Reviews Camptosar Injection


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Camptosar Injection Drug Description
Camptosar®
(irinotecan hydrochloride) Injection

WARNINGS
CAMPTOSAR Injection should be administered only under the supervision of a
physician who is experienced in the use of cancer chemotherapeutic agents. Appropriate
management of complications is possible only when adequate diagnostic and treatment
facilities are readily available. CAMPTOSAR can induce both early and late forms
of diarrhea that appear to be mediated by different mechanisms. Both forms of
diarrhea may be severe. Early diarrhea (occurring during or shortly after infusion
of CAMPTOSAR) may be accompanied by cholinergic symptoms of rhinitis, increased
salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis
that can cause abdominal cramping. Early diarrhea and other cholinergic symptoms
may be prevented or ameliorated by atropine (see PRECAUTIONS, General).
Late diarrhea (generally occurring more than 24 hours after administration of
CAMPTOSAR) can be life threatening since it may be prolonged and may lead to
dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated
promptly with loperamide. Patients with diarrhea should be carefully monitored
and given fluid and electrolyte replacement if they become dehydrated or antibiotic
therapy if they develop ileus, fever, or severe neutropenia (see WARNINGS).
Administration of CAMPTOSAR should be interrupted and subsequent doses reduced
if severe diarrhea occurs (see DOSAGE AND ADMINISTRATION).
Severe myelosuppression may occur (see WARNINGS).

DRUG DESCRIPTION



What are the possible side effects of irinotecan (Camptosar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
loose stools, watery diarrhea;
bloody or black stools;
runny nose, watery eyes, increased sweating, stomach cramps, and warmth, tingling, or redness under your skin;
...
Read All Potential Side Effects for Camptosar Injection »




CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic
agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically
investigated as CPT-11.
CAMPTOSAR is supplied as a sterile, pale yellow, clear, aqueous solution. It
is available in two single-dose sizes: 2 mL-fill vials contain 40 mg irinotecan
hydrochloride and 5 mL-fill vials contain 100 mg irinotecan hydrochloride. Each
milliliter of solution contains 20 mg of irinotecan hydrochloride (on the basis
of the trihydrate salt), 45 mg of sorbitol NF powder, and 0.9 mg of lactic acid,
USP. The pH of the solution has been adjusted to 3.5 (range, 3.0 to 3.8) with
sodium hydroxide or hydrochloric acid. CAMPTOSAR is intended for dilution with
5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior
to intravenous infusion. The preferred diluent is 5% Dextrose Injection, USP.

Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an
alkaloid extract from plants such as Camptotheca acuminata or is chemically
synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1Hpyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate,
monohydrochloride, trihydrate. Its structural formula is as follows:








Irinotecan hydrochloride is a pale yellow to yellow crystalline powder, with
the empirical formula C33H38N4O6•HCl•3H2O
and a molecular weight of 677.19. It is slightly soluble in water and organic
solvents.Last reviewed on RxList: 6/10/2010




Camptosar Injection Drug Description
Camptosar®
(irinotecan hydrochloride) Injection

WARNINGS
CAMPTOSAR Injection should be administered only under the supervision of a
physician who is experienced in the use of cancer chemotherapeutic agents. Appropriate
management of complications is possible only when adequate diagnostic and treatment
facilities are readily available. CAMPTOSAR can induce both early and late forms
of diarrhea that appear to be mediated by different mechanisms. Both forms of
diarrhea may be severe. Early diarrhea (occurring during or shortly after infusion
of CAMPTOSAR) may be accompanied by cholinergic symptoms of rhinitis, increased
salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis
that can cause abdominal cramping. Early diarrhea and other cholinergic symptoms
may be prevented or ameliorated by atropine (see PRECAUTIONS, General).
Late diarrhea (generally occurring more than 24 hours after administration of
CAMPTOSAR) can be life threatening since it may be prolonged and may lead to
dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated
promptly with loperamide. Patients with diarrhea should be carefully monitored
and given fluid and electrolyte replacement if they become dehydrated or antibiotic
therapy if they develop ileus, fever, or severe neutropenia (see WARNINGS).
Administration of CAMPTOSAR should be interrupted and subsequent doses reduced
if severe diarrhea occurs (see DOSAGE AND ADMINISTRATION).
Severe myelosuppression may occur (see WARNINGS).

DRUG DESCRIPTION



What are the possible side effects of irinotecan (Camptosar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
loose stools, watery diarrhea;
bloody or black stools;
runny nose, watery eyes, increased sweating, stomach cramps, and warmth, tingling, or redness under your skin;
...
Read All Potential Side Effects for Camptosar Injection »




CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic
agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically
investigated as CPT-11.
CAMPTOSAR is supplied as a sterile, pale yellow, clear, aqueous solution. It
is available in two single-dose sizes: 2 mL-fill vials contain 40 mg irinotecan
hydrochloride and 5 mL-fill vials contain 100 mg irinotecan hydrochloride. Each
milliliter of solution contains 20 mg of irinotecan hydrochloride (on the basis
of the trihydrate salt), 45 mg of sorbitol NF powder, and 0.9 mg of lactic acid,
USP. The pH of the solution has been adjusted to 3.5 (range, 3.0 to 3.8) with
sodium hydroxide or hydrochloric acid. CAMPTOSAR is intended for dilution with
5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior
to intravenous infusion. The preferred diluent is 5% Dextrose Injection, USP.

Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an
alkaloid extract from plants such as Camptotheca acuminata or is chemically
synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1Hpyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate,
monohydrochloride, trihydrate. Its structural formula is as follows:








Irinotecan hydrochloride is a pale yellow to yellow crystalline powder, with
the empirical formula C33H38N4O6•HCl•3H2O
and a molecular weight of 677.19. It is slightly soluble in water and organic
solvents.Last reviewed on RxList: 6/10/2010




Camptosar Injection Drug Description
Camptosar®
(irinotecan hydrochloride) Injection

WARNINGS
CAMPTOSAR Injection should be administered only under the supervision of a
physician who is experienced in the use of cancer chemotherapeutic agents. Appropriate
management of complications is possible only when adequate diagnostic and treatment
facilities are readily available. CAMPTOSAR can induce both early and late forms
of diarrhea that appear to be mediated by different mechanisms. Both forms of
diarrhea may be severe. Early diarrhea (occurring during or shortly after infusion
of CAMPTOSAR) may be accompanied by cholinergic symptoms of rhinitis, increased
salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis
that can cause abdominal cramping. Early diarrhea and other cholinergic symptoms
may be prevented or ameliorated by atropine (see PRECAUTIONS, General).
Late diarrhea (generally occurring more than 24 hours after administration of
CAMPTOSAR) can be life threatening since it may be prolonged and may lead to
dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated
promptly with loperamide. Patients with diarrhea should be carefully monitored
and given fluid and electrolyte replacement if they become dehydrated or antibiotic
therapy if they develop ileus, fever, or severe neutropenia (see WARNINGS).
Administration of CAMPTOSAR should be interrupted and subsequent doses reduced
if severe diarrhea occurs (see DOSAGE AND ADMINISTRATION).
Severe myelosuppression may occur (see WARNINGS).

DRUG DESCRIPTION



What are the possible side effects of irinotecan (Camptosar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
loose stools, watery diarrhea;
bloody or black stools;
runny nose, watery eyes, increased sweating, stomach cramps, and warmth, tingling, or redness under your skin;
...
Read All Potential Side Effects for Camptosar Injection »




CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic
agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically
investigated as CPT-11.
CAMPTOSAR is supplied as a sterile, pale yellow, clear, aqueous solution. It
is available in two single-dose sizes: 2 mL-fill vials contain 40 mg irinotecan
hydrochloride and 5 mL-fill vials contain 100 mg irinotecan hydrochloride. Each
milliliter of solution contains 20 mg of irinotecan hydrochloride (on the basis
of the trihydrate salt), 45 mg of sorbitol NF powder, and 0.9 mg of lactic acid,
USP. The pH of the solution has been adjusted to 3.5 (range, 3.0 to 3.8) with
sodium hydroxide or hydrochloric acid. CAMPTOSAR is intended for dilution with
5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior
to intravenous infusion. The preferred diluent is 5% Dextrose Injection, USP.

Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an
alkaloid extract from plants such as Camptotheca acuminata or is chemically
synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1Hpyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate,
monohydrochloride, trihydrate. Its structural formula is as follows:








Irinotecan hydrochloride is a pale yellow to yellow crystalline powder, with
the empirical formula C33H38N4O6•HCl•3H2O
and a molecular weight of 677.19. It is slightly soluble in water and organic
solvents.Last reviewed on RxList: 6/10/2010




Camptosar Injection Drug Description
Camptosar®
(irinotecan hydrochloride) Injection

WARNINGS
CAMPTOSAR Injection should be administered only under the supervision of a
physician who is experienced in the use of cancer chemotherapeutic agents. Appropriate
management of complications is possible only when adequate diagnostic and treatment
facilities are readily available. CAMPTOSAR can induce both early and late forms
of diarrhea that appear to be mediated by different mechanisms. Both forms of
diarrhea may be severe. Early diarrhea (occurring during or shortly after infusion
of CAMPTOSAR) may be accompanied by cholinergic symptoms of rhinitis, increased
salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis
that can cause abdominal cramping. Early diarrhea and other cholinergic symptoms
may be prevented or ameliorated by atropine (see PRECAUTIONS, General).
Late diarrhea (generally occurring more than 24 hours after administration of
CAMPTOSAR) can be life threatening since it may be prolonged and may lead to
dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated
promptly with loperamide. Patients with diarrhea should be carefully monitored
and given fluid and electrolyte replacement if they become dehydrated or antibiotic
therapy if they develop ileus, fever, or severe neutropenia (see WARNINGS).
Administration of CAMPTOSAR should be interrupted and subsequent doses reduced
if severe diarrhea occurs (see DOSAGE AND ADMINISTRATION).
Severe myelosuppression may occur (see WARNINGS).

DRUG DESCRIPTION



What are the possible side effects of irinotecan (Camptosar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
loose stools, watery diarrhea;
bloody or black stools;
runny nose, watery eyes, increased sweating, stomach cramps, and warmth, tingling, or redness under your skin;
...
Read All Potential Side Effects for Camptosar Injection »




CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic
agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically
investigated as CPT-11.
CAMPTOSAR is supplied as a sterile, pale yellow, clear, aqueous solution. It
is available in two single-dose sizes: 2 mL-fill vials contain 40 mg irinotecan
hydrochloride and 5 mL-fill vials contain 100 mg irinotecan hydrochloride. Each
milliliter of solution contains 20 mg of irinotecan hydrochloride (on the basis
of the trihydrate salt), 45 mg of sorbitol NF powder, and 0.9 mg of lactic acid,
USP. The pH of the solution has been adjusted to 3.5 (range, 3.0 to 3.8) with
sodium hydroxide or hydrochloric acid. CAMPTOSAR is intended for dilution with
5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior
to intravenous infusion. The preferred diluent is 5% Dextrose Injection, USP.

Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an
alkaloid extract from plants such as Camptotheca acuminata or is chemically
synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1Hpyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate,
monohydrochloride, trihydrate. Its structural formula is as follows:








Irinotecan hydrochloride is a pale yellow to yellow crystalline powder, with
the empirical formula C33H38N4O6•HCl•3H2O
and a molecular weight of 677.19. It is slightly soluble in water and organic
solvents.Last reviewed on RxList: 6/10/2010




Camptosar Injection Drug Description
Camptosar®
(irinotecan hydrochloride) Injection

WARNINGS
CAMPTOSAR Injection should be administered only under the supervision of a
physician who is experienced in the use of cancer chemotherapeutic agents. Appropriate
management of complications is possible only when adequate diagnostic and treatment
facilities are readily available. CAMPTOSAR can induce both early and late forms
of diarrhea that appear to be mediated by different mechanisms. Both forms of
diarrhea may be severe. Early diarrhea (occurring during or shortly after infusion
of CAMPTOSAR) may be accompanied by cholinergic symptoms of rhinitis, increased
salivation, miosis, lacrimation, diaphoresis, flushing, and intestinal hyperperistalsis
that can cause abdominal cramping. Early diarrhea and other cholinergic symptoms
may be prevented or ameliorated by atropine (see PRECAUTIONS, General).
Late diarrhea (generally occurring more than 24 hours after administration of
CAMPTOSAR) can be life threatening since it may be prolonged and may lead to
dehydration, electrolyte imbalance, or sepsis. Late diarrhea should be treated
promptly with loperamide. Patients with diarrhea should be carefully monitored
and given fluid and electrolyte replacement if they become dehydrated or antibiotic
therapy if they develop ileus, fever, or severe neutropenia (see WARNINGS).
Administration of CAMPTOSAR should be interrupted and subsequent doses reduced
if severe diarrhea occurs (see DOSAGE AND ADMINISTRATION).
Severe myelosuppression may occur (see WARNINGS).

DRUG DESCRIPTION



What are the possible side effects of irinotecan (Camptosar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

pale skin, easy bruising or bleeding, unusual weakness;
loose stools, watery diarrhea;
bloody or black stools;
runny nose, watery eyes, increased sweating, stomach cramps, and warmth, tingling, or redness under your skin;
...
Read All Potential Side Effects for Camptosar Injection »




CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic
agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically
investigated as CPT-11.
CAMPTOSAR is supplied as a sterile, pale yellow, clear, aqueous solution. It
is available in two single-dose sizes: 2 mL-fill vials contain 40 mg irinotecan
hydrochloride and 5 mL-fill vials contain 100 mg irinotecan hydrochloride. Each
milliliter of solution contains 20 mg of irinotecan hydrochloride (on the basis
of the trihydrate salt), 45 mg of sorbitol NF powder, and 0.9 mg of lactic acid,
USP. The pH of the solution has been adjusted to 3.5 (range, 3.0 to 3.8) with
sodium hydroxide or hydrochloric acid. CAMPTOSAR is intended for dilution with
5% Dextrose Injection, USP (D5W), or 0.9% Sodium Chloride Injection, USP, prior
to intravenous infusion. The preferred diluent is 5% Dextrose Injection, USP.

Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an
alkaloid extract from plants such as Camptotheca acuminata or is chemically
synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1Hpyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate,
monohydrochloride, trihydrate. Its structural formula is as follows:








Irinotecan hydrochloride is a pale yellow to yellow crystalline powder, with
the empirical formula C33H38N4O6•HCl•3H2O
and a molecular weight of 677.19. It is slightly soluble in water and organic
solvents.Last reviewed on RxList: 6/10/2010





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Other reviews about Camptosar Injection on web:

Learn about the prescription medication Camptosar Injection (Irinotecan Hydrochloride), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Camptosar Injection (Irinotecan Hydrochloride) Drug Information ...


Consumer information about the medication IRINOTECAN - INJECTION (Camptosar), includes side effects, drug interactions, recommended dosages, and storage information. Read more ... IRINOTECAN - INJECTION (Camptosar) side effects, medical uses, and ...


CAMPTOSAR Injection (irinotecan hydrochloride injection) is an antineoplastic agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride was clinically investigated as ... CAMPTOSAR® (irinotecan hydrochloride injection)Description


Camptosar ® Injection (irinotecan HCI injection) can cause Diarrhea. If you develop diarrhea, follow these directions. Camptosar Label


Camptosar can cause severe diarrhea, which can be life-threatening if it leads to dehydration. Diarrhea can occur soon after your injection or more than 24 hours later. Camptosar Information from Drugs.com


Product center for CAMPTOSAR® (irinotecan hydrochloride injection) including indication, with links to efficacy, safety, and dosing information, key reprints, and patient ... CAMPTOSAR® (irinotecan hydrochloride injection) for Treatment of ...


WARNINGS; CAMPTOSAR Injection should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. Camptosar Full Prescribing


Camptosar Injection, Solution - CAMPTOSAR Injection is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic ... Camptosar Injection, Solution drug information | MIMS USA


irinotecan - Injection (eye-ree-no-tee-kan) Common Brand Name(s): Camptosar Warning: Irinotecan Can Cause Severe Diarrhea, Both Early In Treatment And 24 Hours Or More After ... CAMPTOSAR Patient Assistance Program


Information on the Pfizer prescription medicine CAMPTOSAR (irinotecan HCl injection). CAMPTOSAR is a chemotherapy drug used to treat advanced cancer of the large intestine and ... CAMPTOSAR (irinotecan HCl injection) | Pfizer: the world's largest ...





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