Reviews Brimonidine Tartrate, Timolol Maleate Ophthalmic Solution .2%/.5%


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Combigan Drug Description
COMBIGAN™
(brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5%)
DRUG DESCRIPTION



What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
bronchospasm (wheezing, chest tightness, trouble breathing);
pounding heartbeats or fluttering in your chest;
slow...
Read All Potential Side Effects for Combigan »




COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%,
sterile, is a relatively selective alpha-2 adrenergic receptor agonist with
a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure
lowering agent).
The structural formulae are: Brimonidine tartrate:







5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:







(-)-1 -(tert-butylamino)-3-[(4-morpholino-l ,2,5-thiadiazol-3-yl)-oxy]-2-propanol
maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution)
0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330
mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3.0 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of COMBIGAN™ contains the active ingredients brimonidine tartrate 0.2%
and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%;
sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and
hydrochloric acid and/or sodium hydroxide to adjust pH.Last reviewed on RxList: 11/14/2007




Combigan Drug Description
COMBIGAN™
(brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5%)
DRUG DESCRIPTION



What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
bronchospasm (wheezing, chest tightness, trouble breathing);
pounding heartbeats or fluttering in your chest;
slow...
Read All Potential Side Effects for Combigan »




COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%,
sterile, is a relatively selective alpha-2 adrenergic receptor agonist with
a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure
lowering agent).
The structural formulae are: Brimonidine tartrate:







5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:







(-)-1 -(tert-butylamino)-3-[(4-morpholino-l ,2,5-thiadiazol-3-yl)-oxy]-2-propanol
maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution)
0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330
mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3.0 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of COMBIGAN™ contains the active ingredients brimonidine tartrate 0.2%
and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%;
sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and
hydrochloric acid and/or sodium hydroxide to adjust pH.Last reviewed on RxList: 11/14/2007




Combigan Drug Description
COMBIGAN™
(brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5%)
DRUG DESCRIPTION



What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
bronchospasm (wheezing, chest tightness, trouble breathing);
pounding heartbeats or fluttering in your chest;
slow...
Read All Potential Side Effects for Combigan »




COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%,
sterile, is a relatively selective alpha-2 adrenergic receptor agonist with
a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure
lowering agent).
The structural formulae are: Brimonidine tartrate:







5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:







(-)-1 -(tert-butylamino)-3-[(4-morpholino-l ,2,5-thiadiazol-3-yl)-oxy]-2-propanol
maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution)
0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330
mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3.0 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of COMBIGAN™ contains the active ingredients brimonidine tartrate 0.2%
and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%;
sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and
hydrochloric acid and/or sodium hydroxide to adjust pH.Last reviewed on RxList: 11/14/2007




Combigan Drug Description
COMBIGAN™
(brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5%)
DRUG DESCRIPTION



What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
bronchospasm (wheezing, chest tightness, trouble breathing);
pounding heartbeats or fluttering in your chest;
slow...
Read All Potential Side Effects for Combigan »




COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%,
sterile, is a relatively selective alpha-2 adrenergic receptor agonist with
a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure
lowering agent).
The structural formulae are: Brimonidine tartrate:







5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:







(-)-1 -(tert-butylamino)-3-[(4-morpholino-l ,2,5-thiadiazol-3-yl)-oxy]-2-propanol
maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution)
0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330
mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3.0 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of COMBIGAN™ contains the active ingredients brimonidine tartrate 0.2%
and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%;
sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and
hydrochloric acid and/or sodium hydroxide to adjust pH.Last reviewed on RxList: 11/14/2007




Combigan Drug Description
COMBIGAN™
(brimonidine tartrate/timolol maleate ophthalmic solution 0.2%/0.5%)
DRUG DESCRIPTION



What are the possible side effects of brimonidine and timolol ophthalmic (Combigan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
bronchospasm (wheezing, chest tightness, trouble breathing);
pounding heartbeats or fluttering in your chest;
slow...
Read All Potential Side Effects for Combigan »




COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%,
sterile, is a relatively selective alpha-2 adrenergic receptor agonist with
a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure
lowering agent).
The structural formulae are: Brimonidine tartrate:







5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.24
Timolol maleate:







(-)-1 -(tert-butylamino)-3-[(4-morpholino-l ,2,5-thiadiazol-3-yl)-oxy]-2-propanol
maleate (1:1) (salt); MW= 432.50 as the maleate salt
In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution)
0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330
mOsmol/kg and a pH during its shelf life of 6.5-7.3.
Brimonidine tartrate appears as an off-white, or white to pale-yellow powder and is soluble in both water (1.5 mg/mL) and in the product vehicle (3.0 mg/mL) at pH 7.2. Timolol maleate appears as a white, odorless, crystalline powder and is soluble in water, methanol, and alcohol.
Each mL of COMBIGAN™ contains the active ingredients brimonidine tartrate 0.2%
and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%;
sodium phosphate, monobasic; sodium phosphate, dibasic; purified water; and
hydrochloric acid and/or sodium hydroxide to adjust pH.Last reviewed on RxList: 11/14/2007





Other reviews about Brimonidine Tartrate, Timolol Maleate Ophthalmic Solution .2%/.5% on web:

COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, sterile, is a relatively ... administration of brimonidine tartrate at doses up to 2.5 mg ... Combigan (Brimonidine Tartrate, Timolol Maleate Ophthalmic ...


Learn about Combigan (Brimonidine Tartrate, Timolol Maleate Ophthalmic Solution .2%/.5%) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Combigan (Brimonidine Tartrate, Timolol Maleate Ophthalmic ...


COMBIGAN (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha adrenergic receptor agonist with a beta adrene... - Price at US Pharmacies: .00 - Our ... Combigan (Brimonidine Tartrate+Timolol Maleate) .2%+.5%-5ml Bott ...


COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) ... Contraindications: COMBIGAN® ophthalmic solution should not be used by patients who have, or ever had ... Combigan News


Combigan Generic Name: Brimonidine tartrate/ timolol maleate ophthalmic solution 0.2%/0.5% Description: Alpha-adrenergic ... Concentration: 0.5% Size: 2.5, 5 mL Indications: For the ... Brimonidine Tartrate Ophthalmic Solution


Brimonidine Tartrate / Timolol Maleate Pronunciation: (bri-MOE-ni-deen TAR-trate/TIM-oh-lol MAL-ee-ate) Class: Antiglaucoma Trade Names: Combigan - Ophthalmic solution brimonidine ... Complete Brimonidine Tartrate/Timolol Maleate information from ...


The uses of Combigan ( Generic Brimonidine Tartrate & Timolol Maleate ) include: Combigan™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha ... Combigan ( Generic Brimonidine Tartrate & Timolol Maleate )


... morpholino-1,2,5-thiadiazol-3-yl)-oxy]-2-propanol maleate (1:1) (salt); MW= 432.50 as the maleate salt. In solution, COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic ... COMBIGAN™ (brimonidine tartrate/timolol maleate ophthalmic ...


The uses of Combigan ( Generic Brimonidine Tartrate & Timolol Maleate ) include: Combigan™ (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha ... RX2world.com :::


Clindamycin Phosphate 1.2% and Benzoyl Peroxide 2.5%: Acanya ... PEG Electrolytes Solution: Combigan: Brimonidine Tartrate, Timolol Maleate Ophthalmic Solution .2%/.5% Vademecum de Argentina - Vademecum USA 2009 - C





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