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Cardiolite Drug Description
CARDIOLITE®
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time


Last reviewed on RxList: 3/9/2009




Cardiolite Drug Description
CARDIOLITE®
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time


Last reviewed on RxList: 3/9/2009




Cardiolite Drug Description
CARDIOLITE®
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time


Last reviewed on RxList: 3/9/2009




Cardiolite Drug Description
CARDIOLITE®
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time


Last reviewed on RxList: 3/9/2009




Cardiolite Drug Description
CARDIOLITE®
Kit for the Preparation of Technetium Tc99m Sestamibi for Injection
DRUG DESCRIPTION
Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate -
1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate -1.0 mg
Mannitol - 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H20)
- 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H20) - 0.075
mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H20) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.
This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.
The precise structure of the technetium complex is Tc99m[MIBI]6+
where MIBI is 2-methoxy isobutyl isonitrile.
Physical Characteristics
Technetium Tc99m decays by isomeric transition with a physical half-life of
6.02 hours1. Photons that are useful for detection and imaging studies
are listed below in Table 4.
Table 4.0 - Principal Radiation Emission Data



Radiation
Mean %/Disintegration
Mean Energy (KeV)


Gamma-2
89.07
140.5


1Kocher, David, C., Radioactive
Decay Data Tables, DOE/TIC-11026, 108 (1981).



External Radiation
The specific gamma ray constant for Tc99m is 5.4 micro coulombs/Kg-MBq-hr (0.78R/mCi-hr) at 1 cm. The first half value layer is 0.017 cm of Pb. A range of values for the relative attenuation of the radiation emitted by this radio nuclide that results from interposition of various thicknesses of Pb is shown in Table 5.0. To facilitate control of the radiation exposure from Megabequerel (millicurie) amounts of this radio nuclide, the use of a 0.25 cm thickness of Pb will attenuate the radiation emitted by a factor of 1,000.
Table 5.0 - Radiation Attenuation by Lead Shielding



Shield Thickness (Pb) cm
Coefficient of Attenuation


0.017
0.5


0.08
10-1


0.16
10-2


0.25
10-3


0.33
10-4



To correct for physical decay of this radio nuclide, the fractions that remain at selected intervals after the time of calibration are shown in Table 6.0.
Table 6.0 - Physical Decay Chart; Tc99m Half-Life 6.02 Hours



Hours
Fraction Remaining
Hours
Fraction Remaining


0*
1.000
8
.398


1
.891
9
.355


2
.794
10
.316


3
.708
11
.282


4
.631
12
.251


5
.562
 
 


6
.501
 
 


7
.447
 
 


* Calibration Time


Last reviewed on RxList: 3/9/2009





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Other reviews about Cardiolite on web:

Accurate, FDA approved Cardiolite information for healthcare professionals and patients - brought to you by Drugs.com. Cardiolite Official FDA information, side effects and uses.


Technetium (99m Tc) sestamibi (trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex of the radioisotope ... Technetium (99mTc) sestamibi - Wikipedia, the free encyclopedia


What is a Cardiolite Stress Test? A stress test with Cardioliteテδづつョ is a way to determine if your heart muscle is getting the blood supply it needs. Cardiolite Test


Learn about the prescription medication Cardiolite (Prep kit for Technetium Tc99 Sestamibi for Injection), drug uses, dosage, side effects, drug interactions, warnings, reviews ... Cardiolite (Prep kit for Technetium Tc99 Sestamibi for Injection ...


Care guide for Cardioliteテδづつョ Stress Test possible causes, signs and symptoms, standard treatment options and means of care and support. Cardioliteテδづつョ Stress Test - Care Guide


Nuclear perfusion studies with thallium and Cardiolite - thallium and Cardiolite scans Nuclear perfusion studies with thallium and Cardiolite - thallium ...


A cardiac stress test is a diagnostic test used in cardiology in which the ability of the heart to respond to stress, either actually induced by physical exercise or stimulated by ... Cardiac stress test - Wikipedia, the free encyclopedia


h. Press the proceed button to initiate the program (the thermal cycler automatically heats & cools the vial and contents). Please see the Recon-o-Stat Instruction Manual for ... CARDIOLITEテδづつョ


T5-B001 May 2003 513121-0503 331 Treble Cove Road N. Billerica, Massachusetts 01862 USA CARDIOLITE テδづつョ Kit for the Preparation of Technetium Tc99m Sestamibi for Injection FOR DIAGNOSTIC USE ... Kit for the Preparation of Technetium Tc99m Sestamibi for Injection





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