Reviews Avandamet


No reviews yet.

Avandamet Drug Description
AVANDAMET®
(rosiglitazone maleate and metformin hydrochloride) Tablets

WARNINGS
Rosiglitazone maleate: CONGESTIVE HEART FAILURE AND MYOCARDIAL
ISCHEMIA

Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive
heart failure in some patients [See WARNINGS AND PRECAUTIONS].
After initiation of AVANDAMET, and after dose increases, observe patients
carefully for signs and symptoms of heart failure (including excessive,
rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop,
the heart failure should be managed according to current standards of care.
Furthermore, discontinuation or dose reduction of AVANDAMET must be considered.

AVANDAMET is not recommended in patients with symptomatic heart failure.
Initiation of AVANDAMET in patients with established NYHA Class III or IV
heart failure is contraindicated. [See CONTRAINDICATIONS
and WARNINGS AND PRECAUTIONS.]
A meta-analysis of 42 clinical studies (mean duration 6 months; 14,237
total patients), most of which compared rosiglitazone to placebo, showed
rosiglitazone to be associated with an increased risk of myocardial ischemic
events such as angina or myocardial infarction. Three other studies (mean
duration 41 months; 14,067 total patients), comparing rosiglitazone to some
other approved oral antidiabetic agents or placebo, have not confirmed or
excluded this risk. In their entirety, the available data on the risk of
myocardial ischemia are inconclusive. [See WARNINGS AND PRECAUTIONS
.]

Metformin hydrochloride:LACTIC ACIDOSIS

Lactic acidosis is a rare, but serious complication that can occur due
to metformin accumulation. The risk increases with conditions such as sepsis,
dehydration, excess alcohol intake, hepatic insufficiency, renal impairment,
and acute congestive heart failure. [See WARNINGS AND PRECAUTIONS.]
Symptoms include malaise, myalgias, respiratory distress, increasing
somnolence, and nonspecific abdominal distress. Laboratory abnormalities
include low pH, increased anion gap and elevated blood lactate. [See WARNINGS
AND PRECAUTIONS.] If acidosis is suspected, discontinue AVANDAMET and hospitalize the patient
immediately [See WARNINGS AND PRECAUTIONS ].



DRUG DESCRIPTION



What are the possible side effects of metformin and rosiglitazone (Avandamet)?

Stop using metformin and rosiglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or...
Read All Potential Side Effects for Avandamet »




AVANDAMET contains 2 oral antidiabetic drugs: rosiglitazone maleate and metformin
hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by
increasing insulin sensitivity. Rosiglitazone improves glycemic control while
reducing circulating insulin levels. Rosiglitazone maleate is not chemically
or functionally related to the sulfonylureas, the biguanides, or the alpha-glucosidase
inhibitors. Chemically, rosiglitazone maleate is (±)-5-[[4-[2­(methyl-2-pyridinylamino)
ethoxy] phenyl] methyl] -2,4-thiazolidinedione, (Z)-2-butenedioate (1:1)
with a molecular weight of 473.52 (357.44 free base). The molecule has a single
chiral center and is present as a racemate. Due to rapid interconversion, the
enantiomers are functionally indistinguishable. The molecular formula is C18H19N3O3S•
C4H4O4. Rosiglitazone maleate is a white to
off-white solid with a melting point range of a values of rosiglitazone maleate
are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution
with pH of 2.3; solubility decreases with increasing pH in the physiological
range. The structural formula of rosiglitazone maleate is:








Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antidiabetic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•
HCl and a molecular weight of 165.63. Metformin hydrochloride is freely
soluble in water and is practically insoluble in acetone, ether, and chloroform.
The pKa of metformin is 12.4. The pH of a 1% aqueous solution of
metformin hydrochloride is 6.68. The structural formula of metformin hydrochloride
is:








AVANDAMET is available for oral administration as film-coated tablets containing
rosiglitazone maleate and metformin hydrochloride equivalent to: 2 mg rosiglitazone
with 500 mg metformin hydrochloride (2 mg/500 mg), 4 mg rosiglitazone with 500
mg metformin hydrochloride (4 mg/500 mg), 2 mg rosiglitazone with 1,000 mg metformin
hydrochloride (2 mg/1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin
hydrochloride (4 mg/1,000 mg). Inactive ingredients are: Hypromellose 2910,
lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene
glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1
or more of the following: Red and yellow iron oxides.Last reviewed on RxList: 1/27/2009




Avandamet Drug Description
AVANDAMET®
(rosiglitazone maleate and metformin hydrochloride) Tablets

WARNINGS
Rosiglitazone maleate: CONGESTIVE HEART FAILURE AND MYOCARDIAL
ISCHEMIA

Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive
heart failure in some patients [See WARNINGS AND PRECAUTIONS].
After initiation of AVANDAMET, and after dose increases, observe patients
carefully for signs and symptoms of heart failure (including excessive,
rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop,
the heart failure should be managed according to current standards of care.
Furthermore, discontinuation or dose reduction of AVANDAMET must be considered.

AVANDAMET is not recommended in patients with symptomatic heart failure.
Initiation of AVANDAMET in patients with established NYHA Class III or IV
heart failure is contraindicated. [See CONTRAINDICATIONS
and WARNINGS AND PRECAUTIONS.]
A meta-analysis of 42 clinical studies (mean duration 6 months; 14,237
total patients), most of which compared rosiglitazone to placebo, showed
rosiglitazone to be associated with an increased risk of myocardial ischemic
events such as angina or myocardial infarction. Three other studies (mean
duration 41 months; 14,067 total patients), comparing rosiglitazone to some
other approved oral antidiabetic agents or placebo, have not confirmed or
excluded this risk. In their entirety, the available data on the risk of
myocardial ischemia are inconclusive. [See WARNINGS AND PRECAUTIONS
.]

Metformin hydrochloride:LACTIC ACIDOSIS

Lactic acidosis is a rare, but serious complication that can occur due
to metformin accumulation. The risk increases with conditions such as sepsis,
dehydration, excess alcohol intake, hepatic insufficiency, renal impairment,
and acute congestive heart failure. [See WARNINGS AND PRECAUTIONS.]
Symptoms include malaise, myalgias, respiratory distress, increasing
somnolence, and nonspecific abdominal distress. Laboratory abnormalities
include low pH, increased anion gap and elevated blood lactate. [See WARNINGS
AND PRECAUTIONS.] If acidosis is suspected, discontinue AVANDAMET and hospitalize the patient
immediately [See WARNINGS AND PRECAUTIONS ].



DRUG DESCRIPTION



What are the possible side effects of metformin and rosiglitazone (Avandamet)?

Stop using metformin and rosiglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or...
Read All Potential Side Effects for Avandamet »




AVANDAMET contains 2 oral antidiabetic drugs: rosiglitazone maleate and metformin
hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by
increasing insulin sensitivity. Rosiglitazone improves glycemic control while
reducing circulating insulin levels. Rosiglitazone maleate is not chemically
or functionally related to the sulfonylureas, the biguanides, or the alpha-glucosidase
inhibitors. Chemically, rosiglitazone maleate is (±)-5-[[4-[2­(methyl-2-pyridinylamino)
ethoxy] phenyl] methyl] -2,4-thiazolidinedione, (Z)-2-butenedioate (1:1)
with a molecular weight of 473.52 (357.44 free base). The molecule has a single
chiral center and is present as a racemate. Due to rapid interconversion, the
enantiomers are functionally indistinguishable. The molecular formula is C18H19N3O3S•
C4H4O4. Rosiglitazone maleate is a white to
off-white solid with a melting point range of a values of rosiglitazone maleate
are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution
with pH of 2.3; solubility decreases with increasing pH in the physiological
range. The structural formula of rosiglitazone maleate is:








Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antidiabetic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•
HCl and a molecular weight of 165.63. Metformin hydrochloride is freely
soluble in water and is practically insoluble in acetone, ether, and chloroform.
The pKa of metformin is 12.4. The pH of a 1% aqueous solution of
metformin hydrochloride is 6.68. The structural formula of metformin hydrochloride
is:








AVANDAMET is available for oral administration as film-coated tablets containing
rosiglitazone maleate and metformin hydrochloride equivalent to: 2 mg rosiglitazone
with 500 mg metformin hydrochloride (2 mg/500 mg), 4 mg rosiglitazone with 500
mg metformin hydrochloride (4 mg/500 mg), 2 mg rosiglitazone with 1,000 mg metformin
hydrochloride (2 mg/1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin
hydrochloride (4 mg/1,000 mg). Inactive ingredients are: Hypromellose 2910,
lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene
glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1
or more of the following: Red and yellow iron oxides.Last reviewed on RxList: 1/27/2009




Avandamet Drug Description
AVANDAMET®
(rosiglitazone maleate and metformin hydrochloride) Tablets

WARNINGS
Rosiglitazone maleate: CONGESTIVE HEART FAILURE AND MYOCARDIAL
ISCHEMIA

Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive
heart failure in some patients [See WARNINGS AND PRECAUTIONS].
After initiation of AVANDAMET, and after dose increases, observe patients
carefully for signs and symptoms of heart failure (including excessive,
rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop,
the heart failure should be managed according to current standards of care.
Furthermore, discontinuation or dose reduction of AVANDAMET must be considered.

AVANDAMET is not recommended in patients with symptomatic heart failure.
Initiation of AVANDAMET in patients with established NYHA Class III or IV
heart failure is contraindicated. [See CONTRAINDICATIONS
and WARNINGS AND PRECAUTIONS.]
A meta-analysis of 42 clinical studies (mean duration 6 months; 14,237
total patients), most of which compared rosiglitazone to placebo, showed
rosiglitazone to be associated with an increased risk of myocardial ischemic
events such as angina or myocardial infarction. Three other studies (mean
duration 41 months; 14,067 total patients), comparing rosiglitazone to some
other approved oral antidiabetic agents or placebo, have not confirmed or
excluded this risk. In their entirety, the available data on the risk of
myocardial ischemia are inconclusive. [See WARNINGS AND PRECAUTIONS
.]

Metformin hydrochloride:LACTIC ACIDOSIS

Lactic acidosis is a rare, but serious complication that can occur due
to metformin accumulation. The risk increases with conditions such as sepsis,
dehydration, excess alcohol intake, hepatic insufficiency, renal impairment,
and acute congestive heart failure. [See WARNINGS AND PRECAUTIONS.]
Symptoms include malaise, myalgias, respiratory distress, increasing
somnolence, and nonspecific abdominal distress. Laboratory abnormalities
include low pH, increased anion gap and elevated blood lactate. [See WARNINGS
AND PRECAUTIONS.] If acidosis is suspected, discontinue AVANDAMET and hospitalize the patient
immediately [See WARNINGS AND PRECAUTIONS ].



DRUG DESCRIPTION



What are the possible side effects of metformin and rosiglitazone (Avandamet)?

Stop using metformin and rosiglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or...
Read All Potential Side Effects for Avandamet »




AVANDAMET contains 2 oral antidiabetic drugs: rosiglitazone maleate and metformin
hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by
increasing insulin sensitivity. Rosiglitazone improves glycemic control while
reducing circulating insulin levels. Rosiglitazone maleate is not chemically
or functionally related to the sulfonylureas, the biguanides, or the alpha-glucosidase
inhibitors. Chemically, rosiglitazone maleate is (±)-5-[[4-[2­(methyl-2-pyridinylamino)
ethoxy] phenyl] methyl] -2,4-thiazolidinedione, (Z)-2-butenedioate (1:1)
with a molecular weight of 473.52 (357.44 free base). The molecule has a single
chiral center and is present as a racemate. Due to rapid interconversion, the
enantiomers are functionally indistinguishable. The molecular formula is C18H19N3O3S•
C4H4O4. Rosiglitazone maleate is a white to
off-white solid with a melting point range of a values of rosiglitazone maleate
are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution
with pH of 2.3; solubility decreases with increasing pH in the physiological
range. The structural formula of rosiglitazone maleate is:








Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antidiabetic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•
HCl and a molecular weight of 165.63. Metformin hydrochloride is freely
soluble in water and is practically insoluble in acetone, ether, and chloroform.
The pKa of metformin is 12.4. The pH of a 1% aqueous solution of
metformin hydrochloride is 6.68. The structural formula of metformin hydrochloride
is:








AVANDAMET is available for oral administration as film-coated tablets containing
rosiglitazone maleate and metformin hydrochloride equivalent to: 2 mg rosiglitazone
with 500 mg metformin hydrochloride (2 mg/500 mg), 4 mg rosiglitazone with 500
mg metformin hydrochloride (4 mg/500 mg), 2 mg rosiglitazone with 1,000 mg metformin
hydrochloride (2 mg/1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin
hydrochloride (4 mg/1,000 mg). Inactive ingredients are: Hypromellose 2910,
lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene
glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1
or more of the following: Red and yellow iron oxides.Last reviewed on RxList: 1/27/2009




Avandamet Drug Description
AVANDAMET®
(rosiglitazone maleate and metformin hydrochloride) Tablets

WARNINGS
Rosiglitazone maleate: CONGESTIVE HEART FAILURE AND MYOCARDIAL
ISCHEMIA

Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive
heart failure in some patients [See WARNINGS AND PRECAUTIONS].
After initiation of AVANDAMET, and after dose increases, observe patients
carefully for signs and symptoms of heart failure (including excessive,
rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop,
the heart failure should be managed according to current standards of care.
Furthermore, discontinuation or dose reduction of AVANDAMET must be considered.

AVANDAMET is not recommended in patients with symptomatic heart failure.
Initiation of AVANDAMET in patients with established NYHA Class III or IV
heart failure is contraindicated. [See CONTRAINDICATIONS
and WARNINGS AND PRECAUTIONS.]
A meta-analysis of 42 clinical studies (mean duration 6 months; 14,237
total patients), most of which compared rosiglitazone to placebo, showed
rosiglitazone to be associated with an increased risk of myocardial ischemic
events such as angina or myocardial infarction. Three other studies (mean
duration 41 months; 14,067 total patients), comparing rosiglitazone to some
other approved oral antidiabetic agents or placebo, have not confirmed or
excluded this risk. In their entirety, the available data on the risk of
myocardial ischemia are inconclusive. [See WARNINGS AND PRECAUTIONS
.]

Metformin hydrochloride:LACTIC ACIDOSIS

Lactic acidosis is a rare, but serious complication that can occur due
to metformin accumulation. The risk increases with conditions such as sepsis,
dehydration, excess alcohol intake, hepatic insufficiency, renal impairment,
and acute congestive heart failure. [See WARNINGS AND PRECAUTIONS.]
Symptoms include malaise, myalgias, respiratory distress, increasing
somnolence, and nonspecific abdominal distress. Laboratory abnormalities
include low pH, increased anion gap and elevated blood lactate. [See WARNINGS
AND PRECAUTIONS.] If acidosis is suspected, discontinue AVANDAMET and hospitalize the patient
immediately [See WARNINGS AND PRECAUTIONS ].



DRUG DESCRIPTION



What are the possible side effects of metformin and rosiglitazone (Avandamet)?

Stop using metformin and rosiglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or...
Read All Potential Side Effects for Avandamet »




AVANDAMET contains 2 oral antidiabetic drugs: rosiglitazone maleate and metformin
hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by
increasing insulin sensitivity. Rosiglitazone improves glycemic control while
reducing circulating insulin levels. Rosiglitazone maleate is not chemically
or functionally related to the sulfonylureas, the biguanides, or the alpha-glucosidase
inhibitors. Chemically, rosiglitazone maleate is (±)-5-[[4-[2­(methyl-2-pyridinylamino)
ethoxy] phenyl] methyl] -2,4-thiazolidinedione, (Z)-2-butenedioate (1:1)
with a molecular weight of 473.52 (357.44 free base). The molecule has a single
chiral center and is present as a racemate. Due to rapid interconversion, the
enantiomers are functionally indistinguishable. The molecular formula is C18H19N3O3S•
C4H4O4. Rosiglitazone maleate is a white to
off-white solid with a melting point range of a values of rosiglitazone maleate
are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution
with pH of 2.3; solubility decreases with increasing pH in the physiological
range. The structural formula of rosiglitazone maleate is:








Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antidiabetic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•
HCl and a molecular weight of 165.63. Metformin hydrochloride is freely
soluble in water and is practically insoluble in acetone, ether, and chloroform.
The pKa of metformin is 12.4. The pH of a 1% aqueous solution of
metformin hydrochloride is 6.68. The structural formula of metformin hydrochloride
is:








AVANDAMET is available for oral administration as film-coated tablets containing
rosiglitazone maleate and metformin hydrochloride equivalent to: 2 mg rosiglitazone
with 500 mg metformin hydrochloride (2 mg/500 mg), 4 mg rosiglitazone with 500
mg metformin hydrochloride (4 mg/500 mg), 2 mg rosiglitazone with 1,000 mg metformin
hydrochloride (2 mg/1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin
hydrochloride (4 mg/1,000 mg). Inactive ingredients are: Hypromellose 2910,
lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene
glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1
or more of the following: Red and yellow iron oxides.Last reviewed on RxList: 1/27/2009




Avandamet Drug Description
AVANDAMET®
(rosiglitazone maleate and metformin hydrochloride) Tablets

WARNINGS
Rosiglitazone maleate: CONGESTIVE HEART FAILURE AND MYOCARDIAL
ISCHEMIA

Thiazolidinediones, including rosiglitazone, cause or exacerbate congestive
heart failure in some patients [See WARNINGS AND PRECAUTIONS].
After initiation of AVANDAMET, and after dose increases, observe patients
carefully for signs and symptoms of heart failure (including excessive,
rapid weight gain, dyspnea, and/or edema). If these signs and symptoms develop,
the heart failure should be managed according to current standards of care.
Furthermore, discontinuation or dose reduction of AVANDAMET must be considered.

AVANDAMET is not recommended in patients with symptomatic heart failure.
Initiation of AVANDAMET in patients with established NYHA Class III or IV
heart failure is contraindicated. [See CONTRAINDICATIONS
and WARNINGS AND PRECAUTIONS.]
A meta-analysis of 42 clinical studies (mean duration 6 months; 14,237
total patients), most of which compared rosiglitazone to placebo, showed
rosiglitazone to be associated with an increased risk of myocardial ischemic
events such as angina or myocardial infarction. Three other studies (mean
duration 41 months; 14,067 total patients), comparing rosiglitazone to some
other approved oral antidiabetic agents or placebo, have not confirmed or
excluded this risk. In their entirety, the available data on the risk of
myocardial ischemia are inconclusive. [See WARNINGS AND PRECAUTIONS
.]

Metformin hydrochloride:LACTIC ACIDOSIS

Lactic acidosis is a rare, but serious complication that can occur due
to metformin accumulation. The risk increases with conditions such as sepsis,
dehydration, excess alcohol intake, hepatic insufficiency, renal impairment,
and acute congestive heart failure. [See WARNINGS AND PRECAUTIONS.]
Symptoms include malaise, myalgias, respiratory distress, increasing
somnolence, and nonspecific abdominal distress. Laboratory abnormalities
include low pH, increased anion gap and elevated blood lactate. [See WARNINGS
AND PRECAUTIONS.] If acidosis is suspected, discontinue AVANDAMET and hospitalize the patient
immediately [See WARNINGS AND PRECAUTIONS ].



DRUG DESCRIPTION



What are the possible side effects of metformin and rosiglitazone (Avandamet)?

Stop using metformin and rosiglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness, weakness, headache, confusion, or problems with vision, speech, or...
Read All Potential Side Effects for Avandamet »




AVANDAMET contains 2 oral antidiabetic drugs: rosiglitazone maleate and metformin
hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by
increasing insulin sensitivity. Rosiglitazone improves glycemic control while
reducing circulating insulin levels. Rosiglitazone maleate is not chemically
or functionally related to the sulfonylureas, the biguanides, or the alpha-glucosidase
inhibitors. Chemically, rosiglitazone maleate is (±)-5-[[4-[2­(methyl-2-pyridinylamino)
ethoxy] phenyl] methyl] -2,4-thiazolidinedione, (Z)-2-butenedioate (1:1)
with a molecular weight of 473.52 (357.44 free base). The molecule has a single
chiral center and is present as a racemate. Due to rapid interconversion, the
enantiomers are functionally indistinguishable. The molecular formula is C18H19N3O3S•
C4H4O4. Rosiglitazone maleate is a white to
off-white solid with a melting point range of a values of rosiglitazone maleate
are 6.8 and 6.1. It is readily soluble in ethanol and a buffered aqueous solution
with pH of 2.3; solubility decreases with increasing pH in the physiological
range. The structural formula of rosiglitazone maleate is:








Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride)
is not chemically or pharmacologically related to any other classes of oral
antidiabetic agents. Metformin hydrochloride is a white to off-white crystalline
compound with a molecular formula of C4H11N5•
HCl and a molecular weight of 165.63. Metformin hydrochloride is freely
soluble in water and is practically insoluble in acetone, ether, and chloroform.
The pKa of metformin is 12.4. The pH of a 1% aqueous solution of
metformin hydrochloride is 6.68. The structural formula of metformin hydrochloride
is:








AVANDAMET is available for oral administration as film-coated tablets containing
rosiglitazone maleate and metformin hydrochloride equivalent to: 2 mg rosiglitazone
with 500 mg metformin hydrochloride (2 mg/500 mg), 4 mg rosiglitazone with 500
mg metformin hydrochloride (4 mg/500 mg), 2 mg rosiglitazone with 1,000 mg metformin
hydrochloride (2 mg/1,000 mg), and 4 mg rosiglitazone with 1,000 mg metformin
hydrochloride (4 mg/1,000 mg). Inactive ingredients are: Hypromellose 2910,
lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene
glycol 400, povidone 29-32, sodium starch glycolate, titanium dioxide, and 1
or more of the following: Red and yellow iron oxides.Last reviewed on RxList: 1/27/2009





Other reviews about Avandamet on wordpress

Buy Avandamet Online Order Cheap Avandamet Generic Purchase Discount Without Prescription
  by worlddnews
FOLLOW THIS LINK FOR ENTER TO TRUSTED & REPUTABLE ONLINE DRUGSTORE WHERE YOU CAN GET ALL QUALIFIED INFORMATION ABOUT Avandamet ONLINE     Whole foods makes great burgers causes of people […]


New meds, and how they suck....
  by Cathi
So my very wonderful doc put me on a new med this week, called Avandamet. For those of you who are new, that's for my diabetes.....Anyway, so […]


GlaxoSmithKline (GSK): Bad News Hits Diabetes Drug Hard
  by 247wallst
Sales of GlaxoSmithKline (GSK) diabetes drug Avandia have taken a pounding since a study showed that the drug increased heart risk. According to a research note from Morgan […]


DIABETES DRUGS TO GET 'BLACK BOX' WARNINGS
  by Sandy G.
Some popular drugs increase risk of heart failureManufacturers of certain drugs approved to treat Type 2 diabetes have agreed to add a stronger warning on the risk of […]


ACTOS® (pioglitazone hydrochloride) Tablets
  by kanlayanee
[caption id="" align="alignleft" width="221" caption=" Actos "][/caption] WARNING: CONGESTIVE HEART FAILURE Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients (see WARNINGS). […]


If only Avandia were more like Toyota
  by Carolyn Thomas
Poor Toyota.  The car maker has been forced to recall more than 8 million vehicles worldwide after news that at least 34 deaths have been linked to Toyota […]


Health Canada: Status of Rosiglitazone Drugs [Avandia, Avandamet, and Avandaryl] in Canada
  by thassodotcom
July 15, 2010 - In the light of recently published scientific studies and an upcoming U.S. Food and Drug Administration (FDA) Advisory Committee meeting examining the heart-related (cardiovascular) […]


European Medicines Agency Recommends Suspension of the Rosaglitazone Containing Drugs Avandia, Avandamet and Avaglim
  by thassodotcom
September 24, 2010 - Please find below a very significant announcement by the European Medicines Agency (EMEA) regarding the market suspensions of Avandia throughout the European Union. 09/23/2010 - […]


K2 Pedia! | European Medicines Agency Recommends S …
  by k2pedia
K2 Pedia! | European Medicines Agency Recommends Suspension Of Avandia, Avandamet And Avaglim | Medicines, Avandia, These, Suspension, Avaglim, Avandamet, Agency, European, Appointment, Their, Make, Taking, Currently, Patients, […]



Other reviews about Avandamet on web:

Avandamet (metformin and rosiglitazone) is used to treat type 2 diabetes. Includes Avandamet side effects, interactions and indications. Avandamet Information from Drugs.com


Avandamet information from Drugs.com. Avandamet is an oral medication used to control blood sugar levels in people with type 2 (non-insulin-dependent) diabetes. It contains two ... Avandamet patient advice including side effects


Learn about the prescription medication Avandamet (Rosiglitazone Maleate and Metformin HCl), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Avandamet (Rosiglitazone Maleate and Metformin HCl) Drug ...


AVANDAMET may cause serious side effects, including: Weight gain. Rosiglitazone, one of the medicines in AVANDAMET, can cause weight gain from fluid retention or extra body fat. Diabetes Medication Questions and important safety information


In 2002, the two drugs were combined into a single product, Avandamet, marketed by GlaxoSmithKline In 2005, all current stock of Avandamet was seized by the FDA and removed from the ... Metformin - Wikipedia, the free encyclopedia


Amaryl Amaryl is used for treating type 2 diabetes in patients who cannot control blood sugar levels by... Special offer: $0.80 per pill Buy avandamet cheap online


Avandamet is a prescription drug that is used for the treatment of type 2 diabetes. This part of the eMedTV Web site provides detailed information on Avandamet and its effects ... Avandamet


Buy Avandamet Online - Buy your next order of Avandamet medication from TheDrugCompany.com. Low prices, Free Shipping, quick delivery, no risk and 90 day ... Buy Avandamet Online - Buy Medicine @ TheDrugCompany.com


The usual starting Avandamet dosage is 2 mg/500 mg once or twice daily. This eMedTV page also lists dosing guidelines for those who are switching to Avandamet from just metformin ... Avandamet Dosage


Avandamet is a combination of an insulin resistance reducer and a biguanide used along with a diet and exercise program to control high blood sugar in diabetic patients. Side ... Avandamet - drugstore.com. Low prices, side effects, interactions.





Featured Reviews

Reviews Cervarix

Cervarix Drug Description CERVARIX [Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant] Suspension for Intramuscular Injection DRUG DESCRIPTION CERVARIX [Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant] ...
Read More  |  Review This
Reviews Protamine

Protamine Drug Description Protamine Sulfate Injection, USP DRUG DESCRIPTION Protamine Sulfate Injection, USP is a sterile, non-pyrogenic, isotonic solution of protamine sulfate in Water for Injection. It acts as a heparin antagonist....
Read More  |  Review This
Reviews Accolate

Accolate Drug Description ACCOLATE (zafirlukast) Tablets DRUG DESCRIPTION What are the possible side effects of zafirlukast (Accolate)? Get emergency medical help if you have any of these signs of an allergic reaction: hives;...
Read More  |  Review This
Reviews Gleevec

Gleevec Drug Description GLEEVEC (imatinib mesylate) Tablets for oral use DRUG DESCRIPTION What are the possible side effects of imatinib (Gleevec)? Get emergency medical help if you have any of these signs of an allergic reaction:...
Read More  |  Review This
Reviews Metrodin

Metrodin Drug Description DRUG DESCRIPTION Metrodin® (urofollitropin for injection) is a preparation of gonadotropin extracted from the urine of postmenopausal women. Each ampule of Metrodin® contains 75 or 150 IU of follicle-stimulating...
Read More  |  Review This
Recent News
59sec - the BEST lead management system around!
We tested 59sec - THE lead management system and we love it. 59sec helps small and medium companies to answer leads in maximum 59 seconds. Why...
MOVEorPAY - our favorite facebook app
We do love MOVEorPAY motivational facebook app, because it is very cool and useful. It makes you finish stuff that you know are good for you, but from various reasons, you never do...
ReviewsAZ is almost ready to be officially launched
yes, we have just a few loose ends to tie and we are ready to go :) meanwhile, I am putting some reviews on the site, so people will not get an empty site at the launch....