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Tegretol Drug Description
Tegretol®
(carbamazepine) USP Chewable Tablets of 100 mg - red-speckled, pink Tablets of
200 mg - pink, Suspension of 100 mg/5 mL

Tegretol®-XR
(carbamazepine) Extended-release tablets 100 mg, 200 mg, 400 mg

WARNING
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE
SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL
NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING
TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6
PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE
RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES
IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE
RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC
VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS
WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY
AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR
TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE
SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE
RISK (SEE WARNINGS AND PRECAUTIONS/LABORATORY
TESTS).
APLASTIC ANEMIA AND AGRANULOCYTOSIS
APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH
THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE
THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE
GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED
GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION
PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER
YEAR FOR APLASTIC ANEMIA.
ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD
CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE
NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE
VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS
CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.
BECAUSE OF THE VERY LOW INCIDENCE OF AGRANULOCYTOSIS AND APLASTIC ANEMIA, THE
VAST MAJORITY OF MINOR HEMATOLOGIC CHANGES OBSERVED IN MONITORING OF PATIENTS
ON TEGRETOL ARE UNLIKELY TO SIGNAL THE OCCURRENCE OF EITHER ABNORMALITY. NONETHELESS,
COMPLETE PRETREATMENT HEMATOLOGICAL TESTING SHOULD BE OBTAINED AS A BASELINE.
IF A PATIENT IN THE COURSE OF TREATMENT EXHIBITS LOW OR DECREASED WHITE BLOOD
CELL OR PLATELET COUNTS, THE PATIENT SHOULD BE MONITORED CLOSELY. DISCONTINUATION
OF THE DRUG SHOULD BE CONSIDERED IF ANY EVIDENCE OF SIGNIFICANT BONE MARROW
DEPRESSION DEVELOPS.

Before prescribing Tegretol, the physician should be thoroughly familiar
with the details of this prescribing information, particularly regarding use
with other drugs, especially those which accentuate toxicity potential.
DRUG DESCRIPTION



What are the possible side effects of carbamazepine (Carbatrol, Equetro, Tegretol, Tegretol XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these...
Read All Potential Side Effects for Tegretol »




Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic for
trigeminal neuralgia, available for oral administration as chewable tablets
of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension
of 100 mg/5 mL (teaspoon). Its chemical name is 5H-dibenz[b,f ]azepine-5-carboxamide,
and its structural formula is








Carbamazepine USP is a white to off-white powder, practically insoluble in
water and soluble in alcohol and in acetone. Its molecular weight is 236.27.
Inactive Ingredients. Tablets: Colloidal silicon dioxide, D&C Red
No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets
only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate,
sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose
(chewable tablets only). Suspension: Citric acid, FD&C Yellow No. 6, flavoring,
polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose,
and xanthan gum. Tegretol-XR tablets: cellulose compounds, dextrates, iron oxides,
magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, titanium
dioxide (200-mg tablets only).Last reviewed on RxList: 1/3/2008




Tegretol Drug Description
Tegretol®
(carbamazepine) USP Chewable Tablets of 100 mg - red-speckled, pink Tablets of
200 mg - pink, Suspension of 100 mg/5 mL

Tegretol®-XR
(carbamazepine) Extended-release tablets 100 mg, 200 mg, 400 mg

WARNING
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE
SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL
NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING
TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6
PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE
RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES
IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE
RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC
VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS
WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY
AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR
TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE
SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE
RISK (SEE WARNINGS AND PRECAUTIONS/LABORATORY
TESTS).
APLASTIC ANEMIA AND AGRANULOCYTOSIS
APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH
THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE
THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE
GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED
GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION
PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER
YEAR FOR APLASTIC ANEMIA.
ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD
CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE
NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE
VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS
CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.
BECAUSE OF THE VERY LOW INCIDENCE OF AGRANULOCYTOSIS AND APLASTIC ANEMIA, THE
VAST MAJORITY OF MINOR HEMATOLOGIC CHANGES OBSERVED IN MONITORING OF PATIENTS
ON TEGRETOL ARE UNLIKELY TO SIGNAL THE OCCURRENCE OF EITHER ABNORMALITY. NONETHELESS,
COMPLETE PRETREATMENT HEMATOLOGICAL TESTING SHOULD BE OBTAINED AS A BASELINE.
IF A PATIENT IN THE COURSE OF TREATMENT EXHIBITS LOW OR DECREASED WHITE BLOOD
CELL OR PLATELET COUNTS, THE PATIENT SHOULD BE MONITORED CLOSELY. DISCONTINUATION
OF THE DRUG SHOULD BE CONSIDERED IF ANY EVIDENCE OF SIGNIFICANT BONE MARROW
DEPRESSION DEVELOPS.

Before prescribing Tegretol, the physician should be thoroughly familiar
with the details of this prescribing information, particularly regarding use
with other drugs, especially those which accentuate toxicity potential.
DRUG DESCRIPTION



What are the possible side effects of carbamazepine (Carbatrol, Equetro, Tegretol, Tegretol XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these...
Read All Potential Side Effects for Tegretol »




Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic for
trigeminal neuralgia, available for oral administration as chewable tablets
of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension
of 100 mg/5 mL (teaspoon). Its chemical name is 5H-dibenz[b,f ]azepine-5-carboxamide,
and its structural formula is








Carbamazepine USP is a white to off-white powder, practically insoluble in
water and soluble in alcohol and in acetone. Its molecular weight is 236.27.
Inactive Ingredients. Tablets: Colloidal silicon dioxide, D&C Red
No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets
only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate,
sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose
(chewable tablets only). Suspension: Citric acid, FD&C Yellow No. 6, flavoring,
polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose,
and xanthan gum. Tegretol-XR tablets: cellulose compounds, dextrates, iron oxides,
magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, titanium
dioxide (200-mg tablets only).Last reviewed on RxList: 1/3/2008




Tegretol Drug Description
Tegretol®
(carbamazepine) USP Chewable Tablets of 100 mg - red-speckled, pink Tablets of
200 mg - pink, Suspension of 100 mg/5 mL

Tegretol®-XR
(carbamazepine) Extended-release tablets 100 mg, 200 mg, 400 mg

WARNING
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE
SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL
NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING
TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6
PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE
RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES
IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE
RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC
VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS
WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY
AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR
TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE
SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE
RISK (SEE WARNINGS AND PRECAUTIONS/LABORATORY
TESTS).
APLASTIC ANEMIA AND AGRANULOCYTOSIS
APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH
THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE
THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE
GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED
GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION
PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER
YEAR FOR APLASTIC ANEMIA.
ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD
CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE
NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE
VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS
CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.
BECAUSE OF THE VERY LOW INCIDENCE OF AGRANULOCYTOSIS AND APLASTIC ANEMIA, THE
VAST MAJORITY OF MINOR HEMATOLOGIC CHANGES OBSERVED IN MONITORING OF PATIENTS
ON TEGRETOL ARE UNLIKELY TO SIGNAL THE OCCURRENCE OF EITHER ABNORMALITY. NONETHELESS,
COMPLETE PRETREATMENT HEMATOLOGICAL TESTING SHOULD BE OBTAINED AS A BASELINE.
IF A PATIENT IN THE COURSE OF TREATMENT EXHIBITS LOW OR DECREASED WHITE BLOOD
CELL OR PLATELET COUNTS, THE PATIENT SHOULD BE MONITORED CLOSELY. DISCONTINUATION
OF THE DRUG SHOULD BE CONSIDERED IF ANY EVIDENCE OF SIGNIFICANT BONE MARROW
DEPRESSION DEVELOPS.

Before prescribing Tegretol, the physician should be thoroughly familiar
with the details of this prescribing information, particularly regarding use
with other drugs, especially those which accentuate toxicity potential.
DRUG DESCRIPTION



What are the possible side effects of carbamazepine (Carbatrol, Equetro, Tegretol, Tegretol XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these...
Read All Potential Side Effects for Tegretol »




Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic for
trigeminal neuralgia, available for oral administration as chewable tablets
of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension
of 100 mg/5 mL (teaspoon). Its chemical name is 5H-dibenz[b,f ]azepine-5-carboxamide,
and its structural formula is








Carbamazepine USP is a white to off-white powder, practically insoluble in
water and soluble in alcohol and in acetone. Its molecular weight is 236.27.
Inactive Ingredients. Tablets: Colloidal silicon dioxide, D&C Red
No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets
only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate,
sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose
(chewable tablets only). Suspension: Citric acid, FD&C Yellow No. 6, flavoring,
polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose,
and xanthan gum. Tegretol-XR tablets: cellulose compounds, dextrates, iron oxides,
magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, titanium
dioxide (200-mg tablets only).Last reviewed on RxList: 1/3/2008




Tegretol Drug Description
Tegretol®
(carbamazepine) USP Chewable Tablets of 100 mg - red-speckled, pink Tablets of
200 mg - pink, Suspension of 100 mg/5 mL

Tegretol®-XR
(carbamazepine) Extended-release tablets 100 mg, 200 mg, 400 mg

WARNING
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE
SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL
NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING
TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6
PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE
RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES
IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE
RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC
VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS
WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY
AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR
TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE
SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE
RISK (SEE WARNINGS AND PRECAUTIONS/LABORATORY
TESTS).
APLASTIC ANEMIA AND AGRANULOCYTOSIS
APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH
THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE
THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE
GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED
GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION
PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER
YEAR FOR APLASTIC ANEMIA.
ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD
CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE
NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE
VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS
CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.
BECAUSE OF THE VERY LOW INCIDENCE OF AGRANULOCYTOSIS AND APLASTIC ANEMIA, THE
VAST MAJORITY OF MINOR HEMATOLOGIC CHANGES OBSERVED IN MONITORING OF PATIENTS
ON TEGRETOL ARE UNLIKELY TO SIGNAL THE OCCURRENCE OF EITHER ABNORMALITY. NONETHELESS,
COMPLETE PRETREATMENT HEMATOLOGICAL TESTING SHOULD BE OBTAINED AS A BASELINE.
IF A PATIENT IN THE COURSE OF TREATMENT EXHIBITS LOW OR DECREASED WHITE BLOOD
CELL OR PLATELET COUNTS, THE PATIENT SHOULD BE MONITORED CLOSELY. DISCONTINUATION
OF THE DRUG SHOULD BE CONSIDERED IF ANY EVIDENCE OF SIGNIFICANT BONE MARROW
DEPRESSION DEVELOPS.

Before prescribing Tegretol, the physician should be thoroughly familiar
with the details of this prescribing information, particularly regarding use
with other drugs, especially those which accentuate toxicity potential.
DRUG DESCRIPTION



What are the possible side effects of carbamazepine (Carbatrol, Equetro, Tegretol, Tegretol XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these...
Read All Potential Side Effects for Tegretol »




Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic for
trigeminal neuralgia, available for oral administration as chewable tablets
of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension
of 100 mg/5 mL (teaspoon). Its chemical name is 5H-dibenz[b,f ]azepine-5-carboxamide,
and its structural formula is








Carbamazepine USP is a white to off-white powder, practically insoluble in
water and soluble in alcohol and in acetone. Its molecular weight is 236.27.
Inactive Ingredients. Tablets: Colloidal silicon dioxide, D&C Red
No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets
only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate,
sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose
(chewable tablets only). Suspension: Citric acid, FD&C Yellow No. 6, flavoring,
polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose,
and xanthan gum. Tegretol-XR tablets: cellulose compounds, dextrates, iron oxides,
magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, titanium
dioxide (200-mg tablets only).Last reviewed on RxList: 1/3/2008




Tegretol Drug Description
Tegretol®
(carbamazepine) USP Chewable Tablets of 100 mg - red-speckled, pink Tablets of
200 mg - pink, Suspension of 100 mg/5 mL

Tegretol®-XR
(carbamazepine) Extended-release tablets 100 mg, 200 mg, 400 mg

WARNING
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE
SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL
NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING
TREATMENT WITH TEGRETOL. THESE REACTIONS ARE ESTIMATED TO OCCUR IN 1 TO 6
PER 10,000 NEW USERS IN COUNTRIES WITH MAINLY CAUCASIAN POPULATIONS, BUT THE
RISK IN SOME ASIAN COUNTRIES IS ESTIMATED TO BE ABOUT 10 TIMES HIGHER. STUDIES
IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE
RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC
VARIANT OF THE HLA-B GENE. HLA-B*1502 IS FOUND ALMOST EXCLUSIVELY IN PATIENTS
WITH ANCESTRY ACROSS BROAD AREAS OF ASIA. PATIENTS WITH ANCESTRY IN GENETICALLY
AT-RISK POPULATIONS SHOULD BE SCREENED FOR THE PRESENCE OF HLA-B*1502 PRIOR
TO INITIATING TREATMENT WITH TEGRETOL. PATIENTS TESTING POSITIVE FOR THE ALLELE
SHOULD NOT BE TREATED WITH TEGRETOL UNLESS THE BENEFIT CLEARLY OUTWEIGHS THE
RISK (SEE WARNINGS AND PRECAUTIONS/LABORATORY
TESTS).
APLASTIC ANEMIA AND AGRANULOCYTOSIS
APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH
THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE
THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE
GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED
GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION
PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER
YEAR FOR APLASTIC ANEMIA.
ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD
CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE
NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE
VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS
CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.
BECAUSE OF THE VERY LOW INCIDENCE OF AGRANULOCYTOSIS AND APLASTIC ANEMIA, THE
VAST MAJORITY OF MINOR HEMATOLOGIC CHANGES OBSERVED IN MONITORING OF PATIENTS
ON TEGRETOL ARE UNLIKELY TO SIGNAL THE OCCURRENCE OF EITHER ABNORMALITY. NONETHELESS,
COMPLETE PRETREATMENT HEMATOLOGICAL TESTING SHOULD BE OBTAINED AS A BASELINE.
IF A PATIENT IN THE COURSE OF TREATMENT EXHIBITS LOW OR DECREASED WHITE BLOOD
CELL OR PLATELET COUNTS, THE PATIENT SHOULD BE MONITORED CLOSELY. DISCONTINUATION
OF THE DRUG SHOULD BE CONSIDERED IF ANY EVIDENCE OF SIGNIFICANT BONE MARROW
DEPRESSION DEVELOPS.

Before prescribing Tegretol, the physician should be thoroughly familiar
with the details of this prescribing information, particularly regarding use
with other drugs, especially those which accentuate toxicity potential.
DRUG DESCRIPTION



What are the possible side effects of carbamazepine (Carbatrol, Equetro, Tegretol, Tegretol XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these...
Read All Potential Side Effects for Tegretol »




Tegretol, carbamazepine USP, is an anticonvulsant and specific analgesic for
trigeminal neuralgia, available for oral administration as chewable tablets
of 100 mg, tablets of 200 mg, XR tablets of 100, 200, and 400 mg, and as a suspension
of 100 mg/5 mL (teaspoon). Its chemical name is 5H-dibenz[b,f ]azepine-5-carboxamide,
and its structural formula is








Carbamazepine USP is a white to off-white powder, practically insoluble in
water and soluble in alcohol and in acetone. Its molecular weight is 236.27.
Inactive Ingredients. Tablets: Colloidal silicon dioxide, D&C Red
No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets
only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate,
sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose
(chewable tablets only). Suspension: Citric acid, FD&C Yellow No. 6, flavoring,
polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose,
and xanthan gum. Tegretol-XR tablets: cellulose compounds, dextrates, iron oxides,
magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, titanium
dioxide (200-mg tablets only).Last reviewed on RxList: 1/3/2008





Other reviews about Carbamazepine on wordpress

Switch to Oxcarbazepine and Regain your Erection
  by rampress
If you’re experiencing symptoms of erectile dysfunction, because you are taking seizure medication Carbamazepine, and it’s time to reclaim your manhood. Flush that Carbamazepine down the toilet. […]


Carbamazepine Prescribing Information to Include Recommendation of Genetic Test for Patients with Asian Ancestry
  by DNADiva
The FDA announced yesterday that the Carbamazepine drug label will now recommend HLA-B* 1502 genetic testing of patients with Asian ancestry prior to initiation of therapy. About 6 […]


FDA Warns of Genetic Link to Carbamazepine Skin Reactions
  by pchalita
  Yael Waknine Medscape Medical News 2007. © 2007 MedscapeDecember 13, 2007 — Patients with Asian ancestry should be […]


Is There A Genetic Predisposition of Asian Patients For Serious Skin Reactions Under Phenytoin and Fosphenytoin Treatment?
  by thassodotcom
FDA is investigating new preliminary data suggesting an increased risk of serious skin reactions from the anti-epileptic drugs phenytoin and fosphenytoin if they are taken by Asian patients […]


Children whose mothers took valproate while pregnant have lower IQ's
  by thassodotcom
April 17, 2009 - Children born to women who took the epilepsy drug valproate while pregnant had lower IQs at least up to age 3 than the children […]


New Medication for Me Bipolar - Carbamazepine
  by Jewells
I went to a mental health clinic to see if I could get some help with my bipolar the other day and spoke with a doctor and case […]


I Quit Lithium and Now Taking Carbamazepine - Will It Work
  by Jewells
I've started a blog on my other blog Journaling for Therapy to talk about this new drug that is actually a generic of Tegretol. "Tegretol is in a group […]


My Second Day On Carbamazepine & Lorezpam for Bipolar
  by Jewells
I'm going to keep you up to date on this drug I have never heard of.  I got it from a mental health clinic. Where the nurse practitioner […]


Paroxysmal staccato tinnitus: a carbamazepine responsive hyperactivity dysfunction symptom of the eighth cranial nerve
  by Callier Library
Hyperactive disorders related to neurovascular compression have been described for several cranial nerves of which trigeminal neuralgia and hemifacial spasm are the best known. The present report on […]



Other reviews about Carbamazepine on web:

Carbamazepine (CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. Carbamazepine - Wikipedia, the free encyclopedia


carbamazepine ( ) n. An anticonvulsant drug, C 15 H 12 N 2 O, used in the treatment of certain forms of epilepsy and to relieve pain associated with carbamazepine: Definition from Answers.com


Carbamazepine (Tegretol) is used to treat epileptic seizures and nerve pain such as trigeminal neuralgia. Includes carbamazepine side effects, interactions and indications. Carbamazepine (Tegretol) Information from Drugs.com


Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. Carbamazepine: MedlinePlus Drug Information


Learn about the prescription medication Tegretol (Carbamazepine), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Tegretol (Carbamazepine) Drug Information: Uses, Side Effects ...


Establishes the medication carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol), a drug used in the treatment of simple and complex partial seizures and in generalized ... carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol) - drug ...


Accurate, FDA approved Carbamazepine information for healthcare professionals and patients - brought to you by Drugs.com. Carbamazepine Official FDA information, side effects and uses.


–noun Pharmacology. a white to whitish toxic powder, C 15 H 12 N 2 O, used as an analgesic in the treatment of trigeminal neuralgia and as an anticonvulsant. Carbamazepine | Define Carbamazepine at Dictionary.com


Consumer information about the medication CARBAMAZEPINE - ORAL (Tegretol), includes side effects, drug interactions, recommended dosages, and storage information. Read more about ... CARBAMAZEPINE - ORAL (Tegretol) side effects, medical uses, and ...


Carbamazepine – Encyclopedia.com has Carbamazepine articles, Carbamazepine pictures, video and information at Encyclopedia.com - a FREE online library Carbamazepine – FREE Carbamazepine information | Encyclopedia ...





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