Reviews Avinza


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Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009




Avinza Drug Description
AVINZA®
(morphine sulfate) Extended-Release Capsules 30 mg, 45 mg, 60 mg, 75 mg, 90 mg, 120 mg

WARNING
AVINZA capsules are a modified-release formulation of morphine sulfate indicated
for once daily administration for the relief of moderate to severe pain requiring
continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA CAPSULES ARE TO BE SWALLOWED WHOLE OR THE CONTENTS OF THE CAPSULES SPRINKLED
ON APPLESAUCE. THE CAPSULE BEADS ARE NOT TO BE CHEWED, CRUSHED, OR DISSOLVED
DUE TO THE RISK OF RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL DOSE
OF MORPHINE. PATIENTS MUST NOT CONSUME ALCOHOLIC BEVERAGES WHILE ON AVINZA THERAPY.
ADDITIONALLY, PATIENTS MUST NOT USE PRESCRIPTION OR NON-PRESCRIPTION MEDICATIONS
CONTAINING ALCOHOL WHILE ON AVINZA THERAPY. CONSUMPTION OF ALCOHOL WHILE TAKING
AVINZA MAY RESULT IN THE RAPID RELEASE AND ABSORPTION OF A POTENTIALLY FATAL
DOSE OF MORPHINE.

DRUG DESCRIPTION



What are the possible side effects of morphine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.

Less serious side effects are more likely to...
Read All Potential Side Effects for Avinza »




AVINZA (morphine sulfate extended-release capsules) 30, 45, 60, 75, 90, and
120 mg contain both immediate release and extended release beads of morphine
sulfate for once daily oral administration.
Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6
alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular weight of 758.
Morphine sulfate occurs as white, feathery, silky crystals; cubical masses of
crystal; or white crystalline powder. It is soluble in water and slightly soluble
in alcohol, but is practically insoluble in chloroform or ether. The octanol:water
partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9
for the tertiary nitrogen (the majority is ionized at pH 7.4).
Each AVINZA Capsule contains either 30, 45, 60, 75, 90, or 120 mg of morphine
sulfate, USP and the following inactive ingredients: ammoniomethacrylate copolymers,
NF, fumaric acid, NF, povidone, USP, sodium lauryl sulfate, NF, sugar starch
spheres, NF, and talc, USP. The capsule shell contains black ink, gelatin, titanium
dioxide, D&C yellow No. 10 (30 mg), FD&C blue No. 2 (45 mg), FD&C
green No. 3 (60 mg), FDA iron oxide and FDA yellow iron oxide (75 mg), FD&C
red No. 40 (90 mg), FD&C red No. 3 (120 mg), and FD&C blue No. 1 (120
mg).
Structure:








AVINZA uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System)
technology to produce the extended release component of AVINZA, which combined
with an immediate release component achieves the desired release profile characteristics
of AVINZA capsules. Within the gastrointestinal tract, due to the permeability
of the ammoni-omethacrylate copolymers of the beads, fluid enters the beads
and solubilizes the drug. This is mediated by fumaric acid, which acts as an
osmotic agent and a local pH modifier. The resultant solution then diffuses
out in a predetermined manner which prolongs the in vivo dissolution and absorption
phases. (See Pharmacokinetics) Last reviewed on RxList: 2/26/2009





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Other reviews about Avinza on web:

Information about treatment of moderate to severe chronic pain with once-daily AVINZA® (morphine sulfate extended-release capsules). AVINZA® Official Home Page


Learn about the prescription medication Avinza (Morphine Sulfate), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Avinza (Morphine Sulfate) Drug Information: Uses, Side Effects ...


Accurate, FDA approved Avinza information for healthcare professionals and patients - brought to you by Drugs.com. Avinza Official FDA information, side effects and uses.


Avinza (morphine) is a narcotic pain reliever used to treat moderate to severe pain. Includes Avinza side effects, interactions and indications. Avinza Information from Drugs.com


Morphine (pronounced /ˈmɔrfiːn/) (MS Contin, MSIR, Avinza, Kadian, Oramorph, Roxanol, Kapanol) is a potent opiate analgesic medication and is considered to be the prototypical ... Morphine - Wikipedia, the free encyclopedia


Avinza is a narcotic that can be prescribed to provide around-the-clock pain relief. This eMedTV Web page describes how Avinza works, lists potential side effects that may occur ... Avinza


Find patient medical information for Avinza Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Avinza Oral : Uses, Side Effects, Interactions, Pictures, Warnings ...


Hi everybody. I am new here, so please bear with me. I was wondering if anyone out there has been on Avinza for some time and could tell me if it works for them. I just started ... Avinza


Important information for patients about AVINZA® (morphine sulfate extended-release capsules), the once-daily treatment for relief of chronic pain, including pain resources ... AVINZA® Information for Patients


Avinza is a narcotic analgesic used in the treatment of severe pain that requires constant long-term treatment. Avinza acts on the central nervous system and interferes with the ... Avinza Side Effects, Uses, & Interactions





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