Reviews Bisoprolol and Hydrochlorothiazide


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Ziac Drug Description
ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets
DRUG DESCRIPTION



What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
chest pain;
easy bruising or bleeding;
sudden numbness...
Read All Potential Side Effects for Ziac »




ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment
of hypertension. It combines two antihypertensive agents in a once-daily dosage:
a synthetic beta1-selective (cardioselective) adrenoceptor blocking
agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1-methylethoxy)eth-oxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure and is
provided as a racemic mixture. The S(-) enantiomer is responsible for most of
the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4
and it has a molecular weight of 766.97. Its structural formula is:








Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.
Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless crystalline
powder. It is slightly soluble in water, sparingly soluble in dilute sodium
hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly
soluble in methanol, and insoluble in ether, chloroform, and dilute mineral
acids. Its empirical formula is C7H8ClN3O4S2
and it has a molecular weight of 297.73. Its structural formula is:








Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................2.5 mg
Hydrochlorothiazide.................................................6.25 mg
Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................5 mg
Hydrochlorothiazide................................................. 6.25 mg
Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate..................................................10 mg
Hydrochlorothiazide.................................................6.25 mg
Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Dibasic
Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose,
Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg/6.25 mg
tablet also contains Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also
contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.Last reviewed on RxList: 3/30/2009




Ziac Drug Description
ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets
DRUG DESCRIPTION



What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
chest pain;
easy bruising or bleeding;
sudden numbness...
Read All Potential Side Effects for Ziac »




ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment
of hypertension. It combines two antihypertensive agents in a once-daily dosage:
a synthetic beta1-selective (cardioselective) adrenoceptor blocking
agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1-methylethoxy)eth-oxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure and is
provided as a racemic mixture. The S(-) enantiomer is responsible for most of
the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4
and it has a molecular weight of 766.97. Its structural formula is:








Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.
Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless crystalline
powder. It is slightly soluble in water, sparingly soluble in dilute sodium
hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly
soluble in methanol, and insoluble in ether, chloroform, and dilute mineral
acids. Its empirical formula is C7H8ClN3O4S2
and it has a molecular weight of 297.73. Its structural formula is:








Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................2.5 mg
Hydrochlorothiazide.................................................6.25 mg
Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................5 mg
Hydrochlorothiazide................................................. 6.25 mg
Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate..................................................10 mg
Hydrochlorothiazide.................................................6.25 mg
Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Dibasic
Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose,
Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg/6.25 mg
tablet also contains Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also
contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.Last reviewed on RxList: 3/30/2009




Ziac Drug Description
ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets
DRUG DESCRIPTION



What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
chest pain;
easy bruising or bleeding;
sudden numbness...
Read All Potential Side Effects for Ziac »




ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment
of hypertension. It combines two antihypertensive agents in a once-daily dosage:
a synthetic beta1-selective (cardioselective) adrenoceptor blocking
agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1-methylethoxy)eth-oxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure and is
provided as a racemic mixture. The S(-) enantiomer is responsible for most of
the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4
and it has a molecular weight of 766.97. Its structural formula is:








Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.
Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless crystalline
powder. It is slightly soluble in water, sparingly soluble in dilute sodium
hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly
soluble in methanol, and insoluble in ether, chloroform, and dilute mineral
acids. Its empirical formula is C7H8ClN3O4S2
and it has a molecular weight of 297.73. Its structural formula is:








Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................2.5 mg
Hydrochlorothiazide.................................................6.25 mg
Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................5 mg
Hydrochlorothiazide................................................. 6.25 mg
Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate..................................................10 mg
Hydrochlorothiazide.................................................6.25 mg
Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Dibasic
Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose,
Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg/6.25 mg
tablet also contains Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also
contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.Last reviewed on RxList: 3/30/2009




Ziac Drug Description
ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets
DRUG DESCRIPTION



What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
chest pain;
easy bruising or bleeding;
sudden numbness...
Read All Potential Side Effects for Ziac »




ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment
of hypertension. It combines two antihypertensive agents in a once-daily dosage:
a synthetic beta1-selective (cardioselective) adrenoceptor blocking
agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1-methylethoxy)eth-oxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure and is
provided as a racemic mixture. The S(-) enantiomer is responsible for most of
the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4
and it has a molecular weight of 766.97. Its structural formula is:








Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.
Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless crystalline
powder. It is slightly soluble in water, sparingly soluble in dilute sodium
hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly
soluble in methanol, and insoluble in ether, chloroform, and dilute mineral
acids. Its empirical formula is C7H8ClN3O4S2
and it has a molecular weight of 297.73. Its structural formula is:








Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................2.5 mg
Hydrochlorothiazide.................................................6.25 mg
Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................5 mg
Hydrochlorothiazide................................................. 6.25 mg
Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate..................................................10 mg
Hydrochlorothiazide.................................................6.25 mg
Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Dibasic
Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose,
Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg/6.25 mg
tablet also contains Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also
contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.Last reviewed on RxList: 3/30/2009




Ziac Drug Description
ZIAC®
(bisoprolol fumarate and hydrochlorothiazide) Tablets
DRUG DESCRIPTION



What are the possible side effects of hydrochlorothiazide and bisoprolol (Ziac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:

swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
chest pain;
easy bruising or bleeding;
sudden numbness...
Read All Potential Side Effects for Ziac »




ZIAC (bisoprolol fumarate and hydrochlorothiazide) is indicated for the treatment
of hypertension. It combines two antihypertensive agents in a once-daily dosage:
a synthetic beta1-selective (cardioselective) adrenoceptor blocking
agent (bisoprolol fumarate) and a benzothiadiazine diuretic (hydrochlorothiazide).
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1-methylethoxy)eth-oxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate
(2:1) (salt). It possesses an asymmetric carbon atom in its structure and is
provided as a racemic mixture. The S(-) enantiomer is responsible for most of
the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4
and it has a molecular weight of 766.97. Its structural formula is:








Bisoprolol fumarate is a white crystalline powder, approximately equally hydrophilic and lipophilic, and readily soluble in water, methanol, ethanol, and chloroform.
Hydrochlorothiazide (HCTZ) is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless crystalline
powder. It is slightly soluble in water, sparingly soluble in dilute sodium
hydroxide solution, freely soluble in n-butylamine and dimethylformamide, sparingly
soluble in methanol, and insoluble in ether, chloroform, and dilute mineral
acids. Its empirical formula is C7H8ClN3O4S2
and it has a molecular weight of 297.73. Its structural formula is:








Each ZIAC®-2.5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................2.5 mg
Hydrochlorothiazide.................................................6.25 mg
Each ZIAC®-5 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate...................................................5 mg
Hydrochlorothiazide................................................. 6.25 mg
Each ZIAC®-10 mg/6.25 mg tablet for oral administration contains:
Bisoprolol fumarate..................................................10 mg
Hydrochlorothiazide.................................................6.25 mg
Inactive ingredients include Colloidal Silicon Dioxide, Corn Starch, Dibasic
Calcium Phosphate, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose,
Polyethylene Glycol, Polysorbate 80, and Titanium Dioxide. The 5 mg/6.25 mg
tablet also contains Red and Yellow Iron Oxide. The 2.5 mg/6.25 mg tablet also
contains Crospovidone, Pregelatinized Starch, and Yellow Iron Oxide.Last reviewed on RxList: 3/30/2009





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Other reviews about Bisoprolol and Hydrochlorothiazide on web:

Accurate, FDA approved Bisoprolol Hydrochlorothiazide information for healthcare professionals and patients - brought to you by Drugs.com. Bisoprolol Hydrochlorothiazide Official FDA information, side ...


Blood pressure information includes high blood pressure (hypertension), low blood pressure (hypotension), causes, medications, prevention, symptoms, treatment, and how to lower ... bisoprolol and hydrochlorothiazide - High Blood Pressure ...


All about Bisoprolol/Hydrochlorothiazide. View complete and up to date Bisoprolol/Hydrochlorothiazide information - part of the Drugs.com trusted medication database. Bisoprolol/Hydrochlorothiazide Facts and Comparisons at Drugs.com


The information on this page is seed content provided by an organization. Please help improve this Article by adding to it. If you are a physician or PhD, learn how to edit. If you ... Clinical:Bisoprolol fumarate hydrochlorothiazide (Bisoprolol ...


Learn about the prescription medication Ziac (Bisoprolol and Hydrochlorothiazide), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Ziac (Bisoprolol and Hydrochlorothiazide) Drug Information: Uses ...


Attention, chocolate lovers: You may not be able to help yourselves. Swiss and British scientists have linked the widespread love of chocolate to a chemical "signature" that may be ... ZIAC(Bisoprolol Fumarate and Hydrochlorothiazide) Tablets Drug ...


Mayo Clinic offers award-winning medical and health information and tools for healthy living. Bisoprolol and Hydrochlorothiazide (Oral Route) - MayoClinic.com


bisoprolol/hydrochlorothiazide pharmacology, dosing, interactions, and patient education at Epocrates Online, the leading provider of drug and disease decision support tools. bisoprolol/hydrochlorothiazide Pharmacology - Epocrates Online


Overview Ziac combines two different drug ingredients in one tablet. Bisoprolol was approved by the FDA in 1992 and is available by itself as Zebeta, while hydrochlorothiazide has ... Bisoprolol and hydrochlorothiazide Side Effects - The People's ...


Bisoprolol And Hydrochlorothiazide Side Effects. Bisoprolol fumarate and hydrochlorothiazide is a prescription drug combination used for the treatment of high blood pressure. Bisoprolol And Hydrochlorothiazide Side Effects | LIVESTRONG.COM





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