totect, Zinecard)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:

fever, chills, body aches, flu symptoms;
easy bruising or bleeding, weakness; or
white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

hair loss;
...
Read All Potential Side Effects for Totect »




Totect® (dexrazoxane) for injection is a sterile, pyrogen-free lyophilizate intended for intravenous (IV) administration. Totect®
is packaged as a kit for single patient use. Each kit contains 10 vials of
Totect® (dexrazoxane for injection) 500 mg and 10 vials of 50 mL diluent, which
provides a complete three day treatment
Chemically, dexrazoxane is
2,6-piperazinedione,4,4'-(1-methyl-1,2ethanediyl)bis-,(S)- or
(S)-(+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. The following diagram shows
the chemical structure:








The molecular formula is C11H16N4O4;
the molecular weight is 268.3. Dexrazoxane is a white to off-white powder, with
a melting point of 194 ± 3 °C. It is soluble in dioxane and 0.1 N HCl,
sparingly soluble in water, tetrahydrofuran, citrate buffer at pH 4.0,
phosphate buffer at pH 7.0, and borate-potassium chloride sodium hydroxide
buffer at pH 9.0. The acid dissociation constants, pKa, are 2.5 (for the
tertiary piperazine nitrogen) and 9.7 (for the nitrogen imide). Log P is
-2.135.
The finished product is supplied in a sterile form for
intravenous infusion only following mixing and diluting.
Each kit contains twenty 50 mL Type I glass vials. Ten vials
each contains dexrazoxane hydrochloride equivalent to 500 mg dexrazoxane and 10
vials each contains diluent (0.167M Sodium Lactate Injection, USP). Each vial
of dexrazoxane for injection is closed with an aluminum flip-off cap covered
with a dark red overcap. Each vial of diluent is closed with an aluminum
flip-off cap covered with a white overcap.
When reconstituted as directed, the admixture contains dexrazoxane and the
following excipients: hydrochloric acid, sodium lactate, water for injection,
sodium hydroxide and lactic acid [see DOSAGE AND
ADMINISTRATION]. The admixture should be further diluted in 0.9 % NaCl
prior to administration to patients.
Last reviewed on RxList: 9/30/2009





Other reviews about Dexrazoxane for Injection, Intravenous Infusion Only on web:

Learn about the prescription medication Totect (Dexrazoxane for Injection, Intravenous Infusion Only), drug uses, dosage, side effects, drug interactions, warnings, and patient ... Totect (Dexrazoxane for Injection, Intravenous Infusion Only ...


Learn about Totect (Dexrazoxane for Injection, Intravenous Infusion Only) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Totect (Dexrazoxane for Injection, Intravenous Infusion Only ...


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NDA 22-025 TOTECTテδ「テつテつ「 (DEXRAZOXANE) FOR INJECTION Totectテδ「テつテつ「 Package Insert Totectテδ「テつテつ「 500 mg* ... The finished product is supplied in a sterile form for intravenous infusion only ... Totect (dexrazoxane) Injection


Totect テδづつョ Kit (dexrazoxane) for injection, for intravenous infusion only Initial U.S. Approval: 2007-----INDICATIONS AND USAGE-----テδッテつづつキ Totect テδづつョ is indicated for the ... HIGHLIGHTS OF PRESCRIBING INFORMATION


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... by Intravenous Anthracycline Chemotherapy. On September 6, 2007, the FDA approved dexrazoxane hydrochloride for injection ... IV infusion ... dexrazoxane hydrochloride treatment, only one ... FDA Approval for Dexrazoxane Hydrochloride - National Cancer Institute


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... beginning of the dexrazoxane infusion), the intravenous injection of doxorubicin should be given. Reconstituted dexrazoxane ... Therefore, dexrazoxane should only be used in those ... Dexrazoxane Injection, Powder, For Solution drug information ...


Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only ... Hospira Announces New Contract With MedAssets for Intravenous Solutions, Renewal of Infusion ... Infusion Nurses Society References Totect(R) (Dexrazoxane For ...





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