Reviews Chloramphenicol Sodium Succinate Injection


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Chloramphenicol Sodium Succinate Drug Description
Chloramphenicol Sodium Succinate
(chloramphenicol sodium succinate) Injection

WARNING
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia,
thrombocytopenia, and granulocytopenia) are known to occur after the administration
of chloramphenicol. In addition, there have been reports of aplastic anemia
attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias
have occurred after both short-term and prolonged therapy with this drug. Chloramphenicol
must not be used when less potentially dangerous agents will be effective, as
described in the INDICATIONS AND USAGE section. It must not be used in the
treatment of trivial infections or where it is not indicated, as in colds, influenza,
infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Precautions: It is essential that adequate blood studies be made during
treatment with the drug. While blood studies may detect early peripheral blood
changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before
they become irreversible, such studies cannot be relied on to detect bone marrow
depression prior to development of aplastic anemia. To facilitate appropriate
studies and observation during therapy, it is desirable that patients be hospitalized.
IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM
SUCCINATE. CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE
ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically
active form, and there is a lag in achieving adequate blood levels compared
with the base given intravenously.
Patients started on intravenous chloramphenicol sodium succinate should
be changed to the oral form of another appropriate antibiotic as soon as practicable.


DRUG DESCRIPTION
Chloramphenicol is an antibiotic that is clinically useful for, and should
be reserved for, serious infections caused by organisms susceptible to its
antimicrobial effects when less potentially hazardous therapeutic agents are
ineffective or contraindicated. Sensitivity testing is essential to determine
its indicated use, but may be performed concurrently with therapy initiated
on clinical impression that one of the indicated conditions exists (see INDICATIONS
AND USAGE section).
When reconstituted as directed, each vial contains a sterile solution equivalent
to 100 mg of chloramphenicol per mL (1g/10mL).
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains
approximately 52 mg (2.25 mEq) of sodium.
The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-
hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium
succinate).
The empirical and structural formulas are:







Last reviewed on RxList: 8/12/2008




Chloramphenicol Sodium Succinate Drug Description
Chloramphenicol Sodium Succinate
(chloramphenicol sodium succinate) Injection

WARNING
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia,
thrombocytopenia, and granulocytopenia) are known to occur after the administration
of chloramphenicol. In addition, there have been reports of aplastic anemia
attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias
have occurred after both short-term and prolonged therapy with this drug. Chloramphenicol
must not be used when less potentially dangerous agents will be effective, as
described in the INDICATIONS AND USAGE section. It must not be used in the
treatment of trivial infections or where it is not indicated, as in colds, influenza,
infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Precautions: It is essential that adequate blood studies be made during
treatment with the drug. While blood studies may detect early peripheral blood
changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before
they become irreversible, such studies cannot be relied on to detect bone marrow
depression prior to development of aplastic anemia. To facilitate appropriate
studies and observation during therapy, it is desirable that patients be hospitalized.
IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM
SUCCINATE. CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE
ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically
active form, and there is a lag in achieving adequate blood levels compared
with the base given intravenously.
Patients started on intravenous chloramphenicol sodium succinate should
be changed to the oral form of another appropriate antibiotic as soon as practicable.


DRUG DESCRIPTION
Chloramphenicol is an antibiotic that is clinically useful for, and should
be reserved for, serious infections caused by organisms susceptible to its
antimicrobial effects when less potentially hazardous therapeutic agents are
ineffective or contraindicated. Sensitivity testing is essential to determine
its indicated use, but may be performed concurrently with therapy initiated
on clinical impression that one of the indicated conditions exists (see INDICATIONS
AND USAGE section).
When reconstituted as directed, each vial contains a sterile solution equivalent
to 100 mg of chloramphenicol per mL (1g/10mL).
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains
approximately 52 mg (2.25 mEq) of sodium.
The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-
hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium
succinate).
The empirical and structural formulas are:







Last reviewed on RxList: 8/12/2008




Chloramphenicol Sodium Succinate Drug Description
Chloramphenicol Sodium Succinate
(chloramphenicol sodium succinate) Injection

WARNING
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia,
thrombocytopenia, and granulocytopenia) are known to occur after the administration
of chloramphenicol. In addition, there have been reports of aplastic anemia
attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias
have occurred after both short-term and prolonged therapy with this drug. Chloramphenicol
must not be used when less potentially dangerous agents will be effective, as
described in the INDICATIONS AND USAGE section. It must not be used in the
treatment of trivial infections or where it is not indicated, as in colds, influenza,
infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Precautions: It is essential that adequate blood studies be made during
treatment with the drug. While blood studies may detect early peripheral blood
changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before
they become irreversible, such studies cannot be relied on to detect bone marrow
depression prior to development of aplastic anemia. To facilitate appropriate
studies and observation during therapy, it is desirable that patients be hospitalized.
IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM
SUCCINATE. CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE
ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically
active form, and there is a lag in achieving adequate blood levels compared
with the base given intravenously.
Patients started on intravenous chloramphenicol sodium succinate should
be changed to the oral form of another appropriate antibiotic as soon as practicable.


DRUG DESCRIPTION
Chloramphenicol is an antibiotic that is clinically useful for, and should
be reserved for, serious infections caused by organisms susceptible to its
antimicrobial effects when less potentially hazardous therapeutic agents are
ineffective or contraindicated. Sensitivity testing is essential to determine
its indicated use, but may be performed concurrently with therapy initiated
on clinical impression that one of the indicated conditions exists (see INDICATIONS
AND USAGE section).
When reconstituted as directed, each vial contains a sterile solution equivalent
to 100 mg of chloramphenicol per mL (1g/10mL).
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains
approximately 52 mg (2.25 mEq) of sodium.
The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-
hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium
succinate).
The empirical and structural formulas are:







Last reviewed on RxList: 8/12/2008




Chloramphenicol Sodium Succinate Drug Description
Chloramphenicol Sodium Succinate
(chloramphenicol sodium succinate) Injection

WARNING
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia,
thrombocytopenia, and granulocytopenia) are known to occur after the administration
of chloramphenicol. In addition, there have been reports of aplastic anemia
attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias
have occurred after both short-term and prolonged therapy with this drug. Chloramphenicol
must not be used when less potentially dangerous agents will be effective, as
described in the INDICATIONS AND USAGE section. It must not be used in the
treatment of trivial infections or where it is not indicated, as in colds, influenza,
infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Precautions: It is essential that adequate blood studies be made during
treatment with the drug. While blood studies may detect early peripheral blood
changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before
they become irreversible, such studies cannot be relied on to detect bone marrow
depression prior to development of aplastic anemia. To facilitate appropriate
studies and observation during therapy, it is desirable that patients be hospitalized.
IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM
SUCCINATE. CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE
ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically
active form, and there is a lag in achieving adequate blood levels compared
with the base given intravenously.
Patients started on intravenous chloramphenicol sodium succinate should
be changed to the oral form of another appropriate antibiotic as soon as practicable.


DRUG DESCRIPTION
Chloramphenicol is an antibiotic that is clinically useful for, and should
be reserved for, serious infections caused by organisms susceptible to its
antimicrobial effects when less potentially hazardous therapeutic agents are
ineffective or contraindicated. Sensitivity testing is essential to determine
its indicated use, but may be performed concurrently with therapy initiated
on clinical impression that one of the indicated conditions exists (see INDICATIONS
AND USAGE section).
When reconstituted as directed, each vial contains a sterile solution equivalent
to 100 mg of chloramphenicol per mL (1g/10mL).
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains
approximately 52 mg (2.25 mEq) of sodium.
The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-
hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium
succinate).
The empirical and structural formulas are:







Last reviewed on RxList: 8/12/2008




Chloramphenicol Sodium Succinate Drug Description
Chloramphenicol Sodium Succinate
(chloramphenicol sodium succinate) Injection

WARNING
Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia,
thrombocytopenia, and granulocytopenia) are known to occur after the administration
of chloramphenicol. In addition, there have been reports of aplastic anemia
attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias
have occurred after both short-term and prolonged therapy with this drug. Chloramphenicol
must not be used when less potentially dangerous agents will be effective, as
described in the INDICATIONS AND USAGE section. It must not be used in the
treatment of trivial infections or where it is not indicated, as in colds, influenza,
infections of the throat; or as a prophylactic agent to prevent bacterial infections.
Precautions: It is essential that adequate blood studies be made during
treatment with the drug. While blood studies may detect early peripheral blood
changes, such as leukopenia, reticulocytopenia, or granulocytopenia, before
they become irreversible, such studies cannot be relied on to detect bone marrow
depression prior to development of aplastic anemia. To facilitate appropriate
studies and observation during therapy, it is desirable that patients be hospitalized.
IMPORTANT CONSIDERATIONS IN PRESCRIBING INJECTABLE CHLORAMPHENICOL SODIUM
SUCCINATE. CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE
ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY.

Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically
active form, and there is a lag in achieving adequate blood levels compared
with the base given intravenously.
Patients started on intravenous chloramphenicol sodium succinate should
be changed to the oral form of another appropriate antibiotic as soon as practicable.


DRUG DESCRIPTION
Chloramphenicol is an antibiotic that is clinically useful for, and should
be reserved for, serious infections caused by organisms susceptible to its
antimicrobial effects when less potentially hazardous therapeutic agents are
ineffective or contraindicated. Sensitivity testing is essential to determine
its indicated use, but may be performed concurrently with therapy initiated
on clinical impression that one of the indicated conditions exists (see INDICATIONS
AND USAGE section).
When reconstituted as directed, each vial contains a sterile solution equivalent
to 100 mg of chloramphenicol per mL (1g/10mL).
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains
approximately 52 mg (2.25 mEq) of sodium.
The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-
hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium
succinate).
The empirical and structural formulas are:







Last reviewed on RxList: 8/12/2008





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FOR INJECTION, USP FOR INTRAVENOUS ADMINISTRATION WARNING Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocy-topeniaandgranulocytopenia) are ... CHLORAMPHENICOL SODIUM SUCCINATE


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Trade offer to sell Chloramphenicol Sodium Succinate Injection from an established company Neiss Labs Limited. Chloramphenicol Sodium Succinate Injection, Mumbai, India, 1922274





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