Reviews Capecitabine


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Xeloda Drug Description
XELODA®
(capecitabine) Tablets

WARNING
XELODA Warfarin Interaction: Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant
response (INR or prothrombin time) monitored frequently in order to adjust
the anticoagulant dose accordingly. A clinically important XELODA-Warfarin
drug interaction was demonstrated in a clinical pharmacology trial (see CLINICAL
PHARMACOLOGY and PRECAUTIONS).
Altered coagulation parameters and/or bleeding, including death, have been
reported in patients taking XELODA concomitantly with coumarin-derivative
anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have
shown clinically significant increases in prothrombin time (PT) and INR in
patients who were stabilized on anticoagulants at the time XELODA was introduced.
These events occurred within several days and up to several months after initiating
XELODA therapy and, in a few cases, within 1 month after stopping XELODA.
These events occurred in patients with and without liver metastases. Age greater
than 60 and a diagnosis of cancer independently predispose patients to an
increased risk of coagulopathy.

DRUG DESCRIPTION



What are the possible side effects of capecitabine (Xeloda)?

If you experience any of the following serious side effects, stop taking capecitabine and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
diarrhea (more than 4 bowel movements each day or any diarrhea at night);
vomiting (more than once in 24 hours);
nausea or a loss of appetite (if the amount of food you...
Read All Potential Side Effects for Xeloda »




XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35. Capecitabine has the following structural formula:








Capecitabine is a white to off-white crystalline powder with an aqueous solubility of 26 mg/mL at 20°C.
XELODA is supplied as biconvex, oblong film-coated tablets for oral administration. Each light peach-colored tablet contains 150 mg capecitabine and each peach-colored tablet contains 500 mg capecitabine. The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate and purified water. The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides.
Last reviewed on RxList: 6/25/2008




Xeloda Drug Description
XELODA®
(capecitabine) Tablets

WARNING
XELODA Warfarin Interaction: Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant
response (INR or prothrombin time) monitored frequently in order to adjust
the anticoagulant dose accordingly. A clinically important XELODA-Warfarin
drug interaction was demonstrated in a clinical pharmacology trial (see CLINICAL
PHARMACOLOGY and PRECAUTIONS).
Altered coagulation parameters and/or bleeding, including death, have been
reported in patients taking XELODA concomitantly with coumarin-derivative
anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have
shown clinically significant increases in prothrombin time (PT) and INR in
patients who were stabilized on anticoagulants at the time XELODA was introduced.
These events occurred within several days and up to several months after initiating
XELODA therapy and, in a few cases, within 1 month after stopping XELODA.
These events occurred in patients with and without liver metastases. Age greater
than 60 and a diagnosis of cancer independently predispose patients to an
increased risk of coagulopathy.

DRUG DESCRIPTION



What are the possible side effects of capecitabine (Xeloda)?

If you experience any of the following serious side effects, stop taking capecitabine and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
diarrhea (more than 4 bowel movements each day or any diarrhea at night);
vomiting (more than once in 24 hours);
nausea or a loss of appetite (if the amount of food you...
Read All Potential Side Effects for Xeloda »




XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35. Capecitabine has the following structural formula:








Capecitabine is a white to off-white crystalline powder with an aqueous solubility of 26 mg/mL at 20°C.
XELODA is supplied as biconvex, oblong film-coated tablets for oral administration. Each light peach-colored tablet contains 150 mg capecitabine and each peach-colored tablet contains 500 mg capecitabine. The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate and purified water. The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides.
Last reviewed on RxList: 6/25/2008




Xeloda Drug Description
XELODA®
(capecitabine) Tablets

WARNING
XELODA Warfarin Interaction: Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant
response (INR or prothrombin time) monitored frequently in order to adjust
the anticoagulant dose accordingly. A clinically important XELODA-Warfarin
drug interaction was demonstrated in a clinical pharmacology trial (see CLINICAL
PHARMACOLOGY and PRECAUTIONS).
Altered coagulation parameters and/or bleeding, including death, have been
reported in patients taking XELODA concomitantly with coumarin-derivative
anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have
shown clinically significant increases in prothrombin time (PT) and INR in
patients who were stabilized on anticoagulants at the time XELODA was introduced.
These events occurred within several days and up to several months after initiating
XELODA therapy and, in a few cases, within 1 month after stopping XELODA.
These events occurred in patients with and without liver metastases. Age greater
than 60 and a diagnosis of cancer independently predispose patients to an
increased risk of coagulopathy.

DRUG DESCRIPTION



What are the possible side effects of capecitabine (Xeloda)?

If you experience any of the following serious side effects, stop taking capecitabine and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
diarrhea (more than 4 bowel movements each day or any diarrhea at night);
vomiting (more than once in 24 hours);
nausea or a loss of appetite (if the amount of food you...
Read All Potential Side Effects for Xeloda »




XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35. Capecitabine has the following structural formula:








Capecitabine is a white to off-white crystalline powder with an aqueous solubility of 26 mg/mL at 20°C.
XELODA is supplied as biconvex, oblong film-coated tablets for oral administration. Each light peach-colored tablet contains 150 mg capecitabine and each peach-colored tablet contains 500 mg capecitabine. The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate and purified water. The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides.
Last reviewed on RxList: 6/25/2008




Xeloda Drug Description
XELODA®
(capecitabine) Tablets

WARNING
XELODA Warfarin Interaction: Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant
response (INR or prothrombin time) monitored frequently in order to adjust
the anticoagulant dose accordingly. A clinically important XELODA-Warfarin
drug interaction was demonstrated in a clinical pharmacology trial (see CLINICAL
PHARMACOLOGY and PRECAUTIONS).
Altered coagulation parameters and/or bleeding, including death, have been
reported in patients taking XELODA concomitantly with coumarin-derivative
anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have
shown clinically significant increases in prothrombin time (PT) and INR in
patients who were stabilized on anticoagulants at the time XELODA was introduced.
These events occurred within several days and up to several months after initiating
XELODA therapy and, in a few cases, within 1 month after stopping XELODA.
These events occurred in patients with and without liver metastases. Age greater
than 60 and a diagnosis of cancer independently predispose patients to an
increased risk of coagulopathy.

DRUG DESCRIPTION



What are the possible side effects of capecitabine (Xeloda)?

If you experience any of the following serious side effects, stop taking capecitabine and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
diarrhea (more than 4 bowel movements each day or any diarrhea at night);
vomiting (more than once in 24 hours);
nausea or a loss of appetite (if the amount of food you...
Read All Potential Side Effects for Xeloda »




XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35. Capecitabine has the following structural formula:








Capecitabine is a white to off-white crystalline powder with an aqueous solubility of 26 mg/mL at 20°C.
XELODA is supplied as biconvex, oblong film-coated tablets for oral administration. Each light peach-colored tablet contains 150 mg capecitabine and each peach-colored tablet contains 500 mg capecitabine. The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate and purified water. The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides.
Last reviewed on RxList: 6/25/2008




Xeloda Drug Description
XELODA®
(capecitabine) Tablets

WARNING
XELODA Warfarin Interaction: Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant
response (INR or prothrombin time) monitored frequently in order to adjust
the anticoagulant dose accordingly. A clinically important XELODA-Warfarin
drug interaction was demonstrated in a clinical pharmacology trial (see CLINICAL
PHARMACOLOGY and PRECAUTIONS).
Altered coagulation parameters and/or bleeding, including death, have been
reported in patients taking XELODA concomitantly with coumarin-derivative
anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have
shown clinically significant increases in prothrombin time (PT) and INR in
patients who were stabilized on anticoagulants at the time XELODA was introduced.
These events occurred within several days and up to several months after initiating
XELODA therapy and, in a few cases, within 1 month after stopping XELODA.
These events occurred in patients with and without liver metastases. Age greater
than 60 and a diagnosis of cancer independently predispose patients to an
increased risk of coagulopathy.

DRUG DESCRIPTION



What are the possible side effects of capecitabine (Xeloda)?

If you experience any of the following serious side effects, stop taking capecitabine and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
diarrhea (more than 4 bowel movements each day or any diarrhea at night);
vomiting (more than once in 24 hours);
nausea or a loss of appetite (if the amount of food you...
Read All Potential Side Effects for Xeloda »




XELODA (capecitabine) is a fluoropyrimidine carbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil.
The chemical name for capecitabine is 5'-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35. Capecitabine has the following structural formula:








Capecitabine is a white to off-white crystalline powder with an aqueous solubility of 26 mg/mL at 20°C.
XELODA is supplied as biconvex, oblong film-coated tablets for oral administration. Each light peach-colored tablet contains 150 mg capecitabine and each peach-colored tablet contains 500 mg capecitabine. The inactive ingredients in XELODA include: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate and purified water. The peach or light peach film coating contains hydroxypropyl methylcellulose, talc, titanium dioxide, and synthetic yellow and red iron oxides.
Last reviewed on RxList: 6/25/2008





Other reviews about Capecitabine on wordpress

Side Effects of Chemotherapy - Xeloda (Capecitabine)
  by Mez
Xeloda (Capecitabine) - Side Effects of Xeloda - Chemotherapy Drugs: Xeloda — Generic Name: “Capecitabine” www.chemocare.com/ bio/ xeloda.aspHand-Foot SyndromeXeloda (Capecitabine) cancer treatment, side-effect: Hand-foot syndrome (Palmar-Plantar Erythrodysesthesia or PPE) […]


Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer
  by journaldokter
Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer David Cunningham, M.D., F.R.C.P., Naureen Starling, M.R.C.P., Sheela Rao, M.R.C.P., Timothy Iveson, M.D., F.R.C.P., Marianne Nicolson, M.D., F.R.C.P., Fareeda Coxon, F.R.C.P., Gary […]


Hand-Foot Syndrome – cont. Further side-effect
  by Mez
Cancer Drug Erases Fingerprints Cancer drug wiped patient's fingerprints (Aust ABC News) Drug erases fingerprints, causing immigration drama (SMH) Cancer drug capecitabine causes patient to lose fingerprints and be detained by […]


Drug Erases Fingerprints, Causing Immigration Drama
  by BGR
A drug that removes your fingerprints? Capecitabine is not the work of a criminal mastermind with a PhD in chemistry. Rather, it is a common cancer drug, routinely given […]


Clinical Trials Webinar: Capecitabine, Gemcitabine, & Radiation Therapy in Treating Patients With Cholangiocarcinoma
  by Mark
  The Cholangiocarcinoma Foundation is generously sponsoring a free Webinar this Tuesday, March 23, 2010 at 11:30am - 12:30 pm EDT. As part of our ongoing Spotlight on Clinical Trials series, The […]


Capecitabine
  by likui0632
Capecitabine Name: Capecitabine Synonyms: Pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate; Xeloda Molecular Structure:    Molecular Formula: C15H22FN3O6 Molecular Weight: 359.35 CAS Registry Number: 154361-50-9  Capecitabine (INN) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. […]


NICE draft guidance recommends capecitabine for advanced gastric cancer
  by rcplondon
In draft guidance NICE has recommended a new treatment for advanced gastric cancer. Capecitabine (Xeloda, Roche Products) is recommended, in combination with a platinum-based regimen, for the first-line […]


Standard Chemo Better Than Oral Capecitabine in Elderly Breast Cancer
  by wngai
Most elderly breast cancer patients would prefer oral chemotherapy such as capecitabine (Xeloda, Roche) over intravenous chemotherapy due to the convenience.  However, a clinical trial conducted in elderly women […]


Efficacy and tolerability of Avastin plus Xeloda as first-line therapy in patients with advanced Liver Cancer
  by wngai
Liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality.  More than 80% of cases occur in East Asia and […]


NICE consults again on appraisal of bevacizumab for the treatment of metastatic colorectal cancer
  by rcplondon
NICE is issuing a second consultation document as part of its appraisal of bevacizumab (Avastin) in combination with chemotherapy (oxaliplatin and either 5-fluorouracil or capecitabine) for treating metastatic […]



Other reviews about Capecitabine on web:

Capecitabine (pronounced /keɪpˈsaɪtəbiːn/) (Xeloda, Roche) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine - Wikipedia, the free encyclopedia


This page contains brief information about capecitabine and a collection of links to more information about the use of this drug, related research results, and ongoing clinical ... Capecitabine - National Cancer Institute


Do not take XELODA if you are allergic to 5-fluorouracil, capecitabine or any of the ingredients in XELODA. Do not take XELODA if you have been told that you lack the enzyme DPD ... XELODA chemotherapy for certain breast and colorectal cancers


Capecitabine Key Terms: Colorectal cancer , Metastasis . Definition Capecitabine (brand name Xeloda) is a drug that interferes with the growth of Capecitabine: Information from Answers.com


Capecitabine is an anti-cancer chemotherapy drug classified as an antimetabolite. Capecitabine is used to treat metastatic colon or rectal cancer and metastatic breast cancer. Capecitabine, Xeloda - Chemotherapy Drugs, Chemo Drug Side Effects


All about Capecitabine. View complete and up to date Capecitabine information - part of the Drugs.com trusted medication database. Capecitabine Facts and Comparisons at Drugs.com


Consumer information about the medication CAPECITABINE - ORAL (Xeloda), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the ... CAPECITABINE - ORAL (Xeloda) side effects, medical uses, and drug ...


When used in combination with anticoagulants ('blood thinners') such as warfarin (Coumadin), capecitabine can cause serious bleeding and death. Capecitabine: MedlinePlus Drug Information


Capecitabine is often used to help treat certain types of breast or colorectal cancer. This eMedTV resource offers an in-depth look at the medicine, including how it works to ... Capecitabine


Physician reviewed capecitabine patient information - includes capecitabine description, dosage and directions. capecitabine medical facts from Drugs.com





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