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Definity Drug Description
DEFINITY®
Vial For (perflutern lipid microsphere) Injectable Suspension
For Intravenous Use

WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes DEFINITY®
administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography and cutaneous oxygen
saturation during and for at least 30 minutes after DEFINITY® administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
The DEFINITY® vial contains components that upon activation yield perflutren
lipid microspheres, a diagnostic drug that is intended to be used for contrast
enhancement during the indicated echocardiographic procedures. The vial contains
a clear, colorless, sterile, non-pyrogenic, hypertonic liquid, which upon activation
with the aid of a Vialmix®, provides a homogeneous, opaque, milky white
injectable suspension of perflutren lipid microspheres. The suspension of activated
DEFINITY® is administered by intravenous injection.
The perflutren lipid microspheres are composed of octafluoropropane encapsulated
in an outer lipid shell consisting of (R) - hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl
ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-
3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated
DPPC); and (R)-α-[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11- trioxa-2-aza-6-phosphahexacos-1-yl]-
ω-methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000
DPPE).
Octafluoropropane is chemically characterized as 1,1,1,2,2,3,3,3- octafluoropropane.
It has a molecular weight of 188, empirical formula of C3F8
and has the following structural formula:








DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa,
and following structural formula:








DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following
structural formula:







MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical
formula C265H527NO123PNa, and the following
structural formula:








Prior to Vialmix® activation, the DEFINITY® vial contains 6.52 mg/mL
octafluoropropane in the headspace. Each mL of the clear liquid contains 0.75
mg lipid blend (consisting of 0.045 mg DPPA, 0.401 mg DPPC, and 0.304 mg MPEG5000
DPPE), 103.5 mg propylene glycol, 126.2 mg glycerin, 2.34 mg sodium phosphate
monobasic monohydrate, 2.16 mg sodium phosphate dibasic heptahydrate, and 4.87
mg sodium chloride in Water for Injection. The pH is 6.2-6.8.
After activating the contents of the vial in a Vialmix®, each mL of the
milky white suspension contains a maximum of 1.2 X 1010 perflutren
lipid microspheres, and about 150 µL/mL (1.1 mg/mL) octafluoropropane.
The microsphere particle size parameters are listed in Table 1 below:
Table. 1: Microsphere Size Distribution



 
Microsphere particle size parameters


Mean diameter range


1.1 µm -3.3 µm




Percent less than 10 µm


98%




Maximum diameter


20 µm





See DEFINITY® Activation, Preparation, and Handling
Instructions.Last reviewed on RxList: 6/16/2008




Definity Drug Description
DEFINITY®
Vial For (perflutern lipid microsphere) Injectable Suspension
For Intravenous Use

WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes DEFINITY®
administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography and cutaneous oxygen
saturation during and for at least 30 minutes after DEFINITY® administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
The DEFINITY® vial contains components that upon activation yield perflutren
lipid microspheres, a diagnostic drug that is intended to be used for contrast
enhancement during the indicated echocardiographic procedures. The vial contains
a clear, colorless, sterile, non-pyrogenic, hypertonic liquid, which upon activation
with the aid of a Vialmix®, provides a homogeneous, opaque, milky white
injectable suspension of perflutren lipid microspheres. The suspension of activated
DEFINITY® is administered by intravenous injection.
The perflutren lipid microspheres are composed of octafluoropropane encapsulated
in an outer lipid shell consisting of (R) - hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl
ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-
3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated
DPPC); and (R)-α-[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11- trioxa-2-aza-6-phosphahexacos-1-yl]-
ω-methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000
DPPE).
Octafluoropropane is chemically characterized as 1,1,1,2,2,3,3,3- octafluoropropane.
It has a molecular weight of 188, empirical formula of C3F8
and has the following structural formula:








DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa,
and following structural formula:








DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following
structural formula:







MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical
formula C265H527NO123PNa, and the following
structural formula:








Prior to Vialmix® activation, the DEFINITY® vial contains 6.52 mg/mL
octafluoropropane in the headspace. Each mL of the clear liquid contains 0.75
mg lipid blend (consisting of 0.045 mg DPPA, 0.401 mg DPPC, and 0.304 mg MPEG5000
DPPE), 103.5 mg propylene glycol, 126.2 mg glycerin, 2.34 mg sodium phosphate
monobasic monohydrate, 2.16 mg sodium phosphate dibasic heptahydrate, and 4.87
mg sodium chloride in Water for Injection. The pH is 6.2-6.8.
After activating the contents of the vial in a Vialmix®, each mL of the
milky white suspension contains a maximum of 1.2 X 1010 perflutren
lipid microspheres, and about 150 µL/mL (1.1 mg/mL) octafluoropropane.
The microsphere particle size parameters are listed in Table 1 below:
Table. 1: Microsphere Size Distribution



 
Microsphere particle size parameters


Mean diameter range


1.1 µm -3.3 µm




Percent less than 10 µm


98%




Maximum diameter


20 µm





See DEFINITY® Activation, Preparation, and Handling
Instructions.Last reviewed on RxList: 6/16/2008




Definity Drug Description
DEFINITY®
Vial For (perflutern lipid microsphere) Injectable Suspension
For Intravenous Use

WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes DEFINITY®
administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography and cutaneous oxygen
saturation during and for at least 30 minutes after DEFINITY® administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
The DEFINITY® vial contains components that upon activation yield perflutren
lipid microspheres, a diagnostic drug that is intended to be used for contrast
enhancement during the indicated echocardiographic procedures. The vial contains
a clear, colorless, sterile, non-pyrogenic, hypertonic liquid, which upon activation
with the aid of a Vialmix®, provides a homogeneous, opaque, milky white
injectable suspension of perflutren lipid microspheres. The suspension of activated
DEFINITY® is administered by intravenous injection.
The perflutren lipid microspheres are composed of octafluoropropane encapsulated
in an outer lipid shell consisting of (R) - hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl
ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-
3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated
DPPC); and (R)-α-[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11- trioxa-2-aza-6-phosphahexacos-1-yl]-
ω-methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000
DPPE).
Octafluoropropane is chemically characterized as 1,1,1,2,2,3,3,3- octafluoropropane.
It has a molecular weight of 188, empirical formula of C3F8
and has the following structural formula:








DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa,
and following structural formula:








DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following
structural formula:







MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical
formula C265H527NO123PNa, and the following
structural formula:








Prior to Vialmix® activation, the DEFINITY® vial contains 6.52 mg/mL
octafluoropropane in the headspace. Each mL of the clear liquid contains 0.75
mg lipid blend (consisting of 0.045 mg DPPA, 0.401 mg DPPC, and 0.304 mg MPEG5000
DPPE), 103.5 mg propylene glycol, 126.2 mg glycerin, 2.34 mg sodium phosphate
monobasic monohydrate, 2.16 mg sodium phosphate dibasic heptahydrate, and 4.87
mg sodium chloride in Water for Injection. The pH is 6.2-6.8.
After activating the contents of the vial in a Vialmix®, each mL of the
milky white suspension contains a maximum of 1.2 X 1010 perflutren
lipid microspheres, and about 150 µL/mL (1.1 mg/mL) octafluoropropane.
The microsphere particle size parameters are listed in Table 1 below:
Table. 1: Microsphere Size Distribution



 
Microsphere particle size parameters


Mean diameter range


1.1 µm -3.3 µm




Percent less than 10 µm


98%




Maximum diameter


20 µm





See DEFINITY® Activation, Preparation, and Handling
Instructions.Last reviewed on RxList: 6/16/2008




Definity Drug Description
DEFINITY®
Vial For (perflutern lipid microsphere) Injectable Suspension
For Intravenous Use

WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes DEFINITY®
administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography and cutaneous oxygen
saturation during and for at least 30 minutes after DEFINITY® administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
The DEFINITY® vial contains components that upon activation yield perflutren
lipid microspheres, a diagnostic drug that is intended to be used for contrast
enhancement during the indicated echocardiographic procedures. The vial contains
a clear, colorless, sterile, non-pyrogenic, hypertonic liquid, which upon activation
with the aid of a Vialmix®, provides a homogeneous, opaque, milky white
injectable suspension of perflutren lipid microspheres. The suspension of activated
DEFINITY® is administered by intravenous injection.
The perflutren lipid microspheres are composed of octafluoropropane encapsulated
in an outer lipid shell consisting of (R) - hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl
ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-
3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated
DPPC); and (R)-α-[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11- trioxa-2-aza-6-phosphahexacos-1-yl]-
ω-methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000
DPPE).
Octafluoropropane is chemically characterized as 1,1,1,2,2,3,3,3- octafluoropropane.
It has a molecular weight of 188, empirical formula of C3F8
and has the following structural formula:








DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa,
and following structural formula:








DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following
structural formula:







MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical
formula C265H527NO123PNa, and the following
structural formula:








Prior to Vialmix® activation, the DEFINITY® vial contains 6.52 mg/mL
octafluoropropane in the headspace. Each mL of the clear liquid contains 0.75
mg lipid blend (consisting of 0.045 mg DPPA, 0.401 mg DPPC, and 0.304 mg MPEG5000
DPPE), 103.5 mg propylene glycol, 126.2 mg glycerin, 2.34 mg sodium phosphate
monobasic monohydrate, 2.16 mg sodium phosphate dibasic heptahydrate, and 4.87
mg sodium chloride in Water for Injection. The pH is 6.2-6.8.
After activating the contents of the vial in a Vialmix®, each mL of the
milky white suspension contains a maximum of 1.2 X 1010 perflutren
lipid microspheres, and about 150 µL/mL (1.1 mg/mL) octafluoropropane.
The microsphere particle size parameters are listed in Table 1 below:
Table. 1: Microsphere Size Distribution



 
Microsphere particle size parameters


Mean diameter range


1.1 µm -3.3 µm




Percent less than 10 µm


98%




Maximum diameter


20 µm





See DEFINITY® Activation, Preparation, and Handling
Instructions.Last reviewed on RxList: 6/16/2008




Definity Drug Description
DEFINITY®
Vial For (perflutern lipid microsphere) Injectable Suspension
For Intravenous Use

WARNING: Serious Cardiopulmonary Reactions
Serious cardiopulmonary reactions, including fatalities, have occurred during
or following perflutren-containing microsphere administration.

Assess all patients for the presence of any condition that precludes DEFINITY®
administration (see CONTRAINDICATIONS).
In patients with pulmonary hypertension or unstable cardiopulmonary conditions,
monitor vital sign measurements, electrocardiography and cutaneous oxygen
saturation during and for at least 30 minutes after DEFINITY® administration
(see WARNINGS).
Always have resuscitation equipment and trained personnel readily available.


DRUG DESCRIPTION
The DEFINITY® vial contains components that upon activation yield perflutren
lipid microspheres, a diagnostic drug that is intended to be used for contrast
enhancement during the indicated echocardiographic procedures. The vial contains
a clear, colorless, sterile, non-pyrogenic, hypertonic liquid, which upon activation
with the aid of a Vialmix®, provides a homogeneous, opaque, milky white
injectable suspension of perflutren lipid microspheres. The suspension of activated
DEFINITY® is administered by intravenous injection.
The perflutren lipid microspheres are composed of octafluoropropane encapsulated
in an outer lipid shell consisting of (R) - hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl
ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-
3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated
DPPC); and (R)-α-[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11- trioxa-2-aza-6-phosphahexacos-1-yl]-
ω-methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000
DPPE).
Octafluoropropane is chemically characterized as 1,1,1,2,2,3,3,3- octafluoropropane.
It has a molecular weight of 188, empirical formula of C3F8
and has the following structural formula:








DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa,
and following structural formula:








DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following
structural formula:







MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical
formula C265H527NO123PNa, and the following
structural formula:








Prior to Vialmix® activation, the DEFINITY® vial contains 6.52 mg/mL
octafluoropropane in the headspace. Each mL of the clear liquid contains 0.75
mg lipid blend (consisting of 0.045 mg DPPA, 0.401 mg DPPC, and 0.304 mg MPEG5000
DPPE), 103.5 mg propylene glycol, 126.2 mg glycerin, 2.34 mg sodium phosphate
monobasic monohydrate, 2.16 mg sodium phosphate dibasic heptahydrate, and 4.87
mg sodium chloride in Water for Injection. The pH is 6.2-6.8.
After activating the contents of the vial in a Vialmix®, each mL of the
milky white suspension contains a maximum of 1.2 X 1010 perflutren
lipid microspheres, and about 150 µL/mL (1.1 mg/mL) octafluoropropane.
The microsphere particle size parameters are listed in Table 1 below:
Table. 1: Microsphere Size Distribution



 
Microsphere particle size parameters


Mean diameter range


1.1 µm -3.3 µm




Percent less than 10 µm


98%




Maximum diameter


20 µm





See DEFINITY® Activation, Preparation, and Handling
Instructions.Last reviewed on RxList: 6/16/2008





Other reviews about Definity on wordpress

Definity
  by alloutcarnybrawl
Memory cuts a jagged line Ahead Dragging with- Out quite accuracy Nor even desire. Jokes skip by, skip over, Pass by what could have been Great commiseration. Not action, Hardly even consciousness Of their definity— The choking immortal Lapses For barely […]


Olay Definity: A Complexion Pick-Me-Up
  by Janine Falcon
Olay Definity Refining Lotion with UV Protection (SPF 15) makes my skin look happy. Anything that makes my skin look happy makes me happy. I must confess to a […]


Lucent Avaya Definity Phones
  by gregmitros1
Every business requires a good network of telecommunication to climb the ladder of success in quick time. Small business telephone systems are the right choice to give a […]


Definity 2. We think we have a better name for this PAL
  by lenschic
Anyone out there tried a Definity lens? Wow don't all raise your hands at once. The secret is Essilor isn't selling very many Definity lenses.  The quiet launch […]


Olay Definity Illuminating Cream Cleanser, 5 fl oz
  by skinsummersurf
Enhance moisture barrier structure Moisturize to allow the natural regeneration of collagen Smooth the look of lines and wrinkles Reveal luminous, more flawless skin that appears lit from within Product DescriptionHighly defined […]


Olay Definity Eye Treatment, .5-Ounces
  by ladysquare
Dual action formula to illuminates the complete eye area and smoothes the look of fine lines and wrinkles with a spiral of concentrated serumStrengthens delicate eye skin, firming […]


Olay Definity Night Cream, 1.7-Ounce
  by skinsummersurf
It helps to reverse the appearance of skin damage while your body savors the restorative effects of deep sleep. Olay Definity Anti-aging Cream. Its super rich and luxurious hydrators penetrate […]


Avaya Definity 6400 Series Sets
  by theilsnetwork
Definity 6400 series phones are way ahead of their time and will define the quality of your business. Avaya only makes top quality products for your business and […]


Avaya AWH55+ Digital Wireless Headset SystemThe Av …
  by theilsnetwork
Avaya AWH55+ Digital Wireless Headset SystemThe Avaya AWH-55+ is the new wireless headset solution for most Definity and IP Office phone systems. This totally wireless headset offers hands-free […]


Relativity & Definity: Like Oil to Water?
  by Amelia Noor
Doesn't it seem like the world is against you when you rush to the train terminal and the doors JUST closed? The time board shows a slow countdown of […]



Other reviews about Definity on web:

The following information is intended for use by healthcare professionals in the United States. Countries outside of the United States may have regulatory or legal DEFINITY®


Whether you golf, hike, play tennis, or just enjoy taking a stroll during your lunch break, DEFINITY ® is the ideal progressive lens for you. DEFINITY uses patented DUAL ADD ® 2.0 ... DEFINITY - Progressive Lenses


The path to better health and more cost-effective health benefits can be found here at Definity Health. We’ve left behind the managed care principles of ... DefinityHealth - Homepage


*Pooled data on file from 126 patients in two open-label multicenter trials with similar study design and patient populations. Results from institutional reads refer to percentage ... DEFINITY®


Learn about the prescription medication Definity (Perflutren Lipid Microsphere), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Definity (Perflutren Lipid Microsphere) Drug Information: Uses ...


All about Definity. View complete and up to date Definity information - part of the Drugs.com trusted medication database. Definity Facts and Comparisons at Drugs.com


Definity Partners works with your team to address the immediate organizational obstacles, while creating an environment of long-term improvement. Definity Partners: Business Improvement Firm


Accurate, FDA approved Definity information for healthcare professionals and patients - brought to you by Drugs.com. Definity Official FDA information, side effects and uses.


Definity SM Health Savings Accounts from UnitedHealthcare can help you save and pay for qualified medical expenses – tax-free – for use today and in the future. Definity Health Savings Account - Home


DEFINITY is a digital film recorder for motion picture applications, produced by CCG Digital Image Technology, the successor of Agfa-Gevaert's film recorder division. Definity - Wikipedia, the free encyclopedia





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