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Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25ツー (C=1, water) = ~ -17ツー.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (ツュ11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25ツー (C=1, water) = ~ -17ツー.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (ツュ11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25ツー (C=1, water) = ~ -17ツー.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (ツュ11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25ツー (C=1, water) = ~ -17ツー.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (ツュ11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010




Cosopt Drug Description
COSOPT®
(dorzolamide hydrochloride-timolol maleate) Sterile Ophthalmic
Solution
DRUG DESCRIPTION



What are the possible side effects of dorzolamide and timolol ophthalmic (Cosopt)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache...
Read All Potential Side Effects for Cosopt »




COSOPT (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent.
Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide
7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active.
The specific rotation is:
α 25ツー (C=1, water) = ~ -17ツー.
405 nm
Its empirical formula is C10H16N2O4S3•HCl
and its structural formula is:








Dorzolamide hydrochloride has a molecular weight of 360.91. It is a white to
off-white, crystalline powder, which is soluble in water and slightly soluble
in methanol and ethanol.
Timolol maleate is described chemically as: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt). Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer. The optical rotation of timolol
maleate is:
[α] 25°C in 1N HCl (C = 5) = -12.2° (ツュ11.7° to -12.5°).

405 nm
Its molecular formula is C13H24N4O3S•C4H4O4
and its structural formula is:








Timolol maleate has a molecular weight of 432.50. It is a white, odorless,
crystalline powder which is soluble in water, methanol, and alcohol. Timolol
maleate is stable at room temperature.
COSOPT is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution. The pH of the solution is approximately 5.65, and the osmolarity is 242-323 mOsM. Each mL of COSOPT contains 20 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5 mg timolol (6.83 mg timolol maleate). Inactive ingredients are sodium citrate, hydroxyethyl cellulose, sodium hydroxide, mannitol, and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.Last reviewed on RxList: 7/20/2010





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As promised, here is the combined Merck/Schering-Plough "in substance" patent cliff data, in one handy table. Let me know if you see errors in it, but $16.8 billion […]


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Cosopt is a combination of two medicines Timolol, a beta-adrenergic blocking agent and Dorzolamide,a […]



Other reviews about Cosopt on web:

Learn about the prescription medication Cosopt (Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution), drug uses, dosage, side effects, drug interactions, warnings ... Cosopt (Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic ...


Cosopt (dorzolamide and timolol) reduces the amount of fluid in the eye and is used to treat glaucoma. Includes Cosopt side effects, interactions and indications. Cosopt Information from Drugs.com


The Web site for COSOPT is no longer available. The Prescribing and Patient Product Information for COSOPT テδづつョ are available by clicking on the links below. Merck - COSOPTテδづつョ


Cosopt information from Drugs.com. Cosopt lowers high pressure in the eye, a problem typically caused by the condition known as open-angle glaucoma. Cosopt works by reducing ... Cosopt patient advice including side effects


COSOPTテδづつョ (dorzolamide hydrochloride-timolol maleate ophthalmic solution) 9711305 2 Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. COSOPTテδづつョ (dorzolamide hydrochloride-timolol maleate ophthalmic ...


Dorzolamide/timolol eyedrops (trade name Cosopt) are used for lowering pressure in the eye to normal levels, and a treatment for glaucoma. The drug is a combination of two ... Dorzolamide/timolol - Wikipedia, the free encyclopedia


Cosopt is a carbonic anhydrase inhibitor and beta-blocker combination used for treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma in patients ... Cosopt - drugstore.com. Low prices, side effects, interactions.


What is Cosopt (Dorzolamide Timolol Ophthalmic)? Dorzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye. Cosopt - Drugs & Treatments - Revolution Health


Find patient medical information for Cosopt Opht on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cosopt Opht : Uses, Side Effects, Interactions, Pictures, Warnings ...


テδづつョRegistered Trademark of Merck & Co., Inc., Whitehouse Station, NJ, USA. 10-2007-CST-06-ZA-140-I COSOPT | Home





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